Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4

Developmental Biology

Volumn 325, Issue 1, 2009, Pages 225-237

  Cortellino, Salvatore ^a   Wang, Chengbing ^b   Wang, Baolin ^b   Bassi, Maria Rosaria ^a   Caretti, Elena ^a   Champeval, Delphine ^c,d   Calmont, Amelie ^a   Jarnik, Michal ^a   Burch, John ^a   Zaret, Kenneth S ^a   Larue, Lionel ^c,d   Bellacosa, Alfonso ^a,e  

^a FOX CHASE CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c INSTITUT CURIE   (France)

^d CNRS UMR146   (France)

^e REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Ciliogenesis; Gli3; Intraflagellar transport; Limb patterning; Neuronal patterning; Situs viscerum inversus; Sonic Hedgehog

Indexed keywords

CARRIER PROTEIN; INTRAFLAGELLAR TRANSPORT PROTEIN; PROTEIN ARL 13B; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; UNCLASSIFIED DRUG;

ALLELE; ANIMAL TISSUE; ARTICLE; BLEEDING; CILIARY MOTILITY; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPAIR; EMBRYO; EMBRYO DEATH; EUKARYOTIC FLAGELLUM; EXENCEPHALY; GENE EXPRESSION; GENE MUTATION; GENE STRUCTURE; GENETIC DISORDER; HOMOZYGOSITY; IMMUNOHISTOCHEMISTRY; LIMB DEVELOPMENT; MOTONEURON; MOUSE; NEURAL TUBE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SITUS INVERSUS VISCERUM;

ERINACEIDAE; MAMMALIA;

EID: 58049208156     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2008.10.020     Document Type: Article

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