Impact of the gut microbiome on mucosal inflammation

Trends in Immunology

Volumn 34, Issue 9, 2013, Pages 423-430

  Strober, Warren ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Anti inflammatory organisms; Gut microbiome; Inflammatory Bowel Disease; Mucosal regulatory T cells; Proinflammatory (colitogenic organisms)

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; CYTOKINE; TOLL LIKE RECEPTOR 2;

BACTEROIDES; BACTEROIDES FRAGILIS; CLOSTRIDIUM; COLITIS; CROHN DISEASE; CYTOKINE PRODUCTION; ENTERITIS; ESCHERICHIA COLI; FIRMICUTES; HELICOBACTER; HUMAN; IMMUNE SYSTEM; INFLAMMATION; INTESTINE FLORA; INTESTINE MUCOSA; KLEBSIELLA PNEUMONIAE; LACTOBACILLUS; MYCOBACTERIUM AVIUM; NONHUMAN; PREVOTELLA; PROTEOBACTERIA; PROTEUS MIRABILIS; REGULATORY T LYMPHOCYTE; REVIEW;

ANTI-INFLAMMATORY ORGANISMS; GUT MICROBIOME; INFLAMMATORY BOWEL DISEASE; MUCOSAL REGULATORY T CELLS; PROINFLAMMATORY (COLITOGENIC ORGANISMS);

ANIMALS; HUMANS; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MICROBIOTA;

EID: 84883764224     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2013.07.001     Document Type: Review

References (47)

1. Strober W., et al. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 2001, 20:495-549.
2. Kaser A., et al. Inflammatory bowel disease. Annu. Rev. Immunol. 2010, 28:573-621.
3. Strober W., et al. The fundamental basis of inflammatory bowel disease. J. Clin. Invest. 2007, 117:514-521.
4. Strober W., Watanabe T. NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease. Mucosal Immunol. 2011, 4:484-495.
5. Saitoh T., et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008, 456:264-268.
6. Sarin R., et al. Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:9560-9565.
7. Boirivant M., et al. A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitis. Gastroenterology 2008, 135:1612-1623.
8. Geuking M.B., et al. Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity 2011, 34:794-806.
9. Hermiston M.L., Gordon J.I. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 1995, 270:1203-1207.
10. Mazmanian S.K., et al. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008, 453:620-625.
11. Round J.L., Mazmanian S.K. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:12204-12209.
12. Round J.L., et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 2011, 332:974-977.
13. Atarashi K., et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 2011, 331:337-341.
14. Garrett W.S., et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 2007, 131:33-45.
15. Powell N., et al. The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells. Immunity 2012, 37:674-684.
16. Garrett W.S., et al. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe 2010, 8:292-300.
17. Chen G.Y., et al. A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J. Immunol. 2011, 186:7187-7194.
18. Normand S., et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:9601-9606.
19. Elinav E., et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011, 145:745-757.
20. Hirota S.A., et al. NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm. Bowel Dis. 2011, 17:1359-1372.
21. Couturier-Mallard A., et al. NOD2-mediated dysbiosis pre-disposes mice to transmissible colitis and colorectal cancer. J. Clin. Invest. 2013, 123:700-711.
22. Ubeda C., et al. Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J. Exp. Med. 2012, 209:1445-1456.
23. Frank D.N., et al. Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Proc. Natl. Acad. Sci. U.S.A. 2011, 17:179-184.
24. Chiodini R.J., et al. Crohn's disease and the mycobacterioses: a quarter century later. Causation or simple association?. Crit. Rev. Microbiol. 2012, 36:52-93.
25. Vanderploeg R., et al. Influence of intestinal bacteria in human inflammatory bowel disease. Infect. Dis. Clin. N. Am. 2010, 24:977-993.
26. Gophna U., et al. Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis. J. Clin. Microbiol. 2006, 44:4136-4141.
27. Baumgart M., et al. Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum. ISME J. 2007, 1:403-418.
28. Willing B., et al. Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease. Inflamm. Bowel Dis. 2009, 15:653-660.
29. Sokol H., et al. Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm. Bowel Dis. 2009, 15:1183-1189.
30. Swidsinski A., et al. Active Crohn's disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora. Inflamm. Bowel Dis. 2008, 14:147-161.
31. Schwiertz A., et al. Microbiota in pediatric inflammatory bowel disease. J. Pediatr. 2010, 157:240-244.
32. Kang S., et al. Dysbiosis of fecal microbiota in Crohn's disease patients as revealed by a custom phylogenetic microarray. Inflamm. Bowel Dis. 2010, 16:2034-2042.
33. Swidsinski A., et al. Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease. J. Clin. Microbiol. 2005, 43:3380-3389.
34. Swidsinski A., et al. Mucosal flora in inflammatory bowel disease. Gastroenterology 2002, 122:44-54.
35. Sokol H., et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:16731-16736.
36. Darfeuille-Michaud A., et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 2004, 127:412-421.
37. Chambrun G., et al. Pathogenic agents in inflammatory bowel diseases Curr. Opin. Gastroenterol. 2008, 24:440-447.
38. Barnich N., et al. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J. Clin. Invest. 2007, 117:1566-1574.
39. Carvalho F.A., et al. Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM. J. Exp. Med. 2009, 206:2179-2189.
40. Denizot J., et al. Adherent-invasive Escherichia coli induce claudin-2 expression and barrier defect in CEABAC10 mice and Crohn's disease patients. Inflamm. Bowel Dis. 2012, 18:294-304.
41. Chaissaing B., et al. Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae. J. Clin. Invest. 2011, 121:966-975.
42. Glasser A.L., et al. Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death. Infect. Immun. 2001, 69:5529-5537.
43. Bringer M.A., et al. Replication of Crohn's disease-associated AIEC within macrophages is dependent on TNF-α secretion. Lab. Invest. 2012, 92:411-419.
44. Lapaquette P., et al. Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response. Cell. Microbiol. 2012, 14:791-807.
45. Khan K.J., et al. Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis. Am. J. Gastroenterol. 2011, 106:661-673.
46. Strober W. Adherent-invasive E. coli in Crohn disease: bacterial "agent provocateur." J. Clin. Invest. 2011, 121:841-844.
47. Carvalho F.A., et al. Transient inability to manage Proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host Microbe 2012, 12:139-152.