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Volumn 16, Issue 5, 2015, Pages 11013-11033

The real culprit in systemic lupus erythematosus: Abnormal epigenetic regulation

Author keywords

DNA methylation; Epigenetics; Histone modification; MicroRNA; SLE

Indexed keywords

HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; INTERFERON; MICRORNA; HISTONE; HISTONE DEACETYLASE INHIBITOR;

EID: 84929346691     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160511013     Document Type: Review
Times cited : (32)

References (131)
  • 2
    • 33744822178 scopus 로고    scopus 로고
    • Epidemiology of systemic lupus erythematosus: A comparison of worldwide disease burden
    • Danchenko, N.; Satia, J.A.; Anthony, M.S. Epidemiology of systemic lupus erythematosus: A comparison of worldwide disease burden. Lupus 2006, 15, 308–318.
    • (2006) Lupus , vol.15 , pp. 308-318
    • Danchenko, N.1    Satia, J.A.2    Anthony, M.S.3
  • 3
    • 79958814986 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • O’Neill, S.; Cervera, R. Systemic lupus erythematosus. Clin. Rheumatol. 2010, 24, 841–855.
    • (2010) Clin. Rheumatol , vol.24 , pp. 841-855
    • O’Neill, S.1    Cervera, R.2
  • 4
    • 0013886630 scopus 로고
    • Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus
    • Tan, E.M.; Kunkel, H.G. Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J. Immunol. 1966, 96, 464–471.
    • (1966) J. Immunol , vol.96 , pp. 464-471
    • Tan, E.M.1    Kunkel, H.G.2
  • 6
    • 0032006227 scopus 로고    scopus 로고
    • Autoreactive B cell regulation: Peripheral induction of developmental arrest by lupus-associated autoantigens
    • Santulli-Marotto, S.; Retter, M.W.; Gee, R.; Mamula, M.J.; Clarke, S.H. Autoreactive B cell regulation: Peripheral induction of developmental arrest by lupus-associated autoantigens. Immunity 1998, 8, 209–219.
    • (1998) Immunity , vol.8 , pp. 209-219
    • Santulli-Marotto, S.1    Retter, M.W.2    Gee, R.3    Mamula, M.J.4    Clarke, S.H.5
  • 9
    • 81155151965 scopus 로고    scopus 로고
    • Cutaneous lupus erythematosus: Update of therapeutic options part II
    • Kuhn, A.; Ruland, V.; Bonsmann, G. Cutaneous lupus erythematosus: Update of therapeutic options part II. J. Am. Acad. Dermatol. 2011, 65, e195–e213.
    • (2011) J. Am. Acad. Dermatol , vol.65 , pp. e195-e213
    • Kuhn, A.1    Ruland, V.2    Bonsmann, G.3
  • 10
    • 84870340050 scopus 로고    scopus 로고
    • Joint and tendon involvement in systemic lupus erythematosus: An ultrasound study of hands and wrists in 108 patients
    • Gabba, A.; Piga, M.; Vacca, A.; Porru, G.; Garau, P.; Cauli, A.; Mathieu, A. Joint and tendon involvement in systemic lupus erythematosus: An ultrasound study of hands and wrists in 108 patients. Rheumatology 2012, 51, 2278–2285.
    • (2012) Rheumatology , vol.51 , pp. 2278-2285
    • Gabba, A.1    Piga, M.2    Vacca, A.3    Porru, G.4    Garau, P.5    Cauli, A.6    Mathieu, A.7
  • 12
    • 80051973863 scopus 로고    scopus 로고
    • Epigenetics in systemic lupus erythematosus: Leading the way for specific therapeutic agents
    • Jeffries, M.A.; Sawalha, A.H. Epigenetics in systemic lupus erythematosus: Leading the way for specific therapeutic agents. Int. J. Clin. Rheumatol. 2011, 6, 423–439.
    • (2011) Int. J. Clin. Rheumatol , vol.6 , pp. 423-439
    • Jeffries, M.A.1    Sawalha, A.H.2
  • 13
    • 54549093861 scopus 로고    scopus 로고
    • The genetics of SLE: An update in the light of genome-wide association studies
    • Rhodes, B.; Vyse, T.J. The genetics of SLE: An update in the light of genome-wide association studies. Rheumatology 2008, 47, 1603–1611.
    • (2008) Rheumatology , vol.47 , pp. 1603-1611
    • Rhodes, B.1    Vyse, T.J.2
  • 14
    • 0027257146 scopus 로고
    • Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice
    • Quddus, J.; Johnson, K.J.; Gavalchin, J.; Amento, E.P.; Chrisp, C.E.; Yung, R.L.; Richardson, B.C. Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice. J. Clin. Investig. 1993, 92, 38–53.
    • (1993) J. Clin. Investig , vol.92 , pp. 38-53
    • Quddus, J.1    Johnson, K.J.2    Gavalchin, J.3    Amento, E.P.4    Chrisp, C.E.5    Yung, R.L.6    Richardson, B.C.7
  • 16
    • 79959990071 scopus 로고    scopus 로고
    • Regulation of mammalian DNA methyltransferases: A route to new mechanisms
    • Denis, H.; Ndlovu, M.N.; Fuks, F. Regulation of mammalian DNA methyltransferases: A route to new mechanisms. EMBO Rep. 2011, 12, 647–656.
    • (2011) EMBO Rep , vol.12 , pp. 647-656
    • Denis, H.1    Ndlovu, M.N.2    Fuks, F.3
  • 17
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16, 6–21.
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 18
    • 0014243302 scopus 로고
    • Induction by isoniazid and hydrallazine of antinuclear factors in mice
    • Cannat, A.; Seligmann, M. Induction by isoniazid and hydrallazine of antinuclear factors in mice. Clin. Exp. Immunol. 1968, 3, 99–105.
    • (1968) Clin. Exp. Immunol , vol.3 , pp. 99-105
    • Cannat, A.1    Seligmann, M.2
  • 20
    • 84908483075 scopus 로고    scopus 로고
    • DNA methylation and mRNA and microRNA expression of sle CD4+ T cells correlate with disease phenotype
    • Zhao, M.; Liu, S.; Luo, S.; Wu, H.; Tang, M.; Cheng, W.; Zhang, Q.; Zhang, P.; Yu, X.; Xia, Y., et al. DNA methylation and mRNA and microRNA expression of sle CD4+ T cells correlate with disease phenotype. J. Autoimmun. 2014, 54, 127–136.
    • (2014) J. Autoimmun , vol.54 , pp. 127-136
    • Zhao, M.1    Liu, S.2    Luo, S.3    Wu, H.4    Tang, M.5    Cheng, W.6    Zhang, Q.7    Zhang, P.8    Yu, X.9    Xia, Y.10
  • 21
    • 77954948735 scopus 로고    scopus 로고
    • Effector T cell plasticity: Flexibility in the face of changing circumstances
    • Murphy, K.M.; Stockinger, B. Effector T cell plasticity: Flexibility in the face of changing circumstances. Nat. Immunol. 2010, 11, 674–680.
    • (2010) Nat. Immunol , vol.11 , pp. 674-680
    • Murphy, K.M.1    Stockinger, B.2
  • 22
    • 74049099080 scopus 로고    scopus 로고
    • Autoimmunity: Increasing suspects in the CD4+ T cell lineup
    • Palmer, M.T.; Weaver, C.T. Autoimmunity: Increasing suspects in the CD4+ T cell lineup. Nat. Immunol. 2010, 11, 36–40.
    • (2010) Nat. Immunol , vol.11 , pp. 36-40
    • Palmer, M.T.1    Weaver, C.T.2
  • 23
    • 33746930141 scopus 로고    scopus 로고
    • Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis
    • Chan, R.W.; Lai, F.M.; Li, E.K.; Tam, L.S.; Chow, K.M.; Li, P.K.; Szeto, C.C. Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis. Rheumatology 2006, 45, 951–957.
    • (2006) Rheumatology , vol.45 , pp. 951-957
    • Chan, R.W.1    Lai, F.M.2    Li, E.K.3    Tam, L.S.4    Chow, K.M.5    Li, P.K.6    Szeto, C.C.7
  • 24
    • 66049151440 scopus 로고    scopus 로고
    • Th17 and natural Treg cell population dynamics in systemic lupus erythematosus
    • Yang, J.; Chu, Y.; Yang, X.; Gao, D.; Zhu, L.; Yang, X.; Wan, L.; Li, M. Th17 and natural Treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum. 2009, 60, 1472–1483.
    • (2009) Arthritis Rheum , vol.60 , pp. 1472-1483
    • Yang, J.1    Chu, Y.2    Yang, X.3    Gao, D.4    Zhu, L.5    Yang, X.6    Wan, L.7    Li, M.8
  • 25
    • 84871272970 scopus 로고    scopus 로고
    • Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus
    • Feng, X.; Wang, D.; Chen, J.; Lu, L.; Hua, B.; Li, X.; Tsao, B.P.; Sun, L. Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus. PLoS ONE 2012, 7, e51982.
    • (2012) Plos ONE , vol.7
    • Feng, X.1    Wang, D.2    Chen, J.3    Lu, L.4    Hua, B.5    Li, X.6    Tsao, B.P.7    Sun, L.8
  • 27
    • 0025666735 scopus 로고
    • Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • Richardson, B.; Scheinbart, L.; Strahler, J.; Gross, L.; Hanash, S.; Johnson, M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum. 1990, 33, 1665–1673.
    • (1990) Arthritis Rheum , vol.33 , pp. 1665-1673
    • Richardson, B.1    Scheinbart, L.2    Strahler, J.3    Gross, L.4    Hanash, S.5    Johnson, M.6
  • 28
    • 0023936754 scopus 로고
    • Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
    • Cornacchia, E.; Golbus, J.; Maybaum, J.; Strahler, J.; Hanash, S.; Richardson, B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J. Immunol. 1988, 140, 2197–2200.
    • (1988) J. Immunol , vol.140 , pp. 2197-2200
    • Cornacchia, E.1    Golbus, J.2    Maybaum, J.3    Strahler, J.4    Hanash, S.5    Richardson, B.6
  • 29
    • 0021237183 scopus 로고
    • The use of 5-azacytidine to establish constitutive interleukin 2-producing clones of the EL4 thymoma
    • Ballas, Z.K. The use of 5-azacytidine to establish constitutive interleukin 2-producing clones of the EL4 thymoma. J. Immunol. 1984, 133, 7–9.
    • (1984) J. Immunol , vol.133 , pp. 7-9
    • Ballas, Z.K.1
  • 30
    • 0032412441 scopus 로고    scopus 로고
    • Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
    • Agarwal, S.; Rao, A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 1998, 9, 765–775.
    • (1998) Immunity , vol.9 , pp. 765-775
    • Agarwal, S.1    Rao, A.2
  • 31
    • 0032575727 scopus 로고    scopus 로고
    • Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells
    • Bix, M.; Locksley, R.M. Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells. Science 1998, 281, 1352–1354.
    • (1998) Science , vol.281 , pp. 1352-1354
    • Bix, M.1    Locksley, R.M.2
  • 33
    • 79957615493 scopus 로고    scopus 로고
    • Hypomethylation of the HTR1A promoter region and high expression of HTR1A in the peripheral blood lymphocytes of patients with systemic lupus erythematosus
    • Xu, J.; Zhang, G.; Cheng, Y.; Chen, B.; Dong, Y.; Li, L.; Xu, L.; Xu, X.; Lu, Z.; Wen, J. Hypomethylation of the HTR1A promoter region and high expression of HTR1A in the peripheral blood lymphocytes of patients with systemic lupus erythematosus. Lupus 2011, 20, 678–689.
    • (2011) Lupus , vol.20 , pp. 678-689
    • Xu, J.1    Zhang, G.2    Cheng, Y.3    Chen, B.4    Dong, Y.5    Li, L.6    Xu, L.7    Xu, X.8    Lu, Z.9    Wen, J.10
  • 34
    • 0036095885 scopus 로고    scopus 로고
    • Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus
    • Lu, Q.; Kaplan, M.; Ray, D.; Ray, D.; Zacharek, S.; Gutsch, D.; Richardson, B. Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus. Arthritis Rheum. 2002, 46, 1282–1291.
    • (2002) Arthritis Rheum , vol.46 , pp. 1282-1291
    • Lu, Q.1    Kaplan, M.2    Ray, D.3    Ray, D.4    Zacharek, S.5    Gutsch, D.6    Richardson, B.7
  • 35
    • 77953288009 scopus 로고    scopus 로고
    • Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells
    • Zhao, M.; Sun, Y.; Gao, F.; Wu, X.; Tang, J.; Yin, H.; Luo, Y.; Richardson, B.; Lu, Q. Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells. J. Autoimmun. 2010, 35, 58–69.
    • (2010) J. Autoimmun , vol.35 , pp. 58-69
    • Zhao, M.1    Sun, Y.2    Gao, F.3    Wu, X.4    Tang, J.5    Yin, H.6    Luo, Y.7    Richardson, B.8    Lu, Q.9
  • 36
    • 78650626621 scopus 로고    scopus 로고
    • RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1
    • Zhao, M.; Wu, X.; Zhang, Q.; Luo, S.; Liang, G.; Su, Y.; Tan, Y.; Lu, Q. RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1. Arthritis Res. Ther. 2010, 12, R227.
    • (2010) Arthritis Res. Ther , vol.12 , pp. R227
    • Zhao, M.1    Wu, X.2    Zhang, Q.3    Luo, S.4    Liang, G.5    Su, Y.6    Tan, Y.7    Lu, Q.8
  • 37
    • 34548398164 scopus 로고    scopus 로고
    • Primer: Epigenetics of autoimmunity
    • Richardson, B. Primer: Epigenetics of autoimmunity. Nat. Clin. Pract. Rheumatol. 2007, 3, 521–527.
    • (2007) Nat. Clin. Pract. Rheumatol , vol.3 , pp. 521-527
    • Richardson, B.1
  • 38
    • 79955693133 scopus 로고    scopus 로고
    • Epigenetics and autoimmunity, with special emphasis on methylation
    • Renaudineau, Y.; Youinou, P. Epigenetics and autoimmunity, with special emphasis on methylation. Keio J. Med. 2011, 60, 10–16.
    • (2011) Keio J. Med , vol.60 , pp. 10-16
    • Renaudineau, Y.1    Youinou, P.2
  • 39
    • 0037287976 scopus 로고    scopus 로고
    • Preferential expression of B7.2 (CD86), but not B7.1 (CD80), on B cells induced by CD40/CD40L interaction is essential for anti-DNA autoantibody production in patients with systemic lupus erythematosus
    • Nagafuchi, H.; Shimoyama, Y.; Kashiwakura, J.; Takeno, M.; Sakane, T.; Suzuki, N. Preferential expression of B7.2 (CD86), but not B7.1 (CD80), on B cells induced by CD40/CD40L interaction is essential for anti-DNA autoantibody production in patients with systemic lupus erythematosus. Clin. Exp. Rheumatol. 2003, 21, 71–77.
    • (2003) Clin. Exp. Rheumatol , vol.21 , pp. 71-77
    • Nagafuchi, H.1    Shimoyama, Y.2    Kashiwakura, J.3    Takeno, M.4    Sakane, T.5    Suzuki, N.6
  • 40
    • 77951745847 scopus 로고    scopus 로고
    • Overexpression of the growth arrest and DNA damage-induced 45α gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells
    • Li, Y.; Zhao, M.; Yin, H.; Gao, F.; Wu, X.; Luo, Y.; Zhao, S.; Zhang, X.; Su, Y.; Hu, N., et al. Overexpression of the growth arrest and DNA damage-induced 45α gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells. Arthritis Rheum. 2010, 62, 1438–1447.
    • (2010) Arthritis Rheum , vol.62 , pp. 1438-1447
    • Li, Y.1    Zhao, M.2    Yin, H.3    Gao, F.4    Wu, X.5    Luo, Y.6    Zhao, S.7    Zhang, X.8    Su, Y.9    Hu, N.10
  • 41
    • 84885332506 scopus 로고    scopus 로고
    • A possible role of HMGB1 in DNA demethylation in CD4+ T cells from patients with systemic lupus erythematosus
    • 2013
    • Li, Y.; Huang, C.; Zhao, M.; Liang, G.; Xiao, R.; Yung, S.; Chan, T.M.; Lu, Q. A possible role of HMGB1 in DNA demethylation in CD4+ T cells from patients with systemic lupus erythematosus. Clin. Dev. Immunol. 2013, 2013, 206298.
    • (2013) Clin. Dev. Immunol
    • Li, Y.1    Huang, C.2    Zhao, M.3    Liang, G.4    Xiao, R.5    Yung, S.6    Chan, T.M.7    Lu, Q.8
  • 42
    • 84878361920 scopus 로고    scopus 로고
    • Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients
    • Coit, P.; Jeffries, M.; Altorok, N.; Dozmorov, M.G.; Koelsch, K.A.; Wren, J.D.; Merrill, J.T.; McCune, W.J.; Sawalha, A.H. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients. J. Autoimmun. 2013, 43, 78–84.
    • (2013) J. Autoimmun , vol.43 , pp. 78-84
    • Coit, P.1    Jeffries, M.2    Altorok, N.3    Dozmorov, M.G.4    Koelsch, K.A.5    Wren, J.D.6    Merrill, J.T.7    McCune, W.J.8    Sawalha, A.H.9
  • 43
    • 67649967556 scopus 로고    scopus 로고
    • Decreased DNA methyltransferase levels contribute to abnormal gene expression in “senescent” CD4+CD28− T cells
    • Liu, Y.; Chen, Y.; Richardson, B. Decreased DNA methyltransferase levels contribute to abnormal gene expression in “senescent” CD4+CD28− T cells. Clin. Immunol. 2009, 132, 257–265.
    • (2009) Clin. Immunol , vol.132 , pp. 257-265
    • Liu, Y.1    Chen, Y.2    Richardson, B.3
  • 44
    • 77954548251 scopus 로고    scopus 로고
    • Hypomethylation of IL-10 and IL-13 promoters in CD4+ T cells of patients with systemic lupus erythematosus
    • 2010
    • Zhao, M.; Tang, J.; Gao, F.; Wu, X.; Liang, Y.; Yin, H.; Lu, Q. Hypomethylation of IL-10 and IL-13 promoters in CD4+ T cells of patients with systemic lupus erythematosus. J. Biomed. Biotechnol. 2010, 2010, 931018.
    • (2010) J. Biomed. Biotechnol
    • Zhao, M.1    Tang, J.2    Gao, F.3    Wu, X.4    Liang, Y.5    Yin, H.6    Lu, Q.7
  • 45
    • 0037333972 scopus 로고    scopus 로고
    • Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling
    • Deng, C.; Lu, Q.; Zhang, Z.; Rao, T.; Attwood, J.; Yung, R.; Richardson, B. Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling. Arthritis Rheum. 2003, 48, 746–756.
    • (2003) Arthritis Rheum , vol.48 , pp. 746-756
    • Deng, C.1    Lu, Q.2    Zhang, Z.3    Rao, T.4    Attwood, J.5    Yung, R.6    Richardson, B.7
  • 46
    • 38449104652 scopus 로고    scopus 로고
    • Impaired T cell protein kinase Cδ activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus
    • Gorelik, G.; Fang, J.Y.; Wu, A.; Sawalha, A.H.; Richardson, B. Impaired T cell protein kinase Cδ activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus. J. Immunol. 2007, 179, 5553–5563.
    • (2007) J. Immunol , vol.179 , pp. 5553-5563
    • Gorelik, G.1    Fang, J.Y.2    Wu, A.3    Sawalha, A.H.4    Richardson, B.5
  • 47
    • 84928616162 scopus 로고    scopus 로고
    • T cell PKCδ kinase inactivation induces lupus-like autoimmunity in mice
    • Gorelik, G.; Sawalha, A.H.; Patel, D.; Johnson, K.; Richardson, B. T cell PKCδ kinase inactivation induces lupus-like autoimmunity in mice. Clin. Immunol. 2015, 158, 193–203.
    • (2015) Clin. Immunol , vol.158 , pp. 193-203
    • Gorelik, G.1    Sawalha, A.H.2    Patel, D.3    Johnson, K.4    Richardson, B.5
  • 49
    • 0037171439 scopus 로고    scopus 로고
    • Protein kinase Cδ controls self-antigen-induced B cell tolerance
    • Mecklenbrauker, I.; Saijo, K.; Zheng, N.Y.; Leitges, M.; Tarakhovsky, A. Protein kinase Cδ controls self-antigen-induced B cell tolerance. Nature 2002, 416, 860–865.
    • (2002) Nature , vol.416 , pp. 860-865
    • Mecklenbrauker, I.1    Saijo, K.2    Zheng, N.Y.3    Leitges, M.4    Tarakhovsky, A.5
  • 50
    • 44849087740 scopus 로고    scopus 로고
    • Defective T cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients
    • Sawalha, A.H.; Jeffries, M.; Webb, R.; Lu, Q.; Gorelik, G.; Ray, D.; Osban, J.; Knowlton, N.; Johnson, K.; Richardson, B. Defective T cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun. 2008, 9, 368–378.
    • (2008) Genes Immun , vol.9 , pp. 368-378
    • Sawalha, A.H.1    Jeffries, M.2    Webb, R.3    Lu, Q.4    Gorelik, G.5    Ray, D.6    Osban, J.7    Knowlton, N.8    Johnson, K.9    Richardson, B.10
  • 51
    • 84865654244 scopus 로고    scopus 로고
    • Protein kinase Cδ oxidation contributes to ERK inactivation in lupus T cells
    • Gorelik, G.J.; Yarlagadda, S.; Patel, D.R.; Richardson, B.C. Protein kinase Cδ oxidation contributes to ERK inactivation in lupus T cells. Arthritis Rheum. 2012, 64, 2964–2974.
    • (2012) Arthritis Rheum , vol.64 , pp. 2964-2974
    • Gorelik, G.J.1    Yarlagadda, S.2    Patel, D.R.3    Richardson, B.C.4
  • 52
    • 0036330337 scopus 로고    scopus 로고
    • Proceedings of the trans-HHS workshop: Diet, DNA methylation processes and health
    • Ross, S.A.; Poirier, L. Proceedings of the trans-HHS workshop: Diet, DNA methylation processes and health. J. Nutr. 2002, 132, 2329S–2332S.
    • (2002) J. Nutr , vol.132 , pp. 2329S-2332S
    • Ross, S.A.1    Poirier, L.2
  • 53
    • 84899512224 scopus 로고    scopus 로고
    • Environmental exposures, epigenetic changes and the risk of lupus
    • Somers, E.C.; Richardson, B.C. Environmental exposures, epigenetic changes and the risk of lupus. Lupus 2014, 23, 568–576.
    • (2014) Lupus , vol.23 , pp. 568-576
    • Somers, E.C.1    Richardson, B.C.2
  • 54
    • 0036278549 scopus 로고    scopus 로고
    • DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines
    • Danbara, M.; Kameyama, K.; Higashihara, M.; Takagaki, Y. DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines. Mol. Immunol. 2002, 38, 1161–1166.
    • (2002) Mol. Immunol , vol.38 , pp. 1161-1166
    • Danbara, M.1    Kameyama, K.2    Higashihara, M.3    Takagaki, Y.4
  • 55
    • 0033377786 scopus 로고    scopus 로고
    • DNA methylation and chromatin structure regulate PU.1 expression
    • Amaravadi, L.; Klemsz, M.J. DNA methylation and chromatin structure regulate PU.1 expression. DNA Cell Biol. 1999, 18, 875–884.
    • (1999) DNA Cell Biol , vol.18 , pp. 875-884
    • Amaravadi, L.1    Klemsz, M.J.2
  • 56
    • 52649146908 scopus 로고    scopus 로고
    • Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse CD19 locus
    • Walter, K.; Bonifer, C.; Tagoh, H. Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse CD19 locus. Blood 2008, 112, 1673–1682.
    • (2008) Blood , vol.112 , pp. 1673-1682
    • Walter, K.1    Bonifer, C.2    Tagoh, H.3
  • 59
    • 34247630966 scopus 로고    scopus 로고
    • Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus
    • Mazari, L.; Ouarzane, M.; Zouali, M. Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus. Proc. Natl. Acad. Sci. USA 2007, 104, 6317–6322.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 6317-6322
    • Mazari, L.1    Ouarzane, M.2    Zouali, M.3
  • 61
    • 52649138951 scopus 로고    scopus 로고
    • Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus
    • Giambra, V.; Volpi, S.; Emelyanov, A.V.; Pflugh, D.; Bothwell, A.L.; Norio, P.; Fan, Y.; Ju, Z.; Skoultchi, A.I.; Hardy, R.R., et al. Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus. Mol. Cell. Biol. 2008, 28, 6123–6133.
    • (2008) Mol. Cell. Biol , vol.28 , pp. 6123-6133
    • Giambra, V.1    Volpi, S.2    Emelyanov, A.V.3    Pflugh, D.4    Bothwell, A.L.5    Norio, P.6    Fan, Y.7    Ju, Z.8    Skoultchi, A.I.9    Hardy, R.R.10
  • 62
    • 66049083160 scopus 로고    scopus 로고
    • X inactivation and the complexities of silencing a sex chromosome
    • Chow, J.; Heard, E. X inactivation and the complexities of silencing a sex chromosome. Curr. Opin. Cell Biol. 2009, 21, 359–366.
    • (2009) Curr. Opin. Cell Biol , vol.21 , pp. 359-366
    • Chow, J.1    Heard, E.2
  • 63
    • 84906069844 scopus 로고    scopus 로고
    • The role of dead cell clearance in the etiology and pathogenesis of systemic lupus erythematosus: Dendritic cells as potential targets
    • Biermann, M.H.; Veissi, S.; Maueroder, C.; Chaurio, R.; Berens, C.; Herrmann, M.; Munoz, L.E. The role of dead cell clearance in the etiology and pathogenesis of systemic lupus erythematosus: Dendritic cells as potential targets. Expert Rev. Clin. Immunol. 2014, 10, 1151–1164.
    • (2014) Expert Rev. Clin. Immunol , vol.10 , pp. 1151-1164
    • Biermann, M.H.1    Veissi, S.2    Maueroder, C.3    Chaurio, R.4    Berens, C.5    Herrmann, M.6    Munoz, L.E.7
  • 64
    • 77649334441 scopus 로고    scopus 로고
    • Dendritic cell function in lupus: Independent contributors or victims of aberrant immune regulation
    • Kis-Toth, K.; Tsokos, G.C. Dendritic cell function in lupus: Independent contributors or victims of aberrant immune regulation. Autoimmunity 2010, 43, 121–130.
    • (2010) Autoimmunity , vol.43 , pp. 121-130
    • Kis-Toth, K.1    Tsokos, G.C.2
  • 65
    • 84866533031 scopus 로고    scopus 로고
    • Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus
    • Chan, V.S.; Nie, Y.J.; Shen, N.; Yan, S.; Mok, M.Y.; Lau, C.S. Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus. Autoimmun. Rev. 2012, 11, 890–897.
    • (2012) Autoimmun. Rev , vol.11 , pp. 890-897
    • Chan, V.S.1    Nie, Y.J.2    Shen, N.3    Yan, S.4    Mok, M.Y.5    Lau, C.S.6
  • 66
    • 79251542357 scopus 로고    scopus 로고
    • Epigenetics in lupus
    • Zouali, M. Epigenetics in lupus. Ann. N. Y. Acad. Sci. 2011, 1217, 154–165.
    • (2011) Ann. N. Y. Acad. Sci , vol.1217 , pp. 154-165
    • Zouali, M.1
  • 67
    • 70350049103 scopus 로고    scopus 로고
    • Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis
    • Lei, W.; Luo, Y.; Lei, W.; Luo, Y.; Yan, K.; Zhao, S.; Li, Y.; Qiu, X.; Zhou, Y.; Long, H., et al. Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. Scand. J. Rheumatol. 2009, 38, 369–374.
    • (2009) Scand. J. Rheumatol , vol.38 , pp. 369-374
    • Lei, W.1    Luo, Y.2    Lei, W.3    Luo, Y.4    Yan, K.5    Zhao, S.6    Li, Y.7    Qiu, X.8    Zhou, Y.9    Long, H.10
  • 68
    • 70349487008 scopus 로고    scopus 로고
    • Ultraviolet B exposure of peripheral blood mononuclear cells of patients with systemic lupus erythematosus inhibits DNA methylation
    • Wang, G.S.; Zhang, M.; Li, X.P.; Zhang, H.; Chen, W.; Kan, M.; Wang, Y.M. Ultraviolet B exposure of peripheral blood mononuclear cells of patients with systemic lupus erythematosus inhibits DNA methylation. Lupus 2009, 18, 1037–1044.
    • (2009) Lupus , vol.18 , pp. 1037-1044
    • Wang, G.S.1    Zhang, M.2    Li, X.P.3    Zhang, H.4    Chen, W.5    Kan, M.6    Wang, Y.M.7
  • 69
    • 18644376210 scopus 로고    scopus 로고
    • Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs
    • Lu, Q.; Wu, A.; Richardson, B.C. Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs. J. Immunol. 2005, 174, 6212–6219.
    • (2005) J. Immunol , vol.174 , pp. 6212-6219
    • Lu, Q.1    Wu, A.2    Richardson, B.C.3
  • 70
    • 0029662353 scopus 로고    scopus 로고
    • Role of the CD6 glycoprotein in antigen-specific and autoreactive responses of cloned human T lymphocytes
    • Singer, N.G.; Richardson, B.C.; Powers, D.; Hooper, F.; Lialios, F.; Endres, J.; Bott, C.M.; Fox, D.A. Role of the CD6 glycoprotein in antigen-specific and autoreactive responses of cloned human T lymphocytes. Immunology 1996, 88, 537–543.
    • (1996) Immunology , vol.88 , pp. 537-543
    • Singer, N.G.1    Richardson, B.C.2    Powers, D.3    Hooper, F.4    Lialios, F.5    Endres, J.6    Bott, C.M.7    Fox, D.A.8
  • 71
    • 38449116161 scopus 로고    scopus 로고
    • Demethylation of CD40LG on the inactive X in T cells from women with lupus
    • Lu, Q.; Wu, A.; Tesmer, L.; Ray, D.; Yousif, N.; Richardson, B. Demethylation of CD40LG on the inactive X in T cells from women with lupus. J. Immunol. 2007, 179, 6352–6358.
    • (2007) J. Immunol , vol.179 , pp. 6352-6358
    • Lu, Q.1    Wu, A.2    Tesmer, L.3    Ray, D.4    Yousif, N.5    Richardson, B.6
  • 72
    • 79955048011 scopus 로고    scopus 로고
    • Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus
    • Sunahori, K.; Juang, Y.T.; Kyttaris, V.C.; Tsokos, G.C. Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus. J. Immunol. 2011, 186, 4508–4517.
    • (2011) J. Immunol , vol.186 , pp. 4508-4517
    • Sunahori, K.1    Juang, Y.T.2    Kyttaris, V.C.3    Tsokos, G.C.4
  • 73
    • 79956330057 scopus 로고    scopus 로고
    • Hypomethylation of line-1 but not alu in lymphocyte subsets of systemic lupus erythematosus patients
    • Nakkuntod, J.; Avihingsanon, Y.; Mutirangura, A.; Hirankarn, N. Hypomethylation of line-1 but not alu in lymphocyte subsets of systemic lupus erythematosus patients. Clin. Chim. Acta Int. J. Clin. Chem. 2011, 412, 1457–1461.
    • (2011) Clin. Chim. Acta Int. J. Clin. Chem , vol.412 , pp. 1457-1461
    • Nakkuntod, J.1    Avihingsanon, Y.2    Mutirangura, A.3    Hirankarn, N.4
  • 74
    • 84904541089 scopus 로고    scopus 로고
    • Interpreting the language of histone and DNA modifications
    • Rothbart, S.B.; Strahl, B.D. Interpreting the language of histone and DNA modifications. Biochim. Biophys. Acta 2014, 1839, 627–643.
    • (2014) Biochim. Biophys. Acta , vol.1839 , pp. 627-643
    • Rothbart, S.B.1    Strahl, B.D.2
  • 75
    • 79251566746 scopus 로고    scopus 로고
    • Physical and functional HAT/HDAC interplay regulates protein acetylation balance
    • 2011
    • Peserico, A.; Simone, C. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. J. Biomed. Biotechnol. 2011, 2011, 371832.
    • (2011) J. Biomed. Biotechnol
    • Peserico, A.1    Simone, C.2
  • 76
    • 84870375316 scopus 로고    scopus 로고
    • Histone lysine methylation dynamics: Establishment, regulation, and biological impact
    • Black, J.C.; van Rechem, C.; Whetstine, J.R. Histone lysine methylation dynamics: Establishment, regulation, and biological impact. Mol. Cell 2012, 48, 491–507.
    • (2012) Mol. Cell , vol.48 , pp. 491-507
    • Black, J.C.1    van Rechem, C.2    Whetstine, J.R.3
  • 78
    • 81555220940 scopus 로고    scopus 로고
    • Histone modifications and methyl-CpG-binding domain protein levels at the TNFSF7 (CD70) promoter in sle CD4+ T cells
    • Zhou, Y.; Qiu, X.; Luo, Y.; Yuan, J.; Li, Y.; Zhong, Q.; Zhao, M.; Lu, Q. Histone modifications and methyl-CpG-binding domain protein levels at the TNFSF7 (CD70) promoter in sle CD4+ T cells. Lupus 2011, 20, 1365–1371.
    • (2011) Lupus , vol.20 , pp. 1365-1371
    • Zhou, Y.1    Qiu, X.2    Luo, Y.3    Yuan, J.4    Li, Y.5    Zhong, Q.6    Zhao, M.7    Lu, Q.8
  • 79
    • 0036235230 scopus 로고    scopus 로고
    • Effect of trichostatin a on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: A new mechanism for TCR ζ chain deficiency and abnormal signaling
    • Nambiar, M.P.; Warke, V.G.; Fisher, C.U.; Tsokos, G.C. Effect of trichostatin a on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: A new mechanism for TCR ζ chain deficiency and abnormal signaling. J. Cell. Biochem. 2002, 85, 459–469.
    • (2002) J. Cell. Biochem , vol.85 , pp. 459-469
    • Nambiar, M.P.1    Warke, V.G.2    Fisher, C.U.3    Tsokos, G.C.4
  • 80
    • 84855961987 scopus 로고    scopus 로고
    • Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases
    • Hedrich, C.M.; Tsokos, G.C. Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol. Med. 2011, 17, 714–724.
    • (2011) Trends Mol. Med , vol.17 , pp. 714-724
    • Hedrich, C.M.1    Tsokos, G.C.2
  • 81
    • 77952746458 scopus 로고    scopus 로고
    • Genome-wide analysis of histone H3 lysine 4 trimethylation by chip-chip in peripheral blood mononuclear cells of systemic lupus erythematosus patients
    • Dai, Y.; Zhang, L.; Hu, C.; Zhang, Y. Genome-wide analysis of histone H3 lysine 4 trimethylation by chip-chip in peripheral blood mononuclear cells of systemic lupus erythematosus patients. Clin. Exp. Rheumatol. 2010, 28, 158–168.
    • (2010) Clin. Exp. Rheumatol , vol.28 , pp. 158-168
    • Dai, Y.1    Zhang, L.2    Hu, C.3    Zhang, Y.4
  • 82
    • 77649340053 scopus 로고    scopus 로고
    • Global H4 acetylation analysis by chip-chip in systemic lupus erythematosus monocytes
    • Zhang, Z.; Song, L.; Maurer, K.; Petri, M.A.; Sullivan, K.E. Global H4 acetylation analysis by chip-chip in systemic lupus erythematosus monocytes. Genes Immun. 2010, 11, 124–133.
    • (2010) Genes Immun , vol.11 , pp. 124-133
    • Zhang, Z.1    Song, L.2    Maurer, K.3    Petri, M.A.4    Sullivan, K.E.5
  • 83
    • 84884197375 scopus 로고    scopus 로고
    • Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling
    • Apostolidis, S.A.; Rauen, T.; Hedrich, C.M.; Tsokos, G.C.; Crispin, J.C. Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling. J. Biol. Chem. 2013, 288, 26775–26784.
    • (2013) J. Biol. Chem , vol.288 , pp. 26775-26784
    • Apostolidis, S.A.1    Rauen, T.2    Hedrich, C.M.3    Tsokos, G.C.4    Crispin, J.C.5
  • 85
    • 33947186736 scopus 로고    scopus 로고
    • The TNFα locus is altered in monocytes from patients with systemic lupus erythematosus
    • Sullivan, K.E.; Suriano, A.; Dietzmann, K.; Lin, J.; Goldman, D.; Petri, M.A. The TNFα locus is altered in monocytes from patients with systemic lupus erythematosus. Clin. Immunol. 2007, 123, 74–81.
    • (2007) Clin. Immunol , vol.123 , pp. 74-81
    • Sullivan, K.E.1    Suriano, A.2    Dietzmann, K.3    Lin, J.4    Goldman, D.5    Petri, M.A.6
  • 86
    • 70450172448 scopus 로고    scopus 로고
    • Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice
    • Hu, N.; Long, H.; Zhao, M.; Yin, H.; Lu, Q. Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice. Scand. J. Rheumatol. 2009, 38, 464–471.
    • (2009) Scand. J. Rheumatol , vol.38 , pp. 464-471
    • Hu, N.1    Long, H.2    Zhao, M.3    Yin, H.4    Lu, Q.5
  • 87
    • 0037330279 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse
    • Mishra, N.; Reilly, C.M.; Brown, D.R.; Ruiz, P.; Gilkeson, G.S. Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. J. Clin. Investig. 2003, 111, 539–552.
    • (2003) J. Clin. Investig , vol.111 , pp. 539-552
    • Mishra, N.1    Reilly, C.M.2    Brown, D.R.3    Ruiz, P.4    Gilkeson, G.S.5
  • 89
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • Chen, C.Z.; Li, L.; Lodish, H.F.; Bartel, D.P. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004, 303, 83–86.
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 90
    • 77953629046 scopus 로고    scopus 로고
    • Regulation of mRNA translation and stability by microRNAs
    • Fabian, M.R.; Sonenberg, N.; Filipowicz, W. Regulation of mRNA translation and stability by microRNAs. Annu. Rev. Biochem. 2010, 79, 351–379.
    • (2010) Annu. Rev. Biochem , vol.79 , pp. 351-379
    • Fabian, M.R.1    Sonenberg, N.2    Filipowicz, W.3
  • 92
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel, D.P. MicroRNAs: Target recognition and regulatory functions. Cell 2009, 136, 215–233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 94
    • 75649139134 scopus 로고    scopus 로고
    • Physiological and pathological roles for microRNAs in the immune system
    • O’Connell, R.M.; Rao, D.S.; Chaudhuri, A.A.; Baltimore, D. Physiological and pathological roles for microRNAs in the immune system. Nat. Rev. Immunol. 2010, 10, 111–122.
    • (2010) Nat. Rev. Immunol , vol.10 , pp. 111-122
    • O’Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3    Baltimore, D.4
  • 95
    • 84922461464 scopus 로고    scopus 로고
    • MicroRNA regulation in systemic lupus erythematosus pathogenesis
    • Yan, S.; Yim, L.Y.; Lu, L.; Lau, C.S.; Chan, V.S. MicroRNA regulation in systemic lupus erythematosus pathogenesis. Immune Netw. 2014, 14, 138–148.
    • (2014) Immune Netw , vol.14 , pp. 138-148
    • Yan, S.1    Yim, L.Y.2    Lu, L.3    Lau, C.S.4    Chan, V.S.5
  • 96
    • 79955569628 scopus 로고    scopus 로고
    • MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1
    • Zhao, S.; Wang, Y.; Liang, Y.; Zhao, M.; Long, H.; Ding, S.; Yin, H.; Lu, Q. MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. Arthritis Rheum. 2011, 63, 1376–1386.
    • (2011) Arthritis Rheum , vol.63 , pp. 1376-1386
    • Zhao, S.1    Wang, Y.2    Liang, Y.3    Zhao, M.4    Long, H.5    Ding, S.6    Yin, H.7    Lu, Q.8
  • 97
    • 77953624215 scopus 로고    scopus 로고
    • MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
    • Pan, W.; Zhu, S.; Yuan, M.; Cui, H.; Wang, L.; Luo, X.; Li, J.; Zhou, H.; Tang, Y.; Shen, N. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J. Immunol. 2010, 184, 6773–6781.
    • (2010) J. Immunol , vol.184 , pp. 6773-6781
    • Pan, W.1    Zhu, S.2    Yuan, M.3    Cui, H.4    Wang, L.5    Luo, X.6    Li, J.7    Zhou, H.8    Tang, Y.9    Shen, N.10
  • 98
    • 84870899591 scopus 로고    scopus 로고
    • MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1
    • Qin, H.; Zhu, X.; Liang, J.; Wu, J.; Yang, Y.; Wang, S.; Shi, W.; Xu, J. MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1. J. Dermatol. Sci. 2013, 69, 61–67.
    • (2013) J. Dermatol. Sci , vol.69 , pp. 61-67
    • Qin, H.1    Zhu, X.2    Liang, J.3    Wu, J.4    Yang, Y.5    Wang, S.6    Shi, W.7    Xu, J.8
  • 99
    • 79959784552 scopus 로고    scopus 로고
    • Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: MiR-21 regulates aberrant T cell responses through regulation of PDCD4 expression
    • Stagakis, E.; Bertsias, G.; Verginis, P.; Nakou, M.; Hatziapostolou, M.; Kritikos, H.; Iliopoulos, D.; Boumpas, D.T. Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression. Ann. Rheum. Dis. 2011, 70, 1496–1506.
    • (2011) Ann. Rheum. Dis , vol.70 , pp. 1496-1506
    • Stagakis, E.1    Bertsias, G.2    Verginis, P.3    Nakou, M.4    Hatziapostolou, M.5    Kritikos, H.6    Iliopoulos, D.7    Boumpas, D.T.8
  • 100
    • 84864865405 scopus 로고    scopus 로고
    • Decreased microRNA-142-3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus
    • Ding, S.; Liang, Y.; Zhao, M.; Liang, G.; Long, H.; Zhao, S.; Wang, Y.; Yin, H.; Zhang, P.; Zhang, Q., et al. Decreased microRNA-142-3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus. Arthritis Rheum. 2012, 64, 2953–2963.
    • (2012) Arthritis Rheum , vol.64 , pp. 2953-2963
    • Ding, S.1    Liang, Y.2    Zhao, M.3    Liang, G.4    Long, H.5    Zhao, S.6    Wang, Y.7    Yin, H.8    Zhang, P.9    Zhang, Q.10
  • 101
    • 84864865406 scopus 로고    scopus 로고
    • Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus
    • Fan, W.; Liang, D.; Tang, Y.; Qu, B.; Cui, H.; Luo, X.; Huang, X.; Chen, S.; Higgs, B.W.; Jallal, B., et al. Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus. Arthritis Rheum. 2012, 64, 3715–3725.
    • (2012) Arthritis Rheum , vol.64 , pp. 3715-3725
    • Fan, W.1    Liang, D.2    Tang, Y.3    Qu, B.4    Cui, H.5    Luo, X.6    Huang, X.7    Chen, S.8    Higgs, B.W.9    Jallal, B.10
  • 102
    • 84929354495 scopus 로고    scopus 로고
    • Mycophenolic acid upregulates miR-142-3p/5p and miR-146a in lupus CD4+ T cells
    • Tang, Q.; Yang, Y.; Zhao, M.; Liang, G.; Wu, H.; Liu, Q.; Xie, Y.; Li, D.; Dai, Y.; Yung, S., et al. Mycophenolic acid upregulates miR-142-3p/5p and miR-146a in lupus CD4+ T cells. Lupus 2015, doi:10.1177/0961203315570685.
    • (2015) Lupus
    • Tang, Q.1    Yang, Y.2    Zhao, M.3    Liang, G.4    Wu, H.5    Liu, Q.6    Xie, Y.7    Li, D.8    Dai, Y.9    Yung, S.10
  • 103
    • 84878551158 scopus 로고    scopus 로고
    • Cell hyperactivity in patients with systemic lupus erythematosus by direct interaction with Lyn
    • Liu, Y.; Dong, J.; Mu, R.; Gao, Y.; Tan, X.; Li, Y.; Li, Z.; Yang, G. MicroRNA-30a promotes B cell hyperactivity in patients with systemic lupus erythematosus by direct interaction with Lyn. Arthritis Rheum. 2013, 65, 1603–1611.
    • (2013) Arthritis Rheum , vol.65 , pp. 1603-1611
    • Liu, Y.1    Dong, J.2    Mu, R.3    Gao, Y.4    Tan, X.5    Li, Y.6    Li, Z.7    Yang, G.8    Microrna-30A Promotes, B.9
  • 107
    • 84927142829 scopus 로고    scopus 로고
    • The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus
    • Luo, S.; Liu, Y.; Liang, G.; Zhao, M.; Wu, H.; Liang, Y.; Qiu, X.; Tan, Y.; Dai, Y.; Yung, S., et al. The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus. Clin. Epigenet. 2015, 7, 24.
    • (2015) Clin. Epigenet , vol.7 , pp. 24
    • Luo, S.1    Liu, Y.2    Liang, G.3    Zhao, M.4    Wu, H.5    Liang, Y.6    Qiu, X.7    Tan, Y.8    Dai, Y.9    Yung, S.10
  • 109
  • 110
    • 84906655584 scopus 로고    scopus 로고
    • Association of miR-146a polymorphisms with systemic lupus erythematosus: A meta-analysis
    • Ji, J.D.; Cha, E.S.; Lee, W.J. Association of miR-146a polymorphisms with systemic lupus erythematosus: A meta-analysis. Lupus 2014, 23, 1023–1030.
    • (2014) Lupus , vol.23 , pp. 1023-1030
    • Ji, J.D.1    Cha, E.S.2    Lee, W.J.3
  • 111
    • 84939962499 scopus 로고    scopus 로고
    • The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: A meta-analysis. Z
    • Lee, Y.H.; Bae, S.C. The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: A meta-analysis. Z. Rheumatol. 2014, 74, 153–156.
    • (2014) Rheumatol , vol.74 , pp. 153-156
    • Lee, Y.H.1    Bae, S.C.2
  • 112
    • 78650668809 scopus 로고    scopus 로고
    • MiR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells
    • Zhou, H.; Huang, X.; Cui, H.; Luo, X.; Tang, Y.; Chen, S.; Wu, L.; Shen, N. miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells. Blood 2010, 116, 5885–5894.
    • (2010) Blood , vol.116 , pp. 5885-5894
    • Zhou, H.1    Huang, X.2    Cui, H.3    Luo, X.4    Tang, Y.5    Chen, S.6    Wu, L.7    Shen, N.8
  • 113
    • 84880724207 scopus 로고    scopus 로고
    • MiR-29b and miR-29c are involved in toll-like receptor control of glucocorticoid-induced apoptosis in human plasmacytoid dendritic cells
    • Hong, Y.; Wu, J.; Zhao, J.; Wang, H.; Liu, Y.; Chen, T.; Kan, X.; Tao, Q.; Shen, X.; Yan, K.; Zhai, Z. miR-29b and miR-29c are involved in toll-like receptor control of glucocorticoid-induced apoptosis in human plasmacytoid dendritic cells. PLoS ONE 2013, 8, e69926.
    • (2013) Plos ONE , vol.8
    • Hong, Y.1    Wu, J.2    Zhao, J.3    Wang, H.4    Liu, Y.5    Chen, T.6    Kan, X.7    Tao, Q.8    Shen, X.9    Yan, K.10    Zhai, Z.11
  • 114
    • 78649731017 scopus 로고    scopus 로고
    • Serum and urinary cell-free miR-146a and miR-155 in patients with systemic lupus erythematosus
    • Wang, G.; Tam, L.S.; Li, E.K.; Kwan, B.C.; Chow, K.M.; Luk, C.C.; Li, P.K.; Szeto, C.C. Serum and urinary cell-free miR-146a and miR-155 in patients with systemic lupus erythematosus. J. Rheumatol. 2010, 37, 2516–2522.
    • (2010) J. Rheumatol , vol.37 , pp. 2516-2522
    • Wang, G.1    Tam, L.S.2    Li, E.K.3    Kwan, B.C.4    Chow, K.M.5    Luk, C.C.6    Li, P.K.7    Szeto, C.C.8
  • 115
    • 79955675453 scopus 로고    scopus 로고
    • Serum and urinary free microrna level in patients with systemic lupus erythematosus
    • Wang, G.; Tam, L.S.; Li, E.K.; Kwan, B.C.; Chow, K.M.; Luk, C.C.; Li, P.K.; Szeto, C.C. Serum and urinary free microrna level in patients with systemic lupus erythematosus. Lupus 2011, 20, 493–500.
    • (2011) Lupus , vol.20 , pp. 493-500
    • Wang, G.1    Tam, L.S.2    Li, E.K.3    Kwan, B.C.4    Chow, K.M.5    Luk, C.C.6    Li, P.K.7    Szeto, C.C.8
  • 116
    • 84865715678 scopus 로고    scopus 로고
    • Circulating microRNAs as candidate biomarkers in patients with systemic lupus erythematosus
    • Wang, H.; Peng, W.; Ouyang, X.; Li, W.; Dai, Y. Circulating microRNAs as candidate biomarkers in patients with systemic lupus erythematosus. Transl. Res. J. Lab. Clin. Med. 2012, 160, 198–206.
    • (2012) Transl. Res. J. Lab. Clin. Med , vol.160 , pp. 198-206
    • Wang, H.1    Peng, W.2    Ouyang, X.3    Li, W.4    Dai, Y.5
  • 119
    • 58049186787 scopus 로고    scopus 로고
    • Suppression of LPS-induced interferon-γ and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: A novel mechanism of immune modulation
    • Dai, R.; Phillips, R.A.; Zhang, Y.; Khan, D.; Crasta, O.; Ahmed, S.A. Suppression of LPS-induced interferon-γ and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: A novel mechanism of immune modulation. Blood 2008, 112, 4591–4597.
    • (2008) Blood , vol.112 , pp. 4591-4597
    • Dai, R.1    Phillips, R.A.2    Zhang, Y.3    Khan, D.4    Crasta, O.5    Ahmed, S.A.6
  • 120
    • 37849031502 scopus 로고    scopus 로고
    • Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients
    • Dai, Y.; Huang, Y.S.; Tang, M.; Lv, T.Y.; Hu, C.X.; Tan, Y.H.; Xu, Z.M.; Yin, Y.B. Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients. Lupus 2007, 16, 939–946.
    • (2007) Lupus , vol.16 , pp. 939-946
    • Dai, Y.1    Huang, Y.S.2    Tang, M.3    Lv, T.Y.4    Hu, C.X.5    Tan, Y.H.6    Xu, Z.M.7    Yin, Y.B.8
  • 122
    • 84875781381 scopus 로고    scopus 로고
    • The role of miR-125b in T lymphocytes in the pathogenesis of systemic lupus erythematosus
    • Luo, X.; Zhang, L.; Li, M.; Zhang, W.; Leng, X.; Zhang, F.; Zhao, Y.; Zeng, X. The role of miR-125b in T lymphocytes in the pathogenesis of systemic lupus erythematosus. Clin. Exp. Rheumatol. 2013, 31, 263–271.
    • (2013) Clin. Exp. Rheumatol , vol.31 , pp. 263-271
    • Luo, X.1    Zhang, L.2    Li, M.3    Zhang, W.4    Leng, X.5    Zhang, F.6    Zhao, Y.7    Zeng, X.8
  • 123
    • 65249138193 scopus 로고    scopus 로고
    • MicroRNA-146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins
    • Tang, Y.; Luo, X.; Cui, H.; Ni, X.; Yuan, M.; Guo, Y.; Huang, X.; Zhou, H.; de Vries, N.; Tak, P.P., et al. MicroRNA-146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum. 2009, 60, 1065–1075.
    • (2009) Arthritis Rheum , vol.60 , pp. 1065-1075
    • Tang, Y.1    Luo, X.2    Cui, H.3    Ni, X.4    Yuan, M.5    Guo, Y.6    Huang, X.7    Zhou, H.8    de Vries, N.9    Tak, P.P.10
  • 124
    • 84870466150 scopus 로고    scopus 로고
    • Decreased microRNA(MiR)-145 and increased miR-224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis
    • Lu, M.C.; Lai, N.S.; Chen, H.C.; Yu, H.C.; Huang, K.Y.; Tung, C.H.; Huang, H.B.; Yu, C.L. Decreased microRNA(miR)-145 and increased miR-224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis. Clin. Exp. Immunol. 2013, 171, 91–99.
    • (2013) Clin. Exp. Immunol , vol.171 , pp. 91-99
    • Lu, M.C.1    Lai, N.S.2    Chen, H.C.3    Yu, H.C.4    Huang, K.Y.5    Tung, C.H.6    Huang, H.B.7    Yu, C.L.8
  • 126
    • 79957949655 scopus 로고    scopus 로고
    • The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro
    • Lewis, E.C.; Blaabjerg, L.; Storling, J.; Ronn, S.G.; Mascagni, P.; Dinarello, C.A.; Mandrup-Poulsen, T. The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro. Mol. Med. 2011, 17, 369–377.
    • (2011) Mol. Med , vol.17 , pp. 369-377
    • Lewis, E.C.1    Blaabjerg, L.2    Storling, J.3    Ronn, S.G.4    Mascagni, P.5    Dinarello, C.A.6    Mandrup-Poulsen, T.7
  • 128
    • 77955414503 scopus 로고    scopus 로고
    • Trichostatin a blocks type I interferon production by activated plasmacytoid dendritic cells
    • Salvi, V.; Bosisio, D.; Mitola, S.; Andreoli, L.; Tincani, A.; Sozzani, S. Trichostatin a blocks type I interferon production by activated plasmacytoid dendritic cells. Immunobiology 2010, 215, 756–761.
    • (2010) Immunobiology , vol.215 , pp. 756-761
    • Salvi, V.1    Bosisio, D.2    Mitola, S.3    Andreoli, L.4    Tincani, A.5    Sozzani, S.6
  • 130
    • 84890284251 scopus 로고    scopus 로고
    • Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Faslpr mouse
    • Thai, T.H.; Patterson, H.C.; Pham, D.H.; Kis-Toth, K.; Kaminski, D.A.; Tsokos, G.C. Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Faslpr mouse. Proc. Natl. Acad. Sci. USA 2013, 110, 20194–20199.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 20194-20199
    • Thai, T.H.1    Patterson, H.C.2    Pham, D.H.3    Kis-Toth, K.4    Kaminski, D.A.5    Tsokos, G.C.6


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