메뉴 건너뛰기




Volumn 10, Issue 7, 2015, Pages 703-711

Rodent models for Alzheimer's disease drug discovery

Author keywords

Aging; Alzheimer's disease; Behavior; Memory; Synaptic plasticity; Transgenic models

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; TAU PROTEIN;

EID: 84932088556     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2015.1041913     Document Type: Review
Times cited : (170)

References (89)
  • 1
    • 0000858425 scopus 로고
    • Über einen eigenartigen schweren Erkrankungsproze der Hirnrinde
    • Alzheimer A. Über einen eigenartigen schweren Erkrankungsproze der Hirnrinde. Neurol Centralblatt 1906;23:1129-36
    • (1906) Neurol Centralblatt , vol.23 , pp. 1129-1136
    • Alzheimer, A.1
  • 2
    • 0030981585 scopus 로고    scopus 로고
    • Auguste D and Alzheimer's disease
    • Maurer K, Volk S, Gerbaldo H. Auguste D and Alzheimer's disease. Lancet 1997;349:1546-9
    • (1997) Lancet , vol.349 , pp. 1546-1549
    • Maurer, K.1    Volk, S.2    Gerbaldo, H.3
  • 4
    • 0022628623 scopus 로고
    • Epidemiology of clinically diagnosed Alzheimer's disease
    • Rocca WA, Amaducci LA, Schoenberg BS. Epidemiology of clinically diagnosed Alzheimer's disease. Ann Neurol 1986;19:415-24
    • (1986) Ann Neurol , vol.19 , pp. 415-424
    • Rocca, W.A.1    Amaducci, L.A.2    Schoenberg, B.S.3
  • 5
    • 0033968306 scopus 로고    scopus 로고
    • Molecular genetics of Alzheimer's disease
    • St George-Hyslop PH. Molecular genetics of Alzheimer's disease. Biol Psychiatry 2000;47:183-99
    • (2000) Biol Psychiatry , vol.47 , pp. 183-199
    • St George-Hyslop, P.H.1
  • 7
    • 84924262484 scopus 로고    scopus 로고
    • Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer's Disease
    • Xia D, Watanabe H, Wu B, et al. Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer's Disease. Neuron 2015;85:967-81
    • (2015) Neuron , vol.85 , pp. 967-981
    • Xia, D.1    Watanabe, H.2    Wu, B.3
  • 8
    • 0025743350 scopus 로고
    • Formation of beta-amyloid protein deposits in brains of transgenic mice
    • Quon D, Wang Y, Catalano R, et al. Formation of beta-amyloid protein deposits in brains of transgenic mice. Nature 1991;352:239-41
    • (1991) Nature , vol.352 , pp. 239-241
    • Quon, D.1    Wang, Y.2    Catalano, R.3
  • 9
    • 0028232799 scopus 로고
    • Transgenic mouse brain histopathology resembles early Alzheimer's disease
    • Higgins LS, Holtzman DM, Rabin J, et al. Transgenic mouse brain histopathology resembles early Alzheimer's disease. Ann Neurol 1994;35:598-607
    • (1994) Ann Neurol , vol.35 , pp. 598-607
    • Higgins, L.S.1    Holtzman, D.M.2    Rabin, J.3
  • 10
    • 0025880935 scopus 로고
    • Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice
    • Sandhu FA, Salim M, Zain SB. Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice. J Biol Chem 1991;266:21331-4
    • (1991) J Biol Chem , vol.266 , pp. 21331-21334
    • Sandhu, F.A.1    Salim, M.2    Zain, S.B.3
  • 11
    • 0027242091 scopus 로고
    • Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]
    • Lamb BT, Sisodia SS, Lawler AM, et al. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nat Genet 1993;5:22-30
    • (1993) Nat Genet , vol.5 , pp. 22-30
    • Lamb, B.T.1    Sisodia, S.S.2    Lawler, A.M.3
  • 12
    • 0027332052 scopus 로고
    • Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice
    • Pearson BE, Choi TK. Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice. Proc Natl Acad Sci USA 1993;90:10578-82
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10578-10582
    • Pearson, B.E.1    Choi, T.K.2
  • 13
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
    • Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 1995;373:523-7
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1    Adams, D.2    Alessandrini, R.3
  • 14
    • 0029813177 scopus 로고    scopus 로고
    • Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease
    • Masliah E, Sisk A, Mallory M, et al. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J Neurosci 1996;16:5795-811
    • (1996) J Neurosci , vol.16 , pp. 5795-5811
    • Masliah, E.1    Sisk, A.2    Mallory, M.3
  • 15
    • 0033501744 scopus 로고    scopus 로고
    • Behavioral disturbances in transgenic mice overexpressing the V717F betaamyloid precursor protein
    • Dodart JC, Meziane H, Mathis C, et al. Behavioral disturbances in transgenic mice overexpressing the V717F betaamyloid precursor protein. Behav Neurosci 1999;113:982-90
    • (1999) Behav Neurosci , vol.113 , pp. 982-990
    • Dodart, J.C.1    Meziane, H.2    Mathis, C.3
  • 16
    • 0034700480 scopus 로고    scopus 로고
    • A learning deficit related to age and betaamyloid plaques in a mouse model of Alzheimer's disease
    • Chen G, Chen KS, Knox J, et al. A learning deficit related to age and betaamyloid plaques in a mouse model of Alzheimer's disease. Nature 2000;408:975-9
    • (2000) Nature , vol.408 , pp. 975-979
    • Chen, G.1    Chen, K.S.2    Knox, J.3
  • 17
    • 0037112079 scopus 로고    scopus 로고
    • Behavioral impairment of APP(V717F) mice in fear conditioning: Is it only cognition?
    • Gerlai R, Fitch T, Bales KR, et al. Behavioral impairment of APP(V717F) mice in fear conditioning: is it only cognition? Behav Brain Res 2002;136:503-9
    • (2002) Behav Brain Res , vol.136 , pp. 503-509
    • Gerlai, R.1    Fitch, T.2    Bales, K.R.3
  • 18
    • 0034107615 scopus 로고    scopus 로고
    • Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice
    • Dodart JC, Mathis C, Saura J, et al. Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice. Neurobiol Dis 2000;7:71-85
    • (2000) Neurobiol Dis , vol.7 , pp. 71-85
    • Dodart, J.C.1    Mathis, C.2    Saura, J.3
  • 19
    • 0345636018 scopus 로고    scopus 로고
    • Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model
    • Reilly JF, Games D, Rydel RE, et al. Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model. Proc Natl Acad Sci USA 2003;100:4837-42
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4837-4842
    • Reilly, J.F.1    Games, D.2    Rydel, R.E.3
  • 20
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996;274:99-102
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3
  • 21
    • 0036743625 scopus 로고    scopus 로고
    • Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease
    • Corcoran KA, Lu Y, Turner RS, et al. Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease. Learn Mem 2002;9:243-52
    • (2002) Learn Mem , vol.9 , pp. 243-252
    • Corcoran, K.A.1    Lu, Y.2    Turner, R.S.3
  • 22
    • 0037088956 scopus 로고    scopus 로고
    • Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months
    • King DL, Arendash GW. Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months. Physiol Behav 2002;75:627-42
    • (2002) Physiol Behav , vol.75 , pp. 627-642
    • King, D.L.1    Arendash, G.W.2
  • 23
    • 0033360356 scopus 로고    scopus 로고
    • Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
    • Chapman PF, White GL, Jones MW, et al. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 1999;2:271-6
    • (1999) Nat Neurosci , vol.2 , pp. 271-276
    • Chapman, P.F.1    White, G.L.2    Jones, M.W.3
  • 24
    • 2442711566 scopus 로고    scopus 로고
    • Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques
    • Stern EA, Bacskai BJ, Hickey GA, et al. Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques. J Neurosci 2004;24:4535-40
    • (2004) J Neurosci , vol.24 , pp. 4535-4540
    • Stern, E.A.1    Bacskai, B.J.2    Hickey, G.A.3
  • 25
    • 0038022595 scopus 로고    scopus 로고
    • Transgenic mice expressing the betaAPP695SWE mutation: Effects on exploratory activity, anxiety, and motor coordination
    • Lalonde R, Lewis TL, Strazielle C, et al. Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination. Brain Res 2003;977:38-45
    • (2003) Brain Res , vol.977 , pp. 38-45
    • Lalonde, R.1    Lewis, T.L.2    Strazielle, C.3
  • 26
    • 34249733132 scopus 로고    scopus 로고
    • Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice
    • Gil-Bea FJ, Aisa B, Schliebs R, et al. Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice. Behav Neurosci 2007;121:340-4
    • (2007) Behav Neurosci , vol.121 , pp. 340-344
    • Gil-Bea, F.J.1    Aisa, B.2    Schliebs, R.3
  • 27
    • 79960980430 scopus 로고    scopus 로고
    • Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice
    • Bedrosian TA, Herring KL, Weil ZM, et al. Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice. Proc Natl Acad Sci USA 2011;108:11686-91
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11686-11691
    • Bedrosian, T.A.1    Herring, K.L.2    Weil, Z.M.3
  • 28
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb L, Gordon MN, McGowan E, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 1998;4:97-100
    • (1998) Nat Med , vol.4 , pp. 97-100
    • Holcomb, L.1    Gordon, M.N.2    McGowan, E.3
  • 29
    • 2542584749 scopus 로고    scopus 로고
    • Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice
    • Trinchese F, Liu S, Battaglia F, et al. Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Ann Neurol 2004;55:801-14
    • (2004) Ann Neurol , vol.55 , pp. 801-814
    • Trinchese, F.1    Liu, S.2    Battaglia, F.3
  • 30
    • 34447316702 scopus 로고    scopus 로고
    • Genetics of Alzheimer's disease: A centennial review
    • Ertekin-Taner N. Genetics of Alzheimer's disease: a centennial review. Neurol Clin 2007;25:611-67
    • (2007) Neurol Clin , vol.25 , pp. 611-667
    • Ertekin-Taner, N.1
  • 31
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
    • Duff K, Eckman C, Zehr C, et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 1996;383:710-13
    • (1996) Nature , vol.383 , pp. 710-713
    • Duff, K.1    Eckman, C.2    Zehr, C.3
  • 32
    • 13044278313 scopus 로고    scopus 로고
    • Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
    • Herreman A, Hartmann D, Annaert W, et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci USA 1999;96:11872-7
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11872-11877
    • Herreman, A.1    Hartmann, D.2    Annaert, W.3
  • 33
    • 0030293676 scopus 로고    scopus 로고
    • Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
    • Borchelt DR, Thinakaran G, Eckman CB, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 1996;17:1005-13
    • (1996) Neuron , vol.17 , pp. 1005-1013
    • Borchelt, D.R.1    Thinakaran, G.2    Eckman, C.B.3
  • 34
    • 0030833055 scopus 로고    scopus 로고
    • Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
    • Borchelt DR, Ratovitski T, van Lare J, et al. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 1997;19:939-45
    • (1997) Neuron , vol.19 , pp. 939-945
    • Borchelt, D.R.1    Ratovitski, T.2    Van Lare, J.3
  • 35
    • 85047694516 scopus 로고    scopus 로고
    • Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment
    • Gong B, Vitolo OV, Trinchese F, et al. Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest 2004;114:1624-34
    • (2004) J Clin Invest , vol.114 , pp. 1624-1634
    • Gong, B.1    Vitolo, O.V.2    Trinchese, F.3
  • 36
    • 33747199933 scopus 로고    scopus 로고
    • Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
    • Gong B, Cao Z, Zheng P, et al. Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell 2006;126:775-88
    • (2006) Cell , vol.126 , pp. 775-788
    • Gong, B.1    Cao, Z.2    Zheng, P.3
  • 37
    • 48749089723 scopus 로고    scopus 로고
    • Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
    • Trinchese F, Fa' M, Liu S, et al. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest 2008;118:2796-807
    • (2008) J Clin Invest , vol.118 , pp. 2796-2807
    • Trinchese, F.1    Fa, M.2    Liu, S.3
  • 38
    • 67649342620 scopus 로고    scopus 로고
    • Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloidbeta load in an Alzheimer's disease mouse model
    • Puzzo D, Staniszewski A, Deng SX, et al. Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloidbeta load in an Alzheimer's disease mouse model. J Neurosci 2009;29:8075-86
    • (2009) J Neurosci , vol.29 , pp. 8075-8086
    • Puzzo, D.1    Staniszewski, A.2    Deng, S.X.3
  • 39
    • 84878926831 scopus 로고    scopus 로고
    • Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease
    • Perez-Gonzalez R, Pascual C, Antequera D, et al. Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease. Neurobiol Aging 2013;34:2133-45
    • (2013) Neurobiol Aging , vol.34 , pp. 2133-2145
    • Perez-Gonzalez, R.1    Pascual, C.2    Antequera, D.3
  • 40
    • 84878735316 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers betaamyloid levels and improves cognitive performance in APP/PS1 transgenic mice
    • Zhang J, Guo J, Zhao X, et al. Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers betaamyloid levels and improves cognitive performance in APP/PS1 transgenic mice. Behav Brain Res 2013;250:230-7
    • (2013) Behav Brain Res , vol.250 , pp. 230-237
    • Zhang, J.1    Guo, J.2    Zhao, X.3
  • 41
    • 84901809066 scopus 로고    scopus 로고
    • Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice
    • Liu MY, Wang S, Yao WF, et al. Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice. Neuroscience 2014;273:141-51
    • (2014) Neuroscience , vol.273 , pp. 141-151
    • Liu, M.Y.1    Wang, S.2    Yao, W.F.3
  • 42
    • 84886592674 scopus 로고    scopus 로고
    • Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease
    • McClean PL, Hölscher C. Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease. Neuropharmacology 2014;76:57-67
    • (2014) Neuropharmacology , vol.76 , pp. 57-67
    • McClean, P.L.1    Hölscher, C.2
  • 43
    • 84886247782 scopus 로고    scopus 로고
    • Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D
    • Sierksma AS, van den Hove DL, Pfau F, et al. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology 2014;77:120-30
    • (2014) Neuropharmacology , vol.77 , pp. 120-130
    • Sierksma, A.S.1    Van Den Hove, D.L.2    Pfau, F.3
  • 44
    • 84911390394 scopus 로고    scopus 로고
    • Lamotrigine attenuates deficits in synaptic plasticity and accumulation of amyloid plaques in APP/PS1 transgenic mice
    • Zhang MY, Zheng CY, Zou MM, et al. Lamotrigine attenuates deficits in synaptic plasticity and accumulation of amyloid plaques in APP/PS1 transgenic mice. Neurobiol Aging 2014;35:2713-25
    • (2014) Neurobiol Aging , vol.35 , pp. 2713-2725
    • Zhang, M.Y.1    Zheng, C.Y.2    Zou, M.M.3
  • 45
    • 84928714878 scopus 로고    scopus 로고
    • Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice
    • [Epub ahead of print]
    • Li H, Ruberu K, Muñoz SS, et al. Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice. Neurobiol Aging 2015. [Epub ahead of print]
    • (2015) Neurobiol Aging
    • Li, H.1    Ruberu, K.2    Muñoz, S.S.3
  • 46
    • 84921830348 scopus 로고    scopus 로고
    • Acute oral Bryostatin-1 administration improves learning deficits in the APP/PS1 transgenic mouse model of Alzheimer's disease
    • Schrott LM, Jackson K, Yi P, et al. Acute oral Bryostatin-1 administration improves learning deficits in the APP/PS1 transgenic mouse model of Alzheimer's disease. Curr Alzheimer Res 2015;12:22-31
    • (2015) Curr Alzheimer Res , vol.12 , pp. 22-31
    • Schrott, L.M.1    Jackson, K.2    Yi, P.3
  • 47
    • 0035830686 scopus 로고    scopus 로고
    • Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
    • Arendash GW, King DL, Gordon MN, et al. Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res 2001;891:42-53
    • (2001) Brain Res , vol.891 , pp. 42-53
    • Arendash, G.W.1    King, D.L.2    Gordon, M.N.3
  • 48
    • 84888135522 scopus 로고    scopus 로고
    • Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease
    • Lok K, Zhao H, Zhang C, et al. Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease. J Neurol Sci 2013;335:145-54
    • (2013) J Neurol Sci , vol.335 , pp. 145-154
    • Lok, K.1    Zhao, H.2    Zhang, C.3
  • 49
    • 10044297055 scopus 로고    scopus 로고
    • Lifelong immunization with human beta-amyloid (1-42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging
    • Jensen MT, Mottin MD, Cracchiolo JR, et al. Lifelong immunization with human beta-amyloid (1-42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging. Neuroscience 2005;130:667-84
    • (2005) Neuroscience , vol.130 , pp. 667-684
    • Jensen, M.T.1    Mottin, M.D.2    Cracchiolo, J.R.3
  • 50
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
    • Oddo S, Caccamo A, Shepherd JD, et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003;39:409-21
    • (2003) Neuron , vol.39 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3
  • 51
    • 14644442872 scopus 로고    scopus 로고
    • Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
    • Billings LM, Oddo S, Green KN, et al. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 2005;45:675-88
    • (2005) Neuron , vol.45 , pp. 675-688
    • Billings, L.M.1    Oddo, S.2    Green, K.N.3
  • 52
    • 84906561770 scopus 로고    scopus 로고
    • Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease
    • Kazim SF, Blanchard J, Dai CL, et al. Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease. Neurobiol Dis 2014;71:110-30
    • (2014) Neurobiol Dis , vol.71 , pp. 110-130
    • Kazim, S.F.1    Blanchard, J.2    Dai, C.L.3
  • 53
    • 84909619128 scopus 로고    scopus 로고
    • Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study
    • Stevens LM, Brown RE. Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study. Behav Brain Res 2015;278:496-505
    • (2015) Behav Brain Res , vol.278 , pp. 496-505
    • Stevens, L.M.1    Brown, R.E.2
  • 54
    • 84925229148 scopus 로고    scopus 로고
    • Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer's disease
    • Cantarella G, Di Benedetto G, Puzzo D, et al. Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer's disease. Brain 2015;138:203-16
    • (2015) Brain , vol.138 , pp. 203-216
    • Cantarella, G.1    Di Benedetto, G.2    Puzzo, D.3
  • 55
    • 33845462134 scopus 로고    scopus 로고
    • Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: A role for intraneuronal amyloid
    • Gimenez-Llort L, Blázquez G, Cañete T, et al. Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid. Neurosci Biobehav Rev 2007;31:125-47
    • (2007) Neurosci Biobehav Rev , vol.31 , pp. 125-147
    • Gimenez-Llort, L.1    Blázquez, G.2    Cañete, T.3
  • 56
    • 50849089646 scopus 로고    scopus 로고
    • Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease
    • Pietropaolo S, Feldon J, Yee BK. Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease. Behav Neurosci 2008;122:733-47
    • (2008) Behav Neurosci , vol.122 , pp. 733-747
    • Pietropaolo, S.1    Feldon, J.2    Yee, B.K.3
  • 57
    • 77955711695 scopus 로고    scopus 로고
    • Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes
    • Sterniczuk R, Antle MC, Laferla FM, et al. Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes. Brain Res 2010;1348:149-55
    • (2010) Brain Res , vol.1348 , pp. 149-155
    • Sterniczuk, R.1    Antle, M.C.2    Laferla, F.M.3
  • 58
    • 42649141628 scopus 로고    scopus 로고
    • Decreased presence of perforated synapses in a triple-transgenic mouse model of Alzheimer's disease
    • Bertoni-Freddari C, Sensi SL, Giorgetti B, et al. Decreased presence of perforated synapses in a triple-transgenic mouse model of Alzheimer's disease. Rejuvenation Res 2008;11:309-13
    • (2008) Rejuvenation Res , vol.11 , pp. 309-313
    • Bertoni-Freddari, C.1    Sensi, S.L.2    Giorgetti, B.3
  • 59
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation
    • Oakley H, Cole SL, Logan S, et al. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci 2006;26:10129-40
    • (2006) J Neurosci , vol.26 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3
  • 60
    • 81355124089 scopus 로고    scopus 로고
    • Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Ab aggregation in the 5XFAD mouse model of Alzheimer's disease
    • Jawhar S, Trawicka A, Jenneckens C, et al. Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Ab aggregation in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Aging 2012;33:196.e29-40
    • (2012) Neurobiol Aging , vol.33 , pp. 196e29-196e40
    • Jawhar, S.1    Trawicka, A.2    Jenneckens, C.3
  • 61
    • 0041803006 scopus 로고    scopus 로고
    • Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
    • Andorfer C, Kress Y, Espinoza M, et al. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 2003;86:582-90
    • (2003) J Neurochem , vol.86 , pp. 582-590
    • Andorfer, C.1    Kress, Y.2    Espinoza, M.3
  • 62
    • 84873687399 scopus 로고    scopus 로고
    • Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice
    • Ma QL, Zuo X, Yang F, et al. Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. J Biol Chem 2013;288:4056-65
    • (2013) J Biol Chem , vol.288 , pp. 4056-4065
    • Ma, Q.L.1    Zuo, X.2    Yang, F.3
  • 63
    • 84901776466 scopus 로고    scopus 로고
    • Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds
    • Castillo-Carranza DL, Gerson JE, Sengupta U, et al. Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds. J Alzheimers Dis 2014;40:S97-111
    • (2014) J Alzheimers Dis , vol.40 , pp. S97-111
    • Castillo-Carranza, D.L.1    Gerson, J.E.2    Sengupta, U.3
  • 64
    • 69449093036 scopus 로고    scopus 로고
    • Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology
    • Polydoro M, Acker CM, Duff K, et al. Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J Neurosci 2009;29:10741-9
    • (2009) J Neurosci , vol.29 , pp. 10741-10749
    • Polydoro, M.1    Acker, C.M.2    Duff, K.3
  • 65
    • 34547252566 scopus 로고    scopus 로고
    • Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: Functionbased and target-based discovery approaches
    • Van Eldik LJ, Thompson WL, Ralay Ranaivo H, et al. Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: functionbased and target-based discovery approaches. Int Rev Neurobiol 2007;82:277-96
    • (2007) Int Rev Neurobiol , vol.82 , pp. 277-296
    • Van Eldik, L.J.1    Thompson, W.L.2    Ralay Ranaivo, H.3
  • 66
    • 84903699375 scopus 로고    scopus 로고
    • In vivo application of beta amyloid oligomers: A simple tool to evaluate mechanisms of action and new therapeutic approaches
    • Balducci C, Forloni G. In vivo application of beta amyloid oligomers: a simple tool to evaluate mechanisms of action and new therapeutic approaches. Curr Pharm Des 2014;20:2491-505
    • (2014) Curr Pharm des , vol.20 , pp. 2491-2505
    • Balducci, C.1    Forloni, G.2
  • 67
    • 84897464856 scopus 로고    scopus 로고
    • Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines
    • Puzzo D, Lee L, Palmeri A, et al. Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines. Biochem Pharmacol 2014;88:450-67
    • (2014) Biochem Pharmacol , vol.88 , pp. 450-467
    • Puzzo, D.1    Lee, L.2    Palmeri, A.3
  • 68
    • 84932152759 scopus 로고    scopus 로고
    • Evaluation of the effect of extracellular tau oligomers on synaptic function
    • Washington DC, USA
    • Moe JG, Puzzo D, Chatterjee I, et al. Evaluation of the effect of extracellular tau oligomers on synaptic function. Society for Neurosciences; Washington DC, USA. 2008
    • (2008) Society for Neurosciences
    • Moe, J.G.1    Puzzo, D.2    Chatterjee, I.3
  • 69
    • 80052686419 scopus 로고    scopus 로고
    • Modulation of synaptic function by extracellular tau enriched in oligomers
    • Moe JG, Chatterjee I, Davidowitz EJ, et al. Modulation of synaptic function by extracellular tau enriched in oligomers. Alzheimers Dement 2009;5:P499
    • (2009) Alzheimers Dement , vol.5 , pp. P499
    • Moe, J.G.1    Chatterjee, I.2    Davidowitz, E.J.3
  • 71
    • 84897446700 scopus 로고    scopus 로고
    • Extracellular oligomeric tau inhibits memory formation in mice
    • Moe JG, Chatterjee I, Puzzo D, et al. Extracellular oligomeric tau inhibits memory formation in mice. Alzheimers Dement 2010;6:S277
    • (2010) Alzheimers Dement , vol.6 , pp. S277
    • Moe, J.G.1    Chatterjee, I.2    Puzzo, D.3
  • 72
    • 58149385218 scopus 로고    scopus 로고
    • Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus
    • Puzzo D, Privitera L, Leznik E, et al. Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci 2008;28:14537-45
    • (2008) J Neurosci , vol.28 , pp. 14537-14545
    • Puzzo, D.1    Privitera, L.2    Leznik, E.3
  • 73
    • 79955474315 scopus 로고    scopus 로고
    • Endogenous amyloid-b is necessary for hippocampal synaptic plasticity and memory
    • Puzzo D, Privitera L, Fa' M, et al. Endogenous amyloid-b is necessary for hippocampal synaptic plasticity and memory. Ann Neurol 2011;69:819-30
    • (2011) Ann Neurol , vol.69 , pp. 819-830
    • Puzzo, D.1    Privitera, L.2    Fa, M.3
  • 74
    • 84861198956 scopus 로고    scopus 로고
    • Hormetic effect of amyloid-b peptide in synaptic plasticity and memory
    • Puzzo D, Privitera L, Palmeri A. Hormetic effect of amyloid-b peptide in synaptic plasticity and memory. Neurobiol Aging 2012;33:1484.e15-24
    • (2012) Neurobiol Aging , vol.33 , pp. 1484e15-1484e24
    • Puzzo, D.1    Privitera, L.2    Palmeri, A.3
  • 75
    • 84872115394 scopus 로고    scopus 로고
    • Synthesis of quinoline derivatives: Discovery of a potent and selective phosphodiesterase 5 inhibitor for thetreatment of Alzheimer's disease
    • Fiorito J, Saeed F, Zhang H, et al. Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for thetreatment of Alzheimer's disease. Eur J Med Chem 2013;60:285-94
    • (2013) Eur J Med Chem , vol.60 , pp. 285-294
    • Fiorito, J.1    Saeed, F.2    Zhang, H.3
  • 76
    • 84879526339 scopus 로고    scopus 로고
    • Development of Novel in Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction
    • Watterson DM, Grum-Tokars VL, Roy SM, et al. Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. PLoS One 2013;8:e66226
    • (2013) PLoS One , vol.8 , pp. e66226
    • Watterson, D.M.1    Grum-Tokars, V.L.2    Roy, S.M.3
  • 77
    • 84875080648 scopus 로고    scopus 로고
    • Inhibition of phosphodiesterase-5 rescues age-related impairment of synaptic plasticity and memory
    • Palmeri A, Privitera L, Giunta S, et al. Inhibition of phosphodiesterase-5 rescues age-related impairment of synaptic plasticity and memory. Behav Brain Res 2013;240:11-20
    • (2013) Behav Brain Res , vol.240 , pp. 11-20
    • Palmeri, A.1    Privitera, L.2    Giunta, S.3
  • 78
    • 84889560709 scopus 로고    scopus 로고
    • Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice
    • Puzzo D, Loreto C, Giunta S, et al. Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice. Neurobiol Aging 2014;35:520-31
    • (2014) Neurobiol Aging , vol.35 , pp. 520-531
    • Puzzo, D.1    Loreto, C.2    Giunta, S.3
  • 79
    • 84925304108 scopus 로고    scopus 로고
    • Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice
    • Puzzo D, Bizzoca A, Loreto C, et al. Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice. Neurobiol Aging 2015;36:1702-15
    • (2015) Neurobiol Aging , vol.36 , pp. 1702-1715
    • Puzzo, D.1    Bizzoca, A.2    Loreto, C.3
  • 80
    • 0019850002 scopus 로고
    • A new murine model of accelerated senescence
    • Takeda T, Hosokawa M, Takeshita S, et al. A new murine model of accelerated senescence. Mech Ageing Dev 1981;17:183-94
    • (1981) Mech Ageing Dev , vol.17 , pp. 183-194
    • Takeda, T.1    Hosokawa, M.2    Takeshita, S.3
  • 81
    • 0036346458 scopus 로고    scopus 로고
    • Generation of genetically altered mouse models for aging studies
    • Treuting PM, Hopkins HC, Ware CA, et al. Generation of genetically altered mouse models for aging studies. Exp Mol Pathol 2002;72:49-55
    • (2002) Exp Mol Pathol , vol.72 , pp. 49-55
    • Treuting, P.M.1    Hopkins, H.C.2    Ware, C.A.3
  • 82
    • 79960949693 scopus 로고    scopus 로고
    • Introduction: Animal models of aging: Something old, something new
    • Sprott RL. Introduction: animal models of aging: something old, something new. ILAR J 2011;52:1-3
    • (2011) ILAR J , vol.52 , pp. 1-3
    • Sprott, R.L.1
  • 83
    • 84862112368 scopus 로고    scopus 로고
    • Insights into CNS ageing from animal models of senescence
    • Yeoman M, Scutt G, Faragher R. Insights into CNS ageing from animal models of senescence. Nat Rev Neurosci 2012;13:435-45
    • (2012) Nat Rev Neurosci , vol.13 , pp. 435-445
    • Yeoman, M.1    Scutt, G.2    Faragher, R.3
  • 84
    • 63349105631 scopus 로고    scopus 로고
    • Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding protein signaling cascade
    • Li Q, Zhao HF, Zhang ZF, et al. Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding protein signaling cascade. Neuroscience 2009;159:1208-15
    • (2009) Neuroscience , vol.159 , pp. 1208-1215
    • Li, Q.1    Zhao, H.F.2    Zhang, Z.F.3
  • 85
    • 78650719643 scopus 로고    scopus 로고
    • Spatial and emotional memory in aged rats: A behavioral-statistical analysis
    • Bergado JA, Almaguer W, Rojas Y, et al. Spatial and emotional memory in aged rats: a behavioral-statistical analysis. Neuroscience 2011;172:256-69
    • (2011) Neuroscience , vol.172 , pp. 256-269
    • Bergado, J.A.1    Almaguer, W.2    Rojas, Y.3
  • 86
    • 67449161543 scopus 로고    scopus 로고
    • Differential impairment of spatial and nonspatial cognition in a mouse model of brain aging
    • Wang W, Li S, Dong HP, et al. Differential impairment of spatial and nonspatial cognition in a mouse model of brain aging. Life Sci 2009;85:127-35
    • (2009) Life Sci , vol.85 , pp. 127-135
    • Wang, W.1    Li, S.2    Dong, H.P.3
  • 87
    • 84860261447 scopus 로고    scopus 로고
    • Hippocampal calbindin-1 immunoreactivity correlate of recognition memory performance in aged mice
    • Soontornniyomkij V, Risbrough VB, Young JW, et al. Hippocampal calbindin-1 immunoreactivity correlate of recognition memory performance in aged mice. Neurosci Lett 2012;516:161-5
    • (2012) Neurosci Lett , vol.516 , pp. 161-165
    • Soontornniyomkij, V.1    Risbrough, V.B.2    Young, J.W.3
  • 88
    • 64549113016 scopus 로고    scopus 로고
    • Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease
    • Placanica L, Zhu L, Li YM. Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. PLoS One 2009;4:e5088
    • (2009) PLoS One , vol.4 , pp. e5088
    • Placanica, L.1    Zhu, L.2    Li, Y.M.3
  • 89
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe DJ. Alzheimer's disease is a synaptic failure. Science 2002;298:789-91
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.