Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases

Journal of Ethnopharmacology

Volumn 151, Issue 1, 2014, Pages 93-107

  Li, Peng ^a   Chen, Jianxin ^b   Wang, Jinan ^a   Zhou, Wei ^a   Wang, Xia ^a   Li, Bohui ^a   Tao, Weiyang ^a   Wang, Wei ^b   Wang, Yonghua ^a   Yang, Ling ^c  

^a NORTHWEST A F UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

Cardiovascular diseases; Drug discovery and combination; Systems biology; Systems pharmacology

Indexed keywords

HERBACEOUS AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG METABOLISM; DRUG TARGETING; HEART INFARCTION; HERBAL MEDICINE; MACHINE LEARNING; MALE; MEMBRANE TRANSPORT; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PHARMACOLOGY; PHYSICAL CHEMISTRY; PLASMA PROTEIN BINDING; RAT; REFERENCE DATABASE; SYSTEMS BIOLOGY; SYSTEMS PHARMACOLOGY;

A5L; ABSORPTION, DISTRIBUTION, METABOLISM AND ELIMINATION; ADME; ARACHIDONATE 5-LIPOXYGENASE; B1AR; BETA-1 ADRENERGIC RECEPTOR; CARDIOVASCULAR DISEASES; CARTHAMUS TINCTORIUS; CDK2; CGMP-INHIBITED 3′,5′-CYCLIC PHOSPHODIESTERASE A; CGMPA; CT; CVD; CYCLIN DEPENDENT KINASE 2; DD NETWORK; DRUG DISCOVERY AND COMBINATION; DRUG-DRUG NETWORK; DRUG-TARGET NETWORK; DSH; DT NETWORK; ERB; ESTROGEN RECEPTOR BETA; FC; FRUCTUS CARTAEGI; M2; MAPK14; MITOGEN-ACTIVATED PROTEIN KINASE14; MUSCARINIC ACETYLCHOLINE RECEPTOR 2; NITRIC-OXIDE SYNTHASE ENDOTHELIAL; NOSE; OB; ORAL BIOAVAILABILITY; PEROXISOME PROLIFERATOR-ACTIVAED RECEPTOR GAMMA; PGS; PPAR; PROSTAGLANDIN G/H SYTHASE1; RADIX SALVIAE MILTIORRHIZAE; RSM; RSM, FC AND CT; SYSTEMS BIOLOGY; SYSTEMS PHARMACOLOGY; TANIMOTO SIMILARITY; TARGET-TARGET NETWORK; THERAPEUTIC TARGET DATABASE; TS; TT NETWORK; TTD;

ANIMALS; CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; COMPUTATIONAL BIOLOGY; DATABASES, FACTUAL; DRUG DISCOVERY; HUMANS; PLANT PREPARATIONS; PLANTS, MEDICINAL; SOFTWARE; SYSTEMS BIOLOGY;

EID: 84891493732     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.07.001     Document Type: Article

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