Lupus T cells switched on by DNA hypomethylation via microRNA?

Arthritis and Rheumatism

Volumn 63, Issue 5, 2011, Pages 1177-1181

  Ceribelli, Angela ^a   Yao, Bing ^a   Dominguez Gutierrez, Paul R ^a   Chan, Edward K L ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; MESSENGER RNA; MICRORNA; MICRORNA 126; MICRORNA 148A; MICRORNA 21; TRICHOSTATIN A; UNCLASSIFIED DRUG; VORINOSTAT;

3' UNTRANSLATED REGION; B LYMPHOCYTE ACTIVATION; CD4+ T LYMPHOCYTE; DNA METHYLATION; DNA MODIFICATION; DNA SEQUENCE; EDITORIAL; EPIGENETICS; GENE EXPRESSION; HISTONE MODIFICATION; HUMAN; IMMUNE RESPONSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROCESSING; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

DNA METHYLATION; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICRORNAS; T-LYMPHOCYTES;

EID: 79955564971     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30192     Document Type: Editorial

References (8)

1. Zhao S, Wang Y, Liang Y, Zhao M, Long H, Ding S, et al. MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. Arthritis Rheum 2011; 63: 1376-86.
2. Ballestar E, Esteller M, Richardson BC,. The epigenetic face of systemic lupus erythematosus. J Immunol 2006; 176: 7143-7. (Pubitemid 43849013)
3. + T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 2010; 184: 6773-81.
4. Krol J, Loedige I, Filipowicz W,. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 2010; 11: 597-610.
5. Tang Y, Luo X, Cui H, Ni X, Yuan M, Guo Y, et al. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum 2009; 60: 1065-75.
6. Zhao X, Tang Y, Qu B, Cui H, Wang S, Wang L, et al. MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus. Arthritis Rheum 2010; 62: 3425-35.
7. Pauley KM, Cha S, Chan EK,. MicroRNA in autoimmunity and autoimmune diseases. J Autoimmun 2009; 32: 189-94.
8. Miranda KC, Huynh T, Tay Y, Ang YS, Tam WL, Thomson AM, et al. A pattern-based method for the identification of microRNA binding sites and their corresponding heteroduplexes. Cell 2006; 126: 1203-17. (Pubitemid 44380294)