The HMGB1-TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis

Gene

Volumn 527, Issue 1, 2013, Pages 389-393

  Ding, Hua Sheng ^a   Yang, Jun ^a   Chen, Ping ^a   Yang, Jian ^a   Bo, Sun Qing ^a   Ding, Jia Wang ^a   Yu, Qin Qin ^a  

^a CHINA THREE GORGES UNIVERSITY   (China)

Author keywords

Apoptosis; High mobility group box 1; Myocardial ischemia reperfusion injury; Toll like receptor 4; Tumor necrosis factor

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; PROTEIN BAX; PROTEIN BCL 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; WESTERN BLOTTING;

AAR; ACUTE MYOCARDIAL INFARCTION; AI; AMI; ANOVA; APOPTOSIS; APOPTOSIS INDEX; C-JUN N-TERMINAL KINASES; ECL; ENHANCED CHEMILUMINESCENCE; HIGH MOBILITY GROUP BOX 1; HMGB1; I/R; ISCHEMIA/REPERFUSION; JNKS; LAD; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; NF-ΚB; NUCLEAR FACTOR KAPPA B; ONE-WAY ANALYSIS OF VARIANCE; PCR; POLYMERASE CHAIN REACTION; RAGE; RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS; THE AREA AT RISK; TLR4; TNF-Α; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-Α;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; GENE EXPRESSION; HMGB1 PROTEIN; MALE; MICE; MICE, INBRED C3H; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-BCL-2; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84881241307     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.05.041     Document Type: Article

References (22)

1. Akira S., Takeda K., Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2001, 2:675-680.
2. Andrassy M., et al. High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 2008, 117:3216-3226.
3. de Oliveira F.M., et al. Cloning the genes and DNA binding properties of High Mobility Group B1 (HMGB1) proteins from the human blood flukes Schistosoma mansoni and Schistosoma japonicum. Gene 2006, 1(377):33-45.
4. Frangogiannis N.G., Smith C.W., Entman M.L. The inflammatory response in myocardial infarction. Cardiovasc. Res. 2002, 53:31-47.
5. Hamacher-Brady A., Brady N.R., Gottlieb R.A. The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: apoptosis meets autophagy. Cardiovasc. Drugs Ther. 2006, 20(6):445-462.
6. Hansen P.R. Myocardial reperfusion injury: experimental evidence and clinical relevance. Eur. Heart J. 1995, 16:734-740.
7. Hillis L.D., Lange R.A. Myocardial infarction and the open-artery hypothesis. N. Engl. J. Med. 2006, 355(23):2475-2477.
8. Ding Hua-Sheng, Yang Jun HMGB1 and cardiovascular diseases. Saudi Med. J. 2010, 31:486-489.
9. Ding Hua-Sheng, et al. High mobility group box 1 mediates neutrophil recruitment in myocardial ischemia-reperfusion injury through toll like receptor 4-related pathway. Gene 2012, 509(1):149-153.
10. Kiilerich B., Stemmer C., Merkle T., Launholt D., Gorr G., Grasser K.D. Chromosomal high mobility group (HMG) proteins of the HMGB-type occurring in the moss Physcomitrella patens. Gene 2008, 407(1-2):86-97.
11. Liao Y.H., et al. Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration. J. Am. Coll. Cardiol. 2012, 59(4):420-429.
12. Marino J.H., Cook P., Miller K.S. Accurate and statistically verified quantification of relative mRNA abundances using SYBR Green I and real-time RT-PCR. J. Immunol. Methods 2003, 283:291-306.
13. Nakamura M., et al. Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart. Cardiovasc. Res. 2000, 45(3):661-670.
14. Nemoto S., et al. Escherichia coli LPS-induced LV dysfunction: role of toll-like receptor-4 in the adult heart. Am. J. Physiol. Heart Circ. Physiol. 2002, 282:H2316-H2323.
15. Scaffidi P., Misteli T., Bianchi M.E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002, 418:191-195.
16. Shibata R., et al. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat. Med. 2005, 11:1096-1103.
17. Vakeva A.P., Agah A., Rollins S.A., Matis L.A., Li L., Stahl G.L. Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy. Circulation 1998, 97:2259-2267.
18. Yang J., Huang C., Yang J., Jiang H., Ding J. Statins attenuate high mobility group box-1 protein induced vascular endothelial activation: a key role for TLR4/NF-κB signaling pathway. Mol. Cell. Biochem. 2010, 345(1-2):189-195.
19. Yang J., et al. High mobility group box-1 induces migration of vascular smooth muscle cells via TLR4-dependent PI3K/Akt pathway activation. Mol. Biol. Rep. 2012, 39(3):3361-3367.
20. Yao Y., Xu X., Zhang G., Zhang Y., Qian W., Rui T. Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway. Basic Res. Cardiol. 2012, 107(3):267-273.
21. Yellon D.M., Hausenloy D.J. Myocardial reperfusion injury. N. Engl. J. Med. 2007, 357(11):1121-1135. (13).
22. Zeuke S., Ulmer A.J., Kusumoto S., Katus H.A., Heine H. TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS. Cardiovasc. Res. 2002, 56:126-134.