메뉴 건너뛰기




Volumn 69, Issue 2, 2009, Pages 422-430

Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL PROLIFERATION; CILIARY MOTILITY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; ONCOGENE; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREAS DUCT; PANCREAS INJURY; PANCREAS INTRAEPITHELIAL NEOPLASIA; PRIORITY JOURNAL;

EID: 58349099851     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-1290     Document Type: Article
Times cited : (226)

References (56)
  • 1
    • 0035498717 scopus 로고    scopus 로고
    • Bending the MDCK cell primary cilium increases intracellular calcium
    • Praetorius HA, Spring KR. Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol 2001;184:71-9.
    • (2001) J Membr Biol , vol.184 , pp. 71-79
    • Praetorius, H.A.1    Spring, K.R.2
  • 3
    • 24344482068 scopus 로고    scopus 로고
    • PKD2 functions as an epidermal growth factor-activated plasmamembrane channel
    • Ma R, Li WP, Rundle D, Kong J, Akbarali HI, Tsiokas L. PKD2 functions as an epidermal growth factor-activated plasmamembrane channel. Mol Cell Biol 2005;25:8285-98.
    • (2005) Mol Cell Biol , vol.25 , pp. 8285-8298
    • Ma, R.1    Li, W.P.2    Rundle, D.3    Kong, J.4    Akbarali, H.I.5    Tsiokas, L.6
  • 4
    • 40749144679 scopus 로고    scopus 로고
    • Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
    • Haycraft CJ, Banizs B, Aydin-Son Y, Zhang Q, Michaud EJ, Yoder BK. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 2005;1:e53.
    • (2005) PLoS Genet , vol.1
    • Haycraft, C.J.1    Banizs, B.2    Aydin-Son, Y.3    Zhang, Q.4    Michaud, E.J.5    Yoder, B.K.6
  • 5
    • 27144529532 scopus 로고    scopus 로고
    • PDGFR a signaling is regulated through the primary cilium in fibroblasts
    • Schneider L, Clement CA, Teilmann SC, et al. PDGFR a signaling is regulated through the primary cilium in fibroblasts. Curr Biol 2005;15:1861-6.
    • (2005) Curr Biol , vol.15 , pp. 1861-1866
    • Schneider, L.1    Clement, C.A.2    Teilmann, S.C.3
  • 6
    • 0015048017 scopus 로고
    • The relationship of cilia with cell division and differentiation
    • Fonte VG, Searls RL, Hilfer SR. The relationship of cilia with cell division and differentiation. J Cell Biol 1971;49:226-9.
    • (1971) J Cell Biol , vol.49 , pp. 226-229
    • Fonte, V.G.1    Searls, R.L.2    Hilfer, S.R.3
  • 7
    • 0018287375 scopus 로고
    • Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells
    • Tucker RW, Pardee AB, Fujiwara K. Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells. Cell 1979;17:527-35.
    • (1979) Cell , vol.17 , pp. 527-535
    • Tucker, R.W.1    Pardee, A.B.2    Fujiwara, K.3
  • 8
    • 0031750484 scopus 로고    scopus 로고
    • Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons
    • Cole DG, Diener DR, Himelblau AL, Beech PL, Fuster JC, Rosenbaum JL. Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons. J Cell Biol 1998;141:993-1008.
    • (1998) J Cell Biol , vol.141 , pp. 993-1008
    • Cole, D.G.1    Diener, D.R.2    Himelblau, A.L.3    Beech, P.L.4    Fuster, J.C.5    Rosenbaum, J.L.6
  • 9
    • 0018694416 scopus 로고
    • The resorption of primary cilia during mitosis in a vertebrate (PtK1) cell line
    • Rieder CL, Jensen CG, Jensen LC. The resorption of primary cilia during mitosis in a vertebrate (PtK1) cell line. J Ultrastruct Res 1979;68:173-85.
    • (1979) J Ultrastruct Res , vol.68 , pp. 173-185
    • Rieder, C.L.1    Jensen, C.G.2    Jensen, L.C.3
  • 10
    • 0028322016 scopus 로고
    • Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice
    • Moyer JH, Lee-Tischler MJ, Kwon HY, et al. Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science 1994;264:1329-33.
    • (1994) Science , vol.264 , pp. 1329-1333
    • Moyer, J.H.1    Lee-Tischler, M.J.2    Kwon, H.Y.3
  • 11
    • 0029826384 scopus 로고    scopus 로고
    • Oval cell proliferation associated with the murine insertional mutation TgN737Rpw
    • Richards WG, Yoder BK, Isfort RJ, et al. Oval cell proliferation associated with the murine insertional mutation TgN737Rpw. Am J Pathol 1996;149:1919-30.
    • (1996) Am J Pathol , vol.149 , pp. 1919-1930
    • Richards, W.G.1    Yoder, B.K.2    Isfort, R.J.3
  • 12
    • 0034735526 scopus 로고    scopus 로고
    • Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella
    • Pazour GJ, Dickert BL, Vucica Y, et al. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol 2000;151:709-18.
    • (2000) J Cell Biol , vol.151 , pp. 709-718
    • Pazour, G.J.1    Dickert, B.L.2    Vucica, Y.3
  • 13
    • 3042738924 scopus 로고    scopus 로고
    • Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport
    • Blacque OE, Reardon MJ, Li C, et al. Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev 2004;18:1630-42.
    • (2004) Genes Dev , vol.18 , pp. 1630-1642
    • Blacque, O.E.1    Reardon, M.J.2    Li, C.3
  • 14
    • 4243144134 scopus 로고    scopus 로고
    • Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
    • Cano DA, Murcia NS, Pazour GJ, Hebrok M. Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 2004;131:3457-67.
    • (2004) Development , vol.131 , pp. 3457-3467
    • Cano, D.A.1    Murcia, N.S.2    Pazour, G.J.3    Hebrok, M.4
  • 15
    • 33845661591 scopus 로고    scopus 로고
    • Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis
    • Cano DA, Sekine S, Hebrok M. Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology 2006;131:1856-69.
    • (2006) Gastroenterology , vol.131 , pp. 1856-1869
    • Cano, D.A.1    Sekine, S.2    Hebrok, M.3
  • 16
    • 9844262261 scopus 로고    scopus 로고
    • The tetratrico-peptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene
    • Isfort RJ, Cody DB, Doersen CJ, et al. The tetratrico-peptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene. Oncogene 1997;15:1797-803.
    • (1997) Oncogene , vol.15 , pp. 1797-1803
    • Isfort, R.J.1    Cody, D.B.2    Doersen, C.J.3
  • 17
    • 1542395668 scopus 로고    scopus 로고
    • Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors
    • Bowers AJ, Boylan JF. Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors. Gene 2004;328:135-42.
    • (2004) Gene , vol.328 , pp. 135-142
    • Bowers, A.J.1    Boylan, J.F.2
  • 18
    • 22344446254 scopus 로고    scopus 로고
    • A NIMA-related kinase, Cnk2p, regulates both flagellar length and cell size in Chlamydomonas
    • Bradley BA, Quarmby LM. A NIMA-related kinase, Cnk2p, regulates both flagellar length and cell size in Chlamydomonas. J Cell Sci 2005;118:3317-26.
    • (2005) J Cell Sci , vol.118 , pp. 3317-3326
    • Bradley, B.A.1    Quarmby, L.M.2
  • 19
    • 33645904854 scopus 로고    scopus 로고
    • NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes
    • Mahjoub MR, Trapp ML, Quarmby LM. NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes. J Am Soc Nephrol 2005;16:3485-9.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3485-3489
    • Mahjoub, M.R.1    Trapp, M.L.2    Quarmby, L.M.3
  • 20
    • 33745819269 scopus 로고    scopus 로고
    • Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein
    • Esteban MA, Harten SK, Tran MG, Maxwell PH. Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. J Am Soc Nephrol 2006;17:1801-6.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1801-1806
    • Esteban, M.A.1    Harten, S.K.2    Tran, M.G.3    Maxwell, P.H.4
  • 21
    • 33746886185 scopus 로고    scopus 로고
    • Primary cilium formation requires von hippel-lindau gene function in renal-derived cells
    • Lutz MS, Burk RD. Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Cancer Res 2006;66:6903-7.
    • (2006) Cancer Res , vol.66 , pp. 6903-6907
    • Lutz, M.S.1    Burk, R.D.2
  • 22
    • 34250758641 scopus 로고    scopus 로고
    • HEF1-dependent Aurora A activation induces disassembly of the primary cilium
    • Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 2007;129:1351-63.
    • (2007) Cell , vol.129 , pp. 1351-1363
    • Pugacheva, E.N.1    Jablonski, S.A.2    Hartman, T.R.3    Henske, E.P.4    Golemis, E.A.5
  • 23
    • 0032840429 scopus 로고    scopus 로고
    • Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas
    • Bonura C, Paterlini-Brechot P, Brechot C. Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas. Hepatology 1999;30:677-81.
    • (1999) Hepatology , vol.30 , pp. 677-681
    • Bonura, C.1    Paterlini-Brechot, P.2    Brechot, C.3
  • 25
    • 0020602127 scopus 로고
    • A light and electron microscopic study on the pancreatic ductal system
    • Kodama T. A light and electron microscopic study on the pancreatic ductal system. Acta Pathol Jpn 1983;33:297-321.
    • (1983) Acta Pathol Jpn , vol.33 , pp. 297-321
    • Kodama, T.1
  • 26
    • 3242744313 scopus 로고    scopus 로고
    • An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms
    • Hruban RH, Takaori K, Klimstra DS, et al. An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 2004;28:977-87.
    • (2004) Am J Surg Pathol , vol.28 , pp. 977-987
    • Hruban, R.H.1    Takaori, K.2    Klimstra, D.S.3
  • 27
    • 24944572259 scopus 로고    scopus 로고
    • Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
    • Stanger BZ, Stiles B, Lauwers GY, et al. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 2005;8:185-95.
    • (2005) Cancer Cell , vol.8 , pp. 185-195
    • Stanger, B.Z.1    Stiles, B.2    Lauwers, G.Y.3
  • 29
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani SR, Petricoin EF, Maitra A, et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003;4:437-50.
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1    Petricoin, E.F.2    Maitra, A.3
  • 30
    • 0346455774 scopus 로고    scopus 로고
    • Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    • Aguirre AJ, Bardeesy N, Sinha M, et al. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 2003;17:3112-26.
    • (2003) Genes Dev , vol.17 , pp. 3112-3126
    • Aguirre, A.J.1    Bardeesy, N.2    Sinha, M.3
  • 31
    • 34248372925 scopus 로고    scopus 로고
    • The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia
    • Carriere C, Seeley ES, Goetze T, Longnecker DS, Korc M. The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia. Proc Natl Acad Sci U S A 2007;104:4437-42.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4437-4442
    • Carriere, C.1    Seeley, E.S.2    Goetze, T.3    Longnecker, D.S.4    Korc, M.5
  • 32
    • 0033872039 scopus 로고    scopus 로고
    • Genetic progression in the pancreatic ducts
    • Hruban RH, Wilentz RE, Kern SE. Genetic progression in the pancreatic ducts. Am J Pathol 2000;156:1821-5.
    • (2000) Am J Pathol , vol.156 , pp. 1821-1825
    • Hruban, R.H.1    Wilentz, R.E.2    Kern, S.E.3
  • 33
    • 0345736922 scopus 로고    scopus 로고
    • Nestin expression in pancreatic exocrine cell lineages
    • Delacour A, Nepote V, Trumpp A, Herrera PL. Nestin expression in pancreatic exocrine cell lineages. Mech Dev 2004;121:3-14.
    • (2004) Mech Dev , vol.121 , pp. 3-14
    • Delacour, A.1    Nepote, V.2    Trumpp, A.3    Herrera, P.L.4
  • 34
    • 31544467540 scopus 로고    scopus 로고
    • Pathology of genetically engineered mouse models of pancreatic exocrine cancer: Consensus report and recommendations
    • Hruban RH, Adsay NV, Albores-Saavedra J, et al. Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res 2006;66:95-106.
    • (2006) Cancer Res , vol.66 , pp. 95-106
    • Hruban, R.H.1    Adsay, N.V.2    Albores-Saavedra, J.3
  • 35
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000;351:95-105.
    • (2000) Biochem J , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 36
    • 34249100668 scopus 로고    scopus 로고
    • Stopping ras in its tracks
    • Der CJ, Van Dyke T. Stopping ras in its tracks. Cell 2007;129:855-7.
    • (2007) Cell , vol.129 , pp. 855-857
    • CJ, D.1    Van Dyke, T.2
  • 37
    • 0036230171 scopus 로고    scopus 로고
    • Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): Additional evidence for a recently proposed model of progression
    • Klein WM, Hruban RH, Klein-Szanto AJ, Wilentz RE. Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression. Mod Pathol 2002;15:441-7.
    • (2002) Mod Pathol , vol.15 , pp. 441-447
    • Klein, W.M.1    Hruban, R.H.2    Klein-Szanto, A.J.3    Wilentz, R.E.4
  • 38
    • 8444236782 scopus 로고    scopus 로고
    • Proliferative activity in pancreatic intraepithelial neoplasias of chronic pancreatitis resection specimens: Detection of a high-risk lesion
    • Hermanova M, Nenutil R, Kren L, Feit J, Pavlovsky Z, Dite P. Proliferative activity in pancreatic intraepithelial neoplasias of chronic pancreatitis resection specimens: detection of a high-risk lesion. Neoplasma 2004;51:400-4.
    • (2004) Neoplasma , vol.51 , pp. 400-404
    • Hermanova, M.1    Nenutil, R.2    Kren, L.3    Feit, J.4    Pavlovsky, Z.5    Dite, P.6
  • 40
    • 34547939469 scopus 로고    scopus 로고
    • Cep97 and CP110 suppress a cilia assembly program
    • Spektor A, Tsang WY, Khoo D, Dynlacht BD. Cep97 and CP110 suppress a cilia assembly program. Cell 2007;130:678-90.
    • (2007) Cell , vol.130 , pp. 678-690
    • Spektor, A.1    Tsang, W.Y.2    Khoo, D.3    Dynlacht, B.D.4
  • 41
    • 34547667454 scopus 로고    scopus 로고
    • Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia
    • Zhu L, Shi G, Schmidt CM, Hruban RH, Konieczny SF. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol 2007;171:263-73.
    • (2007) Am J Pathol , vol.171 , pp. 263-273
    • Zhu, L.1    Shi, G.2    Schmidt, C.M.3    Hruban, R.H.4    Konieczny, S.F.5
  • 42
    • 0032898263 scopus 로고    scopus 로고
    • The morphological changes of exocrine pancreas in chronic pancreatitis
    • Ashizawa N, Niigaki M, Hamamoto N, et al. The morphological changes of exocrine pancreas in chronic pancreatitis. Histol Histopathol 1999;14:539-52.
    • (1999) Histol Histopathol , vol.14 , pp. 539-552
    • Ashizawa, N.1    Niigaki, M.2    Hamamoto, N.3
  • 43
    • 33847419143 scopus 로고    scopus 로고
    • Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    • Guerra C, Schuhmacher AJ, Canamero M, et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 2007;11:291-302.
    • (2007) Cancer Cell , vol.11 , pp. 291-302
    • Guerra, C.1    Schuhmacher, A.J.2    Canamero, M.3
  • 44
    • 36549077062 scopus 로고    scopus 로고
    • In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia
    • Strobel O, Dor Y, Alsina J, et al. In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology 2007;133:1999-2009.
    • (2007) Gastroenterology , vol.133 , pp. 1999-2009
    • Strobel, O.1    Dor, Y.2    Alsina, J.3
  • 45
    • 34247897276 scopus 로고    scopus 로고
    • Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis [see comment]
    • Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, Chodosh LA. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis [see comment]. Nat Cell Biol 2007;9:493-505.
    • (2007) Nat Cell Biol , vol.9 , pp. 493-505
    • Sarkisian, C.J.1    Keister, B.A.2    Stairs, D.B.3    Boxer, R.B.4    Moody, S.E.5    Chodosh, L.A.6
  • 46
    • 49449100123 scopus 로고    scopus 로고
    • Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines
    • Nielsen SK, Møllgård K, Clement CA, et al. Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines. Dev Dyn 2008;237:2039-52.
    • (2008) Dev Dyn , vol.237 , pp. 2039-2052
    • Nielsen, S.K.1    Møllgård, K.2    Clement, C.A.3
  • 48
    • 33745348878 scopus 로고    scopus 로고
    • Cytotoxic chemotherapy for pancreatic cancer: Advances to date and future directions
    • Xiong HQ, Carr K, Abbruzzese JL. Cytotoxic chemotherapy for pancreatic cancer: advances to date and future directions. Drugs 2006;66:1059-72.
    • (2006) Drugs , vol.66 , pp. 1059-1072
    • Xiong, H.Q.1    Carr, K.2    Abbruzzese, J.L.3
  • 49
    • 34249933404 scopus 로고    scopus 로고
    • National Cancer Institute of Canada Clinical Trials Group. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, et al. National Cancer Institute of Canada Clinical Trials Group. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007;25:1960-6.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 50
    • 23844517889 scopus 로고    scopus 로고
    • A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: A Southwest oncology group (SWOG 9924) study
    • Macdonald JS, McCoy S, Whitehead RP, et al. A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest oncology group (SWOG 9924) study. Invest New Drugs 2005;23:485-7.
    • (2005) Invest New Drugs , vol.23 , pp. 485-487
    • Macdonald, J.S.1    McCoy, S.2    Whitehead, R.P.3
  • 51
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott MP. Patched1 regulates hedgehog signaling at the primary cilium. Science 2007;317:372-6.
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 52
    • 54049115162 scopus 로고    scopus 로고
    • An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
    • Feldmann G, Fendrich V, McGovern K, et al. An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol Cancer Ther 2008;7:2725-35.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2725-2735
    • Feldmann, G.1    Fendrich, V.2    McGovern, K.3
  • 53
    • 34347253037 scopus 로고    scopus 로고
    • Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells
    • Ji Z, Mei FC, Xie J, Cheng X. Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem 2007;282:14048-55.
    • (2007) J Biol Chem , vol.282 , pp. 14048-14055
    • Ji, Z.1    Mei, F.C.2    Xie, J.3    Cheng, X.4
  • 54
    • 0031934765 scopus 로고    scopus 로고
    • Role of growth factors in pancreatic cancer
    • Korc M. Role of growth factors in pancreatic cancer. Surg Oncol Clin N Am 1998;7:25-41.
    • (1998) Surg Oncol Clin N Am , vol.7 , pp. 25-41
    • Korc, M.1
  • 55
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    • Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003;425:851-6.
    • (2003) Nature , vol.425 , pp. 851-856
    • Thayer, S.P.1    di Magliano, M.P.2    Heiser, P.W.3
  • 56
    • 42649138943 scopus 로고    scopus 로고
    • Common activation of canonical Wnt signaling in pancreatic adenocarcinoma
    • Pasca di Magliano M, Biankin AV, Heiser PW, et al. Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. PLos ONE 2007;2:e1155.
    • (2007) PLos ONE , vol.2
    • Pasca di Magliano, M.1    Biankin, A.V.2    Heiser, P.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.