Atypical antineutrophil cytoplasmic antibodies with perinuclear fluorescence in chronic inflammatory bowel diseases and hepatobiliary disorders colocalize with nuclear lamina proteins

Hepatology

Volumn 28, Issue 2, 1998, Pages 332-340

  Terjung, Birgit ^a,b   Herzog, Volker ^a   Worman, Howard J ^b   Gestmann, Ingo ^a   Bauer, Christoph ^a   Sauerbruch, Tilman ^a   Spengler, Ulrich ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; NEUTROPHIL CYTOPLASMIC ANTIBODY; POLYCLONAL ANTIBODY;

ADOLESCENT; ADULT; AGED; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNE HEPATITIS; CHILD; CHRONIC DISEASE; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATOBILIARY DISEASE; HUMAN; INFLAMMATORY DISEASE; MAJOR CLINICAL STUDY; MALE; POLYARTERITIS; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; ULCERATIVE COLITIS; WEGENER GRANULOMATOSIS;

ADOLESCENT; ADULT; AGED; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIGENS; BILIARY TRACT DISEASES; CELL NUCLEUS; CHILD; CHRONIC DISEASE; CYTOPLASM; DNA; FEMALE; FLUORESCENCE; HISTONES; HUMANS; INFLAMMATORY BOWEL DISEASES; LAMIN TYPE B; LAMINS; LIVER DISEASES; MALE; MIDDLE AGED; NUCLEAR PROTEINS;

EID: 0031879553     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510280207     Document Type: Article

References (18)

1. Falk RJ, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988;318:1651-1657.
2. Savage CO, Lockwood CM. Antineutrophil antibodies in vasculitis. Adv Nephrol 1990;19:225-236.
3. Duerr RH, Targan SR, Landers CJ, LaRusso NF, Lindsay KL, Wiesner RH, Shanahan E. Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 1991;100:-1385-1391.
4. Seibold F, Weber P, Klein P, Berg PA, Wiedemann KH. Clinical significance of antibodies against neutrophils in patients with inflammatory bowel disease and primary sclerosing cholangitis. Gut 1992;33:657-662.
5. Targan SR, Landers C, Vidrich A, Czaja AJ. High-liter antineutrophil cytoplasmic antibodies in type-1 autoimmune hepatitis. Gastroenterology 1995;108:1159-1166.
6. Zauli D, Ghetti S, Grassi A, Descovich C, Cassani F, Ballardini G, Muratori L, Bianchi FB. Anti-neutrophil cytoplasmic antibodies in type 1 and 2 autoimmune hepatitis. HEPATOLOGY 1997;25:1105-1107.
7. Semrad C, Terjung B, Worman HJ. Antineutrophil cytoplasmic and other autoantibodies in primary sclerosing cholangitis. In: Krawitt EL, Wies-ner RH, Nisioka M, eds. Autoimmune Liver Diseases. 2nd ed. Amsterdam: Elsevier Science Publisher B.V., 1998; in press.
8. Goldschmeding R, van der School CE, ten Bokkel Huinink D, Hack CE, van den Ende ME, Kallenberg CGM, Kr von dem Borne AEG. Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils. J Clin Invest 1989;84:1577-1587.
9. Jenne DE, Tschopp J, Lüdemann J, Utecht B, Gross WL. Wegener's autoantigen decoded. Nature 1990;346:520.
10. Peen E, Sundquist T, Skogh T. Leucocyte activation by anti-lactoferrin antibodies bound to vascular endothelium. Clin Exp Immunol 1996;103:403-407.
11. Mayet WJ, Hermann E, Finsterwalder J, Rieder H, Poralla T, Meyer zum Büschenfelde KH. Antibodies to cathepsin G in Crohn's disease. Eur J Clin Invest 1992;22:427-433.
12. Halbwachs-Mecarelli L, Nusbaum P, Noel LH, Reumaux D, Erlinger S, Grunefeld JP, Lesavre P. Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis. Clin Exp Immun 1992;90:79-84.
13. Stoffel MP, Csernok E, Herzberg C, Johnston T, Carroll SF, Gross WL. Antineutrophil cytoplasmic antibodies (ANCA) directed against bacteriacidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders. Clin Exp Immunol 1996;104:54-59.
14. Walmsley RS, Zhao MH, Hamilton MI, Brownlee A, Chapman P, Pounder RE, Wakefield AJ, Lockwood CM. Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease. Gut 1997;40:105-109.
15. Zhao MH, Lockwood CM. Azurocidin is a novel antigen for antineutrophil cytoplasmic autoantibodies (ANCA) in systemic vasculitis. Clin Exp Immunol 1996;103:397-402.
16. Orth T, Gerken G, Kellner R, Meyer zum Büschenfelde KH, Mayet WJ. Actin is a target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune hepatitis type-1. J Hepatol 1997;26:37-47.
17. Gross WL, Schmitt WH, Csemok E. ANCA and associated diseases: immunodiagnostic and pathogenetic aspects. Clin Exp Immunol 1993;91:1-12.
18. Zhao MH, Lockwood M. Antineutrophil cytoplasmic autoantibodies with specificity other than PR3 and MPO (x-ANCA). In: Peter JB, Shoenfeld Y, eds. Autoantibodies. 1st ed. Amsterdam, The Netherlands: Elsevier Science Publisher B.V, 1996:68-73.