Shh controls epithelial proliferation via independent pathways that converge on N-Myc

Developmental Cell

Volumn 9, Issue 2, 2005, Pages 293-303

  Mill, Pleasantine ^a,c,e   Mo, Rong ^a,c   Hu, Ming Chang ^c   Dagnino, Lina ^d   Rosenblum, Norman D ^a,b,c   Hui, Chi Chung ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF WESTERN ONTARIO   (Canada)

^e WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D2; GLYCOGEN SYNTHASE KINASE 3BETA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL PROLIFERATION; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME REGULATION; HAIR GROWTH; MITOGENESIS; MOUSE; NONHUMAN; ONCOGENE C MYB; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SKIN EPITHELIUM; TRANSCRIPTION REGULATION;

ANIMALS; BETA CATENIN; CELL PROLIFERATION; CYCLINS; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; EPIDERMIS; EPITHELIAL CELLS; G1 PHASE; GLYCOGEN SYNTHASE KINASE 3; HAIR FOLLICLE; HEDGEHOG PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 22944485644     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2005.05.009     Document Type: Article

References (58)

1. T. Andl S.T. Reddy T. Gaddapara and S.E. Millar WNT signals are required for the initiation of hair follicle development Dev. Cell 2 2002 643-653
2. K. Aoto T. Nishimura K. Eto and J. Motoyama Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud Dev. Biol. 251 2002 320-332
3. I. Arnold and F.M. Watt c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny Curr. Biol. 11 2001 558-568
4. P. Aza-Blanc F.A. Ramirez-Weber M.P. Laget C. Schwartz and T.B. Kornberg Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor Cell 89 1997 1043-1053
5. C.B. Bai and A.L. Joyner Gli1 can rescue the in vivo function of Gli2 Development 128 2001 5161-5172
6. C.B. Bai W. Auerbach J.S. Lee D. Stephen and A.L. Joyner Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway Development 129 2002 4753-4761
7. L. Buttitta R. Mo C.C. Hui and C.M. Fan Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction Development 130 2003 6233-6243
8. C. Chiang Y. Litingtung E. Lee K.E. Young J.L. Corden H. Westphal and P.A. Beachy Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function Nature 383 1996 407-413
9. C. Chiang R.Z. Swan M. Grachtchouk M. Bolinger Y. Litingtung E.K. Robertson M.K. Cooper W. Gaffield H. Westphal P.A. Beachy et al. Essential role for Sonic hedgehog during hair follicle morphogenesis Dev. Biol. 205 1999 1-9
10. Q. Ding J. Motoyama S. Gasca R. Mo H. Sasaki J. Rossant and C.C. Hui Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice Development 125 1998 2533-2543
11. B.W. Doble and J.R. Woodgett GSK-3: Tricks of the trade for a multi-tasking kinase J. Cell Sci. 116 2003 1175-1186
12. R.N. Eisenman Deconstructing myc Genes Dev. 15 2001 2023-2030
13. H. Fan A.E. Oro M.P. Scott and P.A. Khavari Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog Nat. Med. 3 1997 788-792
14. M. Frye C. Gardner E.R. Li I. Arnold and F.M. Watt Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development 130 2003 2793-2808
15. E. Fuchs B.J. Merrill C. Jamora and R. DasGupta At the roots of a never-ending cycle Dev. Cell 1 2001 13-25
16. A. Gandarillas and F.M. Watt c-Myc promotes differentiation of human epidermal stem cells Genes Dev. 11 1997 2869-2882
17. U. Gat R. DasGupta L. Degenstein and E. Fuchs De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin Cell 95 1998 605-614
18. M.A. Gregory Y. Qi and S.R. Hann Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization J. Biol. Chem. 278 2003 51606-51612
19. J. Huelsken R. Vogel B. Erdmann G. Cotsarelis and W. Birchmeier beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin Cell 105 2001 533-545
20. C. Jamora R. DasGupta P. Kocieniewski and E. Fuchs Links between signal transduction, transcription and adhesion in epithelial bud development Nature 422 2003 317-322
21. J. Jia K. Amanai G. Wang J. Tang B. Wang and J. Jiang Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus Nature 416 2002 548-552
22. A.M. Kenney M.D. Cole and D.H. Rowitch Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors Development 130 2003 15-28
23. A.M. Kenney H.R. Widlund and D.H. Rowitch Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors Development 131 2004 217-228
24. P.S. Knoepfler P.F. Cheng and R.N. Eisenman N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation Genes Dev. 16 2002 2699-2712
25. Y. Litingtung and C. Chiang Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3 Nat. Neurosci. 3 2000 979-985
26. Y. Litingtung R.D. Dahn Y. Li J.F. Fallon and C. Chiang Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity Nature 418 2002 979-983
27. I.D. Louro E.C. Bailey X. Li L.S. South P.R. McKie-Bell B.K. Yoder C.C. Huang M.R. Johnson A.E. Hill R.L. Johnson and J.M. Ruppert Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation Cancer Res. 62 2002 5867-5873
28. L. Lum and P.A. Beachy The Hedgehog response network: Sensors, switches, and routers Science 304 2004 1755-1759
29. K.M. McGowan and P.A. Coulombe Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development J. Cell Biol. 143 1998 469-486
30. A.P. McMahon P.W. Ingham and C.J. Tabin Developmental roles and clinical significance of hedgehog signaling Curr. Top. Dev. Biol. 53 2003 1-114
31. B.A. Malynn I.M. de Alboran R.C. O'Hagan R. Bronson L. Davidson R.A. DePinho and F.W. Alt N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation Genes Dev. 14 2000 1390-1399
32. N. Méthot and K. Basler Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus Cell 96 1999 819-831
33. N. Méthot and K. Basler An absolute requirement for Cubitus interruptus in Hedgehog signaling Development 128 2001 733-742
34. P. Mill R. Mo H. Fu M. Grachtchouk P.C. Kim A.A. Dlugosz and C.C. Hui Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development Genes Dev. 17 2003 282-294
35. R. Mo A.M. Freer D.L. Zinyk M.A. Crackower J. Michaud H.H. Heng K.W. Chik X.M. Shi L.C. Tsui S.H. Cheng et al. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development Development 124 1997 113-123
36. J. Motoyama J. Liu R. Mo Q. Ding M. Post and C.C. Hui Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus Nat. Genet. 20 1998 54-57
37. T.G. Oliver L.L. Grasfeder A.L. Carroll C. Kaiser C.L. Gillingham S.M. Lin R. Wickramasinghe M.P. Scott and R.J. Wechsler-Reya Transcriptional profiling of the Sonic hedgehog response: A critical role for N-myc in proliferation of neuronal precursors Proc. Natl. Acad. Sci. USA 100 2003 7331-7336
38. T. Okubo P.S. Knoepfler R.N. Eisenman and B. Hogan Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation Development 132 2005 1363-1374
39. A.E. Oro K.M. Higgins Z. Hu J.M. Bonifas E.H. Epstein Jr. and M.P. Scott Basal cell carcinomas in mice overexpressing sonic hedgehog Science 276 1997 817-821
40. H.L. Park C. Bai K.A. Platt M.P. Matise A. Beeghly C.C. Hui M. Nakashima andA.L. Joyner Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation Development 127 2000 1593-1605
41. S. Pelengaris T. Littlewood M. Khan and G. Elia G. Evan Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion Mol. Cell 3 1999 565-577
42. M. Persson D. Stamataki P. te Welscher E. Andersson J. Bose U. Ruther J. Ericson and J. Briscoe Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity Genes Dev. 16 2002 2865-2878
43. M.A. Price and D. Kalderon Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1 Cell 108 2002 823-835
44. M. Rallu R. Machold N. Gaiano J.G. Corbin A.P. McMahon and G. Fishell Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling Development 129 2002 4963-4974
45. S. Reddy T. Andl A. Bagasra M.M. Lu D.J. Epstein E.E. Morrisey and S.E. Millar Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis Mech. Dev. 107 2001 69-82
46. D.J. Robbins K.E. Nybakken R. Kobayashi J.C. Sisson J.M. Bishop and P.P. Therond Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2 Cell 90 1997 225-234
47. S.E. Salghetti S.Y. Kim and W.P. Tansey Destruction of Myc by ubiquitin-mediated proteolysis: Cancer-associated and transforming mutations stabilize Myc EMBO J. 18 1999 717-726
48. N. Sato P.L. Leopold and R.G. Crystal Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog J. Clin. Invest. 104 1999 855-864
49. B. St-Jacques H.R. Dassule I. Karavanova V.A. Botchkarev J. Li P.S. Danielian J.A. McMahon P.M. Lewis R. Paus and A.P. McMahon Sonic hedgehog signaling is essential for hair development Curr. Biol. 8 1998 1058-1068
50. P. te Welscher A. Zuniga S. Kuijper T. Drenth H.J. Goedemans F. Meijlink and R. Zeller Progression of vertebrate limb development through SHH-mediated counteraction of Gli3 Science 298 2002 827-830
51. R.L. Waikel Y. Kawachi P.A. Waikel X.J. Wang and D.R. Roop Deregulated expression of c-Myc depletes epidermal stem cells Nat. Genet. 28 2001 165-168
52. B. Wang J.F. Fallon and P.A. Beachy Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb Cell 100 2000 423-434
53. L.C. Wang Z.Y. Liu L. Gambardella A. Delacour R. Shapiro J. Yang I. Sizing P. Rayhorn E.A. Garber C.D. Benjamin et al. Conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration J. Invest. Dermatol. 114 2000 901-908
54. M. Wijgerde J.A. McMahon M. Rule and A.P. McMahon A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord Genes Dev. 16 2002 2849-2864
55. J. Xie M. Aszterbaum X. Zhang J.M. Bonifas C. Zachary E. Epstein and F. McCormick A role of PDGFRalpha in basal cell carcinoma proliferation Proc. Natl. Acad. Sci. USA 98 2001 9255-9259
56. J.W. Yoon Y. Kita D.J. Frank R.R. Majewski B.A. Konicek M.A. Nobrega H. Jacob D. Walterhouse and P. Iannaccone Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation J. Biol. Chem. 277 2002 5548-5555
57. J. Zanet S. Pibre C. Jacquet A. Ramirez I.M. de Alboran and A. Gandarillas Endogenous Myc controls mammalian epidermal cell size, hyperproliferation, endoreplication and stem cell amplification J. Cell Sci. 118 2005 1693-1704
58. W. Zhang Y. Zhao C. Tong G. Wang B. Wang J. Jia and J. Jiang Hedgehog-regulated Costal2-Kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus Dev. Cell 8 2005 267-278