Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum

Current Opinion in Immunology

Volumn 23, Issue 1, 2011, Pages 35-40

  Martinon, Fabio ^a   Glimcher, Laurie H ^b,c,d  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; X BOX BINDING PROTEIN 1;

APOPTOSIS; CELL PROLIFERATION; CELLULAR STRESS RESPONSE; DNA DAMAGE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE TARGETING; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; INNATE IMMUNITY; MACROPHAGE; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; UPREGULATION;

ANIMALS; ENDOPLASMIC RETICULUM; HUMANS; IMMUNITY, INNATE; PROTEIN UNFOLDING; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

EID: 79951676940     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2010.10.016     Document Type: Review

References (41)

1. Marciniak S.J., Ron D. Endoplasmic reticulum stress signaling in disease. Physiol Rev 2006, 86:1133-1149.
2. Bernales S., Papa F.R., Walter P. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol 2006, 22:487-508.
3. Calfon M., Zeng H., Urano F., Till J.H., Hubbard S.R., Harding H.P., Clark S.G., Ron D. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002, 415:92-96.
4. Shen X., Ellis R.E., Lee K., Liu C.Y., Yang K., Solomon A., Yoshida H., Morimoto R., Kurnit D.M., Mori K., et al. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 2001, 107:893-903.
5. Yoshida H., Matsui T., Yamamoto A., Okada T., Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001, 107:881-891.
6. Lin J.H., Li H., Yasumura D., Cohen H.R., Zhang C., Panning B., Shokat K.M., Lavail M.M., Walter P. IRE1 signaling affects cell fate during the unfolded protein response. Science 2007, 318:944-949.
7. Reimold A.M., Iwakoshi N.N., Manis J., Vallabhajosyula P., Szomolanyi-Tsuda E., Gravallese E.M., Friend D., Grusby M.J., Alt F., Glimcher L.H. Plasma cell differentiation requires the transcription factor XBP-1. Nature 2001, 412:300-307.
8. Kaser A., Lee A.-H., Franke A., Glickman J.N., Zeissig S., Tilg H., Nieuwenhuis E.E.S., Higgins D.E., Schreiber S., Glimcher L.H., et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008, 134:743-756.
9. Lee A.-H., Chu G.C., Iwakoshi N.N., Glimcher L.H. XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J 2005, 24:4368-4380.
10. Iwakoshi N.N., Pypaert M., Glimcher L.H. The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med 2007, 204:2267-2275.
11. Kaufman R.J., Cao S. Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism. EMBO Mol Med 2010.
12. Lee A.-H., Scapa E., Cohen D., Glimcher L. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 2008, 320:1492.
13. Zhang K., Kaufman R.J. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008, 454:455-462.
14. Kawai T., Akira S. TLR signaling. Semin Immunol 2007, 19:24-32.
15. Hu P., Han Z., Couvillon A.D., Kaufman R.J., Exton J.H. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol 2006, 26:3071-3084.
16. Urano F., Wang X., Bertolotti A., Zhang Y., Chung P., Harding H.P., Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000, 287:664-666.
17. Malathi K., Dong B., Gale M., Silverman R.H. Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature 2007, 448:816-819.
18. Wek R.C., Jiang H.-Y., Anthony T.G. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans 2006, 34:7-11.
19. Berlanga J.J., Ventoso I., Harding H.P., Deng J., Ron D., Sonenberg N., Carrasco L., De Haro C. Antiviral effect of the mammalian translation initiation factor 2α kinase GCN2 against RNA viruses. EMBO J 2006, 25:1730-1740.
20. Liu S., Suragani R.N.V.S., Wang F., Han A., Zhao W., Andrews N.C., Chen J.-J. The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. J Clin Invest 2007, 117:3296-3305.
21. García M.A., Meurs E.F., Esteban M. The dsRNA protein kinase PKR: virus and cell control. Biochimie 2007, 89:799-811.
22. Martinon F., Chen X., Lee A.-H., Glimcher L.H. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 2010, 11:411-418.
23. Woo C.W., Cui D., Arellano J., Dorweiler B., Harding H., Fitzgerald K.A., Ron D., Tabas I. Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol 2009, 11:1473-1480.
24. Nakamura T., Furuhashi M., Li P., Cao H., Tuncman G., Sonenberg N., Gorgun C.Z., Hotamisligil G.S. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010, 140:338-348.
25. He B. Viruses, endoplasmic reticulum stress, and interferon responses. Cell Death Differ 2006, 13:393-403.
26. Hotamisligil G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917.
27. Ozcan U., Cao Q., Yilmaz E., Lee A.-H., Iwakoshi N.N., Ozdelen E., Tuncman G., Görgün C., Glimcher L.H., Hotamisligil G.S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306:457-461.
28. Gasser S. The DNA damage response arouses the immune system. Cancer Res 2006, 66:3959-3962.
29. Hensley K., Robinson K.A., Gabbita S.P., Salsman S., Floyd R.A. Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 2000, 28:1456-1462.
30. Xu Y. DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis. Nat Rev Immunol 2006, 6:261-270.
31. Malhotra J.D., Kaufman R.J. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?. Antioxid Redox Signal 2007, 9:2277-2293.
32. Todd D., Lee A., Glimcher L. The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 2008, 8:663-674.
33. Gargalovic P.S., Gharavi N.M., Clark M.J., Pagnon J., Yang W.-P., He A., Truong A., Baruch-Oren T., Berliner J.A., Kirchgessner T.G., et al. The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol 2006, 26:2490-2496.
34. Delay M.L., Turner M.J., Klenk E.I., Smith J.A., Sowders D.P., Colbert R.A. HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum 2009, 60:2633-2643.
35. Smith J.A., Turner M.J., Delay M.L., Klenk E.I., Sowders D.P., Colbert R.A. Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1. Eur J Immunol 2008, 38:1194-1203.
36. Bischof L.J., Kao C.-Y., Los F.C.O., Gonzalez M.R., Shen Z., Briggs S.P., van der Goot F.G., Aroian R.V. Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo. PLoS Pathog 2008, 4:e1000176.
37. Richardson C.E., Kooistra T., Kim D.H. An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature 2010, 463:1092-1095.
38. Urade R. The endoplasmic reticulum stress signaling pathways in plants. BioFactors 2009, 35:326-331.
39. Tateda C., Ozaki R., Onodera Y., Takahashi Y., Yamaguchi K., Berberich T., Koizumi N., Kusano T. NtbZIP60, an endoplasmic reticulum-localized transcription factor, plays a role in the defense response against bacterial pathogens in Nicotiana tabacum. J Plant Res 2008, 121:603-611.
40. Asselah T., Bièche I., Mansouri A., Laurendeau I., Cazals-Hatem D., Feldmann G., Bedossa P., Paradis V., Martinot-Peignoux M., Lebrec D., et al. In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C. J Pathol 2010, 221:264-274.
41. Tardif K.D., Mori K., Kaufman R.J., Siddiqui A. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J Biol Chem 2004, 279:17158-17164.