A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA-negative primary biliary cirrhosis

Hepatology

Volumn 45, Issue 3, 2007, Pages 659-665

  Oertelt, Sabine ^a,b   Rieger, Roman ^a   Selmi, Carlo ^a,b   Invernizzi, Pietro ^b   Ansari, Aftab A ^c   Coppel, Ross L ^d   Podda, Mauro ^b   Leung, Patrick S C ^a   Gershwin, M Eric ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MILAN   (Italy)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MONASH UNIVERSITY   (Australia)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIGEN; BCOADC E2 ANTIGEN; MITOCHONDRION ANTIBODY; OGDC E2 ANTIGEN; PDC E2 ANTIGEN; RECOMBINANT ANTIGEN; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOASSAY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MALE; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODY SPECIFICITY; AUTOANTIGENS; CASE-CONTROL STUDIES; CELL SEPARATION; FEMALE; HUMANS; IMMUNOASSAY; LIVER CIRRHOSIS, BILIARY; MALE; MICROSPHERES; MIDDLE AGED; MITOCHONDRIA, LIVER;

EID: 33947366024     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21583     Document Type: Article

References (31)

1. Talwalkar JA, Souto E, Jorgensen RA, Lindor KD. Natural history of pruritus in primary biliary cirrhosis. Clin Gastroenterol Hepatol 2003;1:297-302.
2. Kaplan MM, Gershwin ME. Primary biliary cirrhosis. N Engl J Med 2005;353:1261-1273.
3. Miyakawa H, Tanaka A, Kikuchi K, Matsushita M, Kitazawa E, Kawaguchi N, et al. Detection of antimitochondrial autoantibodies in immunofluorescent AMA-negative patients with primary biliary cirrhosis using recombinant autoantigens. HEPATOLOGY 2001;34:243-248.
4. Bogdanos DP, Baum H, Vergani D. Antimitochondrial and other autoantibodies. Clin Liver Dis 2003;7:759-777, vi.
5. Vignali DA. Multiplexed particle-based flow cytometric assays. J Immunol Methods 2000;243:243-255.
6. Ludwig J, Dickson ER, McDonald GS. Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis). Virchows Arch A Pathol Anat Histol 1978;379:103-112.
7. Gershwin ME, Mackay IR, Sturgess A, Coppel RL. Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis. J Immunol 1987;138:3525-3531.
8. Van de Water J, Surh CD, Leung PS, Krams SM, Fregeau D, Davis P, et al. Molecular definitions, autoepitopes, and enzymatic activities of the mitochondrial autoantigens of primary biliary cirrhosis. Semin Liver Dis 1989;9:132-137.
9. Robertson CA, Coppel RL, Prindiville T, Fregeau D, Kaplan M, Dickson ER, et al. The relative affinity of recombinant dihydrolipoamide transacetylase for autoantibodies in primary biliary cirrhosis. HEPATOLOGY 1990;11:717-722.
10. Van de Water J, Gershwin ME, Leung P, Ansari A, Coppel RL. The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. J Exp Med 1988;167:1791-1799.
11. Migliaccio C, Nishio A, Van de Water J, Ansari AA, Leung PS, Nakanuma Y, et al. Monoclonal antibodies to mitochondrial E2 components define autoepitopes in primary biliary cirrhosis. J Immunol 1998;161:5157-5163.
12. Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J. Antinuclear antibodies in primary biliary cirrhosis. Semin Liver Dis 2005;25:298-310.
13. Surh CD, Ahmed-Ansari A, Gershwin ME. Comparative epitope mapping of murine monoclonal and human autoantibodies to human PDH-E2, the major mitochondrial autoantigen of primary biliary cirrhosis. J Immunol 1990;144:2647-2652.
14. Mattalia A, Quaranta S, Leung PS, Bauducci M, Van de Water J, Calvo PL, et al. Characterization of antimitochondrial antibodies in health adults. HEPATOLOGY 1998;27:656-661.
15. Pascual V, Cha S, Gershwin ME, Capra JD, Leung PS. Nucleotide sequence analysis of natural and combinatorial anti-PDC-E2 antibodies in patients with primary biliary cirrhosis: recapitulating immune selection with molecular biology. J Immunol 1994;152:2577-2585.
16. Gershwin ME, Ansari AA, Mackay IR, Nakanuma Y, Nishio A, Rowley MJ, et al. Primary biliary cirrhosis: an orchestrated immune response against epithelial cells. Immunol Rev 2000;174:210-225.
17. Leung PS, Iwayama T, Prindiville T, Chuang DT, Ansari AA, Wynn RM, et al. Use of designer recombinant mitochondrial antigens in the diagnosis of primary biliary cirrhosis. HEPATOLOGY 1992;15:367-372.
18. Van de Water J, Cooper A, Surh CD, Coppel R, Danner D, Ansari A, et al. Detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary cirrhosis. N Engl J Med 1989;320:1377-1380.
19. Moteki S, Leung PS, Coppel RL, Dickson ER, Kaplan MM, Munoz S, et al. Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies. HEPATOLOGY 1996;24:97-103.
20. Nakanuma Y, Harada K, Kaji K, Terasaki S, Tsuneyama K, Moteki S, et al. Clinicopathological study of primary biliary cirrhosis negative for antimitochondrial antibodies. Liver 1997;17:281-287.
21. Fulton RJ, McDade RL, Smith PL, Kienker LJ, Kettman JR, Jr. Advanced multiplexed analysis with the FlowMetrix system. Clin Chem 1997;43:1749-1756.
22. de Jager W, te Velthuis H, Prakken BJ, Kuis W, Rijkers GT. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 2003;10:133-139.
23. Jia XC, Raya R, Zhang L, Foord O, Walker WL, Gallo ML, et al. A novel method of multiplexed competitive antibody binning for the characterization of monoclonal antibodies. J Immunol Methods 2004;288:91-98.
24. Surh CD, Coppel R, Gershwin ME. Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis: implication for a conformational autoepitope. J Immunol 1990;144:3367-3374.
25. Vergani D, Bogdanos DP. Positive markers in AMA-negative PBC. Am J Gastroenterol 2003;98:241-243.
26. Invernizzi P, Podda M, Battezzati PM, Crosignani A, Zuin M, Hitchman E, et al. Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis. J Hepatol 2001;34:366-372.
27. Wesierska-Gadek J, Penner E, Battezzati PM, Selmi C, Zuin M, Hitchman E, et al. Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis. HEPATOLOGY 2006;43:1135-1144.
28. von Landenberg P, Baumgartner M, Schoelmerich J, Lackner KJ, Klein R. Clinical relevance of antiphospholipid antibodies in primary biliary cirrhosis. Ann N Y Acad Sci 2005;1051:20-28.
29. Invernizzi P, Battezzati PM, Crosignani A, Zermiani P, Bignotto M, Del Papa N, et al. Antibody to carbonic anhydrase II is present in primary biliary cirrhosis (PBC) irrespective of antimitochondrial antibody status. Clin Exp Immunol 1998;114:448-454.
30. Orth T, Gerken G, Meyer Zum Buschenfelde KH, Mayet WJ. Antineutrophil nuclear antibodies (ANNA) in primary biliary cirrhosis: their prevalence and antigen specificity. Z Gastroenterol 1997;35:113-121.
31. Worman HJ, Courvalin JC. Antinuclear antibodies specific for primary biliary cirrhosis. Autoimmun Rev 2003;2:211-217.