Role of innate immunity in cardiac inflammation after myocardial infarction

Frontiers in Bioscience - Scholar

Volumn 5 S, Issue 1, 2013, Pages 86-104

  Liaudet, Lucas ^a   Rosenblatt Velin, Nathalie ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Chemokine; Cytokine; Heart; High mobility group box 1; Inflammasome; Inflammation; Innate immunity; Myocardial infarction; NOD like receptor; Nuclear factor kappaB; Oxidative stress; Remodeling; Review; Toll like receptor

Indexed keywords

CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CXCR4; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLYCOPROTEIN GP 130; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 27; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ALPHA; MATRIX METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PROTEIN P50; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; STAT3 PROTEIN; THROMBOSPONDIN 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; VASCULAR CELL ADHESION MOLECULE 1;

ANGIOGENESIS; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HEART INFARCTION; HEART MUSCLE; HEART MUSCLE CELL; HEART REGENERATION; HUMAN; INNATE IMMUNITY; MACROPHAGE; MESENCHYMAL STEM CELL; MONONUCLEAR PHAGOCYTE; MYOCARDITIS; MYOFIBROBLAST; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; PLEIOTROPY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REGENERATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STABLE EXPRESSION; TISSUE REPAIR; ANIMAL; IMMUNOLOGY; REVIEW;

ANIMALS; HUMANS; IMMUNITY, INNATE; MYOCARDIAL INFARCTION; MYOCARDITIS;

EID: 84883210648     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/s359     Document Type: Article

References (166)

1. AT Turer, JA Hill. Pathogenesis of myocardial ischemiareperfusion injury and rationale for therapy. Am J Cardiol 106, 360-8 (2010)
2. DM Yellon, DJ Hausenloy. Myocardial reperfusion injury. N Engl J Med 357, 1121-35 (2007)
3. NG Frangogiannis. The immune system and cardiac repair. Pharmacol Res 58, 88-111 (2008)
4. S Steffens, F Montecucco, F Mach. The inflammatory response as a target to reduce myocardial ischaemia and reperfusion injury. Thromb Haemost 102, 240-7 (2009)
5. S Frantz, J Bauersachs, G Ertl. Post-infarct remodelling: contribution of wound healing and inflammation. Cardiovasc Res 81, 474-81 (2009)
6. P Knuefermann, J Vallejo, DL Mann. The role of innate immune responses in the heart in health and disease. Trends Cardiovasc Med 14, 1-7 (2004) (Pubitemid 38071815)
7. F Mookadam, SE Moustafa. Prevention of late postmyocardial infarction left ventricular remodeling: an update. Curr Heart Fail Rep 6, 245-53 (2009)
8. N Maekawa, H Wada, T Kanda, T Niwa, Y Yamada, K Saito, H Fujiwara, K Sekikawa, M Seishima. Improved myocardial ischemia/reperfusion injury in mice lacking tumor necrosis factor-alpha. J Am Coll Cardiol 39, 1229-35 (2002) (Pubitemid 34267430)
9. DA Siwik, DL Chang, WS Colucci. Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro. Circ Res 86, 1259-65 (2000) (Pubitemid 30436667)
10. V Stangl, G Baumann, K Stangl, SB Felix. Negative inotropic mediators released from the heart after myocardial ischaemia-reperfusion. Cardiovasc Res 53, 12-30 (2002) (Pubitemid 34020763)
11. KM Kurrelmeyer, LH Michael, G Baumgarten, GE Taffet, JJ Peschon, N Sivasubramanian, ML Entman, DL Mann. Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. Proc Natl Acad Sci U S A 97, 5456-61 (2000) (Pubitemid 30313740)
12. ES Chung, M Packer, KH Lo, AA Fasanmade, J. T. Willerson. Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-tosevere heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial. Circulation 107, 3133-40 (2003) (Pubitemid 36793081)
13. A Louis, JG Cleland, S Crabbe, S Ford, S Thackray, T Houghton, A Clark. Clinical Trials Update: Capricorn, Copernicus, Miracle, Staf, Ritz-2, Recover And Renaissance and cachexia and cholesterol in heart failure. Highlights of the Scientific Sessions of the American College of Cardiology, 2001. Eur J Heart Fail 3, 381-7. (2001)
14. R Kishore, T Tkebuchava, SP Sasi, M Silver, HY Gilbert, YS Yoon, HY Park, T Thorne, DW Losordo, DA Goukassian. Tumor necrosis factor-alpha signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium. Adv Exp Med Biol 691, 433-48 (2011)
15. M Bujak, NG Frangogiannis. The role of IL-1 in the pathogenesis of heart disease. Arch Immunol Ther Exp (Warsz) 57, 165-76 (2009)
16. CA Dinarello. A clinical perspective of IL-1beta as the gatekeeper of inflammation. Eur J Immunol 41, 1203-17 (2011)
17. M Bujak, M Dobaczewski, K Chatila, LH Mendoza, N Li, A Reddy, NG Frangogiannis. Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol 173, 57-67 (2008) (Pubitemid 351947955)
18. K Nishikawa, M Yoshida, M Kusuhara, N Ishigami, K Isoda, K Miyazaki, F Ohsuzu. Left ventricular hypertrophy in mice with a cardiac-specific overexpression of interleukin-1. Am J Physiol Heart Circ Physiol 291, H176- 83 (2006)
19. Y Maekawa, N Mizue, A Chan, Y Shi, Y Liu, S Dawood, M Chen, F Dawood, G de Couto, GH Li, N Suzuki, WC Yeh, A Gramolini, JA Medin, PP Liu. Survival and cardiac remodeling after myocardial infarction are critically dependent on the host innate immune interleukin- 1 receptor-associated kinase-4 signaling: a regulator of bone marrow-derived dendritic cells. Circulation 120, 1401-14 (2009)
20. A Abbate, MC Kontos, JD Grizzard, GG Biondi- Zoccai, BW Van Tassell, R Robati, LM Roach, RA Arena, CS Roberts, A Varma, CC Gelwix, FN Salloum, A Hastillo, CA Dinarello, GW Vetrovec. Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study). Am J Cardiol 105, 1371-1377 e1 (2010)
21. PR Woldbaek, T Tonnessen, UL Henriksen, G Florholmen, PK Lunde, T Lyberg, G Christensen. Increased cardiac IL-18 mRNA, pro-IL-18 and plasma IL- 18 after myocardial infarction in the mouse; a potential role in cardiac dysfunction. Cardiovasc Res 59, 122-31 (2003) (Pubitemid 36776378)
22. M Hartford, O Wiklund, LM Hulten, A Persson, T Karlsson, J Herlitz, J Hulthe, K Caidahl. Interleukin-18 as a Predictor of Future Events in Patients With Acute Coronary Syndromes. Arterioscler Thromb Vasc Biol 30, 2039-46 (2010)
23. I Banerjee, JW Fuseler, AR Intwala, TA Baudino. IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart. Am J Physiol Heart Circ Physiol 296, H1694-704 (2009)
24. D Kamimura, K Ishihara, T Hirano. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 149, 1-38 (2003)
25. A. Haghikia, B. Stapel, M. Hoch and D. Hilfiker- Kleiner. STAT3 and cardiac remodeling. Heart Fail Rev 16, 35-47 (2011)
26. M Fuchs, A Hilfiker, K Kaminski, D Hilfiker-Kleiner, Z Guener, G Klein, E Podewski, B Schieffer, S Rose-John, H Drexler. Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction. Faseb J 17, 2118-20 (2003)
27. M Kobara, K Noda, M Kitamura, A Okamoto, T Shiraishi, H Toba, H Matsubara, T Nakata. Antibody against interleukin-6 receptor attenuates left ventricular remodelling after myocardial infarction in mice. Cardiovasc Res 87, 424-30 (2010)
28. D Hilfiker-Kleiner, P Shukla, G Klein, A Schaefer, B Stapel, M Hoch, W Muller, M Scherr, G Theilmeier, M Ernst, A Hilfiker, H Drexler. Continuous glycoprotein-130- mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction. Circulation 122, 145-55 (2010)
29. S Orn, UM Breland, TE Mollnes, C Manhenke, K Dickstein, P Aukrust, T Ueland. The chemokine network in relation to infarct size and left ventricular remodeling following acute myocardial infarction. Am J Cardiol 104, 1179-83 (2009)
30. J Vinten-Johansen. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc Res 61, 481-97 (2004) (Pubitemid 38210154)
31. M Nahrendorf, FK Swirski, E Aikawa, L Stangenberg, T Wurdinger, JL Figueiredo, P Libby, R Weissleder, MJ Pittet. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 204, 3037-47 (2007) (Pubitemid 350179569)
32. FK. Swirski, M Nahrendorf, M Etzrodt, M Wildgruber, V Cortez-Retamozo, P Panizzi, JL Figueiredo, RH Kohler, A Chudnovskiy, P Waterman, E Aikawa, TR Mempel, P Libby, R Weissleder, MJ Pittet. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science 325, 612-6 (2009)
33. F Leuschner, P Panizzi, I Chico-Calero, WW Lee, T Ueno, V Cortez-Retamozo, P Waterman, R Gorbatov, B Marinelli, Y Iwamoto, A Chudnovskiy, JL Figueiredo, DE Sosnovik, MJ Pittet, FK Swirski, R Weissleder, M Nahrendorf. Angiotensinconverting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ Res 107, 1364-73 (2010)
34. M Bujak, M Dobaczewski, C Gonzalez-Quesada, Y Xia, T Leucker, P Zymek, V Veeranna, AM Tager, AD Luster, NG Frangogiannis. Induction of the CXC chemokine interferongamma- inducible protein 10 regulates the reparative response following myocardial infarction. Circ Res 105, 973-83 (2009)
35. M Takahashi. Role of the SDF-1/CXCR4 system in myocardial infarction. Circ J 74, 418-23 (2010)
36. S Kanki, VF Segers, W Wu, R Kakkar, J Gannon, SU Sys, A Sandrasagra, RT.Lee. Stromal Cell-derived Factor-1 Retention and Cardioprotection for Ischemic Myocardium. Circ Heart Fail 4, 509-18 (2011)
37. U Agarwal, W Ghalayini, F Dong, K Weber, YR Zou, SY Rabbany, S Rafii, MS Penn. Role of cardiac myocyte CXCR4 expression in development and left ventricular remodeling after acute myocardial infarction. Circ Res 107, 667-76 (2010)
38. O Dewald, P Zymek, K Winkelmann, A Koerting, G Ren, T Abou-Khamis, LH Michael, BJ Rollins, ML Entman, NG Frangogiannis. CCL2/Monocyte Chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts. Circ Res 96, 881-9 (2005) (Pubitemid 40604972)
39. K Kaikita, T Hayasaki, T Okuma, WA Kuziel, H Ogawa, M Takeya. Targeted deletion of CC chemokine receptor 2 attenuates left ventricular remodeling after experimental myocardial infarction. Am J Pathol 165, 439-47 (2004) (Pubitemid 38971374)
40. RA Weir, CA Murphy, CJ Petrie, TN Martin, S Clements, T Steedman, GS Wagner, JJ McMurray, HJ Dargie. Monocyte chemoattractant protein-1: a dichotomous role in cardiac remodeling following acute myocardial infarction in man? Cytokine 50, 158-62 (2010)
41. F Montecucco, V Braunersreuther, S Lenglet, BM Delattre, G Pelli, V Buatois, F Guilhot, K Galan, N Vuilleumier, W Ferlin, N Fischer, JP Vallee, M Kosco-Vilbois, F Mach. CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice. Eur Heart J (2011)
42. EA Liehn, MW Merx, O Postea, S Becher, Y Djalali- Talab, E Shagdarsuren, M Kelm, A Zernecke, C Weber. Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction. J Cell Mol Med 12, 496-506 (2008) (Pubitemid 351555130)
43. T Harel-Adar, T Ben Mordechai, Y Amsalem, MS Feinberg, J Leor, S Cohen. Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair. Proc Natl Acad Sci U S A 108, 1827- 32 (2011)
44. M Dobaczewski, W Chen, NG Frangogiannis. Transforming growth factor (TGF)-beta signaling in cardiac remodeling. J Mol Cell Cardiol 51, 600-6 (2010)
45. M Bujak, G Ren, HJ Kweon, M Dobaczewski, A Reddy, G Taffet, XF Wang, NG Frangogiannis. Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation 116, 2127-38 (2007) (Pubitemid 350060350)
46. LA O'Neill, AG Bowie. The family of five: TIR-domaincontaining adaptors in Toll-like receptor signalling. Nat Rev Immunol 7, 353-64 (2007) (Pubitemid 46674493)
47. K Schroder, J Tschopp. The inflammasomes. Cell 140, 821-32 (2010)
48. F Arslan, DP de Kleijn, G Pasterkamp. Innate immune signaling in cardiac ischemia. Nat Rev Cardiol 8, 292-300 (2011)
49. R Gill, A Tsung, T Billiar. Linking oxidative stress to inflammation: Toll-like receptors. Free Radic Biol Med 48, 1121-32 (2010)
50. NJ Gay, M Gangloff, LA O'Neill. What the Myddosome structure tells us about the initiation of innate immunity. Trends Immunol 32, 104-9 (2011)
51. G Bonizzi, M Karin. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25, 280-8 (2004) (Pubitemid 38610351)
52. H Hacker, M Karin. Regulation and function of IKK and IKK-related kinases. Sci STKE 357, re13 (2006)
53. V Baud, M Karin. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 8, 33-40 (2009)
54. S Vallabhapurapu, M Karin. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27, 693-733 (2009)
55. PJ Shaw, MF McDermott, TD Kanneganti. Inflammasomes and autoimmunity. Trends Mol Med 17, 57-64 (2011)
56. M Lamkanfi, TD Kanneganti. Nlrp3: an immune sensor of cellular stress and infection. Int J Biochem Cell Biol 42, 792-5 (2010)
57. J Tschopp, K Schroder. NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 10, 210-5 (2010)
58. JW Gordon, JA Shaw, LA Kirshenbaum. Multiple facets of NF-kappaB in the heart: to be or not to NFkappaB. Circ Res 108, 1122-32 (2011)
59. R Morishita, T Sugimoto, M Aoki, I Kida, N Tomita, A Moriguchi, K Maeda, Y Sawa, Y Kaneda, J Higaki, T Ogihara. In vivo transfection of cis element "decoy" against nuclear factor- kappaB binding site prevents myocardial infarction. Nat Med 3, 894-9 (1997) (Pubitemid 27353450)
60. Y Sawa, R Morishita, K Suzuki, K Kagisaki, Y Kaneda, K Maeda, K Kadoba, H Matsuda. A novel strategy for myocardial protection using in vivo transfection of cis element 'decoy' against NFkappaB binding site: evidence for a role of NFkappaB in ischemia-reperfusion injury. Circulation 96, II-280-4 (1997)
61. NC Moss, WE Stansfield, MS Willis, RH Tang, CH Selzman. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 293, H2248-53 (2007) (Pubitemid 47605868)
62. S Frantz, K Hu, B Bayer, S Gerondakis, J Strotmann, A Adamek, G Ertl, J Bauersachs. Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction. Faseb J 20, 1918-20 (2006)
63. S Kawano, T Kubota, Y Monden, T Tsutsumi, T Inoue, N Kawamura, H Tsutsui, K Sunagawa. Blockade of NF kappaB improves cardiac function and survival after myocardial infarction. Am J Physiol Heart Circ Physiol 291, H1337-44 (2006) (Pubitemid 44343679)
64. T Hamid, SZ Guo, JR Kingery, X Xiang, B Dawn, SD Prabhu. Cardiomyocyte NF-kappaB p65 promotes adverse remodelling, apoptosis, and endoplasmic reticulum stress in heart failure. Cardiovasc Res 89, 129-38 (2011)
65. NH Purcell, JD Molkentin. Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy? Circulation 108, 638-40 (2003) (Pubitemid 36999241)
66. D Baetz, KM Regula, K Ens, J Shaw, S Kothari, N Yurkova, LA Kirshenbaum. Nuclear factor-kappaBmediated cell survival involves transcriptional silencing of the mitochondrial death gene BNIP3 in ventricular myocytes. Circulation 112, 3777-85 (2005) (Pubitemid 43739519)
67. KM Regula, D Baetz, LA Kirshenbaum. Nuclear factorkappaB represses hypoxia-induced mitochondrial defects and cell death of ventricular myocytes. Circulation 110, 3795-802 (2004) (Pubitemid 40023978)
68. A Misra, SB Haudek, P Knuefermann, JG Vallejo, ZJ Chen, LH Michael, N Sivasubramanian, EN Olson, ML Entman, DL Mann. Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction. Circulation 108, 3075-8 (2003) (Pubitemid 38031794)
69. L Timmers, JK van Keulen, IE Hoefer, MF Meijs, B van Middelaar, K den Ouden, CJ van Echteld, G Pasterkamp, DP de Kleijn. Targeted deletion of nuclear factor kappaB p50 enhances cardiac remodeling and dysfunction following myocardial infarction. Circ Res 104, 699-706 (2009)
70. W Chao. Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. Am J Physiol Heart Circ Physiol 296, H1-12 (2009)
71. J Rolli, N Rosenblatt-Velin, J Li, N Loukili, S Levrand, P Pacher, B Waeber, F Feihl, P Ruchat, L Liaudet. Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction. PLoS One 5, e12687 (2010)
72. P Knuefermann, M Schwederski, M Velten, P Krings, H Ehrentraut, M Rudiger, O Boehm, K Fink, U Dreiner, C Grohe, A Hoeft, G Baumgarten, A Koch, K Zacharowski, R Meyer. Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of Toll-like receptor 9. Cardiovasc Res 78, 26-35 (2008) (Pubitemid 351430962)
73. JH Boyd, S Mathur, Y Wang, RM Bateman, KR Walley. Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response. Cardiovasc Res 72, 384-93 (2006) (Pubitemid 44665856)
74. JG Vallejo. Role of toll-like receptors in cardiovascular diseases. Clin Sci (Lond) 121, 1-10 (2011)
75. S Frantz, L Kobzik, YD Kim, R Fukazawa, R Medzhitov, RT Lee, RA Kelly. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest 104, 271-80 (1999)
76. EJ Birks, LE Felkin, NR Banner, A Khaghani, PJ Barton, MH Yacoub. Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices. J Heart Lung Transplant 23, 228-35 (2004) (Pubitemid 38175301)
77. G Vilahur, O Juan-Babot, E Pena, B Onate, L Casani, L Badimon. Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction. J Mol Cell Cardiol 50, 522-33 (2011)
78. AJ Chong, A Shimamoto, CR Hampton, H Takayama, DJ Spring, CL Rothnie, M Yada, TH Pohlman, ED Verrier. Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J Thorac Cardiovasc Surg 128, 170-9 (2004) (Pubitemid 38969797)
79. J. Oyama, C. Blais, Jr., X. Liu, M. Pu, L. Kobzik, R. A. Kelly and T. Bourcier. Reduced myocardial ischemiareperfusion injury in toll-like receptor 4-deficient mice. Circulation 109, 784-9 (2004) (Pubitemid 38222900)
80. A Shimamoto, AJ Chong, M Yada, S Shomura, H Takayama, AJ. Fleisig, ML Agnew, CR Hampton, CL Rothnie, DJ Spring, TH Pohlman, H Shimpo, ED Verrier. Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury. Circulation 114, I270-4 (2006) (Pubitemid 44297162)
81. L Timmers, JP Sluijter, JK van Keulen, IE Hoefer, MG Nederhoff, MJ Goumans, PA Doevendans, CJ van Echteld, JA Joles, PH Quax, JJ Piek, G Pasterkamp, DP de Kleijn. Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circ Res 102, 257-64 (2008) (Pubitemid 351674064)
82. A Riad, S Jager, M Sobirey, F Escher, A Yaulema-Riss, D Westermann, A Karatas, MM. Heimesaat, S Bereswill, D Dragun, M Pauschinger, HP Schultheiss, C Tschope. Tolllike receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice. J Immunol 180, 6954-61 (2008)
83. T Ha, Y Li, F Hua, J Ma, X Gao, J Kelley, A Zhao, GE Haddad, DL Williams, I William Browder, RL Kao, C Li. Reduced cardiac hypertrophy in toll-like receptor 4- deficient mice following pressure overload. Cardiovasc Res 68, 224-34 (2005) (Pubitemid 41428419)
84. J Favre, P Musette, V Douin-Echinard, K Laude, JP Henry, JF Arnal, C Thuillez, V Richard. Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction. Arterioscler Thromb Vasc Biol 27, 1064-71 (2007) (Pubitemid 46641958)
85. Y Sakata, JW Dong, JG Vallejo, CH Huang, JS Baker, KJ Tracey, O Tacheuchi, S Akira, DL Mann. Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 292, H503-9 (2007) (Pubitemid 46105213)
86. T Shishido, N Nozaki, S Yamaguchi, Y Shibata, J Nitobe, T Miyamoto, H Takahashi, T Arimoto, K Maeda, M Yamakawa, O Takeuchi, S Akira, Y Takeishi, I Kubota. Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation 108, 2905-10 (2003) (Pubitemid 37517819)
87. F Arslan, MB Smeets, LA O'Neill, B Keogh, P McGuirk, L Timmers, C Tersteeg, IE Hoefer, PA Doevendans, G Pasterkamp, DP de Kleijn. Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. Circulation 121, 80-90 (2010)
88. GW Schmid-Schonbein. Toll-like receptor signaling mechanisms in hostile neutrophils. Focus on "Bone marrow MyD88 signaling modulates neutrophil function and ischemic myocardial injury". Am J Physiol Cell Physiol 299, C731-2 (2010)
89. Y Feng, L Zou, R Si, Y Nagasaka, W Chao. Bone marrow MyD88 signaling modulates neutrophil function and ischemic myocardial injury. Am J Physiol Cell Physiol 299, C760-9 (2010)
90. F Hua, T Ha, J Ma, X Gao, J Kelley, DL Williams, IW Browder, RL Kao, C Li. Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts. Biochem Biophys Res Commun 338, 1118-25 (2005) (Pubitemid 41597753)
91. BW Van Tassell, IM Seropian, S Toldo, FN Salloum, L Smithson, A Varma, NN Hoke, C Gelwix, V Chau, A Abbate. Pharmacologic inhibition of myeloid differentiation factor 88 (MyD88) prevents left ventricular dilation and hypertrophy after experimental acute myocardial infarction in the mouse. J Cardiovasc Pharmacol 55, 385-90 (2010)
92. Y Feng, H Zhao, X Xu, ES Buys, MJ Raher, JC Bopassa, H Thibault, M Scherrer-Crosbie, U Schmidt, W Chao. Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice. Am J Physiol Heart Circ Physiol 295, H1311-H1318 (2008)
93. F Arslan, B Keogh, P McGuirk, AE Parker. TLR2 and TLR4 in ischemia reperfusion injury. Mediators Inflamm 2010, 704202 (2010)
94. M Andrassy, HC Volz, JC Igwe, B Funke, SN Eichberger, Z Kaya, S Buss, F Autschbach, ST Pleger, IK Lukic, F Bea, SE Hardt, PM Humpert, ME Bianchi, H Mairbaurl, PP Nawroth, A Remppis, HA Katus, A Bierhaus. High-mobility group box-1 in ischemiareperfusion injury of the heart. Circulation 117, 3216-26 (2008)
95. P Scaffidi, T Misteli, ME Bianchi. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418, 191-5 (2002) (Pubitemid 34773774)
96. N Loukili, N Rosenblatt-Velin, J Li, S Clerc, P Pacher, F Feihl, B Waeber, L Liaudet. Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo. Cardiovasc Res 89, 586-94 (2011)
97. H Xu, Y Yao, Z Su, Y Yang, R Kao, CM Martin, T Rui. Endogenous HMGB1 contributes to ischemiareperfusion- induced myocardial apoptosis by potentiating the effect of TNF-alpha/JNK. Am J Physiol Heart Circ Physiol 300, H913-21 (2011)
98. T Kohno, T Anzai, K Naito, T Miyasho, M Okamoto, H Yokota, S Yamada, Y Maekawa, T Takahashi, T Yoshikawa, A Ishizaka, S Ogawa. Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling. Cardiovasc Res 81, 565-73 (2009)
99. T Kitahara, Y Takeishi, M Harada, T Niizeki, S Suzuki, T Sasaki, M Ishino, O Bilim, O Nakajima, I Kubota. Highmobility group box 1 restores cardiac function after myocardial infarction in transgenic mice. Cardiovasc Res 80, 40-6 (2008)
100. F Limana, A Germani, A Zacheo, J Kajstura, A Di Carlo, G Borsellino, O Leoni, R Palumbo, L Battistini, R Rastaldo, S Muller, G Pompilio, P Anversa, ME Bianchi, MC Capogrossi. Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation. Circ Res 97, e73-83 (2005)
101. A Rossini, A Zacheo, D Mocini, P Totta, A Facchiano, R Castoldi, P Sordini, G Pompilio, D Abeni, MC Capogrossi, A Germani. HMGB1-stimulated human primary cardiac fibroblasts exert a paracrine action on human and murine cardiac stem cells. J Mol Cell Cardiol 44, 683-93 (2008)
102. K Takahashi, S Fukushima, K Yamahara, K Yashiro, Y Shintani, SR Coppen, HK Salem, SW Brouilette, MH Yacoub, K Suzuki. Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart. Circulation 118, S106-14 (2008)
103. JN Tsoporis, S Izhar, H Leong-Poi, JF Desjardins, HJ Huttunen, TG Parker. S100B interaction with the receptor for advanced glycation end products (RAGE): a novel receptor-mediated mechanism for myocyte apoptosis postinfarction. Circ Res 106, 93-101 (2010)
104. SC Kim, JP Stice, L Chen, JS Jung, S Gupta, Y Wang, G Baumgarten, J Trial, AA Knowlton. Extracellular heat shock protein 60, cardiac myocytes, and apoptosis. Circ Res 105, 1186-95 (2009)
105. Y Li, R Si, Y Feng, HH Chen, L Zou, E Wang, M Zhang, HS Warren, DE Sosnovik, W Chao. Myocardial Ischemia Activates an Injurious Innate Immune Signaling via Cardiac Heat Shock Protein 60 and Tolllike Receptor 4. J Biol Chem 286, 31308-19 (2011)
106. N Zou, L Ao, JC Cleveland, Jr, X Yang, X Su, GY Cai, A Banerjee, DA Fullerton, X Meng. Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion. Am J Physiol Heart Circ Physiol 294, H2805-13 (2008)
107. P Zhang, CJ Cox, KM Alvarez, MW Cunningham. Cutting edge: cardiac myosin activates innate immune responses through TLRs. J Immunol 183, 27-31 (2009)
108. F Arslan, MB Smeets, PW Riem Vis, JC Karper, PH Quax, LG Bongartz, JH Peters, IE Hoefer, PA Doevendans, G Pasterkamp, DP de Kleijn. Lack of fibronectin-EDA promotes survival and prevents adverse remodeling and heart function deterioration after myocardial infarction. Circ Res 108, 582-92 (2011)
109. M Hori, K Nishida. Toll-like receptor signaling: defensive or offensive for the heart? Circ Res 102, 137-9 (2008) (Pubitemid 351651112)
110. Q Zhang, M Raoof, Y Chen, Y Sumi, T Sursal, W Junger, K Brohi, K Itagaki, CJ Hauser. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464, 104-7 (2010)
111. SS Iyer, WP Pulskens, JJ Sadler, LM Butter, GJ Teske, TK Ulland, SC Eisenbarth, S Florquin, RA Flavell, JC. Leemans, F S Sutterwala. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A 106, 20388-93 (2009)
112. SB Willingham, IC Allen, DT Bergstralh, WJ Brickey, MT Huang, DJ Taxman, JA Duncan, JP Ting. NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways. J Immunol 183, 2008-15 (2009)
113. P Duewell, H Kono, KJ Rayner, CM Sirois, G Vladimer, FG Bauernfeind, GS Abela, L Franchi, G Nunez, M Schnurr, T Espevik, E Lien, KA Fitzgerald, KL Rock, KJ Moore, SD Wright, V Hornung, E Latz. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357-61 (2010)
114. S Frantz, A Ducharme, D Sawyer, LE Rohde, L Kobzik, R Fukazawa, D Tracey, H Allen, RT Lee, RA Kelly. Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction. J Mol Cell Cardiol 35, 685-94 (2003) (Pubitemid 36677452)
115. M Kawaguchi, M Takahashi, T Hata, Y Kashima, F Usui, H Morimoto, A Izawa, Y Takahashi, J Masumoto, J Koyama, M Hongo, T Noda, J Nakayama, J Sagara, S Taniguchi, U Ikeda. Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury. Circulation 123, 594-604 (2011)
116. M Valko, D Leibfritz, J Moncol, MT Cronin, M Mazur, J Telser. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39, 44-84 (2007) (Pubitemid 44566469)
117. N Loukili, N Rosenblatt-Velin, J Rolli, S Levrand, F Feihl, B Waeber, P Pacher, L Liaudet. Oxidants positively or negatively regulate nuclear factor kappa B in a context-dependent manner. J Biol Chem 285, 15746-52 (2010)
118. P Pacher, JS Beckman, L Liaudet. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87, 315-424 (2007) (Pubitemid 46217686)
119. L Liaudet, FG Soriano, C Szabo. Biology of nitric oxide signaling. Crit Care Med 28, N37-52 (2000) (Pubitemid 30262046)
120. P Ferdinandy, R Schulz. Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning. Br J Pharmacol 138, 532-43 (2003) (Pubitemid 36315301)
121. L Liaudet, G Szabo, C Szabo. Oxidative stress and regional ischemia-reperfusion injury: the peroxynitritepoly( ADP-ribose) polymerase connection. Coron Artery Dis 14, 115-22 (2003) (Pubitemid 36543414)
122. S Levrand, C Vannay-Bouchiche, B Pesse, P Pacher, F Feihl, B Waeber, L Liaudet. Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo. Free Radic Biol Med 41, 886-95 (2006) (Pubitemid 44262482)
123. P Pacher, R Schulz, L Liaudet, C Szabo. Nitrosative stress and pharmacological modulation of heart failure. Trends Pharmacol Sci 26, 302-10 (2005) (Pubitemid 40733523)
124. L Liaudet, G Vassalli, P Pacher. Role of peroxynitrite in the redox regulation of cell signal transduction pathways. Front Biosci E1, 590-605 (2009)
125. G Gloire, S Legrand-Poels, J Piette. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 72, 1493-505 (2006) (Pubitemid 44666727)
126. D Altavilla, B Deodato, GM Campo, M Arlotta, M Miano, G Squadrito, A Saitta, D Cucinotta, S Ceccarelli, M Ferlito, M Tringali, L Minutoli, AP Caputi, F Squadrito. IRFI 042, a novel dual vitamin E-like antioxidant, inhibits activation of nuclear factor-kappaB and reduces the inflammatory response in myocardial ischemia-reperfusion injury. Cardiovasc Res 47, 515-28. (2000) (Pubitemid 30646073)
127. S Levrand, B Pesse, F Feihl, B Waeber, P Pacher, J Rolli, MD Schaller, L Liaudet. Peroxynitrite is a potent inhibitor of NF-kappaB activation triggered by inflammatory stimuli in cardiac and endothelial cell lines. J Biol Chem 280, 34878-87 (2005) (Pubitemid 41504622)
128. A Tsung, R Sahai, H Tanaka, A Nakao, MP Fink, MT Lotze, H Yang, J Li, KJ Tracey, DA Geller, TR Billiar. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 201, 1135-43 (2005) (Pubitemid 40524681)
129. F Martinon. Signaling by ROS drives inflammasome activation. Eur J Immunol 40, 616-9 (2010)
130. CA Souders, SL Bowers, TA Baudino. Cardiac fibroblast: the renaissance cell. Circ Res 105, 1164-76 (2009)
131. KE Porter, NA Turner. Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol Ther 123, 255-78 (2009)
132. S Ausoni, S Sartore. The cardiovascular unit as a dynamic player in disease and regeneration. Trends Mol Med 15, 543-52 (2009)
133. M Dobaczewski, C Gonzalez-Quesada, NG Frangogiannis. The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mol Cell Cardiol 48, 504-11 (2010)
134. RJ Henning. Stem cells in cardiac repair. Future Cardiol 7, 99-117 (2011)
135. P Anversa, J Kajstura. Ventricular myocytes are not terminally differentiated in the adult mammalian heart. Circ Res 83, 1-14 (1998) (Pubitemid 28322094)
136. AP Beltrami, K Urbanek, J Kajstura, SM Yan, N Finato, R Bussani, B Nadal-Ginard, F Silvestri, A Leri, CA Beltrami, P Anversa. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 344, 1750-7 (2001) (Pubitemid 32497029)
137. K Bersell, S Arab, B Haring, B Kuhn. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 138, 257-70 (2009)
138. K Urbanek, D Cesselli, M Rota, A Nascimbene, A De Angelis, T Hosoda, C
139. Y Zhang, TS Li, ST Lee, KA Wawrowsky, K Cheng, G Galang, K Malliaras, MR Abraham, C Wang and E Marban. Dedifferentiation and proliferation of mammalian cardiomyocytes. PLoS One 5, e12559 (2010)
140. AP Beltrami, L Barlucchi, D Torella, M Baker, F Limana, S Chimenti, H Kasahara, M Rota, E Musso, K Urbanek, A Leri, J Kajstura, B Nadal-Ginard, P Anversa. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114, 763-76 (2003) (Pubitemid 37186770)
141. A Moretti, L Caron, A Nakano, JT Lam, A Bernshausen, Y Chen, Y Qyang, L Bu, M Sasaki, S Martin- Puig, Y Sun, SM Evans, KL Laugwitz, KR Chien. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127, 1151-65 (2006) (Pubitemid 44895618)
142. N Rosenblatt-Velin, MG Lepore, C Cartoni, F Beermann, T Pedrazzini. FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes. J Clin Invest 115, 1724-33 (2005) (Pubitemid 40979711)
143. N Krankel, G Spinetti, S Amadesi, P Madeddu. Targeting stem cell niches and trafficking for cardiovascular therapy. Pharmacol Ther 129, 62-81 (2011)
144. F Belema-Bedada, S Uchida, A Martire, S Kostin, T. Braun. Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2. Cell Stem Cell 2, 566-75 (2008) (Pubitemid 351729213)
145. DJ Ceradini, AR Kulkarni, MJ Callaghan, OM Tepper, N Bastidas, ME Kleinman, JM Capla, RD Galiano, JP Levine, GC Gurtner. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10, 858-64 (2004) (Pubitemid 39070860)
146. J Croitoru-Lamoury, FM Lamoury, JJ Zaunders, LA Veas, BJ Brew. Human mesenchymal stem cells constitutively express chemokines and chemokine receptors that can be upregulated by cytokines, IFN-beta, and Copaxone. J Interferon Cytokine Res 27, 53-64 (2007) (Pubitemid 46185062)
147. AL Ponte, E Marais, N Gallay, A Langonne, B Delorme, O Herault, P Charbord, J Domenech. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells 25, 1737-45 (2007) (Pubitemid 47121852)
148. B Ruster, S Gottig, RJ Ludwig, R Bistrian, S Muller, E Seifried, J Gille, R Henschler. Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells. Blood 108, 3938-44 (2006) (Pubitemid 44864580)
149. VF Segers, I Van Riet, LJ Andries, K Lemmens, MJ Demolder, AJ De Becker, MM Kockx, GW De Keulenaer. Mesenchymal stem cell adhesion to cardiac microvascular endothelium: activators and mechanisms. Am J Physiol Heart Circ Physiol 290, H1370-7 (2006)
150. AT Askari, S Unzek, ZB Popovic, CK Goldman, F Forudi, M Kiedrowski, A Rovner, SG Ellis, JD Thomas, PE DiCorleto, EJ Topol, MS Penn. Effect of stromal-cellderived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 362, 697-703 (2003) (Pubitemid 37101067)
151. D Orlic, J Kajstura, S Chimenti, I Jakoniuk, SM Anderson, B Li, J Pickel, R McKay, B Nadal-Ginard, DM Bodine, A Leri, P Anversa. Bone marrow cells regenerate infarcted myocardium. Nature 410, 701-5 (2001) (Pubitemid 32290358)
152. AM Abarbanell, Y Wang, JL Herrmann, BR Weil, JA Poynter, MC Manukyan, DR Meldrum. Toll-like receptor 2 mediates mesenchymal stem cell-associated myocardial recovery and VEGF production following acute ischemiareperfusion injury. Am J Physiol Heart Circ Physiol 298, H1529-36 (2010)
153. S Van Linthout, C Stamm, HP Schultheiss, C Tschope. Mesenchymal stem cells and inflammatory cardiomyopathy: cardiac homing and beyond. Cardiol Res Pract 2011, 757154 (2011)
154. JS Burchfield, M Iwasaki, M Koyanagi, C Urbich, N Rosenthal, AM Zeiher, S Dimmeler. Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction. Circ Res 103, 203-11 (2008)
155. D Wang, K Chen, WT Du, ZB Han, H Ren, Y Chi, SG Yang, F Bayard, D Zhu, ZC Han. CD14+ monocytes promote the immunosuppressive effect of human umbilical cord matrix stem cells. Exp Cell Res 316, 2414-23 (2010)
156. J Tongers, DW Losordo, U Landmesser. Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges. Eur Heart J 32, 1197-206 (2011)
157. T Sato, H Suzuki, M Shibata, T Kusuyama, Y Omori, T Soda, M Shoji, Y Iso, S Koba, E Geshi, T Katagiri, S Shioda, K Sekikawa. Tumor-necrosis-factor-alpha- genedeficient mice have improved cardiac function through reduction of intercellular adhesion molecule-1 in myocardial infarction. Circ J 70, 1635-42 (2006)
158. SP Jones, SD Trocha, DJ Lefer. Cardioprotective actions of endogenous IL-10 are independent of iNOS. Am J Physiol Heart Circ Physiol 281, H48-52 (2001)
159. Z Yang, B Zingarelli, C Szabo. Crucial role of endogenous interleukin-10 production in myocardial ischemia/reperfusion injury. Circulation 101, 1019-26 (2000) (Pubitemid 30131705)
160. P Zymek, DY Nah, M Bujak, G Ren, A Koerting, T Leucker, P Huebener, G Taffet, M Entman, NG Frangogiannis. Interleukin-10 is not a critical regulator of infarct healing and left ventricular remodeling. Cardiovasc Res 74, 313-22 (2007) (Pubitemid 46517506)
161. NG Frangogiannis, G Ren, O Dewald, P Zymek, S Haudek, A Koerting, K Winkelmann, LH Michael, J Lawler, ML Entman. Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts. Circulation 111, 2935-42 (2005) (Pubitemid 40814186)
162. B Metzler, J Mair, A Lercher, C Schaber, F Hintringer, O Pachinger, Q Xu. Mouse model of myocardial remodelling after ischemia: role of intercellular adhesion molecule-1. Cardiovasc Res 49, 399-407 (2001) (Pubitemid 32119557)
163. AJ Palazzo, SP Jones, WG Girod, DC Anderson, DN Granger, DJ Lefer. Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice. Am J Physiol 275, H2300-7 (1998)
164. SA Briaud, ZM Ding, LH Michael, ML Entman, S Daniel, CM Ballantyne. Leukocyte trafficking and myocardial reperfusion injury in ICAM-1/P- selectinknockout mice. Am J Physiol Heart Circ Physiol 280, H60- 7 (2001)
165. S Frantz, J Tillmanns, PJ Kuhlencordt, I Schmidt, A Adamek, C Dienesch, T Thum, S Gerondakis, G Ertl, J Bauersachs. Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury. Am J Pathol 171, 507-12 (2007) (Pubitemid 47344683)
166. A Aleshin, R Ananthakrishnan, Q Li, R Rosario, Y Lu, W Qu, F Song, S Bakr, M Szabolcs, V D'Agati, R Liu, S Homma, AM Schmidt, SF Yan, R Ramasamy. RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model. Am J Physiol Heart Circ Physiol 294, H1823-32 (2008) (Pubitemid 351490612)