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Volumn 12, Issue 4, 2011, Pages 303-311

Exploiting drug-disease relationships for computational drug repositioning

Author keywords

Bioinformatics; Drug development; Drug repositioning; Gene expression; Genomics; Microarrays; Systems biology

Indexed keywords

DRUG;

EID: 79960796417     PISSN: 14675463     EISSN: 14774054     Source Type: Journal    
DOI: 10.1093/bib/bbr013     Document Type: Article
Times cited : (438)

References (43)
  • 2
    • 0035336557 scopus 로고    scopus 로고
    • New drug development in the United States from 1963 to 1999
    • Dimasi JA. New drug development in the United States from 1963 to 1999. Clin Pharmacol Ther 2001;69:286-96.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 286-296
    • Dimasi, J.A.1
  • 3
    • 33645675960 scopus 로고    scopus 로고
    • Estimating the cost of new drug development: Is it really 802 million dollars?
    • Adams CP, Brantner VV. Estimating the cost of new drug development: Is it really 802 million dollars? Health Aff 2006;25:420-8.
    • (2006) Health Aff , vol.25 , pp. 420-428
    • Adams, C.P.1    Brantner, V.V.2
  • 4
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: identifying and developing new uses for existing drugs
    • Ashburn TT, Thor KB. Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 2004;3:673-83.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 6
    • 0033861067 scopus 로고    scopus 로고
    • Bromocriptine: a novel approach to the treatment of Type 2 diabetes
    • Pijl H, Ohashi S, Matsuda M, et al. Bromocriptine: a novel approach to the treatment of Type 2 diabetes. DiabetesCare 2000;23:1154-61.
    • (2000) DiabetesCare , vol.23 , pp. 1154-1161
    • Pijl, H.1    Ohashi, S.2    Matsuda, M.3
  • 7
    • 0031035181 scopus 로고    scopus 로고
    • An information-intensive approach to the molecular pharmacology of cancer
    • Weinstein JN, Myers TG, O'Connor PM, et al. An information-intensive approach to the molecular pharmacology of cancer. Science 1997;275:343-9.
    • (1997) Science , vol.275 , pp. 343-349
    • Weinstein, J.N.1    Myers, T.G.2    O'Connor, P.M.3
  • 8
    • 0742287060 scopus 로고    scopus 로고
    • Old drugs, new tricks: using genetically sensitized yeast to reveal drug targets
    • Hughes T, Andrews B, Boone C. Old drugs, new tricks: using genetically sensitized yeast to reveal drug targets. Cell 2004;116:5-7.
    • (2004) Cell , vol.116 , pp. 5-7
    • Hughes, T.1    Andrews, B.2    Boone, C.3
  • 9
    • 10744225364 scopus 로고    scopus 로고
    • Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes
    • Lum PY, Armour CD, Stepaniants SB, et al. Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell 2004;116: 121-37.
    • (2004) Cell , vol.116 , pp. 121-137
    • Lum, P.Y.1    Armour, C.D.2    Stepaniants, S.B.3
  • 10
    • 0016656842 scopus 로고
    • Biological screening in the US Army antimalarial drug development program
    • Kinnamon KE, Rothe WE. Biological screening in the US Army antimalarial drug development program. Am J Trop Med Hyg 1975;24:174-8.
    • (1975) Am J Trop Med Hyg , vol.24 , pp. 174-178
    • Kinnamon, K.E.1    Rothe, W.E.2
  • 11
    • 70449634957 scopus 로고    scopus 로고
    • Predicting new molecular targets for known drugs
    • Keiser MJ, Setola V, Irwin JJ, et al. Predicting new molecular targets for known drugs. Nature 2009;462:175-81.
    • (2009) Nature , vol.462 , pp. 175-181
    • Keiser, M.J.1    Setola, V.2    Irwin, J.J.3
  • 12
    • 79960777680 scopus 로고    scopus 로고
    • Getting the drug repositioning genie out of the bottle
    • Elvidge S. Getting the drug repositioning genie out of the bottle. Life Sci Leader 2010;14-8.
    • (2010) Life Sci Leader , pp. 14-18
    • Elvidge, S.1
  • 13
  • 14
    • 0032487923 scopus 로고    scopus 로고
    • Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide
    • Soignet SL, Maslak P, Wang ZG, et al. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. N Engl J Med 1998;339:1341-8.
    • (1998) N Engl J Med , vol.339 , pp. 1341-1348
    • Soignet, S.L.1    Maslak, P.2    Wang, Z.G.3
  • 15
    • 0030891936 scopus 로고    scopus 로고
    • Activity of liposomal amphotericin B against experimental cutaneous leishmaniasis
    • Yardley V, Croft SL. Activity of liposomal amphotericin B against experimental cutaneous leishmaniasis. Antimicrob Agents Chemother 1997;41:752-6.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 752-756
    • Yardley, V.1    Croft, S.L.2
  • 16
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 1999;341:1565-71.
    • (1999) N Engl J Med , vol.341 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 17
    • 33847207834 scopus 로고    scopus 로고
    • Molecular similarity analysis in virtual screening: foundations, limitations and novel approaches
    • Eckert H, Bajorath J. Molecular similarity analysis in virtual screening: foundations, limitations and novel approaches. Drug DiscovToday 2007;12:225-33.
    • (2007) Drug DiscovToday , vol.12 , pp. 225-233
    • Eckert, H.1    Bajorath, J.2
  • 18
    • 33750357203 scopus 로고    scopus 로고
    • Predicting compound selectivity by self-organizing maps: cross-activities of metabotropic glutamate receptor antagonists
    • Noeske T, Sasse BC, Stark H, et al. Predicting compound selectivity by self-organizing maps: cross-activities of metabotropic glutamate receptor antagonists. Chem Med Chem 2006;1:1066-8.
    • (2006) Chem Med Chem , vol.1 , pp. 1066-1068
    • Noeske, T.1    Sasse, B.C.2    Stark, H.3
  • 19
    • 65549134255 scopus 로고    scopus 로고
    • Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships
    • Qu XA, Gudivada RC, Jegga AG, et al. Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships. BMC Bioinformatics 2009;10(Suppl 5):S4.
    • (2009) BMC Bioinformatics , vol.10 , Issue.SUPPL. 5
    • Qu, X.A.1    Gudivada, R.C.2    Jegga, A.G.3
  • 20
    • 78049349961 scopus 로고    scopus 로고
    • Trust, but verify: on the importance of chemical structure curation in cheminformatics and QSAR modeling research
    • Fourches D, Muratov E, Tropsha A. Trust, but verify: on the importance of chemical structure curation in cheminformatics and QSAR modeling research. J Chem Inf Model 2010;50:1189-204.
    • (2010) J Chem Inf Model , vol.50 , pp. 1189-1204
    • Fourches, D.1    Muratov, E.2    Tropsha, A.3
  • 21
    • 33749335282 scopus 로고    scopus 로고
    • The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
    • Lamb J, Crawford ED, Peck D, et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006;313:1929-35.
    • (2006) Science , vol.313 , pp. 1929-1935
    • Lamb, J.1    Crawford, E.D.2    Peck, D.3
  • 22
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005;102:15545-50.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3
  • 23
    • 77957044703 scopus 로고    scopus 로고
    • Discovery of drug mode of action and drug repositioning from transcriptional responses
    • Iorio F, Bosotti R, Scacheri E, et al. Discovery of drug mode of action and drug repositioning from transcriptional responses. Proc Natl Acad Sci USA 2010;107:14621-6.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14621-14626
    • Iorio, F.1    Bosotti, R.2    Scacheri, E.3
  • 24
    • 33847172327 scopus 로고    scopus 로고
    • Clustering by passing messages between data points
    • Frey BJ, Dueck D. Clustering by passing messages between data points. Science 2007;315:972-6.
    • (2007) Science , vol.315 , pp. 972-976
    • Frey, B.J.1    Dueck, D.2
  • 25
    • 33749443714 scopus 로고    scopus 로고
    • Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
    • Wei G, Twomey D, Lamb J, et al. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell 2006;10: 331-42.
    • (2006) Cancer Cell , vol.10 , pp. 331-342
    • Wei, G.1    Twomey, D.2    Lamb, J.3
  • 26
    • 70349914727 scopus 로고    scopus 로고
    • PubChem as a source of polypharmacology
    • Chen B, Wild D, Guha R. PubChem as a source of polypharmacology. J Chem Inf Model 2009;49:2044-55.
    • (2009) J Chem Inf Model , vol.49 , pp. 2044-2055
    • Chen, B.1    Wild, D.2    Guha, R.3
  • 27
    • 34548304745 scopus 로고    scopus 로고
    • In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling
    • Ekins S, Mestres J, Testa B. In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling. Br J Pharmacol 2007;152:9-20.
    • (2007) Br J Pharmacol , vol.152 , pp. 9-20
    • Ekins, S.1    Mestres, J.2    Testa, B.3
  • 28
    • 36048962439 scopus 로고    scopus 로고
    • Inverse in silico screening for identification of kinase inhibitor targets
    • Zahler S, Tietze S, Totzke F, et al. Inverse in silico screening for identification of kinase inhibitor targets. Chem Biol 2007; 14:1207-14.
    • (2007) Chem Biol , vol.14 , pp. 1207-1214
    • Zahler, S.1    Tietze, S.2    Totzke, F.3
  • 29
    • 68249144628 scopus 로고    scopus 로고
    • Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis
    • Kinnings SL, Liu N, Buchmeier N, et al. Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis. PLoS Comput Biol 2009;5: e1000423.
    • (2009) PLoS Comput Biol , vol.5
    • Kinnings, S.L.1    Liu, N.2    Buchmeier, N.3
  • 30
    • 78049445175 scopus 로고    scopus 로고
    • Drug off-target effects predicted using structural analysis in the context of a metabolic network model
    • Chang RL, Xie L, Bourne PE, et al. Drug off-target effects predicted using structural analysis in the context of a metabolic network model. PLoS Comput Biol 2010;6: e1000938.
    • (2010) PLoS Comput Biol , vol.6
    • Chang, R.L.1    Xie, L.2    Bourne, P.E.3
  • 31
    • 0031965676 scopus 로고    scopus 로고
    • Flexible ligand docking using conformational ensembles
    • Lorber DM, Shoichet BK. Flexible ligand docking using conformational ensembles. Protein Sci 1998;7:938-50.
    • (1998) Protein Sci , vol.7 , pp. 938-950
    • Lorber, D.M.1    Shoichet, B.K.2
  • 32
    • 78651321625 scopus 로고    scopus 로고
    • PROMISCUOUS: a database for network-based drug-repositioning
    • Database issue
    • von Eichborn J, Murgueitio MS, Dunkel M, et al. PROMISCUOUS: a database for network-based drug-repositioning. Nucleic Acids Res 2010;39(Database issue):D1060-6.
    • (2010) Nucleic Acids Res , vol.39
    • von Eichborn, J.1    Murgueitio, M.S.2    Dunkel, M.3
  • 33
    • 70350227039 scopus 로고    scopus 로고
    • Systematic evaluation of drug-disease relationships to identify leads for novel drug uses
    • Chiang AP, Butte AJ. Systematic evaluation of drug-disease relationships to identify leads for novel drug uses. Clin Pharmacol Ther 2009;86:507-10.
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 507-510
    • Chiang, A.P.1    Butte, A.J.2
  • 35
    • 68449088145 scopus 로고    scopus 로고
    • Human disease-drug network based on genomic expression profiles
    • Hu G, Agarwal P. Human disease-drug network based on genomic expression profiles. PLoS One 2009;4:e6536.
    • (2009) PLoS One , vol.4
    • Hu, G.1    Agarwal, P.2
  • 36
    • 84864288185 scopus 로고    scopus 로고
    • A pathway-based view of human diseases and disease relationships
    • Li Y, Agarwal P. A pathway-based view of human diseases and disease relationships. PLoS One 2009;4:e4346.
    • (2009) PLoS One , vol.4
    • Li, Y.1    Agarwal, P.2
  • 37
    • 70350765132 scopus 로고    scopus 로고
    • Can literature analysis identify innovation drivers in drug discovery?
    • Agarwal P, Searls DB. Can literature analysis identify innovation drivers in drug discovery? Nat Rev Drug Discov 2009;8: 865-78.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 865-878
    • Agarwal, P.1    Searls, D.B.2
  • 38
    • 77649222972 scopus 로고    scopus 로고
    • Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets
    • Suthram S, Dudley JT, Chiang AP, et al. Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets. PLoS Comput Biol 2010;6:e1000662.
    • (2010) PLoS Comput Biol , vol.6
    • Suthram, S.1    Dudley, J.T.2    Chiang, A.P.3
  • 39
    • 6944244084 scopus 로고    scopus 로고
    • A module map showing conditional activity of expression modules in cancer
    • Segal E, Friedman N, Koller D, et al. A module map showing conditional activity of expression modules in cancer. Nat Genet 2004;36:1090-8.
    • (2004) Nat Genet , vol.36 , pp. 1090-1098
    • Segal, E.1    Friedman, N.2    Koller, D.3
  • 40
    • 63449132586 scopus 로고    scopus 로고
    • Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
    • Yang X, Deignan JL, Qi H, et al. Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet 2009;41:415-23.
    • (2009) Nat Genet , vol.41 , pp. 415-423
    • Yang, X.1    Deignan, J.L.2    Qi, H.3
  • 41
    • 77958082168 scopus 로고    scopus 로고
    • Drug discovery in a multidimensional world: systems, patterns, and networks
    • Dudley JT, Schadt E, Sirota M, et al. Drug discovery in a multidimensional world: systems, patterns, and networks. J Cardiovasc Transl Res 2010;3:438-47.
    • (2010) J Cardiovasc Transl Res , vol.3 , pp. 438-447
    • Dudley, J.T.1    Schadt, E.2    Sirota, M.3
  • 42
    • 47249146126 scopus 로고    scopus 로고
    • Drug target identification using side-effect similarity
    • Campillos M, Kuhn M, Gavin AC, et al. Drug target identification using side-effect similarity. Science 2008;321: 263-6.
    • (2008) Science , vol.321 , pp. 263-266
    • Campillos, M.1    Kuhn, M.2    Gavin, A.C.3
  • 43
    • 0345863927 scopus 로고    scopus 로고
    • The Unified Medical Language System (UMLS): integrating biomedical terminology
    • Bodenreider O. The Unified Medical Language System (UMLS): integrating biomedical terminology. Nucleic Acids Res 2004;32:D267-70.
    • (2004) Nucleic Acids Res , vol.32
    • Bodenreider, O.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.