LOX-1, mtDNA damage, and NLRP3 inflammasome activation inmacrophages: Implications in atherogenesis

Cardiovascular Research

Volumn 103, Issue 4, 2014, Pages 619-628

  Ding, Zufeng ^a,b,c   Liu, Shijie ^a,b,d   Wang, Xianwei ^a   Dai, Yao ^a   Khaidakov, Magomed ^a   Deng, Xiaoyan ^b   Fan, Yubo ^b   Xiang, David ^a   Mehta, Jawahar L ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b BEIHANG UNIVERSITY   (China)

^c ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY   (China)

^d UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Autophagy; LOX 1; Mitochondrial DNA; NLRP3; ROS

Indexed keywords

3 METHYLADENINE; APOCYNIN; CRYOPYRIN; DEOXYRIBONUCLEASE II; LIPOPOLYSACCHARIDE; MITOCHONDRIAL DNA; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; YCG 063; CARRIER PROTEIN; INFLAMMASOME; NLRP3 PROTEIN, HUMAN; OLR1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; AUTOPHAGY; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MACROPHAGE; MACROPHAGE CULTURE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ATHEROSCLEROSIS; CELL LINE; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

ATHEROSCLEROSIS; AUTOPHAGY; CARRIER PROTEINS; CELL LINE; DNA, MITOCHONDRIAL; HUMANS; INFLAMMASOMES; LIPOPOLYSACCHARIDES; MACROPHAGES; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SCAVENGER RECEPTORS, CLASS E; SIGNAL TRANSDUCTION;

EID: 84907356094     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu114     Document Type: Article

References (30)

1. Mehta JL, Sanada N, Hu CP, Chen J, Dandapat A, Sugawara F, Satoh H, Inoue K, KawaseY, Jishage K, Suzuki H, Takeya M, Schnackenberg L, Beger R, Hermonat PL, Thomas M, Sawamura T. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res 2007;100: 1634-1642.
2. Lu J, Wang X, WangW, Muniyappa H, Hu C, Mitra S, Long B, Das K, Mehta JL. LOX-1 abrogation reduces cardiac hypertrophy and collagen accumulation following chronic ischemia in the mouse. Gene Ther 2001;19: 522-531.
3. Honjo M, Nakamura K, Yamashiro K, Kiryu J, Tanihara H, McEvoy LM, Honda Y, Butcher EC, Masaki T, Sawamura T. Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Proc Natl Acad Sci USA 2003;100: 1274-1279.
4. Haasken S, Sutterwala FS. Damage control: management of cellular stress by the NLRP3 inflammasome. Eur J Immunol 2013;43: 2003-2005.
5. Cassel SL, Joly S, Sutterwala FS. The NLRP3 inflammasome: a sensor of immune danger signals. Semin Immunol 2009;21: 194-198.
6. HeC, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009;43: 67-93.
7. Stowe DF, Camara AK. Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function. Antioxid Redox Signal 2009;11: 1373-1414.
8. Escames G, López LC, García JA, García-Corzo L, Ortiz F, Acuña-Castroviejo D. Mitochondrial DNA and inflammatory diseases. Hum Genet 2012;131: 161-173.
9. Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 2012;485: 251-255.
10. Konstantinidis K, Kitsis RN. Cardiovascular biology: escaped DNA inflames the heart. Nature 2012;485: 179-180.
11. Ding Z, Wang X, Schnackenberg L, Khaidakov M, Liu S, Singla S, Dai Y, Mehta JL. Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7 g. Int J Cardiol 2013;168: 1378-1385.
12. Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JC, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR. Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation 2013;128: 702-712.
13. Sarkar S, Korolchuk V, Renna M, Winslow A, Rubinsztein DC. Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates. Autophagy 2009;5: 307-313.
14. Keul P1, Lucke S, von Wnuck Lipinski K, Bode C, Gräler M, Heusch G, Levkau B. Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis. Circ Res 2011;108: 314-323.
15. Hoque R, Sohail M, Malik A, Sarwar S, Luo Y, Shah A, Barrat F, Flavell R, Gorelick F, Husain S, MehalW. TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis. Gastroenterology 2011;141: 358-369.
16. Evans CJ, Aguilera RJ. DNase II: genes, enzymes and function. Gene 2003;322: 1-15.
17. Ding Z, Liu S, Wang X, Khaidakov M, Dai Y, Mehta JL. Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis. Sci Rep 2013;3: 1077.
18. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010;464: 1357-1361.
19. Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL. Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis. Antioxid Redox Signal 2011;15: 2301-2333.
20. Pang T, Wang J, Benicky J, Saavedra JM. Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition. Biochim Biophys Acta 2012;1820: 503-510.
21. Ashrafi G, Schwarz TL. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 2013;20: 31-42.
22. Heumüller S, Wind S, Barbosa-Sicard E, Schmidt HH, Busse R, Schröder K, Brandes RP. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 2008;51: 211-217.
23. García-Cazarín ML, Smith JL, Clair DK, Piascik MT. The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism. Mol Pharmacol 2008;74: 1000-1007.
24. Juliet PA, Hayashi T, Daigo S, Matsui-Hirai H, Miyazaki A, Fukatsu A, Funami J, Iguchi A, Ignarro LJ. Combined effect of testosterone and apocynin on nitric oxide and superoxide production in PMA-differentiated THP-1 cells. Biochim Biophys Acta 2004;1693: 185-191.
25. Wind S, Beuerlein K, Eucker T, Müller H, Scheurer P, Armitage ME, Ho H, Schmidt HH, Wingler K. Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. Br J Pharmacol 2010;161: 885-898.
26. Kim SY, Moon KA, Jo HY, Jeong S, Seon SH, Jung E, Cho YS, Chun E, Lee KY. Antiinflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation. Immunol Cell Biol 2012;90: 441-448.
27. Dikalov S. Cross talk between mitochondria and NADPH oxidases. Free Radic Biol Med 2011;5: 1289-1301.
28. Daiber A. Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species. Biochim Biophys Acta 2010;1797: 897-906.
29. Doughan AK, Harrison DG, Dikalov SI. Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction linking mitochondrial oxidative damage and vascular endothelial dysfunction. Circ Res 2008;102: 488-496.
30. Wenzel P, Mollnau H, Oelze M, Schulz E, Wickramanayake JM, Müller J, Schuhmacher S, Hortmann M, Baldus S, Gori T, Brandes RP, Münzel T, Daiber A. First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction. Antioxid Redox Signal 2008;10: 1435-1447.