Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane

Gut

Volumn 46, Issue 4, 2000, Pages 553-561

  Muratori, L ^a   Albano, E ^d   Bianchi, F B ^a   Parola, M ^c   Ripalti, A ^b   Robino, G ^c   Muratori, P ^a   Bellomo, G ^d   Carini, R ^d   Lenzi, M ^a   Landini, M P ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Microbiology Section   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Autoimmune hepatitis; Autoimmunity; Confocal microscopy; Hepatitis C virus infection; Liver kidney microsomal antibody type 1

Indexed keywords

DEBRISOQUINE 4 HYDROXYLASE; EPITOPE; MICROSOME ANTIBODY;

ADOLESCENT; ADULT; ANIMAL CELL; ANTIBODY DETECTION; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNE HEPATITIS; DISEASE MARKER; FEMALE; GENE TARGETING; HEPATITIS C; HUMAN; KIDNEY MICROSOME; LIVER CELL MEMBRANE; LIVER INJURY; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SCHOOL CHILD;

ADULT; ANIMALS; ANTIBODIES; AUTOANTIBODIES; BIOLOGICAL MARKERS; CELL MEMBRANE; CELLS, CULTURED; CHILD; CYTOCHROME P-450 CYP2D6; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEPATITIS C, CHRONIC; HEPATITIS, AUTOIMMUNE; HUMANS; LIVER; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; RABBITS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034071317     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.46.4.553     Document Type: Article

References (49)

1. 1 Homberg JC, Abuaf N, Bernard O, et al. Chronic active hepatitis associated with antiliver/kidney microsome antibody type I: a second type of "autoimmune" hepatitis. Hepatology 1987;7:1333-9.
2. 2 Mieli-Vergani G, Vergani D. Progress in pediatric autoimmune hepatitis. Semin Liver Dis 1994;14:282-8.
3. 3 Gregorio GV, Portmann B, Reid F, et al. Autoimmune hepatitis in childhood: a 20-year experience. Hepatology 1997;25:541-7.
4. 4 Cassani F, Cataleta M, Valentini P, et al. Serum autoantibodies in chronic hepatitis C: comparison with autoimmune hepatitis and impact on the disease profile. Hepatology 1997;26:561-6.
5. 5 Choudhuri K, Mieli-Vergani G, Vergani D. Cytochrome P4502D6: understanding an autoantigen. Clin Exp Immunol 1997;108:381-3.
6. 6 Manns MP, Johnson EF, Griffin KJ, et al. Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1. J Clin Invest 1989;83:1066-72.
7. 7 Myrset AH, Halvorsen B, Ording E, et al. The time courses of intracellular transport of some secretory proteins of rat liver are not affected by an induced acute phase response. Eur J Cell Biol 1993;60:108-14.
8. 8 Robin MA, Maratrat M, Loeper J, et al. Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes. Gastroenterology 1995;108: 1110-23.
9. 9 Neve EP, Eliasson E, Pronzato MA, et al. Enzyme-specific transport of rat liver cytochrome P450 to the Golgi apparatus. Arch Biochem Biophys 1996;333:459-65.
10. 10 Wu D, Cederbaum AI. Presence of functionally active cytochrome P-450IIE1 in the plasma membrane of rat hepatocytes. Hepatology 1992;15:515-24.
11. 11 Robin MA, Maratrat M, Le Roy M, et al. Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera. J Clin Invest 1996;98:1471-80.
12. 12 Robin MA, Le Roy M, Descatoire V, et al. Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis. J Hepatol 1997;26: 23-30.
13. 13 Eliasson E, Kenna JG. Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. Mol Pharmacol 1996;50:573-82.
14. 14 Loeper J, Descatoire V, Maurice M, et al. Presence of functional cytochrome P-450 on isolated rat hepatocyte plasma membrane. Hepatology 1990;11:850-8.
15. 15 Loeper J, Descatoire V, Maurice M, et al. Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies. Gastroenterology 1993;104: 203-16.
16. 16 Trautwein C, Gerken G, Lohr H, et al. Lack of surface expression for the B-cell autoepitope of cytochrome P450 IID6 evidenced by flow cytometry. Z Gastroenterol 1993;31: 225-30.
17. 17 Yamamoto AM, Mura C, De Lemos-Chiarandini C, et al. Cytochrome P450IID6 recognised by LKM1 antibody is not exposed on the surface of hepatocytes. Clin Exp Immunol 1993;92:381-90.
18. 18 Vergani D, Mieli-Vergani G. Type II autoimmune hepatitis: the conundrum of cytochrome P450IID6. Clin Exp Immunol 1993;92:367-8.
19. 19 Johnson PJ, McFarlane IG. Meeting report: international autoimmune hepatitis study group. Hepatology 1993;18: 998-1005.
20. 20 Rizzetto M, Swana G, Doniach D. Microsomal antibodies in active chronic hepatitis and other disorders. Clin Exp Immunol 1973;15:331-4.
21. 21 Muratori L, Lenzi M, Ma Y, et al. Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease. Gut 1995;37:406-12.
22. 22 Ma Y, Gregorio G, Gaken J, et al. Establishment of a novel radioligand assay using eukaryotically expressed cytochrome P4502D6 for the measurement of liver kidney microsomal type 1 antibody in patients with autoimmune hepatitis and hepatitis C virus infection. J Hepatol 1997;26: 1396-402.
23. 23 Bottazzo GF, Florin-Christensen A, Fairfax A, et al. Classification of smooth muscle autoantibodies detected by immunofluorescence. J Clin Pathol 1976;29:403-10.
24. 24 Martini E, Abuaf N, Cavalli F, et al. Antibody to liver cytosol (anti-LC1) in patients with autoimmune chronic active hepatitis type 2. Hepatology 1988;8:1662-6.
25. 25 Clot P, Parola M, Bellomo G, et al. Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol. Gastroenterology 1997;113:265-76.
26. 26 Sambrook J, Fritsh EF, Maniatis T. Molecular cloning. A laboratory manual. 2nd edn. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1989.
27. 27 Zanger UM, Hauri HP, Loeper J, et al. Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II. Proc Natl Acad Sci USA 1988;85:8256-60.
28. 28 Lenzi M, Fusconi M, Selleri L, et al. Counterimmunoelectrophoresis (CIE) for the detection of anti-liver-kidney microsome (LKM) antibodies in the sera of patients with chronic liver disease. J Immunol Methods 1988;111:253-9.
29. 29 Lenzi M, Bianchi FB, Cassani F, et al. Liver cell surface expression of the antigen reacting with liver-kidney microsomal antibody (LKM). Clin Exp Immunol 1984;55:36-40.
30. 30 Sirica AE, Pitot HC. Drug metabolism and effects of carcinogens in cultured hepatic cells. Pharmacol Rev 1979; 31:205-28.
31. 31 Maslansky CJ, Williams GM. Primary cultures and the levels of cytochrome P450 in hepatocytes from mouse, rat, hamster, and rabbit liver. In Vitro 1982;18:683-93.
32. 32 Loeper J, Louerat-Oriou B, Duport C, et al. Yeast expressed cytochrome P450 2D6 (CYP2D6) exposed on the external face of plasma membrane is functionally competent. Mol Pharmacol 1998;54:8-13.
33. 33 Ma Y, Peakman M, Lobo-Yeo A, et al. Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection. Clin Exp Immunol 1994;97:94-9.
34. 34 Yamamoto AM, Cresteil D, Homberg JC, et al. Characterization of anti-liver-kidney microsome antibody (anti-LKM1) from hepatitis C virus-positive and -negative sera. Gastroenterology 1993;104:1762-7.
35. 35 Yamamoto AM, Johanet C, Duclos-Vallee JC, et al. A new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type-2 (AIH-2) and chronic hepatitis C virus (HCV) infection: a sensitive and quantitative radioligand assay. Clin Exp Immunol 1997;108:396-400.
36. 36 Lewis DF, Eddershaw PJ, Goldfarb PS, et al. Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism. Xenobiotica 1997;27:319-39.
37. 37 Beaune P, Pessayre D, Dansette P, et al. Autoantibodies against cytochromes P450: role in human diseases. Adv Pharmacol 1994;30:199-245.
38. 38 Pessayre D. Role of reactive metabolises in drug-induced hepatitis. J Hepatol 1995;23(suppl 1):16-24.
39. 39 Van Pelt FN, Straub P, Manns MP. Molecular basis of drug-induced immunological liver injury. Semin Liver Dis 1995; 15:283-300.
40. 40 Lytton SD, Helander A, Zhang-Gouillon ZQ, et al. Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics. Mol Pharmacol 1999;55:223-33.
41. 41 Riley RJ, Smith G, Wolf CR, et al. Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s) [published erratum appears in Biochem Biophys Res Commun 1993;194:585]. Biochem Biophys Res Commun 1993;191:32-40.
42. 42 Leeder JS, Gaedigk A, Lu X, et al. Epitope mapping studies with human anti-cytochrome P450 3A antibodies. Mol Pharmacol 1996;49:234-43.
43. 43 Winqvist O, Gustafsson J, Rorsman F, et al. Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease. J Clin Invest 1993;92:2377-85.
44. 44 Winqvist O, Karlsson FA, Kampe O. 21-Hydroxylase, a major autoantigen in idiopathic Addison's disease. Lancet 1992;339:1559-62.
45. 45 Krohn K, Uibo R, Aavik E, et al. Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17 alpha-hydroxylase. Lancet 1992;339:770-3.
46. 46 Muratori L, Zauli D, Giostra F, et al. LKM1 appearance in a HLA-DR3+ patient with chronic hepatitis C during interferon treatment. J Hepatol 1993;18:259-60.
47. 47 Mackie FD, Peakman M, Yun M, et al. Primary and secondary liver/kidney microsomal autoantibody response following infection with hepatitis C virus. Gastroenterology 1994;106:1672-5.
48. 48 Lohr H, Manns M, Kyriatsoulis A, et al. Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibody-positive autoimmune chronic active hepatitis. Clin Exp Immunol 1991;84:297-302.
49. 49 Lohr HF, Schlaak JF, Lohse AW, et al. Autoreactive CD4+ LKM-specific and anticlonotypic T-cell responses in LKM-1 antibody-positive autoimmune hepatitis. Hepatology 1996;24:1416-21.