Tumour necrosis factor α impairs function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis

Gut

Volumn 49, Issue 1, 2001, Pages 131-141

  Bo, X ^a   Broome, U ^a   Remberger, M ^a   Sumitran Holgersson, S ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Autoimmune liver diseases; Biliary epithelial cells; Cytokines

Indexed keywords

CONCANAVALIN A; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN; PHYTOHEMAGGLUTININ; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; AUTOIMMUNE HEPATITIS; BILIARY CIRRHOSIS; CELL FUNCTION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; MALE; NATURAL KILLER CELL; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; CASE-CONTROL STUDIES; CELL DIVISION; CHOLANGITIS, SCLEROSING; CONCANAVALIN A; CYTOTOXICITY TESTS, IMMUNOLOGIC; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-2; KILLER CELLS, NATURAL; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; MITOGENS; PHYTOHEMAGGLUTININS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034962227     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.49.1.131     Document Type: Article

References (32)

1. Primary sclerosing cholangitis
2. Current concepts. Primary sclerosing cholangitis
3. Preferential Vβ3 usage by liver T lymphocytes in patients with primary sclerosing cholangitis
4. Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis
5. Immunologic analysis of mononucelar cells in liver tissue and blood of patients with primary sclerosing cholangitis
6. Natural history and prognostic factors in 305 Swedish patients with primary sclerosing cholangitis
7. Primary sclerosing cholangitis: A review of its clinical features, cholangiography, and hepatic histology
8. The regulation and functional consequence of proinflammatory cytokine binding on human intestinal epithelial cells
9. Interleukin 1, tumor necrosis factor, and interleukin 6 as mediators of cartilage destruction
10. Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers
11. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes
12. Cellular localization of inflammatory cytokines in human glomerulonephritis
13. Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine
14. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
15. T cells in inflammatory bowel disease: Protective and pathogenic roles
16. Etiology and pathogenesis in primary sclerosing cholangitis
17. Enhanced autoreactivity of T-lymphocytes in primary sclerosing cholangitis
18. Primary biliary cirrhosis
19. International Autoimmune Hepatitis Group Report: Review of criteria for diagnosis of autoimmune hepatitis
20. Immuno-isolation and culture of biliary epithelial cells from normal human liver
21. Hepatic allograft rejection: Regulation of the immunogenicity of human intrahepatic biliary epithelial cells
22. T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-γ upon mitogen stimulation
23. Cytokines in primary biliary cirrhosis
24. Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation
25. Association of tumor necrosis factor polymorphism with primary sclerosing cholangitis
26. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis
27. Soluble TNF receptor production by activated T lymphocytes: Differential effects of acute and chronic exposure to TNF
28. Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling
29. Regulation of autoimmunity by proinflammatory cytokines
30. Mechanisms of intestinal epithelial cell injury and colitis in interleukin 2 (IL2)-deficient mice
31. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
32. Functional interleukin-2 receptors on intestinal epithelial cells