Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation

Neurobiology of Aging

Volumn 33, Issue 6, 2012, Pages 1121.e13-1121.e24

  Gibson, Gary E ^a   Chen, Huan Lian ^a   Xu, Hui ^a   Qiu, Linghua ^b   Xu, Zuoshang ^b   Denton, Travis T ^c   Shi, Qingli ^a  

^a BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c EASTERN WASHINGTON UNIVERSITY   (United States)

Author keywords

Calcium; Endoplasmic reticulum; Ketoglutarate dehydrogenase; Mitochondria

Indexed keywords

BRADYKININ; CALCIUM CHANNEL; CYTOCHROME C; MESSENGER RNA; OXOGLUTARATE DEHYDROGENASE; POTASSIUM ION; SHORT HAIRPIN RNA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; CALCIUM TRANSPORT; CELL TYPE; CONTROLLED STUDY; DEPOLARIZATION; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME INHIBITION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SECRETION;

EID: 84859502164     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2011.11.003     Document Type: Article

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