메뉴 건너뛰기




Volumn 15, Issue 2, 2015, Pages e157-e170

The role of damage-associated molecular patterns (DAMPs) in human diseases part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine

Author keywords

Adaptive immunity; Autoimmunity; Inflammation; Innate immunity; Pattern recognition; Receptors

Indexed keywords


EID: 84930060402     PISSN: 2075051X     EISSN: 20750528     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (128)

References (120)
  • 1
    • 84922641530 scopus 로고    scopus 로고
    • The role of damage associated molecular patterns in human diseases: Part i: Promoting inflammation and immunity
    • Land WG. The role of damage associated molecular patterns in human diseases: Part I: Promoting inflammation and immunity. Sultan Qaboos Univ Med J 2015; 15:9-21.
    • (2015) Sultan Qaboos Univ Med J , vol.15 , pp. 9-21
    • Land, W.G.1
  • 2
    • 84858999769 scopus 로고    scopus 로고
    • Emerging role of innate immunity in organ transplantation part ii: Potential of damage-associated molecular patterns to generate immunostimulatory dendritic cells
    • Land WG. Emerging role of innate immunity in organ transplantation part II: Potential of damage-associated molecular patterns to generate immunostimulatory dendritic cells. Transplant Rev (Orlando) 2012; 26:73-87.doi: 10.1016/j.trre.2011.02.003.
    • (2012) Transplant Rev (Orlando) , vol.26 , pp. 73-87
    • Land, W.G.1
  • 3
    • 84883785469 scopus 로고    scopus 로고
    • The dendritic cell response to classic, emerging, and homeostatic danger signals: Implications for autoimmunity
    • Gallo PM, Gallucci S. The dendritic cell response to classic, emerging, and homeostatic danger signals: Implications for autoimmunity. Front Immunol 2013; 4:138. doi: 10.3389/fimmu.2013.00138.
    • (2013) Front Immunol , vol.4 , Issue.138
    • Gallo, P.M.1    Gallucci, S.2
  • 4
    • 84930061701 scopus 로고    scopus 로고
    • Working group on damps in cardiovascular disease, et al. Mitochondrial damage-associated molecular patterns and vascular function
    • J2014351172-710.1093/eurheartj/ehu047
    • Wenceslau CF, McCarthy CG, Szasz T, Spitler K, Goulopoulou S, Webb RC; Working Group on DAMPs in Cardiovascular Disease, et al. Mitochondrial damage-associated molecular patterns and vascular function. Eur Heart J2014351172-710.1093/eurheartj/ehu047
    • Eur Heart
    • Wenceslau, C.F.1    McCarthy, C.G.2    Szasz, T.3    Spitler, K.4    Goulopoulou, S.5    Webb, R.C.6
  • 5
    • 35348916535 scopus 로고    scopus 로고
    • Natural igm-mediated innate autoimmunity: A new target for early intervention of ischemiareperfusion injury
    • Zhang M, Carroll MC. Natural IgM-mediated innate autoimmunity: A new target for early intervention of ischemiareperfusion injury. Expert Opin Biol Ther 2007: 7:1575-1582. doi: 10.1517/14712598.7.10.1575.
    • (2007) Expert Opin Biol Ther , vol.7 , pp. 1575-1582
    • Zhang, M.1    Carroll, M.C.2
  • 6
    • 84866791494 scopus 로고    scopus 로고
    • Naturally occurring igm antibodies to oxidationspecific epitopes
    • 20127502-1310.1007/978-1-4614-3461-0_1
    • Binder CJ. Naturally occurring IgM antibodies to oxidationspecific epitopes. Adv Exp Med Biol20127502-1310.1007/978-1-4614-3461-0_1
    • Adv Exp Med Biol
    • Binder, C.J.1
  • 7
    • 84900482765 scopus 로고    scopus 로고
    • Natural antibodies as a sensor of electronegative damage-associated molecular patterns (damps)
    • Uchida K. Natural antibodies as a sensor of electronegative damage-associated molecular patterns (DAMPs). Free Radic Biol Med201472 156-61110.1016/j.freeradbiomed.2014.03.016
    • (2014) Free Radic Biol Med , vol.72 , pp. 156-611
    • Uchida, K.1
  • 8
    • 22244446505 scopus 로고    scopus 로고
    • The mammalian unfolded protein response
    • Schröder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem2005747 39-8910.1146/ annurev.biochem.73.011303.074134
    • (2005) Annu Rev Biochem , vol.747 , pp. 39-89
    • Schröder, M.1    Kaufman, R.J.2
  • 9
    • 84863740827 scopus 로고    scopus 로고
    • The impact of the unfolded protein response on human disease
    • Wang S, Kaufman RJ. The impact of the unfolded protein response on human disease. J Cell Biol 2012 197 857-6710.1083/jcb.201110131
    • (2012) J Cell Biol , vol.197 , pp. 857-867
    • Wang, S.1    Kaufman, R.J.2
  • 11
    • 84908622726 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproducts (rage), its ligands, and soluble rage: Potential biomarkers for diagnosis and therapeutic targets for human renal diseases
    • Lee EJ, Receptor for advanced glycation endproducts (RAGE), its ligands, and soluble RAGE: Potential biomarkers for diagnosis and therapeutic targets for human renal diseases. Genomics Inform 2013; 11:224-9.doi: 10.5808/ GI.2013.11.4.224.
    • (2013) Genomics Inform , vol.11 , pp. 224-229
    • Lee, E.J.1
  • 12
    • 84895889496 scopus 로고    scopus 로고
    • Functions of nod-like receptors in human diseases
    • Zhong Y, Kinio A, Saleh M. Functions of NOD-like receptors in human diseases. Front Immunol 2013; 4:333. doi: 10.3389/fimmu.2013.00333.
    • (2013) Front Immunol , vol.4 , pp. 333
    • Zhong, Y.1    Kinio, A.2    Saleh, M.3
  • 13
    • 84884776453 scopus 로고    scopus 로고
    • Signalling c-type lectins in antimicrobial immunity
    • Drummond RA, Brown GD. Signalling C-type lectins in antimicrobial immunity. PLoS Pathog 2013 9e1003417 10.1371/journal.ppat.1003417.
    • (2013) Plos Pathog , vol.9
    • Drummond, R.A.1    Brown, G.D.2
  • 14
    • 84879125279 scopus 로고    scopus 로고
    • Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccinationfront cell
    • Jounai N, Kobiyama K, Takeshita F, Ishii KJ. Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccinationFront Cell Infect Microbiol 2013 2:168 doi:10.3389/fcimb.2012.00168.
    • (2013) Infect Microbiol , vol.2 , pp. 168
    • Jounai, N.1    Kobiyama, K.2    Takeshita, F.3    Ishii, K.J.4
  • 16
    • 84884138508 scopus 로고    scopus 로고
    • The interferon response to intracellular dna
    • Unterholzner L The interferon response to intracellular DNA: Why so many receptors? Immunobiology 2013; 218:1 312-321doi: 10.1016/j.imbio.2013.07.007.
    • (2013) Why So Many Receptors? Immunobiology , vol.218 , Issue.1 , pp. 312-321
    • Unterholzner, L.1
  • 18
    • 84930060207 scopus 로고    scopus 로고
    • Mechanisms of fibrosis: Therapeutic translation for fibrotic disease
    • Wynn TA, Mechanisms of fibrosis: Therapeutic translation for fibrotic disease. Nat Med 2012 1810 28-4010.1038/nm.2807.
    • (2012) Nat Med , vol.1810 , pp. 28-40
    • Wynn, T.A.1
  • 19
    • 67651004298 scopus 로고    scopus 로고
    • Postinjury multiple organ failure
    • Dewar D, Moore FA, Moore EE, Balogh Z. Postinjury multiple organ failure. Injury 2009; 40:912-918. doi: 10.1016/j. injury.2009.05.024.
    • (2009) Injury , vol.40 , pp. 912-918
    • Dewar, D.1    Moore, F.A.2    Moore, E.E.3    Balogh, Z.4
  • 21
    • 84865455765 scopus 로고    scopus 로고
    • Trauma equals dangerdamage control by the immune system
    • Stoecklein VM, Osuka A, Lederer JA. Trauma equals dangerdamage control by the immune system. J Leukoc Biol 2012 925 39-51.10.1189/jlb.0212072
    • (2012) J Leukoc Biol , vol.925 , pp. 39-51
    • Stoecklein, V.M.1    Osuka, A.2    Lederer, J.A.3
  • 22
    • 43749112963 scopus 로고    scopus 로고
    • High-mobility group box 1 protein in human and murine skin: Involvement in woundhealing
    • Straino S, Di Carlo A, Mangoni A, De Mori R, High-mobility group box 1 protein in human and murine skin: Involvement in woundhealingJ Invest Dermatol 2008;128:154-553.doi: 10.1038/sj.jid.5701212.
    • (2008) J Invest Dermatol , vol.128 , pp. 154-553
    • Straino, S.1    Di Carlo, A.2    Mangoni, A.3    De Mori, R.4
  • 24
    • 79955555551 scopus 로고    scopus 로고
    • Temporal and spatial patterns of endogenous danger signal expression after wound healing and in response tolymphedema
    • Zampell JC, Yan A, Avraham T, Andrade V, Malliaris S, Aschen S, et al. Temporal and spatial patterns of endogenous danger signal expression after wound healing and in response tolymphedema Am J Physiol Cell Physiol 2011;300:1107-1121.doi: 10.1152/ajpcell.00378.2010.
    • (2011) Am J Physiol Cell Physiol , vol.300 , pp. 1107-1121
    • Zampell, J.C.1    Yan, A.2    Avraham, T.3    Andrade, V.4    Malliaris, S.5    Aschen, S.6
  • 26
    • 77950817867 scopus 로고    scopus 로고
    • Early release of high mobility group box nuclear protein 1 after severe trauma in humans: Role of injury severity and tissue hypoperfusion
    • Cohen MJ, Brohi K, Calfee CS, Rahn P, Chesebro BB, Christiaans SC, et al. Early release of high mobility group box nuclear protein 1 after severe trauma in humans: Role of injury severity and tissue hypoperfusion. Crit Care 2009 13 R17410.1186/cc8152.
    • (2009) Crit Care , vol.13 , pp. R174
    • Cohen, M.J.1    Brohi, K.2    Calfee, C.S.3    Rahn, P.4    Chesebro, B.B.5    Christiaans, S.C.6
  • 27
    • 67749091145 scopus 로고    scopus 로고
    • Hmgb1 is markedly elevated within 6 hours of mechanical trauma in humans
    • Peltz ED, Moore EE, Eckels PC, Damle SS, Tsuruta Y, Johnson JL, et al. HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans. Shock 2009; 32:17-22doi: 10.1097/SHK.0b013e3181997173..
    • (2009) Shock , vol.32 , pp. 17-22
    • Peltz, E.D.1    Moore, E.E.2    Eckels, P.C.3    Damle, S.S.4    Tsuruta, Y.5    Johnson, J.L.6
  • 28
    • 84864469515 scopus 로고    scopus 로고
    • Plasma high-mobility group box 1 levels and prediction of outcome in patients with traumatic brain injury
    • Wang KY, Yu GF, Zhang ZY, Huang Q, Dong XQ. Plasma high-mobility group box 1 levels and prediction of outcome in patients with traumatic brain injury. Clin Chim Acta 2012; 413:1737-41doi: 10.1016/j.cca.2012.07.002.
    • (2012) Clin Chim Acta , vol.413 , pp. 1737-1741
    • Wang, K.Y.1    Yu, G.F.2    Zhang, Z.Y.3    Huang, Q.4    Dong, X.Q.5
  • 29
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mitochondrial damps cause inflammatory responses to injury
    • Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010; 464:104-7.10.1038/nature08780
    • (2010) Nature , vol.464 , pp. 104-107
    • Zhang, Q.1    Raoof, M.2    Chen, Y.3    Sumi, Y.4    Sursal, T.5    Junger, W.6
  • 31
    • 77953901974 scopus 로고    scopus 로고
    • Mitochondrial dna is released by shock and activates neutrophils via p38 map kinase
    • Zhang Q, Itagaki K, Hauser CJ. Mitochondrial DNA is released by shock and activates neutrophils via p38 map kinase. Shock 2010; 34:55-9.doi: 10.1097/SHK.0b013e3181cd8c08.
    • (2010) Shock , vol.34 , pp. 55-59
    • Zhang, Q.1    Itagaki, K.2    Hauser, C.J.3
  • 32
    • 84901616866 scopus 로고    scopus 로고
    • Cerebrospinal fluid mitochondrial dna: A novel damp in pediatric traumatic brain injury
    • Walko TD 3rd, Bola RA, Hong JD, Au AK, Bell MJ, Kochanek PM, et al. Cerebrospinal fluid mitochondrial DNA: A novel DAMP in pediatric traumatic brain injury. Shock 2014; 41:499-503. doi: 10.1097/SHK.0000000000000160.
    • (2014) Shock , vol.41 , pp. 499-503
    • Walko, T.D.1    Bola, R.A.2    Hong, J.D.3    Au, A.K.4    Bell, M.J.5    Kochanek, P.M.6
  • 33
    • 84884502884 scopus 로고    scopus 로고
    • Elevated levels of plasma mitochondrial dna damps are linked to clinical outcome in severely injured humansubjects
    • Simmons JD, Lee YL, Mulekar S, Kuck JL, Brevard SB, Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured humansubjects Ann Surg 2013 25 859-1610.1097/SLA.0b013e3182a4ea46
    • (2013) Ann Surg , vol.25 , pp. 859-1610
    • Simmons, J.D.1    Lee, Y.L.2    Mulekar, S.3    Kuck, J.L.4    Brevard, S.B.5
  • 35
    • 79951669207 scopus 로고    scopus 로고
    • Hermansson athe immune system inatherosclerosis
    • Hansson GK, Hermansson AThe immune system inatherosclerosisNat Immunol 2011 12 204-1210.1038/ni.2001
    • (2011) Nat Immunol , vol.12 , pp. 204-1210
    • Hansson, G.K.1
  • 36
    • 84886382942 scopus 로고    scopus 로고
    • Chronic allograft dysfunction: A model disorder of innateimmunity
    • Land WG Chronic allograft dysfunction: A model disorder of innateimmunity Biomed J 2013 362-092810.4103/23194170.117622
    • (2013) Biomed J , pp. 362-0928
    • Land, W.G.1
  • 37
    • 84897018581 scopus 로고    scopus 로고
    • The influence of innate and adaptive immune responses on atherosclerosis
    • Witztum JL, Lichtman AH. The influence of innate and adaptive immune responses on atherosclerosisAnnu Rev Pathol 2014;9:73-102.doi:10.1146/annurev-pathol-020712163936
    • (2014) Annu Rev Pathol , vol.9 , pp. 73-102
    • Witztum, J.L.1    Lichtman, A.H.2
  • 38
    • 0029071540 scopus 로고
    • Mechanical factors associated with the development of intimal and medial thickening in vein grafts subjected to arterial pressurea model of arteries exposed tohypertension
    • Dobrin PB. Mechanical factors associated with the development of intimal and medial thickening in vein grafts subjected to arterial pressureA model of arteries exposed tohypertension. Hypertension 1995; 26:38-43doi: 10.1161/01.HYP.26.1.38.
    • (1995) Hypertension , vol.26 , pp. 38-43
    • Dobrin, P.B.1
  • 40
    • 84866407827 scopus 로고
    • The innate immune response to products of phospholipid peroxidation
    • Weismann D, The innate immune response to products of phospholipid peroxidation Biochim Biophys Acta; 1818:246-575
    • (1818) Biochim Biophys Acta , pp. 246-575
    • Weismann, D.1
  • 41
    • 84866528161 scopus 로고    scopus 로고
    • Hmgb1 in vascular diseases: Its role in vascular inflammation and atherosclerosis
    • de Souza AW, Westra J, Limburg PC, Bijl M, HMGB1 in vascular diseases: Its role in vascular inflammation and atherosclerosis. Autoimmun Rev 2012; 11:909-917. 10.1016/j.autrev.2012.03.007.
    • (2012) Autoimmun Rev , vol.11 , pp. 909-917
    • De Souza, A.W.1    Westra, J.2    Limburg, P.C.3    Bijl, M.4
  • 42
    • 84896360122 scopus 로고    scopus 로고
    • Damps at the crossroads between innate immunity, traditional risk factors, and cardiovascular disease
    • Schiopu A, Cotoi OS. DAMPs at the crossroads between innate immunity, traditional risk factors, and cardiovascular disease. Mediators Inflamm 2013; 2013:828-854.
    • (2013) Mediators Inflamm , pp. 828-854
    • Schiopu, A.1    Cotoi, O.S.2
  • 43
    • 84907356094 scopus 로고    scopus 로고
    • Lox-1, mtdna damage and nlrp3 inflammasome activation in macrophages: Implications in atherogenesis
    • Ding Z, Liu S, Wang X, Dai Y, Khaidakov M, Deng X, et al. LOX-1, mtDNA damage and NLRP3 inflammasome activation in macrophages: Implications in atherogenesis. Cardiovasc Res 2014; 103:619-2810.1093/cvr/cvu114.
    • (2014) Cardiovasc Res , vol.103 , pp. 619-628
    • Ding, Z.1    Liu, S.2    Wang, X.3    Dai, Y.4    Khaidakov, M.5    Deng, X.6
  • 44
    • 84881475673 scopus 로고    scopus 로고
    • The upr in atherosclerosis semin
    • Zhou AX, Tabas I. The UPR in atherosclerosis Semin Immunopatho2013;35:321-32doi:10.1007/s00281-0130372x..
    • (2013) Immunopatho , vol.35 , pp. 321-332
    • Zhou, A.X.1    Tabas, I.2
  • 46
    • 84894165975 scopus 로고    scopus 로고
    • Cardiac mitochondria and reactive oxygen species generation
    • Chen YR, Cardiac mitochondria and reactive oxygen species generationCirc Res 2014 1145-2437doi: 10.1161/CIRCRESAHA.114.300559.
    • (2014) Circ Res , pp. 1145-2437
    • Chen, Y.R.1
  • 47
    • 84920114157 scopus 로고    scopus 로고
    • The use of micrornas to modulate redox and immune response to stroke
    • Ouyang YB, Stary CM, White RE, Giffard RG. The use of microRNAs to modulate redox and immune response to stroke. Antioxid Redox Signal 2015; 22:187-202. doi: 10.1089/ars.2013.5757.
    • (2015) Antioxid Redox Signal , vol.22 , pp. 187-202
    • Ouyang, Y.B.1    Stary, C.M.2    White, R.E.3    Giffard, R.G.4
  • 49
    • 84893840072 scopus 로고    scopus 로고
    • Danger signals in the initiation of the inflammatory response after myocardial infarction
    • de Haan JJ, Smeets MB, Pasterkamp G, Arslan F. Danger signals in the initiation of the inflammatory response after myocardial infarction. Mediators Inflamm 2013; 2013:206-239doi: 10.1155/2013/206039.
    • (2013) Mediators Inflamm , vol.2013 , pp. 206-239
    • De Haan, J.J.1    Smeets, M.B.2    Pasterkamp, G.3    Arslan, F.4
  • 50
    • 84881241307 scopus 로고    scopus 로고
    • The hmgb1-tlr4 axis contributes to myocardial ischemia/ reperfusion injury via regulation of cardiomyocyte apoptosis
    • Ding HS, Yang J, Chen P, Yang J, Bo SQ, Ding JW, et al. The HMGB1-TLR4 axis contributes to myocardial ischemia/ reperfusion injury via regulation of cardiomyocyte apoptosis. Gene 2013; 527:389-9310.1016/j.gene.2013.05.041.
    • (2013) Gene , vol.527 , pp. 389-393
    • Ding, H.S.1    Yang, J.2    Chen, P.3    Yang, J.4    Bo, S.Q.5    Ding, J.W.6
  • 51
    • 84887801106 scopus 로고    scopus 로고
    • Toll-like receptor 3 plays a role in myocardial infarction and ischemia/ reperfusion injury
    • Lu C, Ren D, Wang X, Ha T, Liu L, Lee EJ, et al. Toll-like receptor 3 plays a role in myocardial infarction and ischemia/ reperfusion injury. Biochim Biophys Acta 2014; 1842:22-311016/j.bbadis.2013.10.006.
    • (2014) Biochim Biophys Acta , vol.1842 , pp. 22-31
    • Lu, C.1    Ren, D.2    Wang, X.3    Ha, T.4    Liu, L.5    Lee, E.J.6
  • 52
    • 84879355400 scopus 로고    scopus 로고
    • The nlrp3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemiareperfusion injury
    • Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Alfsnes K, Finsen AV, et al. The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemiareperfusion injury. Cardiovasc Res 2013; 99:164-174. 10.1093/cvr/cvt091.
    • (2013) Cardiovasc Res , vol.99 , pp. 164-174
    • Sandanger, Ø.1    Ranheim, T.2    Vinge, L.E.3    Bliksøen, M.4    Alfsnes, K.5    Finsen, A.V.6
  • 53
    • 84897034479 scopus 로고    scopus 로고
    • Nlrp3 inflammasome as a novel player in myocardial infarction
    • Takahashi M. NLRP3 inflammasome as a novel player in myocardial infarction. Int Heart J20145510-551510.1536/ihj.13-388.
    • (2014) Int Heart J , pp. 5510
    • Takahashi, M.1
  • 54
    • 83755195135 scopus 로고    scopus 로고
    • The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
    • Mezzaroma E, Toldo S, Farkas D, Seropian IM, Van Tassell BW, The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouseProc Natl Acad Sci USA2011;108:197-2530doi: 10.1073/ pnas.1108586108..
    • Proc Natl Acad Sci USA2011 , vol.108 , pp. 197-2530
    • Mezzaroma, E.1    Toldo, S.2    Farkas, D.3    Seropian, I.M.4    Van Tassell, B.W.5
  • 55
    • 84904107470 scopus 로고    scopus 로고
    • "nlrp3 inflammasome as a therapeutic target in myocardial infarction"
    • Mezzaroma E, Marchetti C, Toldo S. Letter by Mezzaroma, et al regarding article, "NLRP3 inflammasome as a therapeutic target in myocardial infarction". Int Heart J 2014; 55:379doi: 10.1536/ihj.14-140..
    • (2014) Int Heart J , vol.55 , pp. 379
    • Mezzaroma, E.1    Marchetti, C.2    Mezzaroma, T.S.L.B.3
  • 56
    • 84883210648 scopus 로고    scopus 로고
    • Role of innate immunity in cardiac inflammation after myocardial infarction
    • Liaudet L, Rosenblatt-Velin N. Role of innate immunity in cardiac inflammation after myocardial infarction. Front Biosci (Schol Ed) 2013; 5:86-104doi: 10.2741/S359..
    • (2013) Front Biosci (Schol Ed) , vol.5 , pp. 86-104
    • Liaudet, L.1    Rosenblatt-Velin, N.2
  • 57
    • 84919952881 scopus 로고    scopus 로고
    • The interplay between central metabolism and innate immune responses
    • Cheng SC, Joosten LA, Netea MG. The interplay between central metabolism and innate immune responses. Cytokine Growth Factor Rev 2014; 25:707‒713. doi: 10.1016/j.cytogfr.2014.06.008.
    • (2014) Cytokine Growth Factor Rev , vol.25 , pp. 707-713
    • Cheng, S.C.1    Joosten, L.A.2    Netea, M.G.3
  • 59
    • 84878777666 scopus 로고    scopus 로고
    • Signalling danger: Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
    • Eizirik DL, Miani M, Cardozo AK. Signalling danger: Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 2013 56 23-44
    • (2013) Diabetologia , vol.56 , pp. 23-44
    • Eizirik, D.L.1    Miani, M.2    Cardozo, A.K.3
  • 60
    • 84930062872 scopus 로고    scopus 로고
    • Innate sensors of pathogen and stress: Linking inflammation to obesity
    • Jin C, Innate sensors of pathogen and stress: Linking inflammation to obesity. J Allergy Clin Immunol 2013 13 228-7941016/j.jaci.2013.06.022.
    • (2013) J Allergy Clin Immunol , vol.13 , pp. 228-794
    • Jin, C.1
  • 61
    • 84899425498 scopus 로고    scopus 로고
    • Toll-like receptors and nlrp3 as central regulators of pancreatic islet inflammation in type 2 diabetes
    • Westwell-Roper C, Nackiewicz D, Dan MEhses JA. Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes. Immunol Cell Biol 2014 92 31-42310.1038/icb.2014.4..
    • (2014) Immunol Cell Biol , vol.92 , pp. 31-423
    • Westwell-Roper, C.1    Nackiewicz, D.2    Dan Mehses, J.A.3
  • 62
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010; 140:900- 17doi: 10.1016/j.cell.2010.02.034..
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 63
    • 79954421880 scopus 로고    scopus 로고
    • The binary switch that controls the life and death decisions of er stressed β cells
    • Oslowski CM, Urano F. The binary switch that controls the life and death decisions of ER stressed β cells. Curr Opin Cell Biol 2011 23 20-71510.1016/j.ceb.2010.11.005.
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 20-715
    • Oslowski, C.M.1    Urano, F.2
  • 64
    • 84864682160 scopus 로고    scopus 로고
    • Ire1α induces thioredoxin-interacting protein to activate the nlrp3 inflammasome and promote programmed cell death under irremediable er stress
    • Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, et al. IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab 2012 162-506410.1016/j.cmet.2012.07.007.
    • (2012) Cell Metab , pp. 162-5064
    • Lerner, A.G.1    Upton, J.P.2    Praveen, P.V.3    Ghosh, R.4    Nakagawa, Y.5    Igbaria, A.6
  • 65
    • 84879778828 scopus 로고    scopus 로고
    • Detection of oxidative damage in response to protein misfolding in the endoplasmic reticulum
    • Landau G, Kodali VK, Malhotra JD, Kaufman RJ. Detection of oxidative damage in response to protein misfolding in the endoplasmic reticulum. Methods Enzymol 2013 52-62315010.1016/B978-0-12-405883-5.00014-4.
    • (2013) Methods Enzymol , pp. 52-623150
    • Landau, G.1    Kodali, V.K.2    Malhotra, J.D.3    Kaufman, R.J.4
  • 66
    • 84903784187 scopus 로고    scopus 로고
    • The thioredoxin superfamily in oxidative protein folding
    • Lu J, Holmgren A. The thioredoxin superfamily in oxidative protein folding. Antioxid Redox Signal 2014 214-577010.1089/ars.2014.5849.
    • (2014) Antioxid Redox Signal , pp. 214-5770
    • Lu, J.1    Holmgren, A.2
  • 68
    • 84872018875 scopus 로고    scopus 로고
    • Upregulated nlrp3 inflammasome activation in patients with type 2 diabetes
    • Lee HM, Kim JJ, Kim HJ, Shong M, Ku BJ, Jo EK. Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes 2013; 62:194-20410.2337/db12-0420..
    • (2013) Diabetes , vol.62 , pp. 194-204
    • Lee, H.M.1    Kim, J.J.2    Kim, H.J.3    Shong, M.4    Ku, B.J.5    Jo, E.K.6
  • 69
    • 84908222221 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress is sufficient for the induction of il-1β production via activation of the nf-κb and inflammasome pathways
    • Kim S, Joe Y, Jeong SO, Zheng M, Back SH, Park SW, et al. Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways. Innate Immun 2014; 20:799-815doi: 10.1177/1753425913508593..
    • (2014) Innate Immun , vol.20 , pp. 799-815
    • Kim, S.1    Joe, Y.2    Jeong, S.O.3    Zheng, M.4    Back, S.H.5    Park, S.W.6
  • 70
    • 84883825948 scopus 로고    scopus 로고
    • Dixit vd. Mechanisms of disease: Inflammasome activation and the development of type 2 diabetes
    • Grant RW, Dixit VD. Mechanisms of disease: Inflammasome activation and the development of type 2 diabetes. Front Immunol 2013; 4:50doi: 10.3389/fimmu.2013.00050..
    • (2013) Front Immunol , vol.4 , pp. 50
    • Grant, R.W.1
  • 71
    • 84885459019 scopus 로고    scopus 로고
    • Cutting edge: Tlr signaling licenses irak1 for rapid activation of the nlrp3 inflammasome
    • Fernandes-Alnemri T, Kang S, Anderson C, Sagara J, Fitzgerald KA, Alnemri ES. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome. J Immunol 2013; 191:3995-9doi: 10.4049/jimmunol.1301681..
    • (2013) J Immunol , vol.191 , pp. 3995-3999
    • Fernandes-Alnemri, T.1    Kang, S.2    Anderson, C.3    Sagara, J.4    Fitzgerald, K.A.5    Alnemri, E.S.6
  • 72
    • 84882285470 scopus 로고    scopus 로고
    • Specific inflammasomes in complex diseases
    • Masters SL. Specific inflammasomes in complex diseases. Clin Immunol 2013; 147:223-810.1016/j.clim.2012.12.006.
    • (2013) Clin Immunol , vol.147 , pp. 223-228
    • Masters, S.L.1
  • 73
    • 84896500701 scopus 로고    scopus 로고
    • Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature il-1β in response to tlr4 stimulation through a caspase-8- and trif-dependent pathway
    • Shenderov K, Riteau N, Yip R, Mayer-Barber KD, Oland S, Hieny S, et al. Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway. J Immunol 2014; 192:2029-33doi: 10.4049/jimmunol.1302549..
    • (2014) J Immunol , vol.192 , pp. 2029-2033
    • Shenderov, K.1    Riteau, N.2    Yip, R.3    Mayer-Barber, K.D.4    Oland, S.5    Hieny, S.6
  • 74
    • 84859449180 scopus 로고    scopus 로고
    • Saturated fatty acid and tlr signaling link β cell dysfunction and islet inflammation
    • Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, et al. Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. Cell Metab 2012; 15:518-33doi: 10.1016/j.cmet.2012.01.023..
    • (2012) Cell Metab , vol.15 , pp. 518-533
    • Eguchi, K.1    Manabe, I.2    Oishi-Tanaka, Y.3    Ohsugi, M.4    Kono, N.5    Ogata, F.6
  • 75
    • 84864693470 scopus 로고    scopus 로고
    • Thioredoxin- interacting protein mediates er stress-induced β cell death through initiation of the inflammasome
    • Oslowski CM, Hara T, O'Sullivan-Murphy B, Kanekura K, Lu S, Hara M, et al. Thioredoxin- interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab 2012; 16:265-273. doi: 10.1016/j.cmet.2012.07.005.
    • (2012) Cell Metab , vol.16 , pp. 265-273
    • Oslowski, C.M.1    Hara, T.2    O'sullivan-Murphy, B.3    Kanekura, K.4    Lu, S.5    Hara, M.6
  • 76
    • 84864712827 scopus 로고    scopus 로고
    • Txnip switches tracks toward a terminal upr
    • Anthony TG, Wek RC. TXNIP switches tracks toward a terminal UPR. Cell Metab 2012 16 13-5710.1016/j.cmet.2012.07.012.
    • (2012) Cell Metab , vol.16 , pp. 13-57
    • Anthony, T.G.1    Wek, R.C.2
  • 77
    • 79951676940 scopus 로고    scopus 로고
    • Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum
    • Martinon F, Glimcher LH. Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum. Curr Opin Immunol 2011; 23:35-40. doi: 10.1016/j.coi.2010.10.016.
    • (2011) Curr Opin Immunol , vol.23 , pp. 35-40
    • Martinon, F.1    Glimcher, L.H.2
  • 78
    • 79952264011 scopus 로고    scopus 로고
    • Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
    • Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 2011 13 184-90101038/ncb0311-184.
    • (2011) Nat Cell Biol , vol.13 , pp. 184-9010
    • Tabas, I.1    Ron, D.2
  • 79
    • 0037264120 scopus 로고    scopus 로고
    • Unfolding the role of protein misfolding in neurodegenerative diseases
    • Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nat Rev Neurosci 2003 44 96010.1038/nrn1007.
    • (2003) Nat Rev Neurosci , vol.44 , pp. 960
    • Soto, C.1
  • 80
    • 84882751308 scopus 로고    scopus 로고
    • Town t. Innate immunity in alzheimer's disease: A complex affair
    • Guillot-Sestier MV, Town T. Innate immunity in Alzheimer's disease: A complex affair. CNS Neurol Disord Drug Targets 2013; 12:593-607.
    • (2013) CNS Neurol Disord Drug Targets , vol.12 , pp. 593-607
    • Guillot-Sestier, M.V.1
  • 81
    • 84865418523 scopus 로고    scopus 로고
    • Alzheimer's disease pathologic cascades: Who comes first, what drives what
    • Swerdlow RH. Alzheimer's disease pathologic cascades: Who comes first, what drives what. Neurotox Res 2012 221-829410.1007/s12640-011-9272-9.
    • (2012) Neurotox Res , pp. 221-8294
    • Swerdlow, R.H.1
  • 82
    • 84881479630 scopus 로고    scopus 로고
    • The unfolded protein response in alzheimer's disease
    • Cornejo VH, Hetz C. The unfolded protein response in Alzheimer's disease. Semin Immunopathol 2013 35 277-92101007/s00281-013-0373-9.
    • (2013) Semin Immunopathol , vol.35 , pp. 277-9210
    • Cornejo, V.H.1    Hetz, C.2
  • 83
    • 84897094564 scopus 로고    scopus 로고
    • Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
    • Hetz C, Mollereau B. Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases. Nat Rev Neurosci 2014 15 233-24910.1038/nrn3689.
    • (2014) Nat Rev Neurosci , vol.15 , pp. 233-249
    • Hetz, C.1    Mollereau, B.2
  • 84
    • 84897360362 scopus 로고    scopus 로고
    • Endoplasmic reticulum dysfunction in alzheimer's disease
    • 839-5101007/s12035-014-8695-8
    • Li JQ, Yu JT, Jiang T, Tan L. Endoplasmic reticulum dysfunction in Alzheimer's disease. Mol Neurobiol 2015 513 839-5101007/s12035-014-8695-8.
    • (2015) Mol Neurobiol , vol.513 , pp. 839
    • Li, J.Q.1    Yu, J.T.2    Jiang, T.3    Tan, L.4
  • 85
    • 84903795970 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease
    • Cao SS, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal 2014 21 396-413101089/ars.2014.5851..
    • (2014) Antioxid Redox Signal , vol.21 , pp. 396-41310
    • Cao, S.S.1    Kaufman, R.J.2
  • 86
    • 84880372596 scopus 로고    scopus 로고
    • Oxidative stress in alzheimer's disease: Primary villain or physiological by-product?
    • Sutherland GT, Chami B, Youssef P, Witting PK. Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product? Redox Rep 2013 18 134-14110.1179/1351000213Y.0000000052.
    • (2013) Redox Rep , vol.18 , pp. 134-141
    • Sutherland, G.T.1    Chami, B.2    Youssef, P.3    Witting, P.K.4
  • 87
    • 84903304059 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in alzheimer's disease
    • Wang X, Wang W, Li L, Perry G, Lee HG, Zhu X. Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Biochim Biophys Acta 2014; 1842:1240-1247. doi: 10.1016/j.bbadis.2013.10.015.
    • (2014) Biochim Biophys Acta , vol.1842 , pp. 1240-1247
    • Wang, X.1    Wang, W.2    Li, L.3    Perry, G.4    Lee, H.G.5    Zhu, X.6
  • 88
    • 84899895001 scopus 로고    scopus 로고
    • Oxidative stress in alzheimer's disease
    • Chen Z, Zhong C. Oxidative stress in Alzheimer's disease. Neurosci Bull 2014 30 27-18110.1007/s12264-0131423-y.
    • (2014) Neurosci Bull , vol.30 , pp. 27-181
    • Chen, Z.1    Zhong, C.2
  • 89
    • 84859502164 scopus 로고    scopus 로고
    • Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to alzheimer's disease-like calcium dysregulation
    • Gibson GE, Chen HL, Xu H, Qiu L, Xu Z, Denton TT, Shi Q. Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation. Neurobiol Aging 2012; 33:e13-e24. doi: 10.1016/j.neurobiolaging.2011.11.003.
    • (2012) Neurobiol Aging , vol.33 , pp. e13-e24
    • Gibson, G.E.1    Chen, H.L.2    Xu, H.3    Qiu, L.4    Xu, Z.5    Denton, T.T.6    Shi, Q.7
  • 92
    • 84878333056 scopus 로고    scopus 로고
    • Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation
    • Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC 3rd, Li Q, Brady S, et al. Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. J Neurosci 2013; 33:94-98doi: 10.1523/JNEUROSCI.5397-12.2013.
    • (2013) J Neurosci , vol.33 , pp. 94-98
    • Abisambra, J.F.1    Jinwal, U.K.2    Blair, L.J.3    O'leary, J.C.4    Li, Q.5    Brady, S.6
  • 93
    • 84896324370 scopus 로고    scopus 로고
    • The role of inflammasome in alzheimer's disease
    • Liu L, Chan C. The role of inflammasome in Alzheimer's disease. Ageing Res Rev 2014 15-61510.1016/j.arr.2013.12.007.
    • (2014) Ageing Res Rev , pp. 15-615
    • Liu, L.1    Chan, C.2
  • 94
    • 84888007457 scopus 로고    scopus 로고
    • The nlrp3 inflammasome in alzheimer's disease
    • Tan MS, Yu JT, Jiang T, Zhu X., Tan L. The NLRP3 inflammasome in Alzheimer's disease. Mol Neurobiol 2013 488-758210.1007/s12035-013-8475-x..
    • (2013) Mol Neurobiol , pp. 488-7582
    • Tan, M.S.1    Yu, J.T.2    Jiang, T.3    Zhu, X.4    Tan, L.5
  • 96
    • 84873087532 scopus 로고    scopus 로고
    • Nlrp3 is activated in alzheimer's disease and contributes to pathology in app/ps1 mice
    • Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Saecker A, et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 2013 49 36-74810.1038/nature11729..
    • (2013) Nature , vol.49 , pp. 36-748
    • Heneka, M.T.1    Kummer, M.P.2    Stutz, A.3    Delekate, A.4    Schwartz, S.5    Saecker, A.6
  • 98
    • 61349088546 scopus 로고    scopus 로고
    • Inflammation in alzheimer's disease: Amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors
    • Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. Inflammation in Alzheimer's disease: Amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors. Prog Neurobiol 2009; 87:181-94.
    • (2009) Prog Neurobiol , vol.87 , pp. 181-194
    • Salminen, A.1    Ojala, J.2    Kauppinen, A.3    Kaarniranta, K.4    Suuronen, T.5
  • 99
    • 84863011816 scopus 로고    scopus 로고
    • Tlr2 is a primary receptor for alzheimer's amyloid β peptide to trigger neuroinflammatory activation
    • Liu S, Liu Y, Hao W, Wolf L, Kiliaan AJ, Penke B, et al. TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation. J Immunol 2012 18 810-9810710.4049/jimmunol.1101121..
    • (2012) J Immunol , vol.18 , pp. 810-98107
    • Liu, S.1    Liu, Y.2    Hao, W.3    Wolf, L.4    Kiliaan, A.J.5    Penke, B.6
  • 100
    • 84896734547 scopus 로고    scopus 로고
    • Biological role of toll-like receptor-4 in the brain
    • Trotta T, Porro C, Calvello R, Panaro MA. Biological role of Toll-like receptor-4 in the brain. J Neuroimmunol 2014 26 81-81210.1016/j.jneuroim.2014.01.014..
    • (2014) J Neuroimmunol , vol.26 , pp. 81-812
    • Trotta, T.1    Porro, C.2    Calvello, R.3    Panaro, M.A.4
  • 101
    • 84875611419 scopus 로고    scopus 로고
    • Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in appswe/ps1de9 transgenic mice via inhibition of nuclear factor-κb and nlrp3 inflammasome activation
    • Shi JQ, Zhang CC, Sun XL, Cheng XX, Wang JB, Zhang YD, et al. Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation. CNS Neurosci Ther 2013 19 26-2810.1111/cns.12066..
    • (2013) CNS Neurosci Ther , vol.19 , pp. 26-28
    • Shi, J.Q.1    Zhang, C.C.2    Sun, X.L.3    Cheng, X.X.4    Wang, J.B.5    Zhang, Y.D.6
  • 102
    • 84875552922 scopus 로고    scopus 로고
    • Immunogenic cell death in cancer therapy
    • Kroemer G, Galluzzi L, Kepp O, Zitvogel L. Immunogenic cell death in cancer therapy. Annu Rev Immunol 2013; 31:51-72doi: 10.1146/annurev-immunol-032712-100008..
    • (2013) Annu Rev Immunol , vol.31 , pp. 51-72
    • Kroemer, G.1    Galluzzi, L.2    Kepp, O.3    Zitvogel, L.4
  • 106
    • 84890086459 scopus 로고    scopus 로고
    • Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments
    • Inoue H, Tani K. Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments. Cell Death Differ 2014; 21:39-4910.1038/cdd.2013.84..
    • (2014) Cell Death Differ , vol.21 , pp. 39-49
    • Inoue, H.1    Tani, K.2
  • 108
    • 70350569295 scopus 로고    scopus 로고
    • Activation of the nlrp3 inflammasome in dendritic cells induces il-1beta-dependent adaptive immunity against tumors
    • Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med 2009; 15:1170-8doi: 10.1038/nm.2028..
    • (2009) Nat Med , vol.15 , pp. 1170-1178
    • Ghiringhelli, F.1    Apetoh, L.2    Tesniere, A.3    Aymeric, L.4    Ma, Y.5    Ortiz, C.6
  • 109
    • 49949115791 scopus 로고    scopus 로고
    • The co-translocation of erp57 and calreticulin determines the immunogenicity of cell death
    • Panaretakis T, Joza N, Modjtahedi N, Tesniere A, Vitale I, Durchschlag M, et al. The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death. Cell Death Differ 2008; 15:1499-1509. doi:10.1038/cdd.2008.67.
    • (2008) Cell Death Differ , vol.15 , pp. 1499-1509
    • Panaretakis, T.1    Joza, N.2    Modjtahedi, N.3    Tesniere, A.4    Vitale, I.5    Durchschlag, M.6
  • 110
    • 84870984470 scopus 로고    scopus 로고
    • Perk is required at the er-mitochondrial contact sites to convey apoptosis after ros-based er stress
    • Verfaillie T, Rubio N, Garg AD, Bultynck G, Rizzuto R, Decuypere JP, et al. PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell Death Differ 2012; 19:1880-91doi: 10.1038/cdd.2012.74..
    • (2012) Cell Death Differ , vol.19 , pp. 1880-1891
    • Verfaillie, T.1    Rubio, N.2    Garg, A.D.3    Bultynck, G.4    Rizzuto, R.5    Decuypere, J.P.6
  • 111
    • 84891754287 scopus 로고    scopus 로고
    • Strange attractors: Damps and autophagy link tumor cell death and immunity
    • Hou W, Zhang Q, Yan Z, Chen R, Zeh III HJ, Kang R, et al. Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death Dis 2013; 4:e966. doi: 10.1038/cddis.2013.493.
    • (2013) Cell Death Dis , vol.4
    • Hou, W.1    Zhang, Q.2    Yan, Z.3    Chen, R.4    Zeh, I.H.5    Kang, R.6
  • 112
    • 84857282231 scopus 로고    scopus 로고
    • Tolllike receptor-gut microbiota interactions: Perturb at your own risk!
    • Carvalho FA, Aitken JD, Vijay-Kumar M, Gewirtz AT. Tolllike receptor-gut microbiota interactions: Perturb at your own risk! Annu Rev Physiol 2012; 74:177doi: 10.1146/annurevphysiol-020911-153330..
    • (2012) Annu Rev Physiol , vol.74 , pp. 177
    • Carvalho, F.A.1    Aitken, J.D.2    Vijay-Kumar, M.3    Gewirtz, A.T.4
  • 113
    • 84876913132 scopus 로고    scopus 로고
    • Role of the gut microbiota in immunity and inflammatory disease
    • Kamada N, Seo SU, Chen GY, Núñez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol 2013; 13:321-35doi: 10.1038/nri3430..
    • (2013) Nat Rev Immunol , vol.13 , pp. 321-335
    • Kamada, N.1    Seo, S.U.2    Chen, G.Y.3    Núñez, G.4
  • 114
    • 84875934817 scopus 로고    scopus 로고
    • Toll-like receptor signaling and regulation of intestinal immunity
    • Kamdar K, Nguyen V, DePaolo RW. Toll-like receptor signaling and regulation of intestinal immunity. Virulence 2013; 4:207-212doi: 10.4161/viru.23354..
    • (2013) Virulence , vol.4 , pp. 207-212
    • Kamdar, K.1    Nguyen, V.2    Depaolo, R.W.3
  • 115
    • 84883764224 scopus 로고    scopus 로고
    • The impact of the gut microbiome on mucosal inflammation
    • Strober W. The impact of the gut microbiome on mucosal inflammation. Trends Immunol 2013; 34:423-430. doi: 10.1016/j.it.2013.07.001.
    • (2013) Trends Immunol , vol.34 , pp. 423-430
    • Strober, W.1
  • 116
    • 84908318788 scopus 로고    scopus 로고
    • Danger, diversity and priming in innate antiviral immunity
    • Collins SE, Mossman KL. Danger, diversity and priming in innate antiviral immunity. Cytokine Growth Factor Rev 2014 25 525-31101016/j.cytogfr.2014.07.002..
    • (2014) Cytokine Growth Factor Rev , vol.25 , pp. 525-3110
    • Collins, S.E.1    Mossman, K.L.2
  • 117
    • 58149393193 scopus 로고    scopus 로고
    • Differing roles of inner tegument proteins pul36 and pul37 during entry of herpes simplex virus type 1
    • Roberts AP, Abaitua F, O'Hare P, McNab D, Rixon FJ, Pasdeloup D. Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1. J Virol 2009 83 105-1610.1128/JVI.01032-08.
    • (2009) J Virol , vol.83 , pp. 105-116
    • Roberts, A.P.1    Abaitua, F.2    O'hare, P.3    McNab, D.4    Rixon, F.J.5    Pasdeloup, D.6
  • 118
    • 84893754533 scopus 로고    scopus 로고
    • Damp molecule s100a9 acts as a molecular pattern to enhance inflammation during influenza a virus infection: Role of ddx21-trif-tlr4-myd88 pathway
    • Tsai SY, Segovia JA, Chang TH, Morris IR, Berton MT, Tessier PA, et al. DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: Role of DDX21-TRIF-TLR4-MyD88 pathway. PLoS Pathog 2014; 10:e1003848doi: 10.1371/journal.ppat.1003848..
    • (2014) Plos Pathog
    • Tsai, S.Y.1    Segovia, J.A.2    Chang, T.H.3    Morris, I.R.4    Berton, M.T.5    Tessier, P.A.6
  • 119
    • 84871954753 scopus 로고    scopus 로고
    • Plasma bacterial and mitochondrial dna distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates
    • Sursal T, Stearns-Kurosawa DJ, Itagaki K, Oh SY, Sun S, Kurosawa S, Hauser CJ. Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates. Shock 2013 39 55-62101097/SHK.0b013e318276f4ca..
    • (2013) Shock , vol.39 , pp. 55-6210
    • Sursal, T.1    Stearns-Kurosawa, D.J.2    Itagaki, K.3    Oh, S.Y.4    Sun, S.5    Kurosawa, S.6    Hauser, C.J.7
  • 120
    • 84887402250 scopus 로고    scopus 로고
    • Kushimoto s. Plasma mitochondrial dna levels in patients with trauma and severe sepsis: Time course and the association with clinical status
    • Yamanouchi S, Kudo D, Yamada M, Miyagawa N, Furukawa H, Kushimoto S. Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: Time course and the association with clinical status. J Crit Care 2013; 28:1027-1031. doi: 10.1016/j.jcrc.2013.05.006.
    • (2013) J Crit Care , vol.28 , pp. 1027-1031
    • Yamanouchi, S.1    Kudo, D.2    Yamada, M.3    Miyagawa, N.4    Furukawa, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.