Decreased microRNA(miR)-145 and increased miR-224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis

Clinical and Experimental Immunology

Volumn 171, Issue 1, 2013, Pages 91-99

  Lu, M C ^a,b   Lai, N S ^a,b   Chen, H C ^c   Yu, H C ^a   Huang, K Y ^a,b   Tung, C H ^a   Huang, H B ^d   Yu, C L ^e  

^a BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^b TZU CHI UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d NATIONAL CHUNG CHENG UNIVERSITY   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

API5; MiR 145; MiR 224; STAT 1; Systemic lupus erythematosus

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; HYDROXYCHLOROQUINE; MESSENGER RNA; METHYLPREDNISOLONE; MICRORNA; MICRORNA 145; MICRORNA 150; MICRORNA 224; MICRORNA 483 5P; MICRORNA 513 5P; MICRORNA 516A 5P; MICRORNA 629; MYCOPHENOLIC ACID; NEURONAL APOPTOSIS INHIBITORY PROTEIN; NEURONAL APOPTOSIS INHIBITORY PROTEIN 5; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LUPUS ERYTHEMATOSUS NEPHRITIS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

ADULT; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; FEMALE; HUMANS; JURKAT CELLS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MICRORNAS; MIDDLE AGED; NUCLEAR PROTEINS; STAT1 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TRANSCRIPTOME; TRANSFECTION;

EID: 84870466150     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04676.x     Document Type: Article

References (41)

1. Cook HT, Botto M. Mechanisms of disease: the complement system and the pathogenesis of systemic lupus erythematosus. Nat Clin Pract Rheumatol 2006; 2:330-337.
2. Moulton VR, Tsokos GC. Abnormalities of T cell signaling in systemic lupus erythematosus. Arthritis Res Ther 2011; 13:207.
3. Dorner T, Giesecke C, Lipsky PE. Mechanisms of B cell autoimmunity in SLE. Arthritis Res Ther 2011; 13:243.
4. Crispín JC, Kyttaris VC, Terhorst C, Tsokos GC. T cells as therapeutic targets in SLE. Nat Rev Rheumatol 2010; 6:317-325.
5. Pauley KM, Cha S, Chan EK. MicroRNA in autoimmunity and autoimmune diseases. J Autoimmun 2009; 32:189-194.
6. Stanczyk J, Pedrioli DM, Brentano F etal. Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum 2008; 58:1001-1009.
7. Kapsogeorgou EK, Gourzi VC, Manoussakis MN, Moutsopoulos HM, Tzioufas AG. Cellular microRNAs (miRNAs) and Sjogren's syndrome: candidate regulators of autoimmune response and autoantigen expression. J Autoimmun 2011; 37:129-135.
8. Padgett KA, Lan RY, Leung PC etal. Primary biliary cirrhosis is associated with altered hepatic microRNA expression. J Autoimmun 2009; 32:246-253.
9. Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, Chan EK. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther 2008; 10:R101.
10. Stagakis E, Bertsias G, Verginis P etal. Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression. Ann Rheum Dis 2011; 70:1496-1506.
11. Zhao S, Wang Y, Liang Y etal. MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. Arthritis Rheum 2011; 63:1376-1386.
12. Zhao X, Tang Y, Qu B etal. MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus. Arthritis Rheum 2010; 62:3425-3435.
13. Tang Y, Luo X, Cui H etal. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum 2009; 60:1065-1075.
14. Pan W, Zhu S, Yuan M etal. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 2010; 184:6773-6781.
15. Dai Y, Huang YS, Tang M etal. Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients. Lupus 2007; 16:939-946.
16. Wang G, Tam LS, Li EK etal. Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus. J Rheumatol 2010; 37:2516-2522.
17. Wang G, Tam LS, Kwan BC etal. Expression of miR-146a and miR-155 in the urinary sediment of systemic lupus erythematosus. Clin Rheumatol 2012; 31:435-440.
18. Te JL, Dozmorov IM, Guthridge JM etal. Identification of unique microRNA signature associated with lupus nephritis. PLoS ONE 2010; 5:e10344.
19. Dai Y, Sui W, Lan H, Yan Q, Huang H, Huang Y. Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients. Rheumatol Int 2009; 29:749-754.
20. Tan EM, Cohen AS, Fries JF etal. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25:1271-1277.
21. Chen C, Ridzon DA, Broomer AJ etal. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005; 33:e179.
22. Chen HC, Chen GH, Chen YH etal. MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma. Br J Cancer 2009; 100:1002-1011.
23. Gregersen LH, Jacobsen AB, Frankel LB, Wen J, Krogh A, Lund AH. MicroRNA-145 targets YES and STAT1 in colon cancer cells. PLoS ONE 2010; 5:e8836.
24. Wang Y, Lee AT, Ma JZ etal. Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. J Biol Chem 2008; 283:13205-13215.
25. Jordan ET, Collins M, Terefe J, Ugozzoli L, Rubio T. Optimizing electroporation conditions in primary and other difficult-to-transfect cells. J Biomol Tech 2008; 19:328-334.
26. Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R. AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Cancer Res 1997; 57:4063-4069.
27. Dhir V, Singh AP, Aggarwal A, Naik S, Misra R. Increased T-lymphocyte apoptosis in lupus correlates with disease activity and may be responsible for reduced T-cell frequency: a cross-sectional and longitudinal study. Lupus 2009; 18:785-791.
28. Rönnblom L, Alm GV, Eloranta ML. Type I interferon and lupus. Curr Opin Rheumatol 2009; 21:471-477.
29. Bennett L, Palucka AK, Arce E etal. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003; 197:711-723.
30. Baechler EC, Batliwalla FM, Karypis G etal. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 2003; 100:2610-2615.
31. Bengtsson AA, Sturfelt G, Truedsson L etal. Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus 2000; 9:664-671.
32. Karonitsch T, Feierl E, Steiner CW etal. Activation of the interferon-gamma signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells. Arthritis Rheum 2009; 60:1463-1471.
33. Kawasaki M, Fujishiro M, Yamaguchi A etal. Possible role of the JAK/STAT pathways in the regulation of T cell-interferon related genes in systemic lupus erythematosus. Lupus 2011; 20:1231-1239.
34. Dong J, Wang QX, Zhou CY, Ma XF, Zhang YC. Activation of the STAT1 signalling pathway in lupus nephritis in MRL/lpr mice. Lupus 2007; 16:101-109.
35. Martinez-Lostao L, Ordi-Ros J, Balada E etal. Activation of the signal transducer and activator of transcription-1 in diffuse proliferative lupus nephritis. Lupus 2007; 16:483-488.
36. Wang S, Yang N, Zhang L etal. STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice. Lupus 2010; 19:1171-1180.
37. Gianfrancesco F, Esposito T, Ciccodicola A etal. Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene. Cytogenet Cell Genet 1999; 84:164-166.
38. Emlen W, Niebur J, Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 1994; 152:3685-3692.
39. Bengtsson AA, Sturfelt G, Gullstrand B, Truedsson L. Induction of apoptosis in monocytes and lymphocytes by serum from patients with systemic lupus erythematosus - an additional mechanism to increased autoantigen load? Clin Exp Immunol 2004; 135:535-543.
40. Dai R, Zhang Y, Khan D etal. Identification of a common lupus disease-associated microRNA expression pattern in three different murine models of lupus. PLoS ONE 2010; 5:e14302.
41. Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R, Rajewsky N. Widespread changes in protein synthesis induced by microRNAs. Nature 2008; 455:58-63.