Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival

Oncogene

Volumn 28, Issue 39, 2009, Pages 3468-3476

  Sarangi, A ^a   Valadez, J G ^a   Rush, S ^a   Abel, T W ^a   Thompson, R C ^a,b   Cooper, M K ^a,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c MRBIII   (United States)

Author keywords

Brain tumor; Cyclopamine; Glioma; Hedgehog; Xenotransplantation

Indexed keywords

CD133 ANTIGEN; CYCLOPAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GRADING; CANCER INHIBITION; CANCER SURVIVAL; CONTROLLED STUDY; DRUG INHIBITION; GENE EXPRESSION; GLIOBLASTOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR REGRESSION; XENOGRAFT;

ANIMALS; ANTIGENS, CD; BRAIN NEOPLASMS; GLIOMA; GLYCOPROTEINS; HEDGEHOG PROTEINS; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASM TRANSPLANTATION; PEPTIDES; RECEPTORS, CELL SURFACE; SURVIVAL; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROLOGOUS; VERATRUM ALKALOIDS;

ERINACEIDAE; MUS;

EID: 70349653550     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.208     Document Type: Article

References (36)

1. Ahn S, Joyner AL. (2005). in vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 437: 894-897.
2. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB et al. (2006). Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444: 756-760.
3. Bar EE, Chaudhry A, Lin A, Fan X, Schreck K, Matsui W et al. (2007). Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 25: 2524-2533.
4. Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M et al. (2009). Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457: 608-611.
5. Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN et al. (2002). Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297: 1559-1561.
6. Chen JK, Taipale J, Cooper MK, Beachy PA. (2002a). Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 16: 2743-2748.
7. Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. (2002b). Small molecule modulation of Smoothened activity. Proc Natl Acad Sci USA 99: 14071-14076.
8. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL et al. (2006). Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 66: 9339-9344.
9. Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A. (2007). HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 17: 165-172.
10. Ehtesham M, Sarangi A, Valadez JG, Chanthaphaychith S, Becher MW, Abel TW et al. (2007). Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells. Oncogene 26: 5752-5761.
11. Fomchenko EI, Holland EC. (2006). Mouse models of brain tumors and their applications in preclinical trials. Clin Cancer Res 12: 5288-5297.
12. Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H et al. (2002). Small-molecule modulators of Hedgehog signaling: identi.cation and characterization of Smoothened agonists and antagonists. J Biol 1: 10.
13. Gutmann DH, Maher EA, Van Dyke T. (2006). Mouse Models of Human Cancers Consortium Workshop on Nervous System Tumors. Cancer Res 66: 10-13.
14. Karhadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A et al. (2004). Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431: 707-712.
15. Kelly PN, Dakic A, Adams JM, Nutt SL, Strasser A. (2007). Tumor growth need not be driven by rare cancer stem cells. Science 317: 337.
16. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC et al. (2002). The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61: 215-225; discussion 226-229.
17. Kleihues P, Soylemezoglu F, Schauble B, Scheithauer BW, Burger PC. (1995). Histopathology, classification, and grading of gliomas. Glia 15: 211-221.
18. Lee J, Kotliarova S, Kotliarov Y, Li A, Su Q, Donin NM et al. (2006). Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9: 391-403.
19. Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA et al. (2007). Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron 53: 503-517.
20. Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR et al. (2006). Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 5: 67.
21. Ogden AT, Waziri AE, Lochhead RA, Fusco D, Lopez K, Ellis JA et al. (2008). Identi.cation of A2B5+CD133- tumor-initiating cells in adult human gliomas. Neurosurgery 62: 505-514; discussion 514-515.
22. Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G et al. (2006). Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444: 761-765.
23. Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM, Morrison SJ. (2008). Efficient tumour formation by single human melanoma cells. Nature 456: 593-598.
24. Rohatgi R, Scott MP. (2007). Patching the gaps in Hedgehog signalling. Nat Cell Biol 9: 1005-1009.
25. Rubin LL, de Sauvage FJ. (2006). Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 5: 1026-1033.
26. Sanchez P, Ruiz i Altaba A. (2005). In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice. Mech Dev 122: 223-230.
27. Shu Q, Wong KK, Su JM, Adesina AM, Yu LT, Tsang YT et al. (2008). Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma. Stem Cells 26: 1414-1424.
28. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T et al. (2004). Identi.cation of human brain tumour initiating cells. Nature 432: 396-401.
29. Suggitt M, Bibby MC. (2005). 50 years of preclinical anticancer drug screening: empirical to target-driven approaches. Clin Cancer Res 11: 971-981.
30. Trowbridge JJ, Scott MP, Bhatia M. (2006). Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci USA 103: 14134-14139.
31. Uchida N, Buck DW, He D, Reitsma MJ, Masek M, Phan TV et al. (2000). Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci USA 97: 14720-14725.
32. Weinstein IB, Joe A. (2008). Oncogene addiction. Cancer Res 68: 3077-3080; discussion 3080.
33. Xu Q, Yuan X, Liu G, Black KL, Yu JS. (2008). Hedgehog signaling regulates brain tumor-initiating cell proliferation and portends shorter survival for patients with PTEN-coexpressing glioblastomas. Stem Cells 26: 3018-3026.
34. Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP et al. (2008). A paracrine requirement for hedgehog signalling in cancer. Nature 455: 406-410.
35. Zhang XM, Ramalho-Santos M, McMahon AP. (2001). Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell 105: 781-792.
36. Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT et al. (2009). Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 457: 603-607.