-
1
-
-
0030602796
-
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
-
Alcedo J, Ayzenzon M, Von Ohlen T, Noll M, Hooper JE (1996) The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86:221-232
-
(1996)
Cell
, vol.86
, pp. 221-232
-
-
Alcedo, J.1
Ayzenzon, M.2
Von Ohlen, T.3
Noll, M.4
Hooper, J.E.5
-
2
-
-
58149143021
-
Sonic hedgehog promotes desmoplasia in pancreatic cancer
-
Bailey JM, Swanson BJ, Hamada T, Eggers JP, Singh PK, Caffery T, Ouellette MM, Hollingsworth M. A (2008) Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin Cancer Res 14:5995-6004
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5995-6004
-
-
Bailey, J.M.1
Swanson, B.J.2
Hamada, T.3
Eggers, J.P.4
Singh, P.K.5
Caffery, T.6
Ouellette, M.M.7
Hollingsworth, M.A.8
-
3
-
-
70349974840
-
Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
-
Bailey JM, Mohr AM, Hollingsworth M. A (2009) Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene 28:3513-3525
-
(2009)
Oncogene
, vol.28
, pp. 3513-3525
-
-
Bailey, J.M.1
Mohr, A.M.2
Hollingsworth, M.A.3
-
4
-
-
0035054358
-
The hedgehog pathway and basal cell carcinomas
-
Bale AE, Yu KP (2001) The hedgehog pathway and basal cell carcinomas. Hum Mol Genet 10:757-762
-
(2001)
Hum Mol Genet
, vol.10
, pp. 757-762
-
-
Bale, A.E.1
Yu, K.P.2
-
5
-
-
35348837163
-
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
-
Bar EE, Chaudhry A, Lin A, Fan X, Schreck K, Matsui W, Piccirillo S, Vescovi AL, DiMeco F, Olivi A (2007) Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 25:2524-2533
-
(2007)
Stem Cells
, vol.25
, pp. 2524-2533
-
-
Bar, E.E.1
Chaudhry, A.2
Lin, A.3
Fan, X.4
Schreck, K.5
Matsui, W.6
Piccirillo, S.7
Vescovi, A.L.8
Dimeco, F.9
Olivi, A.10
-
6
-
-
33744493376
-
Targeting tyrosine kinases in cancer: The second wave
-
Baselga J (2006) Targeting tyrosine kinases in cancer: the second wave. Science 312:1175-1178
-
(2006)
Science
, vol.312
, pp. 1175-1178
-
-
Baselga, J.1
-
7
-
-
16144368562
-
Identifi cation of sonic hedgehog as a candidate gene responsible for holoprosencephaly
-
Belloni E, Muenke M, Roessler E, Traverso G, Siegel-Bartelt J, Frumkin A, Mitchell HF, Donis-Keller H, Helms C, Hing AV, Heng HH, Koop B, Martindale D, Rommens JM, Tsui LC, Scherer SW (1996) Identifi cation of sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat Genet 14:353-356
-
(1996)
Nat Genet
, vol.14
, pp. 353-356
-
-
Belloni, E.1
Muenke, M.2
Roessler, E.3
Traverso, G.4
Siegel-Bartelt, J.5
Frumkin, A.6
Mitchell, H.F.7
Donis-Keller, H.8
Helms, C.9
Hing, A.V.10
Heng, H.H.11
Koop, B.12
Martindale, D.13
Rommens, J.M.14
Tsui, L.C.15
Scherer, S.W.16
-
8
-
-
84929269777
-
Phase II study of GDC-0449 (HPI) with concurrent chemotherapy and bevacizumab as fi rst-line therapy for metastatic colorectal cancer
-
Milan, Italy, 8-12 Oct 2010
-
Berlin J, Bendell J, Hart LL, Firdaus I, Gore I, Hermann RC, Mackey H, Yacht B, Graham RA, Low JA, Bray GL (2010) Phase II study of GDC-0449 (HPI) with concurrent chemotherapy and bevacizumab as fi rst-line therapy for metastatic colorectal cancer. In: Proceedings of the European Society of Medical Oncology, Milan, Italy, 8-12 Oct 2010, Abstract #LBA21
-
(2010)
Proceedings of the European Society of Medical Oncology
-
-
Berlin, J.1
Bendell, J.2
Hart, L.L.3
Firdaus, I.4
Gore, I.5
Hermann, R.C.6
MacKey, H.7
Yacht, B.8
Graham, R.A.9
Low, J.A.10
Bray, G.L.11
-
9
-
-
0037200078
-
Medulloblastoma growth inhibition by hedgehog pathway blockade
-
Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA (2002) Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297:1559-1561
-
(2002)
Science
, vol.297
, pp. 1559-1561
-
-
Berman, D.M.1
Karhadkar, S.S.2
Hallahan, A.R.3
Pritchard, J.I.4
Eberhart, C.G.5
Watkins, D.N.6
Chen, J.K.7
Cooper, M.K.8
Taipale, J.9
Olson, J.M.10
Beachy, P.A.11
-
10
-
-
0242268525
-
Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumors
-
Berman DM, Karhadkar SS, Maitra A, Montes de Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, Beachy PA (2003) Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumors. Nature 425:846-851
-
(2003)
Nature
, vol.425
, pp. 846-851
-
-
Berman, D.M.1
Karhadkar, S.S.2
Maitra, A.3
Montes De Oca, R.4
Gerstenblith, M.R.5
Briggs, K.6
Parker, A.R.7
Shimada, Y.8
Eshleman, J.R.9
Watkins, D.N.10
Beachy, P.A.11
-
11
-
-
59449104701
-
Role of hedgehog signaling in ovarian cancer
-
Bhattacharya R, Kwon J, Ali B, Wang E, Patra S, Shridhar V, Mukherjee P (2008) Role of hedgehog signaling in ovarian cancer. Clin Cancer Res 14:7659-7666
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7659-7666
-
-
Bhattacharya, R.1
Kwon, J.2
Ali, B.3
Wang, E.4
Patra, S.5
Shridhar, V.6
Mukherjee, P.7
-
12
-
-
84887095053
-
Direct targeting of the Hedgehog pathway in primary chondrosarcoma xenografts with the smoothened inhibitor IPI-926
-
Orlando, FL, 2-6 Apr 2011
-
Campbell VT, Nadesan P, Wang Y, Whetstone H, McGovern K, Read M. A, Alman BA, Wunder JS (2011) Direct targeting of the Hedgehog pathway in primary chondrosarcoma xenografts with the smoothened inhibitor IPI-926. In: Proceedings of the American Association of Cancer Research Annual Meeting, Orlando, FL, 2-6 Apr 2011, Abstract LB380
-
(2011)
Proceedings of the American Association of Cancer Research Annual Meeting
-
-
Campbell, V.T.1
Nadesan, P.2
Wang, Y.3
Whetstone, H.4
McGovern, K.5
Read, M.A.6
Alman, B.A.7
Wunder, J.S.8
-
13
-
-
0036829397
-
Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened
-
Chen JK, Taipale J, Cooper MK, Beachy PA (2002) Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev 16:2743-2748
-
(2002)
Genes Dev
, vol.16
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
14
-
-
11144256194
-
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
-
Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ (2004) Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science 306:2257-2260
-
(2004)
Science
, vol.306
, pp. 2257-2260
-
-
Chen, W.1
Ren, X.R.2
Nelson, C.D.3
Barak, L.S.4
Chen, J.K.5
Beachy, P.A.6
De Sauvage, F.7
Lefkowitz, R.J.8
-
15
-
-
0029777408
-
Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function
-
Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA (1996) Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function. Nature 383:407-413
-
(1996)
Nature
, vol.383
, pp. 407-413
-
-
Chiang, C.1
Litingtung, Y.2
Lee, E.3
Young, K.E.4
Corden, J.L.5
Westphal, H.6
Beachy, P.A.7
-
16
-
-
33750313208
-
Cancer stem cells-perspective on current status and future directions: AACR workshop on cancer stem cells
-
Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CHM, Jones DL, Visvader J, Weissman IL, Wahl GM (2006) Cancer stem cells-perspective on current status and future directions: AACR workshop on cancer stem cells. Cancer Res 66:9339-9344
-
(2006)
Cancer Res
, vol.66
, pp. 9339-9344
-
-
Clarke, M.F.1
Dick, J.E.2
Dirks, P.B.3
Eaves, C.J.4
Chm, J.5
Jones, D.L.6
Visvader, J.7
Weissman, I.L.8
Wahl, G.M.9
-
17
-
-
33846237601
-
Hedgehog-Gli1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
-
Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A (2007) Hedgehog-Gli1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 17:165-172
-
(2007)
Curr Biol
, vol.17
, pp. 165-172
-
-
Clement, V.1
Sanchez, P.2
De Tribolet, N.3
Radovanovic, I.4
Ruizi5
Altaba, A.6
-
18
-
-
0032486433
-
Teratogen-mediated inhibition of target tissue response to Shh signaling
-
Cooper MK, Porter JA, Young KE, Beachy PA (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280:1603-1607
-
(1998)
Science
, vol.280
, pp. 1603-1607
-
-
Cooper, M.K.1
Porter, J.A.2
Young, K.E.3
Beachy, P.A.4
-
19
-
-
69549131213
-
Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
-
Creighton CJ, Lia X, Landis M, Dixon JM, Neumeister VM, Sjolund A, Rimm DL, Wong H, Rodriguez A, Herschkowitz JI, Fan C, Zhang X, He X, Pavlick A, Gutierrez MC, Renshaw L, Larionov AA, Faratian D, Hilsenbeck SG, Perou CM, Lewis MT, Rosen JN, Chang JC (2009) Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci USA 106:13820-13825
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 13820-13825
-
-
Creighton, C.J.1
Lia, X.2
Landis, M.3
Dixon, J.M.4
Neumeister, V.M.5
Sjolund, A.6
Rimm, D.L.7
Wong, H.8
Rodriguez, A.9
Herschkowitz, J.I.10
Fan, C.11
Zhang, X.12
He, X.13
Pavlick, A.14
Gutierrez, M.C.15
Renshaw, L.16
Larionov, A.A.17
Faratian, D.18
Hilsenbeck, S.G.19
Perou, C.M.20
Lewis, M.T.21
Rosen, J.N.22
Chang, J.C.23
more..
-
20
-
-
69249200489
-
The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin
-
Das S, Harris LG, Metge BJ, Liu S, Riker AI, Samant RS, Shevde LA (2009) The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin. J Biol Chem 284:22888-22897
-
(2009)
J Biol Chem
, vol.284
, pp. 22888-22897
-
-
Das, S.1
Harris, L.G.2
Metge, B.J.3
Liu, S.4
Riker, A.I.5
Samant, R.S.6
Shevde, L.A.7
-
21
-
-
34547683699
-
Essential role of stromally induced hedgehog signaling in B-cell malignancies
-
Dierks C, Grbic J, Zirlik K, Beigi R, Englund NP, Guo G-R, Veelken H, Engelhardt M, Mertelsmann R, Kelleher JF, Schultz P, Warmuth M (2007) Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nat Med 13:944-951
-
(2007)
Nat Med
, vol.13
, pp. 944-951
-
-
Dierks, C.1
Grbic, J.2
Zirlik, K.3
Beigi, R.4
Englund, N.P.5
Guo, G.-R.6
Veelken, H.7
Engelhardt, M.8
Mertelsmann, R.9
Kelleher, J.F.10
Schultz, P.11
Warmuth, M.12
-
22
-
-
50649118068
-
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on hedgehog pathway activation
-
Dierks C, Beigi R, Guo G-R, Zirlik K, Stegert MR, Manley P, Trussell C, Schmitt-Graeff A, Landwerlin K, Veelken H, Warmuth M (2008) Expansion of Bcr-Abl-positive leukemic stem cells is dependent on hedgehog pathway activation. Cancer Cell 14:238-249
-
(2008)
Cancer Cell
, vol.14
, pp. 238-249
-
-
Dierks, C.1
Beigi, R.2
Guo, G.-R.3
Zirlik, K.4
Stegert, M.R.5
Manley, P.6
Trussell, C.7
Schmitt-Graeff, A.8
Landwerlin, K.9
Veelken, H.10
Warmuth, M.11
-
23
-
-
45549109227
-
GLI2-specifi c transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells
-
Eichberger T, Kaser A, Pixner C, Schmid C, Klingler S, Winklmayr M, Hauser-Kronberger C, Aberger F, Frischauf AM (2008) GLI2-specifi c transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells. J Biol Chem 283:12426-12437
-
(2008)
J Biol Chem
, vol.283
, pp. 12426-12437
-
-
Eichberger, T.1
Kaser, A.2
Pixner, C.3
Schmid, C.4
Klingler, S.5
Winklmayr, M.6
Hauser-Kronberger, C.7
Aberger, F.8
Frischauf, A.M.9
-
24
-
-
84929278978
-
An investigatorinitiated, phase II randomized, double-blind, placebo-controlled trial of GDC-0449 for prevention of BCCs in basal cell nevus syndrome (BCNS) patients
-
Orlando, FL, 2-6 Apr 2011
-
Epstein E, Tang JY, Mackay-Wiggan JM, Aszterbaum M, Lindgren J, Chang K, Coppola C, Campbell A, Chanana A, Marji J, Callahan C, Yacht R, Bickers DR (2011) An investigatorinitiated, phase II randomized, double-blind, placebo-controlled trial of GDC-0449 for prevention of BCCs in basal cell nevus syndrome (BCNS) patients. In: Proceedings of the American Association of Cancer Research, Orlando, FL, 2-6 Apr 2011, Abstract #LB01
-
(2011)
Proceedings of the American Association of Cancer Research
-
-
Epstein, E.1
Tang, J.Y.2
MacKay-Wiggan, J.M.3
Aszterbaum, M.4
Lindgren, J.5
Chang, K.6
Coppola, C.7
Campbell, A.8
Chanana, A.9
Marji, J.10
Callahan, C.11
Yacht, R.12
Bickers, D.R.13
-
25
-
-
3843089435
-
Hedgehog signaling promotes prostate xenograft tumor growth
-
Fan L, Pepicelli CV, Dibble CC, Catbagan W, Zarycki JL, Laciak R, Gipp J, Shaw A, Lamm MLG, Munoz A, Lipinski R, Thrasher JB, Bushman W (2004) Hedgehog signaling promotes prostate xenograft tumor growth. Endocrinology 145:3961-3970
-
(2004)
Endocrinology
, vol.145
, pp. 3961-3970
-
-
Fan, L.1
Pepicelli, C.V.2
Dibble, C.C.3
Catbagan, W.4
Zarycki, J.L.5
Laciak, R.6
Gipp, J.7
Shaw, A.8
Mlg, L.9
Munoz, A.10
Lipinski, R.11
Thrasher, J.B.12
Bushman, W.13
-
26
-
-
0034871339
-
Regulation of chondrocyte terminal differentiation in the postembryonic growth plate: The role of the PtHrP-Indian Hh axis
-
Farquharson C, Jefferies D, Seawright E, Houston B (2001) Regulation of chondrocyte terminal differentiation in the postembryonic growth plate: the role of the PtHrP-Indian Hh axis. Endocrinology 142:4131-4140
-
(2001)
Endocrinology
, vol.142
, pp. 4131-4140
-
-
Farquharson, C.1
Jefferies, D.2
Seawright, E.3
Houston, B.4
-
27
-
-
52649169761
-
Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer
-
Feldmann G, Habbe N, Dhara S, Bisht S, Alvarez H, Fendrich V, Beaty R, Mullendore M, Karikari C, Bardeesy N, Ouellette MM, Yu W, Maitra A (2008) Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. Gut 57:1420-1430
-
(2008)
Gut
, vol.57
, pp. 1420-1430
-
-
Feldmann, G.1
Habbe, N.2
Dhara, S.3
Bisht, S.4
Alvarez, H.5
Fendrich, V.6
Beaty, R.7
Mullendore, M.8
Karikari, C.9
Bardeesy, N.10
Ouellette, M.M.11
Yu, W.12
Maitra, A.13
-
28
-
-
35748969866
-
Hedgehog signaling in the murine melanoma microenvironment
-
Geng L, Cuneo KC, Cooper MK, Wang H, Sekhar K, Fu A, Hallahan DF (2007) Hedgehog signaling in the murine melanoma microenvironment. Angiogenesis 10:259-267
-
(2007)
Angiogenesis
, vol.10
, pp. 259-267
-
-
Geng, L.1
Cuneo, K.C.2
Cooper, M.K.3
Wang, H.4
Sekhar, K.5
Fu, A.6
Hallahan, D.F.7
-
29
-
-
0030866154
-
Altered neural cell fates and medulloblastoma in mouse patched mutants
-
Goodrich LV, Milenkovi HKM, Scott MP (1997) Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277:1109-1113
-
(1997)
Science
, vol.277
, pp. 1109-1113
-
-
Goodrich, L.V.1
Hkm, M.2
Scott, M.P.3
-
30
-
-
84929267170
-
Hedgehog pathway inhibitor cyclopamine suppresses Gli1 expression and inhibits serous ovarian cancer xenograft growth (Abstract)
-
TX, 5-8 Feb 2009
-
Growden WB, McCann CR, Curley M, Friel AM, Mandley E, Ferguson J, Foster R, MacDougal J, Rueda BR (2009) Hedgehog pathway inhibitor cyclopamine suppresses Gli1 expression and inhibits serous ovarian cancer xenograft growth (Abstract). In: Society of Gynecologic Oncologists annual meeting, San Antonio, TX, 5-8 Feb 2009, Abstract 18
-
(2009)
Society of Gynecologic Oncologists Annual Meeting, San Antonio
-
-
Growden, W.B.1
McCann, C.R.2
Curley, M.3
Friel, A.M.4
Mandley, E.5
Ferguson, J.6
Foster, R.7
MacDougal, J.8
Rueda, B.R.9
-
31
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
Hahn H, Wicking C, Zaphiropoulos PG, Gailani MR, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden AB, Gillies S, Negus K, Smyth I, Pressman C, Leffell DJ, Gerrard B, Goldstein AM, Dean M, Toftgard R, Chenevix-Trench G, Wainwright B, Bale AE (1996) Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85:841-851
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
Wicking, C.2
Zaphiropoulos, P.G.3
Gailani, M.R.4
Shanley, S.5
Chidambaram, A.6
Vorechovsky, I.7
Holmberg, E.8
Unden, A.B.9
Gillies, S.10
Negus, K.11
Smyth, I.12
Pressman, C.13
Leffell, D.J.14
Gerrard, B.15
Goldstein, A.M.16
Dean, M.17
Toftgard, R.18
Chenevix-Trench, G.19
Wainwright, B.20
Bale, A.E.21
more..
-
32
-
-
69949166247
-
Dual and opposing roles of primary cilia in medulloblastoma development
-
Han Y-G, Kim HJ, Dlugosz AA, Ellison DW, Gilbertson RJ, Alvarez-Buylla AA (2009) Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med 15:1062-1065
-
(2009)
Nat Med
, vol.15
, pp. 1062-1065
-
-
Han, Y.-G.1
Kim, H.J.2
Dlugosz, A.A.3
Ellison, D.W.4
Gilbertson, R.J.5
Alvarez-Buylla, A.A.6
-
33
-
-
33845967146
-
Suppressing Wnt signaling by the hedgehog pathway through sFRP-1
-
He J, Sheng T, Stelter AA, Li C, Xhang X, Sinha M, Luxon BA, Xie J (2006) Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. J Biol Chem 281:35598-35602
-
(2006)
J Biol Chem
, vol.281
, pp. 35598-35602
-
-
He, J.1
Sheng, T.2
Stelter, A.A.3
Li, C.4
Xhang, X.5
Sinha, M.6
Luxon, B.A.7
Xie, J.8
-
34
-
-
57749086958
-
Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: A potential new therapeutic target
-
Hegde GV, Peterson KJ, Emanuel K et al (2008) Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target. Mol Cancer Res 6:1928-1936
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1928-1936
-
-
Hegde, G.V.1
Peterson, K.J.2
Emanuel, K.3
-
35
-
-
0031723219
-
The teratogenic ceratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
-
Incardona JP, Gaffi eld W, Kapur RP, Roellink H (1998) The teratogenic ceratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125:3553-3562
-
(1998)
Development
, vol.125
, pp. 3553-3562
-
-
Incardona, J.P.1
Gaffi Eld, W.2
Kapur, R.P.3
Roellink, H.4
-
36
-
-
84875812522
-
PF-04449913, a small molecule inhibitor of Hedgehog signaling, is effective in inhibiting tumor growth in preclinical models
-
Orlando, FL ,2-6 Apr 2011
-
Jackson-Fisher AJ, McMahon MJ, Lam J, Li C, Engstrom LD, Tsaparikos K, Shields DJ, Fang DD, Lira ME, Zhu Z, Robbins MD, Schwab R, Munchhof MJ, VanArsdale T (2011) PF-04449913, a small molecule inhibitor of Hedgehog signaling, is effective in inhibiting tumor growth in preclinical models. In: Proceedings of the American Association of Cancer Research Annual Meeting, Orlando, FL, 2-6 Apr 2011, Abstract #4504
-
(2011)
Proceedings of the American Association of Cancer Research Annual Meeting
-
-
Jackson-Fisher, A.J.1
McMahon, M.J.2
Lam, J.3
Li, C.4
Engstrom, L.D.5
Tsaparikos, K.6
Shields, D.J.7
Fang, D.D.8
Lira, M.E.9
Zhu, Z.10
Robbins, M.D.11
Schwab, R.12
Munchhof, M.J.13
Vanarsdale, T.14
-
37
-
-
57049089995
-
Hedgehog signaling in development and cancer
-
Jiang J, Hui C (2008) Hedgehog signaling in development and cancer. Dev Cell 15:801-812
-
(2008)
Dev Cell
, vol.15
, pp. 801-812
-
-
Jiang, J.1
Hui, C.2
-
38
-
-
67650999875
-
The basics of epithelial-mesenchymal transition
-
Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420-1428
-
(2009)
J Clin Invest
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
-
39
-
-
6044243650
-
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
-
Karhkadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maltra A, Isaccs JT, Berman DM, Beachy PA (2004) Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431:707-712
-
(2004)
Nature
, vol.431
, pp. 707-712
-
-
Karhkadkar, S.S.1
Bova, G.S.2
Abdallah, N.3
Dhara, S.4
Gardner, D.5
Maltra, A.6
Isaccs, J.T.7
Berman, D.M.8
Beachy, P.A.9
-
40
-
-
53049097596
-
Hedgehog signaling: Epithelial-to-mesenchymal transition and miRNA (review
-
Katoh Y, Katoh M (2008) Hedgehog signaling: epithelial-to-mesenchymal transition and miRNA (review). Int J Mol Med 22:271-275
-
(2008)
Int J Mol Med
, vol.22
, pp. 271-275
-
-
Katoh, Y.1
Katoh, M.2
-
41
-
-
84929264912
-
Phase 2 randomized placebo controlled study of hedgehog pathway inhibitor GDC-0449 as maintenance therapy in patients with ovarian cancer in 2nd or 3rd complete remission
-
Milan, Italy, 8-12 Oct 2010
-
Kaye S, Fehrenbacher L, Holloway R, Horowitz N, Karlan B, Amit A, Slomovitz B, Chang I, Yauch RL, Reddy JC (2010) Phase 2 randomized placebo controlled study of hedgehog pathway inhibitor GDC-0449 as maintenance therapy in patients with ovarian cancer in 2nd or 3rd complete remission. In: Proceedings of the European Society of Medical Oncology, Milan, Italy, 8-12 Oct 2010, Abstract #LBA25
-
(2010)
Proceedings of the European Society of Medical Oncology
-
-
Kaye, S.1
Fehrenbacher, L.2
Holloway, R.3
Horowitz, N.4
Karlan, B.5
Amit, A.6
Slomovitz, B.7
Chang, I.8
Yauch, R.L.9
Reddy, J.C.10
-
42
-
-
2442767513
-
Teratogenic compounds of Veratrum californicum (Durand)-IV
-
Keeler RF (1968) Teratogenic compounds of Veratrum californicum (Durand)-IV. Phytochemistry 7:303-306
-
(1968)
Phytochemistry
, vol.7
, pp. 303-306
-
-
Keeler, R.F.1
-
43
-
-
46449127054
-
B-Arrestin mediated localization of smoothened to the primary cilium
-
Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ (2008) b-Arrestin mediated localization of smoothened to the primary cilium. Science 320:1777-1781
-
(2008)
Science
, vol.320
, pp. 1777-1781
-
-
Kovacs, J.J.1
Whalen, E.J.2
Liu, R.3
Xiao, K.4
Kim, J.5
Chen, M.6
Wang, J.7
Chen, W.8
Lefkowitz, R.J.9
-
44
-
-
4344586961
-
Hedgehog signaling pathway is a new target for patients with breast cancer
-
Kubo M, Nakamura M, Tasaki A, Yamanaka N, Nakashima H, Nomura M, Kuroki S, Katano M (2004) Hedgehog signaling pathway is a new target for patients with breast cancer. Cancer Res 64:6071-6074
-
(2004)
Cancer Res
, vol.64
, pp. 6071-6074
-
-
Kubo, M.1
Nakamura, M.2
Tasaki, A.3
Yamanaka, N.4
Nakashima, H.5
Nomura, M.6
Kuroki, S.7
Katano, M.8
-
45
-
-
73349126115
-
Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: Development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance
-
Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ, Shehata M, Jäger U, Gandhi V, Kay NE, Plunkett W, Burger JA (2009) Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood 114:4441-4450
-
(2009)
Blood
, vol.114
, pp. 4441-4450
-
-
Kurtova, A.V.1
Balakrishnan, K.2
Chen, R.3
Ding, W.4
Schnabl, S.5
Quiroga, M.P.6
Sivina, M.7
Wierda, W.G.8
Estrov, Z.9
Keating, M.J.10
Shehata, M.11
Jäger, U.12
Gandhi, V.13
Kay, N.E.14
Plunkett, W.15
Burger, J.A.16
-
46
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri M. A, Dick JE (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367:645-648
-
(1994)
Nature
, vol.367
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
Murdoch, B.4
Hoang, T.5
Caceres-Cortes, J.6
Minden, M.7
Paterson, B.8
Caligiuri, M.A.9
Dick, J.E.10
-
47
-
-
31544480393
-
Snail induction is an early response to Gli1 that determines the effi ciency of epithelial transformation
-
Li X, Deng W, Nail CD, Bailey SK, Kraus MH, Ruppert JM, Lobo-Ruppert SM (2006) Snail induction is an early response to Gli1 that determines the effi ciency of epithelial transformation. Oncogene 25:609-621
-
(2006)
Oncogene
, vol.25
, pp. 609-621
-
-
Li, X.1
Deng, W.2
Nail, C.D.3
Bailey, S.K.4
Kraus, M.H.5
Ruppert, J.M.6
Lobo-Ruppert, S.M.7
-
48
-
-
78650827256
-
Self-renewal of acute lymphocytic leukemia cells is limited by the hedgehog pathway inhibitors cyclopamine and IPI-926
-
Lin TL, Wang QH, Brown P, Peacock C, Merchant AA, Brennan S, Jones E, McGovern K, Watkins DN, Sakamoto KM, Matsui W (2010) Self-renewal of acute lymphocytic leukemia cells is limited by the hedgehog pathway inhibitors cyclopamine and IPI-926. PLoS One 5:e15262
-
(2010)
PLoS One
, vol.5
, pp. e15262
-
-
Lin, T.L.1
Wang, Q.H.2
Brown, P.3
Peacock, C.4
Merchant, A.A.5
Brennan, S.6
Jones, E.7
McGovern, K.8
Watkins, D.N.9
Sakamoto, K.M.10
-
49
-
-
23144466931
-
Mouse intrafl agellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
-
Liu A, Wang B, Niswander LA (2005) Mouse intrafl agellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132:3103-3111
-
(2005)
Development
, vol.132
, pp. 3103-3111
-
-
Liu, A.1
Wang, B.2
Niswander, L.A.3
-
50
-
-
33745728170
-
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
-
Liu S, Dontu G, Mantle ID, Patel S, Ahn N, Jackson KW, Suri P, Wicha MS (2006) Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 66:6063-6071
-
(2006)
Cancer Res
, vol.66
, pp. 6063-6071
-
-
Liu, S.1
Dontu, G.2
Mantle, I.D.3
Patel, S.4
Ahn, N.5
Jackson, K.W.6
Suri, P.7
Wicha, M.S.8
-
51
-
-
0035691559
-
Genetic manipulation of Hh signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
-
Long F, Zhang XM, Karp S, Yang Y, McMahon AP (2001) Genetic manipulation of Hh signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128:5099-5108
-
(2001)
Development
, vol.128
, pp. 5099-5108
-
-
Long, F.1
Zhang, X.M.2
Karp, S.3
Yang, Y.4
McMahon, A.P.5
-
52
-
-
34250801612
-
Indian Hh produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone
-
Maeda Y, Nakamura E, Nguyen M-T et al (2006) Indian Hh produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc Natl Acad Sci USA 104:6382-6387
-
(2006)
Proc Natl Acad Sci USA
, vol.104
, pp. 6382-6387
-
-
Maeda, Y.1
Nakamura, E.2
Nguyen, M.-T.3
-
53
-
-
34248141223
-
Tumor stroma interactions in pancreatic ductal adenocarcinoma
-
Mahadevan D, Von Hoff DD (2007) Tumor stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther 6:1186-1197
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1186-1197
-
-
Mahadevan, D.1
Von Hoff, D.D.2
-
54
-
-
43049165453
-
The epithelialmesenchymal transition generates cells with properties of stem cells
-
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA (2008) The epithelialmesenchymal transition generates cells with properties of stem cells. Cell 133:704-715
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.J.3
Eaton, E.N.4
Ayyanan, A.5
Zhou, A.Y.6
Brooks, M.7
Reinhard, F.8
Zhang, C.C.9
Shipitsin, M.10
Campbell, L.L.11
Polyak, K.12
Brisken, C.13
Yang, J.14
Weinberg, R.A.15
-
55
-
-
70349205537
-
Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition
-
McCoy EL, Iwanaga R, Jedlicka P, Abbey NS, Chodosh LA, Heichman KA, Welm AL, Ford HL (2009) Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition. J Clin Invest 119:2528-2531
-
(2009)
J Clin Invest
, vol.119
, pp. 2528-2531
-
-
McCoy, E.L.1
Iwanaga, R.2
Jedlicka, P.3
Abbey, N.S.4
Chodosh, L.A.5
Heichman, K.A.6
Welm, A.L.7
Ford, H.L.8
-
56
-
-
22944485644
-
Shh controls epithelial proliferation via independent pathways that converge on N-Myc
-
Mill P, Mo R, Hu MC, Dagnino L, Rosenblum ND, Hui CC (2005) Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell 9:293-303
-
(2005)
Dev Cell
, vol.9
, pp. 293-303
-
-
Mill, P.1
Mo, R.2
Hu, M.C.3
Dagnino, L.4
Rosenblum, N.D.5
Hui, C.C.6
-
57
-
-
34247398806
-
Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation, and ductal dysplasia
-
Moraes RC, Zhang X, Harrington N, Fung JY, Wu MF, Hilsenbeck SG, Allred DC, Lewis MT (2007) Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation, and ductal dysplasia. Development 134:1231-1242
-
(2007)
Development
, vol.134
, pp. 1231-1242
-
-
Moraes, R.C.1
Zhang, X.2
Harrington, N.3
Fung, J.Y.4
Wu, M.F.5
Hilsenbeck, S.G.6
Allred, D.C.7
Lewis, M.T.8
-
58
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
Nüsslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287:795-801
-
(1980)
Nature
, vol.287
, pp. 795-801
-
-
Nüsslein-Volhard, C.1
Wieschaus, E.2
-
59
-
-
57049085407
-
G protein G a i functions immediately downstream of smoothened in hedgehog signalling
-
Ogden SK, Fei DL, Schilling NS, Ahmed YF, Hwa J, Robbins DJ (2008) G protein G a i functions immediately downstream of smoothened in hedgehog signalling. Nature 456(7224):967-970
-
(2008)
Nature
, vol.456
, Issue.7224
, pp. 967-970
-
-
Ogden, S.K.1
Fei, D.L.2
Schilling, N.S.3
Ahmed, Y.F.4
Hwa, J.5
Robbins, D.J.6
-
60
-
-
67149143399
-
Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Michael J, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben M. A, Caldwell ME, Allard D, Frese KK, DeNicola G, Feig C, Combs C, Winter SP, Ireland H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffi ths J, Tuveson DA (2009) Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324:1457-1461
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Michael, J.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
Madhu, B.7
Goldgraben, M.A.8
Caldwell, M.E.9
Allard, D.10
Frese, K.K.11
Denicola, G.12
Feig, C.13
Combs, C.14
Winter, S.P.15
Ireland, H.16
Reichelt, S.17
Howat, W.J.18
Chang, A.19
Dhara, M.20
Wang, L.21
Rückert, F.22
Grützmann, R.23
Pilarsky, C.24
Izeradjene, K.25
Hingorani, S.R.26
Huang, P.27
Davies, S.E.28
Plunkett, W.29
Egorin, M.30
Hruban, R.H.31
Whitebread, N.32
McGovern, K.33
Adams, J.34
Iacobuzio-Donahue, C.35
Griffiths36
Tuveson, D.A.J.37
more..
-
61
-
-
0038132179
-
Transcriptional profi ling of the sonic hedgehog response: A critical role for N-myc in proliferation of neuronal precursors
-
Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP, Wechsler-Reya RJ (2003) Transcriptional profi ling of the sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci USA 100:7331-7336
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7331-7336
-
-
Oliver, T.G.1
Grasfeder, L.L.2
Carroll, A.L.3
Kaiser, C.4
Gillingham, C.L.5
Lin, S.M.6
Wickramasinghe, R.7
Scott, M.P.8
Wechsler-Reya, R.J.9
-
62
-
-
77956292749
-
Discovery of NVP-LDE225, a potent and selective smoothened antagonist
-
Pan S, Wu X, Jiqing J, Gao W, Wan Y, Cheng D, Huan D, Liu J, Englund JP, Wang Y, Peukert S, Miller-Moslin K, Yuan J, Guo R, Matsumoto M, Vattay A, Jiang Y, Tsao J, Sun F, Pferdekamper AC, Dodd S, Tuntland T, Maniara W, Kelleker JF, Yao Y, Warmuth M, Williams J, Dorsch M (2010) Discovery of NVP-LDE225, a potent and selective smoothened antagonist. Med Chem Lett 1:130-134
-
(2010)
Med Chem Lett
, vol.1
, pp. 130-134
-
-
Pan, S.1
Wu, X.2
Jiqing, J.3
Gao, W.4
Wan, Y.5
Cheng, D.6
Huan, D.7
Liu, J.8
Englund, J.P.9
Wang, Y.10
Peukert, S.11
Miller-Moslin, K.12
Yuan, J.13
Guo, R.14
Matsumoto, M.15
Vattay, A.16
Jiang, Y.17
Tsao, J.18
Sun, F.19
Pferdekamper, A.C.20
Dodd, S.21
Tuntland, T.22
Maniara, W.23
Kelleker, J.F.24
Yao, Y.25
Warmuth, M.26
Williams, J.27
Dorsch, M.28
more..
-
63
-
-
34247192972
-
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
-
Peacock CD, Wang Q, Gesell GS, Cocoran-Schwartz IM, Jones E, Kim J, Devereux WL, Rhodes JT, Huff CA, Beachy PA, Watkins DN, Matsui W (2007) Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci USA 104:4048-4053
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 4048-4053
-
-
Peacock, C.D.1
Wang, Q.2
Gesell, G.S.3
Cocoran-Schwartz, I.M.4
Jones, E.5
Kim, J.6
Devereux, W.L.7
Rhodes, J.T.8
Huff, C.A.9
Beachy, P.A.10
Watkins, D.N.11
Matsui, W.12
-
64
-
-
58149333204
-
Cancer induction by restriction of oncogene expression to the stem cell compartment
-
Pérez-Caro M, Cobaleda C, González-Herrero I, Vicente-Duenãs C, Bermejo-Rodríguez C, Sánchez-Beato M, Orfao A, Pintado B, Flores T, Sánchez-Martín M, Jiménez R, Piris M. A, Sánchez-Garciá I (2009) Cancer induction by restriction of oncogene expression to the stem cell compartment. EMBO J 28:8-20
-
(2009)
EMBO J
, vol.28
, pp. 8-20
-
-
Pérez-Caro, M.1
Cobaleda, C.2
González-Herrero, I.3
Vicente-Duenãs, C.4
Bermejo-Rodríguez, C.5
Sánchez-Beato, M.6
Orfao, A.7
Pintado, B.8
Flores, T.9
Sánchez-Martín, M.10
Jiménez, R.11
Piris, M.A.12
Sánchez-Garciá, I.13
-
65
-
-
68949113503
-
Activity of IPI-926, a potent HH pathway inhibitor, in a novel model of medulloblastoma derived from Ptch/HIC +/-mice (Abstract)
-
San Diego, CA, 12-16 Apr 2008
-
Pink M, Proctor J, Briggs KJ, MacDougall J, Whitebread N, Tremblay MR, Grogan M, Palombella VJ, Castro AC, Adams J, Read M. A, Corcoron-Schwartz IM, Harcke T, Eberhart CG, Watkins DN, Sydor J (2008) Activity of IPI-926, a potent HH pathway inhibitor, in a novel model of medulloblastoma derived from Ptch/HIC +/-mice (Abstract). In: Proceedings of the 99th Meeting of the American Association for Cancer Research, San Diego, CA, 12-16 Apr 2008, Abstract 1588
-
(2008)
Proceedings of the 99th Meeting of the American Association for Cancer Research
-
-
Pink, M.1
Proctor, J.2
Briggs, K.J.3
MacDougall, J.4
Whitebread, N.5
Tremblay, M.R.6
Grogan, M.7
Palombella, V.J.8
Castro, A.C.9
Adams, J.10
Read, M.A.11
Corcoron-Schwartz, I.M.12
Harcke, T.13
Eberhart, C.G.14
Watkins, D.N.15
Sydor, J.16
-
66
-
-
70450193142
-
Imatinib and beyond-exploring the full potential of targeted therapy for CML
-
Quintás-Cardama A, Kantarjian H, Cortes J (2009) Imatinib and beyond-exploring the full potential of targeted therapy for CML. Nat Rev Clin Oncol 6:535-543
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 535-543
-
-
Quintás-Cardama, A.1
Kantarjian, H.2
Cortes, J.3
-
67
-
-
7444247429
-
Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2
-
Regl G, Kasper M, Schnidar H, Eichberger T, Neill GW, Philpott MP, Esterbauer H, Hauser-Kronberger C, Frischauf AM, Aberger F (2004) Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res 64:7724-7731
-
(2004)
Cancer Res
, vol.64
, pp. 7724-7731
-
-
Regl, G.1
Kasper, M.2
Schnidar, H.3
Eichberger, T.4
Neill, G.W.5
Philpott, M.P.6
Esterbauer, H.7
Hauser-Kronberger, C.8
Frischauf, A.M.9
Aberger, F.10
-
68
-
-
69949084378
-
GDC-0449-A potent inhibitor of the hedgehog pathway
-
Robarge KD, Brunton SA, Castanedo GM, Cui Y, Dina MS, Goldsmith R, Gould SE, Guichert O, Gunzner JL, Halladay J, Jia W, Khojasteh C, Koehler MF, Kotkow K, La H, Lalonde RL, Lau K, Lee L, Marshall D, Marsters JC Jr, Murray LJ, Qian C, Rubin LL, Salphati L, Stanley MS, Stibbard JH, Sutherlin DP, Ubhayaker S, Wang S, Wong S, Xie M (2009) GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett 19:5576-5581
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 5576-5581
-
-
Robarge, K.D.1
Brunton, S.A.2
Castanedo, G.M.3
Cui, Y.4
Dina, M.S.5
Goldsmith, R.6
Gould, S.E.7
Guichert, O.8
Gunzner, J.L.9
Halladay, J.10
Jia, W.11
Khojasteh, C.12
Koehler, M.F.13
Kotkow, K.14
La Lalonde, H.R.L.15
Lau, K.16
Lee, L.17
Marshall, D.18
Marsters, J.C.19
Murray, L.J.20
Qian, C.21
Rubin, L.L.22
Salphati, L.23
Stanley, M.S.24
Stibbard, J.H.25
Sutherlin, D.P.26
Ubhayaker, S.27
Wang, S.28
Wong, S.29
Xie, M.30
more..
-
69
-
-
0030294408
-
Mutations in the human sonic hedgehog gene cause holoprosencephaly
-
Roessler E, Belloni E, Gaudenz K, Jay P, Berta P, Scherer SW, Tsui LC, Muenke M (1996) Mutations in the human sonic hedgehog gene cause holoprosencephaly. Nat Genet 14:357-360
-
(1996)
Nat Genet
, vol.14
, pp. 357-360
-
-
Roessler, E.1
Belloni, E.2
Gaudenz, K.3
Jay, P.4
Berta, P.5
Scherer, S.W.6
Tsui, L.C.7
Muenke, M.8
-
70
-
-
34547110771
-
Patched-1 regulates hedgehog signaling at the primary cilium
-
Rohatgi R, Milenkovic L, Scott MP (2007) Patched-1 regulates hedgehog signaling at the primary cilium. Science 317:372-376
-
(2007)
Science
, vol.317
, pp. 372-376
-
-
Rohatgi, R.1
Milenkovic, L.2
Scott, M.P.3
-
71
-
-
62549159642
-
Hedgehog signal transduction by smoothened: Pharmacologic evidence for a 2-step activation process
-
Rohatgi R, Milenkovic L, Corcoran RB, Scott MP (2009) Hedgehog signal transduction by smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci USA 106:3196-3201
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 3196-3201
-
-
Rohatgi, R.1
Milenkovic, L.2
Corcoran, R.B.3
Scott, M.P.4
-
72
-
-
4544285754
-
Suppression of the Shh pathway using a small molecule inhibitor eliminated medulloblastoma in Ptc1 +/-p53-/-mice
-
Romer JT, Kimura H, Magdaleno S, Sasai K, Fuller C, Baines H, Connelly M, Stewart CF, Gould S, Rubin LL, Curran T (2004) Suppression of the Shh pathway using a small molecule inhibitor eliminated medulloblastoma in Ptc1 +/-p53-/-mice. Cancer Cell 6:229-240
-
(2004)
Cancer Cell
, vol.6
, pp. 229-240
-
-
Romer, J.T.1
Kimura, H.2
Magdaleno, S.3
Sasai, K.4
Fuller, C.5
Baines, H.6
Connelly, M.7
Stewart, C.F.8
Gould, S.9
Rubin, L.L.10
Curran, T.11
-
73
-
-
41749099463
-
Novel systemic therapies for small cell lung cancer
-
Rudin CM, Hann CL, Peacock CD, Watkins DN (2008) Novel systemic therapies for small cell lung cancer. J Natl Compr Canc Netw 6(3):1-8
-
(2008)
J Natl Compr Canc Netw
, vol.6
, Issue.3
, pp. 1-8
-
-
Rudin, C.M.1
Hann, C.L.2
Peacock, C.D.3
Watkins, D.N.4
-
74
-
-
70349244812
-
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
-
Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, Holcomb T, Stinson J, Gould SE, Coleman B, LoRusso PM, Von Hoff DD, de Sauvage FJ, Low JA (2009) Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 361:1173-1178
-
(2009)
N Engl J Med
, vol.361
, pp. 1173-1178
-
-
Rudin, C.M.1
Hann, C.L.2
Laterra, J.3
Yauch, R.L.4
Callahan, C.A.5
Fu, L.6
Holcomb, T.7
Stinson, J.8
Gould, S.E.9
Coleman, B.10
Lorusso, P.M.11
Von Hoff, D.D.12
De Sauvage, F.J.13
Low, J.A.14
-
75
-
-
84929276895
-
A phase 2 study of IPI-926, a novel hedgehog pathway inhibitor, in patients with advance or metastatic solid tumors
-
Chicago IL, 2-7 Jun 2011
-
Rudin CM, Jimeno A, Miller WH, Eigl B, Gettinger S, Chang A, Faia K, Sweeney J, Loewen G, Ross R, Weiss GJ (2011) A phase 2 study of IPI-926, a novel hedgehog pathway inhibitor, in patients with advance or metastatic solid tumors. In: Proceedings of the American Society of Clinical Oncology, Chicago, IL, 2-7 Jun 2011, Abstract #3014
-
(2011)
Proceedings of the American Society of Clinical Oncology
-
-
Rudin, C.M.1
Jimeno, A.2
Miller, W.H.3
Eigl, B.4
Gettinger, S.5
Chang, A.6
Faia, K.7
Sweeney, J.8
Loewen, G.9
Ross, R.10
Weiss, G.J.11
-
76
-
-
70349653550
-
Targeted inhibition of the hedgehog pathway in established malignant glioma xenografts enhances survival
-
Sarangi A, Valadez JG, Rush S, Abel TW, Thompson RC, Cooper MK (2009) Targeted inhibition of the hedgehog pathway in established malignant glioma xenografts enhances survival. Oncogene 28:3468-3476
-
(2009)
Oncogene
, vol.28
, pp. 3468-3476
-
-
Sarangi, A.1
Valadez, J.G.2
Rush, S.3
Abel, T.W.4
Thompson, R.C.5
Cooper, M.K.6
-
77
-
-
33646231995
-
Shh pathway activity is down-regulated in cultured medulloblastoma cells: Implications for preclinical studies
-
Sasai K, Romer JR, Lee Y, Finkelstein D, Fuller C, McKinnon PJ, Curran T (2006) Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res 66:4215-4222
-
(2006)
Cancer Res
, vol.66
, pp. 4215-4222
-
-
Sasai, K.1
Romer, J.R.2
Lee, Y.3
Finkelstein, D.4
Fuller, C.5
McKinnon, P.J.6
Curran, T.7
-
78
-
-
72449149112
-
The sonic hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofi broblasts
-
Shaw A, Gipp J, Bushman W (2009) The sonic hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofi broblasts. Oncogene 28:4480-4490
-
(2009)
Oncogene
, vol.28
, pp. 4480-4490
-
-
Shaw, A.1
Gipp, J.2
Bushman, W.3
-
79
-
-
33645371509
-
Dysregulation of the hedgehog pathway in human hepatocarcinogenesis
-
Sicklick JK, Li Y-X, Jayaraman A, Kannangai R, Qi Y, Vivekanandan P, Ludlow JW, Owzar K, Chen W, Torbenson MS, Diehl AM (2006) Dysregulation of the hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis 27:748-757
-
(2006)
Carcinogenesis
, vol.27
, pp. 748-757
-
-
Sicklick, J.K.1
Li, Y.-X.2
Jayaraman, A.3
Kannangai, R.4
Qi, Y.5
Vivekanandan, P.6
Ludlow, J.W.7
Owzar, K.8
Chen, W.9
Torbenson, M.S.10
Diehl, A.M.11
-
80
-
-
34347226348
-
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
-
Stecca B, Mas C, Clement V, Zbinden M, Correa R, Piguet V, Beermann F, Ruiz I, Altaba A (2007) Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci USA 104:5895-5900
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5895-5900
-
-
Stecca, B.1
Mas, C.2
Clement, V.3
Zbinden, M.4
Correa, R.5
Piguet, V.6
Beermann, F.7
Ruiz, I.8
Altaba, A.9
-
81
-
-
84929271788
-
The safety of IPI-926, a novel hedgehog pathway inhibitor, in combination with gemcitabine in patients with metastatic pancreatic cancer
-
Chicago IL, 2-7 Jun 2011
-
Stephenson J, Richards D, Wolpin B, Becerra C, Hamm J, Messersmith W, Devens S, Cushing J, Goddard J, Schmalbach T, Fuchs CS (2011) The safety of IPI-926, a novel hedgehog pathway inhibitor, in combination with gemcitabine in patients with metastatic pancreatic cancer. In: Proceedings of the American Society of Clinical Oncology, Chicago, IL, 2-7 Jun 2011, Abstract #4114
-
(2011)
Proceedings of the American Society of Clinical Oncology
-
-
Stephenson, J.1
Richards, D.2
Wolpin, B.3
Becerra, C.4
Hamm, J.5
Messersmith, W.6
Devens, S.7
Cushing, J.8
Goddard, J.9
Schmalbach, T.10
Fuchs, C.S.11
-
82
-
-
0034738979
-
Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine
-
Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA (2000) Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine. Nature 406:1005-1009
-
(2000)
Nature
, vol.406
, pp. 1005-1009
-
-
Taipale, J.1
Chen, J.K.2
Cooper, M.K.3
Wang, B.4
Mann, R.K.5
Milenkovic, L.6
Scott, M.P.7
Beachy, P.A.8
-
83
-
-
84929284955
-
Phase i study of LDE225 in advanced solid tumors: Updated analysis of safety, preliminary effi cacy, and pharmacokinetic-pharmacodynamic correlation
-
Chicago IL, 2-7 Jun 2011
-
Tawbi HA, Ahnert JR, Dummer R, Thomas AL, Granvil C, Shou Y, Dey J, Mita MM, Amakye DD, Mita AC (2011) Phase I study of LDE225 in advanced solid tumors: updated analysis of safety, preliminary effi cacy, and pharmacokinetic-pharmacodynamic correlation. In: Proceedings of the American Society of Clinical Oncology, Chicago, IL, 2-7 Jun 2011, Abstract #3062
-
(2011)
Proceedings of the American Society of Clinical Oncology
-
-
Tawbi, H.A.1
Ahnert, J.R.2
Dummer, R.3
Thomas, A.L.4
Granvil, C.5
Shou, Y.6
Dey, J.7
Mita, M.M.8
Amakye, D.D.9
Mita, A.C.10
-
84
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernández-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw A, Hebrok M (2003) Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425:851-856
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
Di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Lauwers, G.Y.6
Qi, Y.P.7
Gysin, S.8
Fernández-Del Castillo, C.9
Yajnik, V.10
Antoniu, B.11
McMahon, M.12
Warshaw, A.13
Hebrok, M.14
-
85
-
-
30344434306
-
Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation
-
Tiet TD, Hopyan S, Nadesan P, Gokgoz N, Poon R, Lin AC, Yan T, Andrulis IL, Alman BA, Wunder JS (2006) Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. Am J Pathol 168:321-330
-
(2006)
Am J Pathol
, vol.168
, pp. 321-330
-
-
Tiet, T.D.1
Hopyan, S.2
Nadesan, P.3
Gokgoz, N.4
Poon, R.5
Lin, A.C.6
Yan, T.7
Andrulis, I.L.8
Alman, B.A.9
Wunder, J.S.10
-
86
-
-
84929272571
-
TAK-441, a novel investigational small molecule hedgehog pathway inhibitor for use in cancer therapy
-
Orlando, FL, 2-6 Apr 2011
-
Tojo H, Shibata S, Satoh Y, Kawamura M, Inazuka M, Yamakawa H, Kashiwag M, Miyamoto M, Kondo M, Oohashi T, Oguro Y, Sasaki S (2011) TAK-441, a novel investigational small molecule hedgehog pathway inhibitor for use in cancer therapy. In: Proceedings of the American Association of Cancer Research Annual Meeting, Orlando, FL, 2-6 Apr 2011, Abstract 4508
-
(2011)
Proceedings of the American Association of Cancer Research Annual Meeting
-
-
Tojo, H.1
Shibata, S.2
Satoh, Y.3
Kawamura, M.4
Inazuka, M.5
Yamakawa, H.6
Kashiwag, M.7
Miyamoto, M.8
Kondo, M.9
Oohashi, T.10
Oguro, Y.11
Sasaki, S.12
-
87
-
-
73549123905
-
A novel HH pathway inhibitor, IPI-926, delays tumor recurrence post-chemotherapy in a primary human SCLC xenograft model (Abstract)
-
San Diego, CA, 12-16 Apr 2008
-
Travaglione V, Peacock CD, MacDougall J, McGovern J, Cushing J, Yu LC, Trudeau M, Palombella V, Adams J, Hierman J, Rhodes J, Devereux WL, Watkins DN (2008) A novel HH pathway inhibitor, IPI-926, delays tumor recurrence post-chemotherapy in a primary human SCLC xenograft model (Abstract). In: Proceedings of the 99th meeting of the American Association for Cancer Research, San Diego, CA, 12-16 Apr 2008, Abstract 4611
-
(2008)
Proceedings of the 99th Meeting of the American Association for Cancer Research
-
-
Travaglione, V.1
Peacock, C.D.2
MacDougall, J.3
McGovern, J.4
Cushing, J.5
Yu, L.C.6
Trudeau, M.7
Palombella, V.8
Adams, J.9
Hierman, J.10
Rhodes, J.11
Devereux, W.L.12
Watkins, D.N.13
-
89
-
-
67650723106
-
Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926
-
Tremblay M, Lescarbeau A, Grogan MJ, Tan E, Lin G, Austad BC, Yu LC, Behnke ML, Nair SJ, Hagel M, White K, Conley J, Manna JD, Alvarez-Diez TM, Hoyt J, Woodward CN, Sydor JR, Pink M, MacDougall J, Campbell MJ, Cushing J, Ferguson J, Curtis MS, McGovern K, Read M. A, Palombella VJ, Adams J, Castro AC (2009b) Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926). J Med Chem 52:4400-4418
-
(2009)
J Med Chem
, vol.52
, pp. 4400-4418
-
-
Tremblay, M.1
Lescarbeau, A.2
Grogan, M.J.3
Tan, E.4
Lin, G.5
Austad, B.C.6
Yu, L.C.7
Behnke, M.L.8
Nair, S.J.9
Hagel, M.10
White, K.11
Conley, J.12
Manna, J.D.13
Alvarez-Diez, T.M.14
Hoyt, J.15
Woodward, C.N.16
Sydor, J.R.17
Pink, M.18
MacDougall, J.19
Campbell, M.J.20
Cushing, J.21
Ferguson, J.22
Curtis, M.S.23
McGovern, K.24
Read, M.A.25
Palombella, V.J.26
Adams, J.27
Castro, A.C.28
more..
-
90
-
-
73649145223
-
Human colon cancer epithelial cells harbor active hedgehog-Gli signaling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
-
Varnat F, Duquet A, Malerba M, Zbinden M, Mas C, Gervaz P, I Altaba AR (2009) Human colon cancer epithelial cells harbor active hedgehog-Gli signaling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Mol Med 1:1-14
-
(2009)
EMBO Mol Med
, vol.1
, pp. 1-14
-
-
Varnat, F.1
Duquet, A.2
Malerba, M.3
Zbinden, M.4
Mas, C.5
Gervaz, P.6
Altaba, A.R.I.7
-
91
-
-
33646360806
-
Hedgehog signaling in small-cell lung cancer: Frequent in vivo but a rare event in vitro
-
Vestergaard J, Pedersen MW, Pedersen N, Ensinger C, Tümer Z, Tommerup N, Poulsen HS, Larsen LA (2006) Hedgehog signaling in small-cell lung cancer: frequent in vivo but a rare event in vitro. Lung Cancer 52:281-290
-
(2006)
Lung Cancer
, vol.52
, pp. 281-290
-
-
Vestergaard, J.1
Pedersen, M.W.2
Pedersen, N.3
Ensinger, C.4
Tümer, Z.5
Tommerup, N.6
Poulsen, H.S.7
Larsen, L.A.8
-
92
-
-
84929283531
-
Activity of the Shh pathway inhibitor, IPI-926, in a mouse model of medulloblastoma
-
Denver, CO, 18-22 Apr 2009
-
Villavicencio E, Khanna P, Ditzler S, Pullar B, Hansen S, Read M. A, Faia K, Hatton B, Knoblaugh S, Randolph-Habecker J, LeBlanc M, Shaw D, Friedman S, McGovern K, Olson J (2009) Activity of the Shh pathway inhibitor, IPI-926, in a mouse model of medulloblastoma. In: Proceedings of the 100th meeting of the American Association of Cancer Research, Denver, CO, 18-22 Apr 2009, Abstract #3199
-
(2009)
Proceedings of the 100th Meeting of the American Association of Cancer Research
-
-
Villavicencio, E.1
Khanna, P.2
Ditzler, S.3
Pullar, B.4
Hansen, S.5
Read, M.A.6
Faia, K.7
Hatton, B.8
Knoblaugh, S.9
Randolph-Habecker, J.10
Leblanc, M.11
Shaw, D.12
Friedman, S.13
McGovern, K.14
Olson, J.15
-
93
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
Von Hoff DD, LoRusso PM, Rudin CM, Reddy JC, Yauch RL, Tibes R, Weiss GJ, Borad MJ, Hann CL, Brahmer JR, Mackey HM, Lum BL, Darbonne WC, Marsters JC Jr, de Sauvage FJ, Low JA (2009) Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 361:1164-1172
-
(2009)
N Engl J Med
, vol.361
, pp. 1164-1172
-
-
Von Hoff, D.D.1
Lorusso, P.M.2
Rudin, C.M.3
Reddy, J.C.4
Yauch, R.L.5
Tibes, R.6
Weiss, G.J.7
Borad, M.J.8
Hann, C.L.9
Brahmer, J.R.10
MacKey, H.M.11
Lum, B.L.12
Darbonne, W.C.13
Marsters, J.C.14
De Sauvage, F.J.15
Low, J.A.16
-
94
-
-
0242669237
-
Hedgehog signaling within airway epithelial progenitors and in small-cell lung cancer
-
Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB (2003) Hedgehog signaling within airway epithelial progenitors and in small-cell lung cancer. Nature 422:313-317
-
(2003)
Nature
, vol.422
, pp. 313-317
-
-
Watkins, D.N.1
Berman, D.M.2
Burkholder, S.G.3
Wang, B.4
Beachy, P.A.5
Baylin, S.B.6
-
95
-
-
67651148155
-
Cyclopamineinduced synophthalmia in sheep: Defi ning a critical window and toxicokinetic evaluation
-
Welch KD, Panter KE, Lee ST, Gardner DR, Stegelmeier BL, Cook D (2009) Cyclopamineinduced synophthalmia in sheep: defi ning a critical window and toxicokinetic evaluation. J Appl Toxicol 29:414-421
-
(2009)
J Appl Toxicol
, vol.29
, pp. 414-421
-
-
Welch, K.D.1
Panter, K.E.2
Lee, S.T.3
Gardner, D.R.4
Stegelmeier, B.L.5
Cook, D.6
-
96
-
-
0037447269
-
Identifi cation of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions
-
Williams JA, Guicherit OM, Zaharian BI, Xu Y, Chai L, Wichterle H, Kon C, Gatchalian C, Porter JA, Rubin LL, Wang FY (2003) Identifi cation of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci USA 100:4616-4621
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4616-4621
-
-
Williams, J.A.1
Guicherit, O.M.2
Zaharian, B.I.3
Xu, Y.4
Chai, L.5
Wichterle, H.6
Kon, C.7
Gatchalian, C.8
Porter, J.A.9
Rubin, L.L.10
Wang, F.Y.11
-
97
-
-
69949136621
-
Primary cilia can both mediate and suppress hedgehog pathway-dependent tumorigenesis
-
Wong SY, Seol AD, So P-L, Ermilov AN, Bichakjian CK, Epstein EH, Dlugosz AA, Reiter JR (2009) Primary cilia can both mediate and suppress hedgehog pathway-dependent tumorigenesis. Nat Med 15:1055-1061
-
(2009)
Nat Med
, vol.15
, pp. 1055-1061
-
-
Wong, S.Y.1
Seol, A.D.2
So, P.-L.3
Ermilov, A.N.4
Bichakjian, C.K.5
Epstein, E.H.6
Dlugosz, A.A.7
Reiter, J.R.8
-
98
-
-
15644373337
-
Mutations of the patched gene in several types of sporadic extracutaneous tumors
-
Xie J, Johnson RL, Zhang X, Bare JW, Waldman FM, Cogen PH, Menon AG, Warren RS, Chen L-C, Scott MP, Epstein EH Jr (1997) Mutations of the patched gene in several types of sporadic extracutaneous tumors. Cancer Res 57:2369-2372
-
(1997)
Cancer Res
, vol.57
, pp. 2369-2372
-
-
Xie, J.1
Johnson, R.L.2
Zhang, X.3
Bare, J.W.4
Waldman, F.M.5
Cogen, P.H.6
Menon, A.G.7
Warren, R.S.8
Chen, L.-C.9
Scott, M.P.10
Epstein, E.H.11
-
99
-
-
52149119128
-
A paracrine requirement for hedgehog signaling in cancer
-
Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D et al (2008) A paracrine requirement for hedgehog signaling in cancer. Nature 455:406-410
-
(2008)
Nature
, vol.455
, pp. 406-410
-
-
Yauch, R.L.1
Gould, S.E.2
Scales, S.J.3
Tang, T.4
Tian, H.5
Ahn, C.P.6
Marshall, D.7
Fu, L.8
Januario, T.9
Kallop, D.10
-
100
-
-
70350496540
-
Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma science
-
Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, Holcomb T, Pujara K, Stinson J, Callahan CA, Tang T, Bazan JF, Kan Z, Seshagiri S, Hann CL, Gould SE, Low JA, Rudin CM, de Sauvage FJ (2009) Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma science. Science 326(5952):572-574
-
(2009)
Science
, vol.326
, Issue.5952
, pp. 572-574
-
-
Yauch, R.L.1
Dijkgraaf, G.J.2
Alicke, B.3
Januario, T.4
Ahn, C.P.5
Holcomb, T.6
Pujara, K.7
Stinson, J.8
Callahan, C.A.9
Tang, T.10
Bazan, J.F.11
Kan, Z.12
Seshagiri, S.13
Hann, C.L.14
Gould, S.E.15
Low, J.A.16
Rudin, C.M.17
De Sauvage, F.J.18
-
101
-
-
0037085379
-
Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation
-
Yoon JW, Kita Y, Frank DJ, Majewski RR, Konicek BA, Nobrega M. A, Jacob H, Walterhouse D, Iannaccone P (2002) Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem 277:5548-5555
-
(2002)
J Biol Chem
, vol.277
, pp. 5548-5555
-
-
Yoon, J.W.1
Kita, Y.2
Frank, D.J.3
Majewski, R.R.4
Konicek, B.A.5
Nobrega, M.A.6
Jacob, H.7
Walterhouse, D.8
Iannaccone, P.9
-
102
-
-
65549083026
-
Sonic hedgehogresponsive genes in the fetal prostate
-
Yu M, Gipp J, Yoon JW, Iannaccone P, Walterhouse D, Bushman W (2009a) Sonic hedgehogresponsive genes in the fetal prostate. J Biol Chem 287:5620-5629
-
(2009)
J Biol Chem
, vol.287
, pp. 5620-5629
-
-
Yu, M.1
Gipp, J.2
Yoon, J.W.3
Iannaccone, P.4
Walterhouse, D.5
Bushman, W.6
-
103
-
-
68149163281
-
A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression
-
Yu M, Smolen GA, Zhang J, Wittner B, Schott BJ, Brachtel E, Ramaswamy S, Maheswaran S, Haber DA (2009b) A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression. Genes Dev 23:1737-1742
-
(2009)
Genes Dev
, vol.23
, pp. 1737-1742
-
-
Yu, M.1
Smolen, G.A.2
Zhang, J.3
Wittner, B.4
Schott, B.J.5
Brachtel, E.6
Ramaswamy, S.7
Maheswaran, S.8
Haber, D.A.9
-
104
-
-
33847022189
-
Frequent requirement of hedgehog signaling in non-small cell lung carcinoma
-
Yuan Z, Goetz JA, Singh S, Ogden SK, Petty WJ, Black CC, Memoli VA, Dmitrovsky E, Robbins DJ (2007) Frequent requirement of hedgehog signaling in non-small cell lung carcinoma. Oncogene 26:1046-1055
-
(2007)
Oncogene
, vol.26
, pp. 1046-1055
-
-
Yuan, Z.1
Goetz, J.A.2
Singh, S.3
Ogden, S.K.4
Petty, W.J.5
Black, C.C.6
Memoli, V.A.7
Dmitrovsky, E.8
Robbins, D.J.9
-
105
-
-
64749091867
-
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
-
Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA, Reya T (2009) Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 458:776-779
-
(2009)
Nature
, vol.458
, pp. 776-779
-
-
Zhao, C.1
Chen, A.2
Jamieson, C.H.3
Fereshteh, M.4
Abrahamsson, A.5
Blum, J.6
Kwon, H.Y.7
Kim, J.8
Chute, J.P.9
Rizzieri, D.10
Munchhof, M.11
Vanarsdale, T.12
Beachy, P.A.13
Reya, T.14
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