Use of genome-wide association studies for drug repositioning

Nature Biotechnology

Volumn 30, Issue 4, 2012, Pages 317-320

  Sanseau, Philippe ^a   Agarwal, Pankaj ^a   Barnes, Michael R ^a,f   Pastinen, Tomi ^b   Richards, J Brent ^c   Cardon, Lon R ^d   Mooser, Vincent ^d,e  

^a GLAXOSMITHKLINE   (United Kingdom)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d GLAXOSMITHKLINE   (United States)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^f LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BIIB 033; DENOSUMAB; DOPAMINE BETA MONOOXYGENASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 12P40; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR ANTIBODY; INTERLEUKIN 27; LEUCINE RICH REPEAT AND IMMUNOGLOBULIN DOMAIN CONTAINING 1 PROTEIN; NEPICASTAT; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN; ROMOSOZUMAB; SOLUTE CARRIER FAMILY 30 MEMBER 8 PROTEIN; UNCLASSIFIED DRUG; USTEKINUMAB;

BONE CANCER; COCAINE DEPENDENCE; CROHN DISEASE; DRUG MARKETING; DRUG REPOSITIONING; ESSENTIAL TREMOR; GENETIC ASSOCIATION; GENOME; HOUSEKEEPING GENE; HUMAN; HYPERCHOLESTEROLEMIA; LETTER; MULTIPLE SCLEROSIS; OSTEOPOROSIS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSORIASIS; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING CESSATION; ULCERATIVE COLITIS;

DISEASE; DRUG THERAPY; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INDIVIDUALIZED MEDICINE; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84859638338     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2151     Document Type: Letter

References (20)

1. Kathiresan, S. et al. Nat. Genet. 40, 189-197 (2008).
2. Franke, A. et al. Nat. Genet. 42, 1118-1125 (2010).
3. Moschen, A.R. et al. Gut 54, 479-487 (2005).
4. Stefansson, H. et al. Nat. Genet. 41, 277-279 (2009).
5. Clark, L.N. et al. Eur. J. Hum. Genet. 18, 838-843 (2010).
6. Louis, E.D. Lancet Neurol. 4, 100-110 (2005).
7. Tobacco and Genetics Consortium. Nat. Genet. 42, 441-447 (2010).
8. Stuart, P.E. et al. Nat. Genet. 42, 1000-1004 (2010).
9. Ormerod, A.D. et al. Arch. Dermatol. Res. 290, 3-8 (1998).
10. Ormerod, A.D. et al. Br. J. Dermatol. 142, 985-990 (2000).
11. Welsh, P. et al. J. Clin. Endocrinol. Metab. 95, 93-99 (2010).
12. Xu, K. & Coté, T.R. Brief. Bioinform. 12, 341-345 (2011).
13. Nair, R.P. et al. Nat. Genet. 41, 199-204 (2009).
14. Styrkarsdottir, U. et al. Nat. Genet. 41, 15-17 (2009).
15. Zeggini, E. et al. Science 316, 1336-1341 (2007).
16. Imielinski, M. et al. Nat. Genet. 41, 1335-1340 (2009).
17. Barrett, J.C. et al. Nat. Genet. 40, 955-962 (2008).
18. Anderson, C.A. et al. Nat. Genet. 43, 246-252 (2011).
19. Dubois, P.C. et al. Nat. Genet. 42, 295-302 (2010).
20. Baratz, K.H. et al. N. Engl. J. Med. 363, 1016-1024 (2010).