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Volumn 15, Issue 8, 2015, Pages 687-695

Network based approach to drug discovery: A mini review

Author keywords

Drug discovery; Network analysis; Target identification

Indexed keywords

ARTICLE; ARTIFICIAL NEURAL NETWORK; BIOINFORMATICS; COMORBIDITY; DRUG DESIGN; GENE EXPRESSION; MACHINE LEARNING; PATHOGENESIS; PROTEOMICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; ANIMAL; BIOLOGY; DRUG DEVELOPMENT; DRUG INTERACTION; HUMAN; MOLECULARLY TARGETED THERAPY; PROCEDURES;

EID: 84929615899     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557515666150219143933     Document Type: Article
Times cited : (21)

References (73)
  • 1
    • 15044349115 scopus 로고    scopus 로고
    • The efficiency of multitarget drugs: The network approach might help drug design
    • Csermely, P.; Agoston, V.; Pongor, S. The efficiency of multitarget drugs: the network approach might help drug design. Trends Pharmacol. Sci., 2005, 26(4), 178-182.
    • (2005) Trends Pharmacol. Sci , vol.26 , Issue.4 , pp. 178-182
    • Csermely, P.1    Agoston, V.2    Pongor, S.3
  • 3
    • 13844276627 scopus 로고    scopus 로고
    • Target-based drug discovery: Is something wrong?
    • Sams-Dodd, F. Target-based drug discovery: is something wrong? Drug Discov. Today, 2005, 10(2), 139-147.
    • (2005) Drug Discov. Today , vol.10 , Issue.2 , pp. 139-147
    • Sams-Dodd, F.1
  • 4
    • 84855906454 scopus 로고    scopus 로고
    • Systems pharmacology: Network analysis to identify multiscale mechanisms of drug action
    • Zhao, S.; Iyengar, R. Systems pharmacology: network analysis to identify multiscale mechanisms of drug action. Annu. Rev. Pharmacol. Toxicol., 2012, 52, 505-521.
    • (2012) Annu. Rev. Pharmacol. Toxicol , vol.52 , pp. 505-521
    • Zhao, S.1    Iyengar, R.2
  • 5
    • 84855882587 scopus 로고    scopus 로고
    • Novel computational approaches to polypharmacology as a means to define responses to individual drugs
    • Xie, L.; Xie, L.; Kinnings, S.L.; Bourne, P.E. Novel computational approaches to polypharmacology as a means to define responses to individual drugs. Annu. Rev. Pharmacol. Toxicol., 2012, 52, 361-379.
    • (2012) Annu. Rev. Pharmacol. Toxicol , vol.52 , pp. 361-379
    • Xie, L.1    Xie, L.2    Kinnings, S.L.3    Bourne, P.E.4
  • 7
    • 48149106322 scopus 로고    scopus 로고
    • Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
    • Forrest, M.J.; Bloomfield, D.; Briscoe, R.J.; Brown, P.; Cumiskey, A.M.; Ehrhart, J.; Hershey, J.; Keller, W.; Ma, X.; McPherson, H. Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone. Br. J. Pharmacol., 2008, 154(7), 1465-1473.
    • (2008) Br. J. Pharmacol , vol.154 , Issue.7 , pp. 1465-1473
    • Forrest, M.J.1    Bloomfield, D.2    Briscoe, R.J.3    Brown, P.4    Cumiskey, A.M.5    Ehrhart, J.6    Hershey, J.7    Keller, W.8    Ma, X.9    McPherson, H.10
  • 8
    • 2642536741 scopus 로고    scopus 로고
    • Inflammation, immunity, and HMG-CoA reductase inhibitors statins as antiinflammatory agents?
    • Schönbeck, U.; Libby, P. Inflammation, immunity, and HMG-CoA reductase inhibitors statins as antiinflammatory agents? Circulation, 2004, 109(21 Suppl 1), II18-II26.
    • (2004) Circulation , vol.109 , Issue.21 , pp. II18-II26
    • Schönbeck, U.1    Libby, P.2
  • 10
    • 84864222742 scopus 로고    scopus 로고
    • The emerging paradigm of network medicine in the study of human disease
    • Chan, S.Y.; Loscalzo, J. The emerging paradigm of network medicine in the study of human disease. Circ. Res., 2012, 111(3), 359-374.
    • (2012) Circ. Res , vol.111 , Issue.3 , pp. 359-374
    • Chan, S.Y.1    Loscalzo, J.2
  • 11
  • 13
    • 33847207834 scopus 로고    scopus 로고
    • Molecular similarity analysis in virtual screening: Foundations, limitations and novel approaches
    • Eckert, H.; Bajorath, J. Molecular similarity analysis in virtual screening: foundations, limitations and novel approaches. Drug Discov. Today, 2007, 12(5), 225-233.
    • (2007) Drug Discov. Today , vol.12 , Issue.5 , pp. 225-233
    • Eckert, H.1    Bajorath, J.2
  • 14
    • 61949313682 scopus 로고    scopus 로고
    • Self-organizing maps in drug discovery: Compound library design, scaffold-hopping, repurposing
    • Schneider, P.; Tanrikulu, Y.; Schneider, G. Self-organizing maps in drug discovery: compound library design, scaffold-hopping, repurposing. Curr. Med. Chem., 2009, 16(3), 258-266.
    • (2009) Curr. Med. Chem , vol.16 , Issue.3 , pp. 258-266
    • Schneider, P.1    Tanrikulu, Y.2    Schneider, G.3
  • 15
    • 0345548661 scopus 로고    scopus 로고
    • Comparison of support vector machine and artificial neural network systems for drug/nondrug classification
    • Byvatov, E.; Fechner, U.; Sadowski, J.; Schneider, G. Comparison of support vector machine and artificial neural network systems for drug/nondrug classification. J. Chem. Inf. Comput. Sci., 2003, 43(6), 1882-1889.
    • (2003) J. Chem. Inf. Comput. Sci , vol.43 , Issue.6 , pp. 1882-1889
    • Byvatov, E.1    Fechner, U.2    Sadowski, J.3    Schneider, G.4
  • 19
    • 9744222830 scopus 로고    scopus 로고
    • 3D similarity method for scaffold hopping from known drugs or natural ligands to new chemotypes
    • Jenkins, J.L.; Glick, M.; Davies, J.W. A 3D similarity method for scaffold hopping from known drugs or natural ligands to new chemotypes. J. Med. Chem., 2004, 47(25), 6144-6159.
    • (2004) J. Med. Chem , vol.47 , Issue.25 , pp. 6144-6159
    • Jenkins, J.L.1    Glick, M.2    Davies, J.3
  • 20
    • 0033969620 scopus 로고    scopus 로고
    • Morphological similarity: A 3D molecular similarity method correlated with protein-ligand recognition
    • Jain, A.N. Morphological similarity: a 3D molecular similarity method correlated with protein-ligand recognition. J. Comput. Aided Mol. Des., 2000, 14(2), 199-213.
    • (2000) J. Comput. Aided Mol. Des , vol.14 , Issue.2 , pp. 199-213
    • Jain, A.N.1
  • 21
    • 78549270383 scopus 로고    scopus 로고
    • Critical reasoning on causal inference in genome-wide linkage and association studies
    • Li, Y.; Tesson, B.M.; Churchill, G.A.; Jansen, R.C. Critical reasoning on causal inference in genome-wide linkage and association studies. Trends Genet., 2010, 26(12), 493-498.
    • (2010) Trends Genet , vol.26 , Issue.12 , pp. 493-498
    • Li, Y.1    Tesson, B.M.2    Churchill, G.A.3    Jansen, R.C.4
  • 22
    • 47249146126 scopus 로고    scopus 로고
    • Drug target identification using side-effect similarity
    • Campillos, M.; Kuhn, M.; Gavin, A.-C.; Jensen, L.J.; Bork, P. Drug target identification using side-effect similarity. Science, 2008, 321(5886), 263-266.
    • (2008) Science , vol.321 , Issue.5886 , pp. 263-266
    • Campillos, M.1    Kuhn, M.2    Gavin, A.-C.3    Jensen, L.J.4    Bork, P.5
  • 23
    • 0345863927 scopus 로고    scopus 로고
    • The unified medical language system (UMLS): Integrating biomedical terminology
    • Bodenreider, O. The unified medical language system (UMLS): integrating biomedical terminology. Nucleic Acids Res., 2004, 32(suppl 1), D267-D270.
    • (2004) Nucleic Acids Res , vol.32 , pp. D267-D270
    • Bodenreider, O.1
  • 28
    • 69849094133 scopus 로고    scopus 로고
    • Supervised prediction of drug–target interactions using bipartite local models
    • Bleakley, K.; Yamanishi, Y. Supervised prediction of drug–target interactions using bipartite local models. Bioinformatics, 2009, 25(18), 2397-2403.
    • (2009) Bioinformatics , vol.25 , Issue.18 , pp. 2397-2403
    • Bleakley, K.1    Yamanishi, Y.2
  • 29
    • 52749085437 scopus 로고    scopus 로고
    • Protein-ligand interaction prediction: An improved chemogenomics approach
    • Jacob, L.; Vert, J.P. Protein-ligand interaction prediction: an improved chemogenomics approach. Bioinformatics, 2008, 24(19), 2149-2156.
    • (2008) Bioinformatics , vol.24 , Issue.19 , pp. 2149-2156
    • Jacob, L.1    Vert, J.P.2
  • 30
    • 46249090791 scopus 로고    scopus 로고
    • Prediction of drug–target interaction networks from the integration of chemical and genomic spaces
    • Yamanishi, Y.; Araki, M.; Gutteridge, A.; Honda, W.; Kanehisa, M. Prediction of drug–target interaction networks from the integration of chemical and genomic spaces. Bioinformatics, 2008, 24(13), i232-i240.
    • (2008) Bioinformatics , vol.24 , Issue.13 , pp. i232-i240
    • Yamanishi, Y.1    Araki, M.2    Gutteridge, A.3    Honda, W.4    Kanehisa, M.5
  • 31
    • 77954230951 scopus 로고    scopus 로고
    • Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework
    • Yamanishi, Y.; Kotera, M.; Kanehisa, M.; Goto, S. Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework. Bioinformatics, 2010, 26(12), i246-i254.
    • (2010) Bioinformatics , vol.26 , Issue.12 , pp. i246-i254
    • Yamanishi, Y.1    Kotera, M.2    Kanehisa, M.3    Goto, S.4
  • 32
    • 84890842963 scopus 로고    scopus 로고
    • Binding site comparison for function prediction and pharmaceutical discovery
    • Konc, J.; Janežič, D. Binding site comparison for function prediction and pharmaceutical discovery. Curr. Opin. Struct. Biol., 2014, 25, 34-39.
    • (2014) Curr. Opin. Struct. Biol , vol.25 , pp. 34-39
    • Konc, J.1    Janežič, D.2
  • 35
    • 0034609791 scopus 로고    scopus 로고
    • The large-scale organization of metabolic networks
    • Jeong, H.; Tombor, B.; Albert, R.; Oltvai, Z.N.; Barabási, A.L. The large-scale organization of metabolic networks. Nature, 2000, 407(6804), 651-654.
    • (2000) Nature , vol.407 , Issue.6804 , pp. 651-654
    • Jeong, H.1    Tombor, B.2    Albert, R.3    Oltvai, Z.N.4    Barabási, A.L.5
  • 36
    • 0033764169 scopus 로고    scopus 로고
    • The small world of metabolism
    • Fell, D.A.; Wagner, A. The small world of metabolism. Nat. Biotechnol., 2000, 18(11), 1121-1122.
    • (2000) Nat. Biotechnol , vol.18 , Issue.11 , pp. 1121-1122
    • Fell, D.A.1    Wagner, A.2
  • 37
    • 33846910173 scopus 로고    scopus 로고
    • Palsson, B.Ø. Global reconstruction of the human metabolic network based on genomic and bibliomic data
    • Duarte, N.C.; Becker, S.A.; Jamshidi, N.; Thiele, I.; Mo, M.L.; Vo, T.D.; Srivas, R.; Palsson, B.Ø. Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc. Natl. Acad. Sci. U.S.A., 2007, 104(6), 1777-1782.
    • (2007) Proc. Natl. Acad. Sci. U.S.A , vol.104 , Issue.6 , pp. 1777-1782
    • Duarte, N.C.1    Becker, S.A.2    Jamshidi, N.3    Thiele, I.4    Mo, M.L.5    Vo, T.D.6    Srivas, R.7
  • 39
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease
    • Barabási, A.L.; Gulbahce, N.; Loscalzo, J. Network medicine: a network-based approach to human disease. Nat. Rev. Genet., 2011, 12(1), 56-68.
    • (2011) Nat. Rev. Genet , vol.12 , Issue.1 , pp. 56-68
    • Barabási, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 40
    • 33747035889 scopus 로고    scopus 로고
    • Predicting disease genes using protein–protein interactions
    • Oti, M.; Snel, B.; Huynen, M.A.; Brunner, H.G. Predicting disease genes using protein–protein interactions. J. Med. Genet., 2006, 43(8), 691-698.
    • (2006) J. Med. Genet , vol.43 , Issue.8 , pp. 691-698
    • Oti, M.1    Snel, B.2    Huynen, M.A.3    Brunner, H.G.4
  • 41
    • 77951952127 scopus 로고    scopus 로고
    • The power of protein interaction networks for associating genes with diseases
    • Navlakha, S.; Kingsford, C. The power of protein interaction networks for associating genes with diseases. Bioinformatics, 2010, 26(8), 1057-1063.
    • (2010) Bioinformatics , vol.26 , Issue.8 , pp. 1057-1063
    • Navlakha, S.1    Kingsford, C.2
  • 42
    • 76749134818 scopus 로고    scopus 로고
    • Associating genes and protein complexes with disease via network propagation
    • e1000641
    • Vanunu, O.; Magger, O.; Ruppin, E.; Shlomi, T.; Sharan, R. Associating genes and protein complexes with disease via network propagation. PLoS Comput. Biol., 2010, 6(1), e1000641.
    • (2010) Plos Comput. Biol , vol.6 , Issue.1
    • Vanunu, O.1    Magger, O.2    Ruppin, E.3    Shlomi, T.4    Sharan, R.5
  • 43
    • 42349096647 scopus 로고    scopus 로고
    • A global view of drug-therapy interactions
    • Nacher, J.C.; Schwartz, J.M. A global view of drug-therapy interactions. BMC Pharmacol., 2008, 8(1), 5.
    • (2008) BMC Pharmacol , vol.8 , Issue.1
    • Nacher, J.C.1    Schwartz, J.M.2
  • 44
    • 84866384551 scopus 로고    scopus 로고
    • Network-based characterization of drug-regulated genes, drug targets, and toxicity
    • Kotlyar, M.; Fortney, K.; Jurisica, I. Network-based characterization of drug-regulated genes, drug targets, and toxicity. Methods, 2012, 57(4), 499-507.
    • (2012) Methods , vol.57 , Issue.4 , pp. 499-507
    • Kotlyar, M.1    Fortney, K.2    Jurisica, I.3
  • 45
    • 84863010950 scopus 로고    scopus 로고
    • Three-dimensional reconstruction of protein networks provides insight into human genetic disease
    • Wang, X.; Wei, X.; Thijssen, B.; Das, J.; Lipkin, S.M.; Yu, H. Three-dimensional reconstruction of protein networks provides insight into human genetic disease. Nat. Biotechnol., 2012, 30(2), 159-164.
    • (2012) Nat. Biotechnol , vol.30 , Issue.2 , pp. 159-164
    • Wang, X.1    Wei, X.2    Thijssen, B.3    Das, J.4    Lipkin, S.M.5    Yu, H.6
  • 46
    • 84863651163 scopus 로고    scopus 로고
    • Combinatorial drug therapy for cancer in the post-genomic era
    • Al-Lazikani, B.; Banerji, U.; Workman, P. Combinatorial drug therapy for cancer in the post-genomic era. Nat. Biotechnol., 2012, 30(7), 679-692.
    • (2012) Nat. Biotechnol , vol.30 , Issue.7 , pp. 679-692
    • Al-Lazikani, B.1    Banerji, U.2    Workman, P.3
  • 47
    • 84889974464 scopus 로고    scopus 로고
    • Network based elucidation of drug response: From modulators to targets. BMC Syst
    • Iorio, F.; Saez-Rodriguez, J.; Di Bernardo, D. Network based elucidation of drug response: from modulators to targets. BMC Syst. Biol., 2013, 7(1), 139.
    • (2013) Biol , vol.7 , Issue.1
    • Iorio, F.1    Saez-Rodriguez, J.2    Di Bernardo, D.3
  • 48
    • 0037385718 scopus 로고    scopus 로고
    • Genomescale microbial in silico models: The constraints-based approach
    • Price, N.D.; Papin, J.A.; Schilling, C.H.; Palsson, B.O. Genomescale microbial in silico models: the constraints-based approach. Trends Biotechnol., 2003, 21(4), 162-169.
    • (2003) Trends Biotechnol , vol.21 , Issue.4 , pp. 162-169
    • Price, N.D.1    Papin, J.A.2    Schilling, C.H.3    Palsson, B.O.4
  • 49
    • 77957556494 scopus 로고    scopus 로고
    • Predicting enzyme targets for cancer drugs by profiling human metabolic reactions in NCI-60 cell lines
    • Li, L.; Zhou, X.; Ching, W.K.; Wang, P. Predicting enzyme targets for cancer drugs by profiling human metabolic reactions in NCI-60 cell lines. BMC Bioinformatics, 2010, 11(1), 1471-2105.
    • (2010) BMC Bioinformatics , vol.11 , Issue.1 , pp. 1471-2105
    • Li, L.1    Zhou, X.2    Ching, W.K.3    Wang, P.4
  • 51
    • 79958754253 scopus 로고    scopus 로고
    • PREDICT: A method for inferring novel drug indications with application to personalized medicine
    • Gottlieb, A.; Stein, G.Y.; Ruppin, E.; Sharan, R. PREDICT: a method for inferring novel drug indications with application to personalized medicine. Mol. Syst. Biol., 2011, 7(1), 496.
    • (2011) Mol. Syst. Biol , vol.7 , Issue.1
    • Gottlieb, A.1    Stein, G.Y.2    Ruppin, E.3    Sharan, R.4
  • 52
    • 79960796417 scopus 로고    scopus 로고
    • Exploiting drug–disease relationships for computational drug repositioning
    • Dudley, J.T.; Deshpande, T.; Butte, A.J. Exploiting drug–disease relationships for computational drug repositioning. Brief. Bioinform., 2011, 12(4):303-311.
    • (2011) Brief. Bioinform , vol.12 , Issue.4 , pp. 303-311
    • Dudley, J.T.1    Deshpande, T.2    Butte, A.J.3
  • 53
    • 68449088145 scopus 로고    scopus 로고
    • Human disease-drug network based on genomic expression profiles
    • Hu, G.; Agarwal, P. Human disease-drug network based on genomic expression profiles. Plos One, 2009, 4(8), e6536.
    • (2009) Plos One , vol.4 , Issue.8
    • Hu, G.1    Agarwal, P.2
  • 54
    • 84929627416 scopus 로고    scopus 로고
    • Alhajj, R. Prediction of novel drug indications using network driven biological data prioritization and integration
    • Qabaja, A.; Alshalalfa, M.; Alanazi, E.; Alhajj, R. Prediction of novel drug indications using network driven biological data prioritization and integration. J. Cheminformatics, 2014, 6(1), 1.
    • (2014) J. Cheminformatics , vol.6 , Issue.1
    • Qabaja, A.1    Alshalalfa, M.2    Alanazi, E.3
  • 55
    • 84891493732 scopus 로고    scopus 로고
    • Yang, L. Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases
    • Li, P.; Chen, J.; Wang, J.; Zhou, W.; Wang, X.; Li, B.; Tao, W.; Wang, W.; Wang, Y.; Yang, L. Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases. J. Ethnopharmacol., 2014, 151(1), 93-107.
    • (2014) J. Ethnopharmacol , vol.151 , Issue.1 , pp. 93-107
    • Li, P.1    Chen, J.2    Wang, J.3    Zhou, W.4    Wang, X.5    Li, B.6    Tao, W.7    Wang, W.8    Wang, Y.9
  • 56
    • 84871281143 scopus 로고    scopus 로고
    • Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease
    • Tao, W.; Xu, X.; Wang, X.; Li, B.; Wang, Y.; Li, Y.; Yang, L. Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease. J. Ethnopharmacol., 2013, 145(1), 1-10.
    • (2013) J. Ethnopharmacol , vol.145 , Issue.1 , pp. 1-10
    • Tao, W.1    Xu, X.2    Wang, X.3    Li, B.4    Wang, Y.5    Li, Y.6    Yang, L.7
  • 57
    • 84866040675 scopus 로고    scopus 로고
    • A system-level investigation into the mechanisms of chinese traditional medicine: Compound danshen formula for cardiovascular disease treatment
    • Li, X.; Xu, X.; Wang, J.; Yu, H.; Wang, X.; Yang, H.; Xu, H.; Tang, S.; Li, Y.; Yang, L. A system-level investigation into the mechanisms of chinese traditional medicine: compound danshen formula for cardiovascular disease treatment. Plos One, 2012, 7(9), e43918.
    • (2012) Plos One , vol.7 , Issue.9
    • Li, X.1    Xu, X.2    Wang, J.3    Yu, H.4    Wang, X.5    Yang, H.6    Xu, H.7    Tang, S.8    Li, Y.9    Yang, L.10
  • 58
    • 84873297322 scopus 로고    scopus 로고
    • Systems pharmacology uncovers Janus functions of botanical drugs: Activation of host defense system and inhibition of influenza virus replication
    • Wang, X.; Xu, X.; Li, Y.; Li, X.; Tao, W.; Li, B.; Wang, Y.; Yang, L. Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication. Integr. Biol., 2013, 5(2), 351-371.
    • (2013) Integr. Biol , vol.5 , Issue.2 , pp. 351-371
    • Wang, X.1    Xu, X.2    Li, Y.3    Li, X.4    Tao, W.5    Li, B.6    Wang, Y.7    Yang, L.8
  • 59
    • 13444266370 scopus 로고    scopus 로고
    • Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders
    • Hamosh, A.; Scott, A.F.; Amberger, J.S.; Bocchini, C.A.; McKusick, V.A. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res., 2005, 33(suppl 1), D514-D517.
    • (2005) Nucleic Acids Res , vol.33 , pp. D514-D517
    • Hamosh, A.1    Scott, A.F.2    Amberger, J.S.3    Bocchini, C.A.4    McKusick, V.A.5
  • 61
    • 79958795334 scopus 로고    scopus 로고
    • Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases
    • Bauer-Mehren, A.; Bundschus, M.; Rautschka, M.; Mayer, M.A.; Sanz, F.; Furlong, L.I. Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases. Plos One, 2011, 6(6), e20284.
    • (2011) Plos One , vol.6 , Issue.6
    • Bauer-Mehren, A.1    Bundschus, M.2    Rautschka, M.3    Mayer, M.A.4    Sanz, F.5    Furlong, L.I.6
  • 65
    • 34548427938 scopus 로고    scopus 로고
    • Moving toward a system genetics view of disease
    • Sieberts, S.K.; Schadt, E.E. Moving toward a system genetics view of disease. Mamm. Genome, 2007, 18(6-7), 389-401.
    • (2007) Mamm. Genome , vol.18 , Issue.6-7 , pp. 389-401
    • Sieberts, S.K.1    Schadt, E.E.2
  • 67
    • 70350227039 scopus 로고    scopus 로고
    • Systematic evaluation of drug–disease relationships to identify leads for novel drug uses
    • Chiang, A.P.; Butte, A.J. Systematic evaluation of drug–disease relationships to identify leads for novel drug uses. Clin. Pharmacol. Ther., 2009, 86(5), 507-510.
    • (2009) Clin. Pharmacol. Ther , vol.86 , Issue.5 , pp. 507-510
    • Chiang, A.P.1    Butte, A.J.2
  • 69
    • 55049095941 scopus 로고    scopus 로고
    • Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases
    • Ray, M.; Ruan, J.; Zhang, W. Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases. Genome Biol., 2008, 9(10), R148.
    • (2008) Genome Biol , vol.9 , Issue.10
    • Ray, M.1    Ruan, J.2    Zhang, W.3
  • 70
    • 79959264888 scopus 로고    scopus 로고
    • A novel integrative network approach to understand the interplay between cardiovascular disease and other complex disorders
    • Rende, D.; Baysal, N.; Kirdar, B. A novel integrative network approach to understand the interplay between cardiovascular disease and other complex disorders. Mol. BioSyst., 2011, 7(7), 2205-2219.
    • (2011) Mol. Biosyst , vol.7 , Issue.7 , pp. 2205-2219
    • Rende, D.1    Baysal, N.2    Kirdar, B.3
  • 71
    • 84883576667 scopus 로고    scopus 로고
    • VisANT 4.0: Integrative network platform to connect genes, drugs, diseases and therapies
    • Hu, Z.; Chang, Y. C.; Wang, Y.; Huang, C. L.; Liu, Y.; Tian, F.; Granger, B.; DeLisi, C. VisANT 4.0: Integrative network platform to connect genes, drugs, diseases and therapies. Nucleic Acids Res., 2013, 41(1), W225-W231.
    • (2013) Nucleic Acids Res , vol.41 , Issue.1 , pp. W225-W231
    • Hu, Z.1    Chang, Y.C.2    Wang, Y.3    Huang, C.L.4    Liu, Y.5    Tian, F.6    Granger, B.7    Delisi, C.8
  • 72
    • 84877580262 scopus 로고    scopus 로고
    • Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review
    • Csermely, P.; Korcsmáros, T.; Kiss, H.J.; London, G.; Nussinov, R. Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review. Pharmacol. Ther., 2013, 138(3), 333-408.
    • (2013) Pharmacol. Ther , vol.138 , Issue.3 , pp. 333-408
    • Csermely, P.1    Korcsmáros, T.2    Kiss, H.J.3    London, G.4    Nussinov, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.