메뉴 건너뛰기




Volumn 97, Issue 5, 2015, Pages 849-857

Role of the intestinal cytokine microenvironment in shaping the intraepithelial lymphocyte repertoire

Author keywords

IL 15; IL 2; IL 7; Stem cell factor; Transforming growth factor b

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 7; STEM CELL FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 84929192703     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.3RU1014-465R     Document Type: Review
Times cited : (17)

References (124)
  • 1
    • 78649906561 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes: To serve and protect
    • Sheridan, B. S., Lefrançois, L. (2010) Intraepithelial lymphocytes: to serve and protect. Curr. Gastroenterol. Rep. 12, 513–521.
    • (2010) Curr. Gastroenterol. Rep , vol.12 , pp. 513-521
    • Sheridan, B.S.1    Lefrançois, L.2
  • 2
    • 34247160955 scopus 로고    scopus 로고
    • Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation
    • Makita, S., Kanai, T., Nemoto, Y., Totsuka, T., Okamoto, R., Tsuchiya, K., Yamamoto, M., Kiyono, H., Watanabe, M. (2007) Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J. Immunol. 178, 4937–4946.
    • (2007) J. Immunol , vol.178 , pp. 4937-4946
    • Makita, S.1    Kanai, T.2    Nemoto, Y.3    Totsuka, T.4    Okamoto, R.5    Tsuchiya, K.6    Yamamoto, M.7    Kiyono, H.8    Watanabe, M.9
  • 5
    • 84866092059 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes in celiac disease immunopathology
    • Abadie, V., Discepolo, V., Jabri, B. (2012) Intraepithelial lymphocytes in celiac disease immunopathology. Semin. Immunopathol. 34, 551–566.
    • (2012) Semin. Immunopathol , vol.34 , pp. 551-566
    • Abadie, V.1    Discepolo, V.2    Jabri, B.3
  • 7
    • 0025936929 scopus 로고
    • Phenotypic complexity of intraepithelial lymphocytes of the small intestine
    • Lefrancois, L. (1991) Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J. Immunol. 147, 1746–1751.
    • (1991) J. Immunol , vol.147 , pp. 1746-1751
    • Lefrancois, L.1
  • 9
    • 0023875745 scopus 로고
    • Expression of the gamma-delta Tcell receptor on intestinal CD8+ intraepithelial lymphocytes
    • Goodman, T., Lefrançois, L. (1988) Expression of the gamma-delta Tcell receptor on intestinal CD8+ intraepithelial lymphocytes. Nature 333, 855–858.
    • (1988) Nature , vol.333 , pp. 855-858
    • Goodman, T.1    Lefrançois, L.2
  • 10
    • 0035162229 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes: Exploring the third way in immunology
    • Hayday, A., Theodoridis, E., Ramsburg, E., Shires, J. (2001) Intraepithelial lymphocytes: exploring the third way in immunology. Nat. Immunol. 2, 997–1003.
    • (2001) Nat. Immunol , vol.2 , pp. 997-1003
    • Hayday, A.1    Theodoridis, E.2    Ramsburg, E.3    Shires, J.4
  • 11
    • 33846783082 scopus 로고    scopus 로고
    • Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs
    • Lambolez, F., Kronenberg, M., Cheroutre, H. (2007) Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs. Immunol. Rev. 215, 178–188.
    • (2007) Immunol. Rev , vol.215 , pp. 178-188
    • Lambolez, F.1    Kronenberg, M.2    Cheroutre, H.3
  • 12
    • 1842731811 scopus 로고    scopus 로고
    • Acquired and natural memory T cells join forces at the mucosal front line
    • Cheroutre, H., Madakamutil, L. (2004) Acquired and natural memory T cells join forces at the mucosal front line. Nat. Rev. Immunol. 4, 290–300.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 290-300
    • Cheroutre, H.1    Madakamutil, L.2
  • 13
    • 0034741125 scopus 로고    scopus 로고
    • Biological insights into TCRgammadelta+ and TCRalphabeta+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE)
    • Shires, J., Theodoridis, E., Hayday, A. C. (2001) Biological insights into TCRgammadelta+ and TCRalphabeta+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity 15, 419–434.
    • (2001) Immunity , vol.15 , pp. 419-434
    • Shires, J.1    Theodoridis, E.2    Hayday, A.C.3
  • 14
    • 0028170171 scopus 로고
    • Oligoclonal repertoire of the CD8 alpha alpha and the CD8 alpha beta TCR-alpha/beta murine intestinal intraepithelial T lymphocytes: Evidence for the random emergence of T cells
    • Regnault, A., Cumano, A., Vassalli, P., Guy-Grand, D., Kourilsky, P. (1994) Oligoclonal repertoire of the CD8 alpha alpha and the CD8 alpha beta TCR-alpha/beta murine intestinal intraepithelial T lymphocytes: evidence for the random emergence of T cells. J. Exp. Med. 180, 1345–1358.
    • (1994) J. Exp. Med , vol.180 , pp. 1345-1358
    • Regnault, A.1    Cumano, A.2    Vassalli, P.3    Guy-Grand, D.4    Kourilsky, P.5
  • 15
    • 33846798312 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes: Their shared and divergent immunological behaviors in the small and large intestine
    • Kunisawa, J., Takahashi, I., Kiyono, H. (2007) Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine. Immunol. Rev. 215, 136–153.
    • (2007) Immunol. Rev , vol.215 , pp. 136-153
    • Kunisawa, J.1    Takahashi, I.2    Kiyono, H.3
  • 16
    • 33846781580 scopus 로고    scopus 로고
    • The extrathymic T-cell differentiation in the murine gut
    • Rocha, B. (2007) The extrathymic T-cell differentiation in the murine gut. Immunol. Rev. 215, 166–177.
    • (2007) Immunol. Rev , vol.215 , pp. 166-177
    • Rocha, B.1
  • 18
    • 0025019254 scopus 로고
    • Homing of a gamma delta thymocyte subset with homogeneous T-cell receptors to mucosal epithelia
    • Itohara, S., Farr, A. G., Lafaille, J. J., Bonneville, M., Takagaki, Y., Haas, W., Tonegawa, S. (1990) Homing of a gamma delta thymocyte subset with homogeneous T-cell receptors to mucosal epithelia. Nature 343, 754–757.
    • (1990) Nature , vol.343 , pp. 754-757
    • Itohara, S.1    Farr, A.G.2    Lafaille, J.J.3    Bonneville, M.4    Takagaki, Y.5    Haas, W.6    Tonegawa, S.7
  • 19
    • 77954657540 scopus 로고    scopus 로고
    • K. (2010) gammadelta T cell subsets: A link between TCR and function?
    • O’Brien, R. L., Born, W. K. (2010) gammadelta T cell subsets: a link between TCR and function? Semin. Immunol. 22, 193–198.
    • Semin. Immunol , vol.22 , pp. 193-198
    • O’Brien, R.L.1    Born, W.2
  • 20
    • 2542477129 scopus 로고    scopus 로고
    • Starting at the beginning: New perspectives on the biology of mucosal T cells
    • Cheroutre, H. (2004) Starting at the beginning: new perspectives on the biology of mucosal T cells. Annu. Rev. Immunol. 22, 217–246.
    • (2004) Annu. Rev. Immunol , vol.22 , pp. 217-246
    • Cheroutre, H.1
  • 21
    • 0032513388 scopus 로고    scopus 로고
    • Recognition of stressinduced MHC molecules by intestinal epithelial gammadelta T cells
    • Groh, V., Steinle, A., Bauer, S., Spies, T. (1998) Recognition of stressinduced MHC molecules by intestinal epithelial gammadelta T cells. Science 279, 1737–1740.
    • (1998) Science , vol.279 , pp. 1737-1740
    • Groh, V.1    Steinle, A.2    Bauer, S.3    Spies, T.4
  • 22
    • 0033621917 scopus 로고    scopus 로고
    • The importance of gamma delta T cells in the resolution of pathogen-induced inflammatory immune responses
    • Carding, S. R., Egan, P. J. (2000) The importance of gamma delta T cells in the resolution of pathogen-induced inflammatory immune responses. Immunol. Rev. 173, 98–108.
    • (2000) Immunol. Rev , vol.173 , pp. 98-108
    • Carding, S.R.1    Egan, P.J.2
  • 23
    • 84885626972 scopus 로고    scopus 로고
    • Effects of intraepithelial lymphocyte-derived cytokines on intestinal mucosal barrier function
    • Qiu, Y., Yang, H. (2013) Effects of intraepithelial lymphocyte-derived cytokines on intestinal mucosal barrier function. J. Interferon Cytokine Res. 33, 551–562.
    • (2013) J. Interferon Cytokine Res , vol.33 , pp. 551-562
    • Qiu, Y.1    Yang, H.2
  • 25
    • 44849096173 scopus 로고    scopus 로고
    • IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursors and mature CD8 alpha alpha+ IELs in the intestine
    • Lai, Y. G., Hou, M. S., Hsu, Y. W., Chang, C. L., Liou, Y. H., Tsai, M. H., Lee, F., Liao, N. S. (2008) IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursors and mature CD8 alpha alpha+ IELs in the intestine. J. Immunol. 180, 3757–3765.
    • (2008) J. Immunol , vol.180 , pp. 3757-3765
    • Lai, Y.G.1    Hou, M.S.2    Hsu, Y.W.3    Chang, C.L.4    Liou, Y.H.5    Tsai, M.H.6    Lee, F.7    Liao, N.S.8
  • 26
    • 0027982384 scopus 로고
    • Progenies of fetal thymocytes are the major source of CD42CD8+ alpha alpha intestinal intraepithelial lymphocytes early in ontogeny
    • Lin, T., Matsuzaki, G., Kenai, H., Nomoto, K. (1994) Progenies of fetal thymocytes are the major source of CD42CD8+ alpha alpha intestinal intraepithelial lymphocytes early in ontogeny. Eur. J. Immunol. 24, 1785–1791.
    • (1994) Eur. J. Immunol , vol.24 , pp. 1785-1791
    • Lin, T.1    Matsuzaki, G.2    Kenai, H.3    Nomoto, K.4
  • 27
    • 0027219936 scopus 로고
    • Thymus influences the development of extrathymically derived intestinal intraepithelial lymphocytes
    • Lin, T., Matsuzaki, G., Kenai, H., Nakamura, T., Nomoto, K. (1993) Thymus influences the development of extrathymically derived intestinal intraepithelial lymphocytes. Eur. J. Immunol. 23, 1968–1974.
    • (1993) Eur. J. Immunol , vol.23 , pp. 1968-1974
    • Lin, T.1    Matsuzaki, G.2    Kenai, H.3    Nakamura, T.4    Nomoto, K.5
  • 28
    • 9144259224 scopus 로고    scopus 로고
    • The fourth way? Harnessing aggressive tendencies in the thymus
    • Baldwin, T. A., Hogquist, K. A., Jameson, S. C. (2004) The fourth way? Harnessing aggressive tendencies in the thymus. J. Immunol. 173, 6515–6520.
    • (2004) J. Immunol , vol.173 , pp. 6515-6520
    • Baldwin, T.A.1    Hogquist, K.A.2    Jameson, S.C.3
  • 29
    • 2942640089 scopus 로고    scopus 로고
    • Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells
    • Yamagata, T., Mathis, D., Benoist, C. (2004) Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells. Nat. Immunol. 5, 597–605.
    • (2004) Nat. Immunol , vol.5 , pp. 597-605
    • Yamagata, T.1    Mathis, D.2    Benoist, C.3
  • 30
    • 17144374753 scopus 로고    scopus 로고
    • Toward an understanding of NKT cell biology: Progress and paradoxes
    • Kronenberg, M. (2005) Toward an understanding of NKT cell biology: progress and paradoxes. Annu. Rev. Immunol. 23, 877–900.
    • (2005) Annu. Rev. Immunol , vol.23 , pp. 877-900
    • Kronenberg, M.1
  • 31
    • 33749526537 scopus 로고    scopus 로고
    • Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus
    • Gangadharan, D., Lambolez, F., Attinger, A., Wang-Zhu, Y., Sullivan, B. A., Cheroutre, H. (2006) Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus. Immunity 25, 631–641.
    • (2006) Immunity , vol.25 , pp. 631-641
    • Gangadharan, D.1    Lambolez, F.2    Attinger, A.3    Wang-Zhu, Y.4    Sullivan, B.A.5    Cheroutre, H.6
  • 32
    • 0035753991 scopus 로고    scopus 로고
    • Autoreactivity by design: Innate B and T lymphocytes
    • Bendelac, A., Bonneville, M., Kearney, J. F. (2001) Autoreactivity by design: innate B and T lymphocytes. Nat. Rev. Immunol. 1, 177–186.
    • (2001) Nat. Rev. Immunol , vol.1 , pp. 177-186
    • Bendelac, A.1    Bonneville, M.2    Kearney, J.F.3
  • 33
    • 0037013968 scopus 로고    scopus 로고
    • A unique subset of self-specific intraintestinal T cells maintains gut integrity
    • Poussier, P., Ning, T., Banerjee, D., Julius, M. (2002) A unique subset of self-specific intraintestinal T cells maintains gut integrity. J. Exp. Med. 195, 1491–1497.
    • (2002) J. Exp. Med , vol.195 , pp. 1491-1497
    • Poussier, P.1    Ning, T.2    Banerjee, D.3    Julius, M.4
  • 34
    • 84896726196 scopus 로고    scopus 로고
    • The unique surface molecules on intestinal intraepithelial lymphocytes: From tethering to recognizing
    • Qiu, Y., Yang, Y., Yang, H. (2014) The unique surface molecules on intestinal intraepithelial lymphocytes: from tethering to recognizing. Dig. Dis. Sci. 59, 520–529.
    • (2014) Dig. Dis. Sci , vol.59 , pp. 520-529
    • Qiu, Y.1    Yang, Y.2    Yang, H.3
  • 36
    • 77954411290 scopus 로고    scopus 로고
    • Mucosal T cells in gut homeostasis and inflammation
    • Van Wijk, F., Cheroutre, H. (2010) Mucosal T cells in gut homeostasis and inflammation. Expert Rev. Clin. Immunol. 6, 559–566.
    • (2010) Expert Rev. Clin. Immunol , vol.6 , pp. 559-566
    • Van Wijk, F.1    Cheroutre, H.2
  • 37
    • 44649202770 scopus 로고    scopus 로고
    • The thymus chapter in the life of gut-specific intra epithelial lymphocytes
    • Cheroutre, H., Lambolez, F. (2008) The thymus chapter in the life of gut-specific intra epithelial lymphocytes. Curr. Opin. Immunol. 20, 185–191.
    • (2008) Curr. Opin. Immunol , vol.20 , pp. 185-191
    • Cheroutre, H.1    Lambolez, F.2
  • 38
    • 70349456230 scopus 로고    scopus 로고
    • The importance of being earnestly selfish
    • Cheroutre, H., Mucida, D., Lambolez, F. (2009) The importance of being earnestly selfish. Nat. Immunol. 10, 1047–1049.
    • (2009) Nat. Immunol , vol.10 , pp. 1047-1049
    • Cheroutre, H.1    Mucida, D.2    Lambolez, F.3
  • 39
    • 83655191565 scopus 로고    scopus 로고
    • Epithelial barrier: An interface for the crosscommunication between gut flora and immune system
    • Goto, Y., Kiyono, H. (2012) Epithelial barrier: an interface for the crosscommunication between gut flora and immune system. Immunol. Rev. 245, 147–163.
    • (2012) Immunol. Rev , vol.245 , pp. 147-163
    • Goto, Y.1    Kiyono, H.2
  • 43
    • 34548738275 scopus 로고    scopus 로고
    • CD8+ T cells are kept in tune by modulating IL-7 responsiveness
    • Zúñiga-Pflücker, J. C. (2007) CD8+ T cells are kept in tune by modulating IL-7 responsiveness. Nat. Immunol. 8, 1027–1028.
    • (2007) Nat. Immunol , vol.8 , pp. 1027-1028
    • Zúñiga-Pflücker, J.C.1
  • 44
    • 84879111657 scopus 로고    scopus 로고
    • IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRgd+ intraepithelial lymphocytes
    • Shitara, S., Hara, T., Liang, B., Wagatsuma, K., Zuklys, S., Holländer, G. A., Nakase, H., Chiba, T., Tani-ichi, S., Ikuta, K. (2013) IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRgd+ intraepithelial lymphocytes. J. Immunol. 190, 6173–6179.
    • (2013) J. Immunol , vol.190 , pp. 6173-6179
    • Shitara, S.1    Hara, T.2    Liang, B.3    Wagatsuma, K.4    Zuklys, S.5    Holländer, G.A.6    Nakase, H.7    Chiba, T.8    Tani-Ichi, S.9    Ikuta, K.10
  • 45
    • 84861196509 scopus 로고    scopus 로고
    • The human IL-7 receptor gene: Deletions, polymorphisms and mutations
    • Mazzucchelli, R. I., Riva, A., Durum, S. K. (2012) The human IL-7 receptor gene: deletions, polymorphisms and mutations. Semin. Immunol. 24, 225–230.
    • (2012) Semin. Immunol , vol.24 , pp. 225-230
    • Mazzucchelli, R.I.1    Riva, A.2    Durum, S.K.3
  • 46
    • 84878596429 scopus 로고    scopus 로고
    • IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia
    • Ribeiro, D., Melão, A., Barata, J. T. (2013) IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia. Adv. Biol. Regul. 53, 211–222.
    • (2013) Adv. Biol. Regul , vol.53 , pp. 211-222
    • Ribeiro, D.1    Melão, A.2    Barata, J.T.3
  • 49
    • 0035010979 scopus 로고    scopus 로고
    • IL-7 prevents both caspasedependent and -independent pathways that lead to the spontaneous apoptosis of i-IEL
    • Yada, S., Nukina, H., Kishihara, K., Takamura, N., Yoshida, H., Inagaki-Ohara, K., Nomoto, K., Lin, T. (2001) IL-7 prevents both caspasedependent and -independent pathways that lead to the spontaneous apoptosis of i-IEL. Cell. Immunol. 208, 88–95.
    • (2001) Cell. Immunol , vol.208 , pp. 88-95
    • Yada, S.1    Nukina, H.2    Kishihara, K.3    Takamura, N.4    Yoshida, H.5    Inagaki-Ohara, K.6    Nomoto, K.7    Lin, T.8
  • 50
    • 0030587133 scopus 로고    scopus 로고
    • Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice
    • Moore, T. A., von Freeden-Jeffry, U., Murray, R., Zlotnik, A. (1996) Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice. J. Immunol. 157, 2366–2373.
    • (1996) J. Immunol , vol.157 , pp. 2366-2373
    • Moore, T.A.1    Von Freeden-Jeffry, U.2    Murray, R.3    Zlotnik, A.4
  • 53
    • 24144487439 scopus 로고    scopus 로고
    • Interleukin-7 administration alters intestinal intraepithelial lymphocyte phenotype and function in vivo
    • Yang, H., Spencer, A. U., Teitelbaum, D. H. (2005) Interleukin-7 administration alters intestinal intraepithelial lymphocyte phenotype and function in vivo. Cytokine 31, 419–428.
    • (2005) Cytokine , vol.31 , pp. 419-428
    • Yang, H.1    Spencer, A.U.2    Teitelbaum, D.H.3
  • 54
    • 0030442579 scopus 로고    scopus 로고
    • The V-J recombination of T cell receptor-gamma genes is blocked in interleukin-7 receptor-deficient mice
    • Maki, K., Sunaga, S., Ikuta, K. (1996) The V-J recombination of T cell receptor-gamma genes is blocked in interleukin-7 receptor-deficient mice. J. Exp. Med. 184, 2423–2427.
    • (1996) J. Exp. Med , vol.184 , pp. 2423-2427
    • Maki, K.1    Sunaga, S.2    Ikuta, K.3
  • 55
    • 0033549813 scopus 로고    scopus 로고
    • Continued RAG expression in late stages of B cell development and no apparent reinduction after immunization
    • Yu, W., Nagaoka, H., Jankovic, M., Misulovin, Z., Suh, H., Rolink, A., Melchers, F., Meffre, E., Nussenzweig, M. C. (1999) Continued RAG expression in late stages of B cell development and no apparent reinduction after immunization. Nature 400, 682–687.
    • (1999) Nature , vol.400 , pp. 682-687
    • Yu, W.1    Nagaoka, H.2    Jankovic, M.3    Misulovin, Z.4    Suh, H.5    Rolink, A.6    Melchers, F.7    Meffre, E.8    Nussenzweig, M.C.9
  • 56
    • 0037415594 scopus 로고    scopus 로고
    • Extrathymic T cell lymphopoiesis: Ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice
    • Guy-Grand, D., Azogui, O., Celli, S., Darche, S., Nussenzweig, M. C., Kourilsky, P., Vassalli, P. (2003) Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J. Exp. Med. 197, 333–341.
    • (2003) J. Exp. Med , vol.197 , pp. 333-341
    • Guy-Grand, D.1    Azogui, O.2    Celli, S.3    Darche, S.4    Nussenzweig, M.C.5    Kourilsky, P.6    Vassalli, P.7
  • 58
    • 84874900996 scopus 로고    scopus 로고
    • Up-regulation of intestinal epithelial cell derived IL-7 expression by keratinocyte growth factor through STAT1/IRF-1, IRF-2 pathway
    • Cai, Y. J., Wang, W. S., Yang, Y., Sun, L. H., Teitelbaum, D. H., Yang, H. (2013) Up-regulation of intestinal epithelial cell derived IL-7 expression by keratinocyte growth factor through STAT1/IRF-1, IRF-2 pathway. PLoS ONE 8, e58647.
    • (2013) Plos ONE , vol.8
    • Cai, Y.J.1    Wang, W.S.2    Yang, Y.3    Sun, L.H.4    Teitelbaum, D.H.5    Yang, H.6
  • 59
    • 79959705363 scopus 로고    scopus 로고
    • Interleukin 7 from maternal milk crosses the intestinal barrier and modulates T-cell development in offspring
    • Aspinall, R., Prentice, A. M., Ngom, P. T. (2011) Interleukin 7 from maternal milk crosses the intestinal barrier and modulates T-cell development in offspring. PLoS ONE 6, e20812.
    • (2011) Plos ONE , vol.6
    • Aspinall, R.1    Prentice, A.M.2    Ngom, P.T.3
  • 60
    • 33846151651 scopus 로고    scopus 로고
    • Intestinal epithelial cell-derived interleukin-7: A mechanism for the alteration of intraepithelial lymphocytes in a mouse model of total parenteral nutrition
    • Yang, H., Sun, X., Haxhija, E. Q., Teitelbaum, D. H. (2007) Intestinal epithelial cell-derived interleukin-7: a mechanism for the alteration of intraepithelial lymphocytes in a mouse model of total parenteral nutrition. Am. J. Physiol. Gastrointest. Liver Physiol. 292, G84–G91.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol , vol.292 , pp. G84-G91
    • Yang, H.1    Sun, X.2    Haxhija, E.Q.3    Teitelbaum, D.H.4
  • 61
    • 0037377449 scopus 로고    scopus 로고
    • Intraepithelial lymphocytederived interferon-gamma evokes enterocyte apoptosis with parenteral nutrition in mice
    • Yang, H., Fan, Y., Teitelbaum, D. H. (2003) Intraepithelial lymphocytederived interferon-gamma evokes enterocyte apoptosis with parenteral nutrition in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 284, G629–G637.
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol , vol.284 , pp. G629-G637
    • Yang, H.1    Fan, Y.2    Teitelbaum, D.H.3
  • 62
    • 56149116052 scopus 로고    scopus 로고
    • Intestinal specific overexpression of interleukin-7 attenuates the alternation of intestinal intraepithelial lymphocytes after total parenteral nutrition administration
    • Yang, H., Gumucio, D. L., Teitelbaum, D. H. (2008) Intestinal specific overexpression of interleukin-7 attenuates the alternation of intestinal intraepithelial lymphocytes after total parenteral nutrition administration. Ann. Surg. 248, 849–856.
    • (2008) Ann. Surg , vol.248 , pp. 849-856
    • Yang, H.1    Gumucio, D.L.2    Teitelbaum, D.H.3
  • 63
    • 84896320488 scopus 로고    scopus 로고
    • Disturbance of intraepithelial lymphocytes in a murine model of acute intestinal ischemia/reperfusion
    • Qiu, Y., Yu, M., Yang, Y., Sheng, H., Wang, W., Sun, L., Chen, G., Liu, Y., Xiao, W., Yang, H. (2014) Disturbance of intraepithelial lymphocytes in a murine model of acute intestinal ischemia/reperfusion. J. Mol. Histol. 45, 217–227.
    • (2014) J. Mol. Histol , vol.45 , pp. 217-227
    • Qiu, Y.1    Yu, M.2    Yang, Y.3    Sheng, H.4    Wang, W.5    Sun, L.6    Chen, G.7    Liu, Y.8    Xiao, W.9    Yang, H.10
  • 64
    • 84866043300 scopus 로고    scopus 로고
    • Keratinocyte growth factor up-regulates interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo
    • Cai, Y. J., Wang, W. S., Liang, H. Y., Sun, L. H., Teitelbaum, D. H., Yang, H. (2012) Keratinocyte growth factor up-regulates interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo. Int. J. Clin. Exp. Pathol. 5, 569–580.
    • (2012) Int. J. Clin. Exp. Pathol , vol.5 , pp. 569-580
    • Cai, Y.J.1    Wang, W.S.2    Liang, H.Y.3    Sun, L.H.4    Teitelbaum, D.H.5    Yang, H.6
  • 65
    • 0029074399 scopus 로고
    • Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes
    • Watanabe, M., Ueno, Y., Yajima, T., Iwao, Y., Tsuchiya, M., Ishikawa, H., Aiso, S., Hibi, T., Ishii, H. (1995) Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J. Clin. Invest. 95, 2945–2953.
    • (1995) J. Clin. Invest , vol.95 , pp. 2945-2953
    • Watanabe, M.1    Ueno, Y.2    Yajima, T.3    Iwao, Y.4    Tsuchiya, M.5    Ishikawa, H.6    Aiso, S.7    Hibi, T.8    Ishii, H.9
  • 67
    • 0029098563 scopus 로고
    • Interleukin-15: A novel anabolic cytokine for skeletal muscle
    • Quinn, L. S., Haugk, K. L., Grabstein, K. H. (1995) Interleukin-15: a novel anabolic cytokine for skeletal muscle. Endocrinology 136, 3669–3672.
    • (1995) Endocrinology , vol.136 , pp. 3669-3672
    • Quinn, L.S.1    Haugk, K.L.2    Grabstein, K.H.3
  • 69
    • 33749685051 scopus 로고    scopus 로고
    • Utilizing IL-12, IL-15 and IL-7 as mucosal vaccine adjuvants
    • Stevceva, L., Moniuszko, M., Ferrari, M. G. (2006) Utilizing IL-12, IL-15 and IL-7 as mucosal vaccine adjuvants. Lett. Drug Des. Discov. 3, 586–592.
    • (2006) Lett. Drug Des. Discov , vol.3 , pp. 586-592
    • Stevceva, L.1    Moniuszko, M.2    Ferrari, M.G.3
  • 70
    • 43549096677 scopus 로고    scopus 로고
    • IL- 15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation
    • Mortier, E., Woo, T., Advincula, R., Gozalo, S., and Ma, A. (2008) IL- 15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J. Exp. Med. 205, 1213–1225.
    • (2008) J. Exp. Med , vol.205 , pp. 1213-1225
    • Mortier, E.1    Woo, T.2    Advincula, R.3    Gozalo, S.4    Ma, A.5
  • 71
    • 0036826914 scopus 로고    scopus 로고
    • IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells
    • Dubois, S., Mariner, J., Waldmann, T. A., Tagaya, Y. (2002) IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 17, 537–547.
    • (2002) Immunity , vol.17 , pp. 537-547
    • Dubois, S.1    Mariner, J.2    Waldmann, T.A.3    Tagaya, Y.4
  • 73
    • 0033000334 scopus 로고    scopus 로고
    • P70(S6k) Integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes
    • Brennan, P., Babbage, J. W., Thomas, G., Cantrell, D. (1999) p70(s6k) Integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes. Mol. Cell. Biol. 19, 4729–4738.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 4729-4738
    • Brennan, P.1    Babbage, J.W.2    Thomas, G.3    Cantrell, D.4
  • 74
    • 84902592657 scopus 로고    scopus 로고
    • IL-15: A central regulator of celiac disease immunopathology
    • Abadie, V., Jabri, B. (2014) IL-15: a central regulator of celiac disease immunopathology. Immunol. Rev. 260, 221–234.
    • (2014) Immunol. Rev , vol.260 , pp. 221-234
    • Abadie, V.1    Jabri, B.2
  • 75
    • 33645120637 scopus 로고    scopus 로고
    • Interleukin 15: Its role in intestinal inflammation
    • Van Heel, D. A. (2006) Interleukin 15: its role in intestinal inflammation. Gut 55, 444–445.
    • (2006) Gut , vol.55 , pp. 444-445
    • Van Heel, D.A.1
  • 76
    • 33646466776 scopus 로고    scopus 로고
    • MyD88-dependent signaling for IL-15 production plays an important role in maintenance of CD8 alpha alpha TCR alpha beta and TCR gamma delta intestinal intraepithelial lymphocytes
    • Yu, Q., Tang, C., Xun, S., Yajima, T., Takeda, K., Yoshikai, Y. (2006) MyD88-dependent signaling for IL-15 production plays an important role in maintenance of CD8 alpha alpha TCR alpha beta and TCR gamma delta intestinal intraepithelial lymphocytes. J. Immunol. 176, 6180–6185.
    • (2006) J. Immunol , vol.176 , pp. 6180-6185
    • Yu, Q.1    Tang, C.2    Xun, S.3    Yajima, T.4    Takeda, K.5    Yoshikai, Y.6
  • 79
    • 44649139904 scopus 로고    scopus 로고
    • Inhibitory effect of dietary n-3 polyunsaturated fatty acids to intestinal IL-15 expression is associated with reduction of TCRalphabeta+CD8alpha+CD8beta-intestinal intraepithelial lymphocytes
    • Wang, J., Zhang, H., Ma, H., Lu, B., Wang, J., Li, Y., Li, J. (2008) Inhibitory effect of dietary n-3 polyunsaturated fatty acids to intestinal IL-15 expression is associated with reduction of TCRalphabeta+CD8alpha+CD8beta-intestinal intraepithelial lymphocytes. J. Nutr. Biochem. 19, 475–481.
    • (2008) J. Nutr. Biochem , vol.19 , pp. 475-481
    • Wang, J.1    Zhang, H.2    Ma, H.3    Lu, B.4    Wang, J.5    Li, Y.6    Li, J.7
  • 81
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce, J. P., Boone, D. L., Chai, S., Swain, R. E., Dassopoulos, T., Trettin, S., Ma, A. (1998) IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9, 669–676.
    • (1998) Immunity , vol.9 , pp. 669-676
    • Lodolce, J.P.1    Boone, D.L.2    Chai, S.3    Swain, R.E.4    Dassopoulos, T.5    Trettin, S.6    Ma, A.7
  • 82
    • 0031051547 scopus 로고    scopus 로고
    • Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain
    • Suzuki, H., Duncan, G. S., Takimoto, H., Mak, T. W. (1997) Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain. J. Exp. Med. 185, 499–505.
    • (1997) J. Exp. Med , vol.185 , pp. 499-505
    • Suzuki, H.1    Duncan, G.S.2    Takimoto, H.3    Mak, T.W.4
  • 83
    • 33846224790 scopus 로고    scopus 로고
    • Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRgammadelta intestinal intraepithelial T lymphocytes in IL-15-deficient mice
    • Nakazato, K., Yamada, H., Yajima, T., Kagimoto, Y., Kuwano, H., Yoshikai, Y. (2007) Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRgammadelta intestinal intraepithelial T lymphocytes in IL-15-deficient mice. J. Immunol. 178, 757–764.
    • (2007) J. Immunol , vol.178 , pp. 757-764
    • Nakazato, K.1    Yamada, H.2    Yajima, T.3    Kagimoto, Y.4    Kuwano, H.5    Yoshikai, Y.6
  • 84
    • 84883506107 scopus 로고    scopus 로고
    • IL-15 modulates the balance between Bcl-2 and Bim via a Jak3/1-PI3K-Akt-ERK pathway to promote CD8aa+ intestinal intraepithelial lymphocyte survival
    • Lai, Y. G., Hou, M. S., Lo, A., Huang, S. T., Huang, Y. W., Yang-Yen, H. F., Liao, N. S. (2013) IL-15 modulates the balance between Bcl-2 and Bim via a Jak3/1-PI3K-Akt-ERK pathway to promote CD8aa+ intestinal intraepithelial lymphocyte survival. Eur. J. Immunol. 43, 2305–2316.
    • (2013) Eur. J. Immunol , vol.43 , pp. 2305-2316
    • Lai, Y.G.1    Hou, M.S.2    Lo, A.3    Huang, S.T.4    Huang, Y.W.5    Yang-Yen, H.F.6    Liao, N.S.7
  • 85
    • 70249096718 scopus 로고    scopus 로고
    • Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs
    • Ma, L. J., Acero, L. F., Zal, T., Schluns, K. S. (2009) Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs. J. Immunol. 183, 1044–1054.
    • (2009) J. Immunol , vol.183 , pp. 1044-1054
    • Ma, L.J.1    Acero, L.F.2    Zal, T.3    Schluns, K.S.4
  • 86
    • 30044448268 scopus 로고    scopus 로고
    • Interleukin 15 controls the generation of the restricted T cell receptor repertoire of gamma delta intestinal intraepithelial lymphocytes
    • Zhao, H., Nguyen, H., Kang, J. (2005) Interleukin 15 controls the generation of the restricted T cell receptor repertoire of gamma delta intestinal intraepithelial lymphocytes. Nat. Immunol. 6, 1263–1271.
    • (2005) Nat. Immunol , vol.6 , pp. 1263-1271
    • Zhao, H.1    Nguyen, H.2    Kang, J.3
  • 89
    • 33645118120 scopus 로고    scopus 로고
    • Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease
    • Di Sabatino, A., Ciccocioppo, R., Cupelli, F., Cinque, B., Millimaggi, D., Clarkson, M. M., Paulli, M., Cifone, M. G., Corazza, G. R. (2006) Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut 55, 469–477.
    • (2006) Gut , vol.55 , pp. 469-477
    • Di Sabatino, A.1    Ciccocioppo, R.2    Cupelli, F.3    Cinque, B.4    Millimaggi, D.5    Clarkson, M.M.6    Paulli, M.7    Cifone, M.G.8    Corazza, G.R.9
  • 92
    • 17844388888 scopus 로고    scopus 로고
    • IL-15 converts human intestinal intraepithelial lymphocytes to CD94 producers of IFN-gamma and IL- 10, the latter promoting Fas ligand-mediated cytotoxicity
    • Ebert, E. C. (2005) IL-15 converts human intestinal intraepithelial lymphocytes to CD94 producers of IFN-gamma and IL- 10, the latter promoting Fas ligand-mediated cytotoxicity. Immunology 115, 118–126.
    • (2005) Immunology , vol.115 , pp. 118-126
    • Ebert, E.C.1
  • 95
    • 0034176003 scopus 로고    scopus 로고
    • IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production
    • Liu, Z., Geboes, K., Colpaert, S., D’Haens, G. R., Rutgeerts, P., Ceuppens, J. L. (2000) IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J. Immunol. 164, 3608–3615.
    • (2000) J. Immunol , vol.164 , pp. 3608-3615
    • Liu, Z.1    Geboes, K.2    Colpaert, S.3    D’Haens, G.R.4    Rutgeerts, P.5    Ceuppens, J.L.6
  • 96
    • 0036644327 scopus 로고    scopus 로고
    • IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation
    • Ohta, N., Hiroi, T., Kweon, M. N., Kinoshita, N., Jang, M. H., Mashimo, T., Miyazaki, J., Kiyono, H. (2002) IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation. J. Immunol. 169, 460–468.
    • (2002) J. Immunol , vol.169 , pp. 460-468
    • Ohta, N.1    Hiroi, T.2    Kweon, M.N.3    Kinoshita, N.4    Jang, M.H.5    Mashimo, T.6    Miyazaki, J.7    Kiyono, H.8
  • 100
    • 33750219508 scopus 로고    scopus 로고
    • Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
    • Kim, H. P., Imbert, J., Leonard, W. J. (2006) Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev. 17, 349–366.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 349-366
    • Kim, H.P.1    Imbert, J.2    Leonard, W.J.3
  • 101
    • 80053608499 scopus 로고    scopus 로고
    • IL-2 family cytokines: New insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation
    • Liao, W., Lin, J. X., Leonard, W. J. (2011) IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr. Opin. Immunol. 23, 598–604.
    • (2011) Curr. Opin. Immunol , vol.23 , pp. 598-604
    • Liao, W.1    Lin, J.X.2    Leonard, W.J.3
  • 102
    • 17444377169 scopus 로고    scopus 로고
    • Cytokine production by intestinal intraepithelial lymphocyte subsets in celiac disease
    • León, F., Sánchez, L., Camarero, C., Roy, G. (2005) Cytokine production by intestinal intraepithelial lymphocyte subsets in celiac disease. Dig. Dis. Sci. 50, 593–600.
    • (2005) Dig. Dis. Sci , vol.50 , pp. 593-600
    • León, F.1    Sánchez, L.2    Camarero, C.3    Roy, G.4
  • 103
    • 1642313753 scopus 로고    scopus 로고
    • Virus-induced activation of self-specific TCR alpha beta CD8 alpha alpha intraepithelial lymphocytes does not abolish their selftolerance in the intestine
    • Saurer, L., Seibold, I., Rihs, S., Vallan, C., Dumrese, T., Mueller, C. (2004) Virus-induced activation of self-specific TCR alpha beta CD8 alpha alpha intraepithelial lymphocytes does not abolish their selftolerance in the intestine. J. Immunol. 172, 4176–4183.
    • (2004) J. Immunol , vol.172 , pp. 4176-4183
    • Saurer, L.1    Seibold, I.2    Rihs, S.3    Vallan, C.4    Dumrese, T.5    Mueller, C.6
  • 104
    • 0033558129 scopus 로고    scopus 로고
    • Differential effects of IL-2 and IL-15 on the death and survival of activated TCR gamma delta+ intestinal intraepithelial lymphocytes
    • Chu, C. L., Chen, S. S., Wu, T. S., Kuo, S. C., Liao, N. S. (1999) Differential effects of IL-2 and IL-15 on the death and survival of activated TCR gamma delta+ intestinal intraepithelial lymphocytes. J. Immunol. 162, 1896–1903.
    • (1999) J. Immunol , vol.162 , pp. 1896-1903
    • Chu, C.L.1    Chen, S.S.2    Wu, T.S.3    Kuo, S.C.4    Liao, N.S.5
  • 105
    • 0033248123 scopus 로고    scopus 로고
    • IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: Roles for both IL-2 and IL-15 in CD8alphaalpha IEL development
    • Porter, B. O., Malek, T. R. (1999) IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development. J. Immunol. 163, 5906–5912.
    • (1999) J. Immunol , vol.163 , pp. 5906-5912
    • Porter, B.O.1    Malek, T.R.2
  • 106
    • 0342844393 scopus 로고    scopus 로고
    • IL-2 promotes the subset restoration of intraepithelial lymphocytes after ischemia/reperfusion injury
    • Nüssler, N. C., O’Brien, J., Stange, B., Platz, K. P., Neuhaus, P., Müller, A. R. (2000) IL-2 promotes the subset restoration of intraepithelial lymphocytes after ischemia/reperfusion injury. Transplant. Proc. 32, 1305–1306.
    • (2000) Transplant. Proc , vol.32 , pp. 1305-1306
    • Nüssler, N.C.1    O’Brien, J.2    Stange, B.3    Platz, K.P.4    Neuhaus, P.5    Müller, A.R.6
  • 109
    • 84899469547 scopus 로고    scopus 로고
    • Transforming growth factor and intestinal inflammation: The role of nutrition
    • Ruemmele, F. M., Garnier-Lengliné, H. (2013) Transforming growth factor and intestinal inflammation: the role of nutrition. Nestle Nutr. Inst. Workshop Ser. 77, 91–98.
    • (2013) Nestle Nutr. Inst. Workshop Ser , vol.77 , pp. 91-98
    • Ruemmele, F.M.1    Garnier-Lengliné, H.2
  • 110
    • 0038375993 scopus 로고    scopus 로고
    • Dietary nucleotides increase the mucosal IgA response and the secretion of transforming growth factor beta from intestinal epithelial cells in mice
    • Nagafuchi, S., Totsuka, M., Hachimura, S., Goto, M., Takahashi, T., Yajima, T., Kuwata, T., Kaminogawa, S. (2002) Dietary nucleotides increase the mucosal IgA response and the secretion of transforming growth factor beta from intestinal epithelial cells in mice. Cytotechnology 40, 49–58.
    • (2002) Cytotechnology , vol.40 , pp. 49-58
    • Nagafuchi, S.1    Totsuka, M.2    Hachimura, S.3    Goto, M.4    Takahashi, T.5    Yajima, T.6    Kuwata, T.7    Kaminogawa, S.8
  • 111
  • 112
    • 0032589097 scopus 로고    scopus 로고
    • Characterization of CD4+ CD8alphaalpha+ and CD4–CD8alphaalpha+ intestinal intraepithelial lymphocytes in rats
    • Yamada, K., Kimura, Y., Nishimura, H., Namii, Y., Murase, M., Yoshikai, Y. (1999) Characterization of CD4+ CD8alphaalpha+ and CD4–CD8alphaalpha+ intestinal intraepithelial lymphocytes in rats. Int. Immunol. 11, 21–28.
    • (1999) Int. Immunol , vol.11 , pp. 21-28
    • Yamada, K.1    Kimura, Y.2    Nishimura, H.3    Namii, Y.4    Murase, M.5    Yoshikai, Y.6
  • 114
    • 0033030517 scopus 로고    scopus 로고
    • Inhibitory effects of transforming growth factor-beta (TGF-beta) on certain functions of intraepithelial lymphocytes. Clin. Exp
    • Ebert, E. C. (1999) Inhibitory effects of transforming growth factor-beta (TGF-beta) on certain functions of intraepithelial lymphocytes. Clin. Exp. Immunol. 115, 415–420.
    • (1999) Immunol , vol.115 , pp. 415-420
    • Ebert, E.C.1
  • 115
    • 0036207312 scopus 로고    scopus 로고
    • Localization of intestinal intraepithelial T lymphocytes involves regulation of alphaEbeta7 expression by transforming growth factorbeta
    • Suzuki, R., Nakao, A., Kanamaru, Y., Okumura, K., Ogawa, H., Ra, C. (2002) Localization of intestinal intraepithelial T lymphocytes involves regulation of alphaEbeta7 expression by transforming growth factorbeta. Int. Immunol. 14, 339–345.
    • (2002) Int. Immunol , vol.14 , pp. 339-345
    • Suzuki, R.1    Nakao, A.2    Kanamaru, Y.3    Okumura, K.4    Ogawa, H.5    Ra, C.6
  • 116
    • 19344361971 scopus 로고    scopus 로고
    • TGF-beta-dependent CD103 expression by CD8(+) T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease
    • El-Asady, R., Yuan, R., Liu, K., Wang, D., Gress, R. E., Lucas, P. J., Drachenberg, C. B., Hadley, G. A. (2005) TGF-beta-dependent CD103 expression by CD8(+) T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease. J. Exp. Med. 201, 1647–1657.
    • (2005) J. Exp. Med , vol.201 , pp. 1647-1657
    • El-Asady, R.1    Yuan, R.2    Liu, K.3    Wang, D.4    Gress, R.E.5    Lucas, P.J.6    Drachenberg, C.B.7    Hadley, G.A.8
  • 117
    • 33748754842 scopus 로고    scopus 로고
    • Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes
    • Baker, K., Chong, G., Foulkes, W. D., Jass, J. R. (2006) Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes. Histopathology 49, 371–380.
    • (2006) Histopathology , vol.49 , pp. 371-380
    • Baker, K.1    Chong, G.2    Foulkes, W.D.3    Jass, J.R.4
  • 118
    • 84867718489 scopus 로고    scopus 로고
    • Stem cell factor receptor/c-Kit: From basic science to clinical implications
    • Lennartsson, J., Rönnstrand, L. (2012) Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol. Rev. 92, 1619–1649.
    • (2012) Physiol. Rev , vol.92 , pp. 1619-1649
    • Lennartsson, J.1    Rönnstrand, L.2
  • 119
    • 0032078804 scopus 로고    scopus 로고
    • Cytokine gene expression in murine fetal intestine: Potential for extrathymic T cell development
    • Murray, A. M., Simm, B., Beagley, K. W. (1998) Cytokine gene expression in murine fetal intestine: potential for extrathymic T cell development. Cytokine 10, 337–345.
    • (1998) Cytokine , vol.10 , pp. 337-345
    • Murray, A.M.1    Simm, B.2    Beagley, K.W.3
  • 120
    • 0028675005 scopus 로고
    • Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis
    • Puddington, L., Olson, S., Lefrançois, L. (1994) Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis. Immunity 1, 733–739.
    • (1994) Immunity , vol.1 , pp. 733-739
    • Puddington, L.1    Olson, S.2    Lefrançois, L.3
  • 121
    • 0030059171 scopus 로고    scopus 로고
    • A role for stem cell factor (SCF): C-kit interaction (s) in the intestinal tract response to Salmonella typhimurium infection
    • Klimpel, G. R., Langley, K. E., Wypych, J., Abrams, J. S., Chopra, A. K., Niesel, D. W. (1996) A role for stem cell factor (SCF): c-kit interaction (s) in the intestinal tract response to Salmonella typhimurium infection. J. Exp. Med. 184, 271–276.
    • (1996) J. Exp. Med , vol.184 , pp. 271-276
    • Klimpel, G.R.1    Langley, K.E.2    Wypych, J.3    Abrams, J.S.4    Chopra, A.K.5    Niesel, D.W.6
  • 122
    • 0033938396 scopus 로고    scopus 로고
    • Stem cell factor (SCF) can regulate the activation and expansion of murine intraepithelial lymphocytes
    • Wang, T., Langley, K. E., Gourley, W. K., Klimpel, G. R. (2000) Stem cell factor (SCF) can regulate the activation and expansion of murine intraepithelial lymphocytes. Cytokine 12, 272–280.
    • (2000) Cytokine , vol.12 , pp. 272-280
    • Wang, T.1    Langley, K.E.2    Gourley, W.K.3    Klimpel, G.R.4
  • 123
    • 0034633535 scopus 로고    scopus 로고
    • Stem cell factor and IL-2 act synergistically in inducing intraepithelial lymphocyte proliferation and cytokine production: Upregulation of the IL-2 receptor gamma-chain and signaling via JAK-3
    • Wang, T., Alam, R., Langley, K. E., Klimpel, G. R. (2000) Stem cell factor and IL-2 act synergistically in inducing intraepithelial lymphocyte proliferation and cytokine production: upregulation of the IL-2 receptor gamma-chain and signaling via JAK-3. Cell. Immunol. 205, 62–71.
    • (2000) Cell. Immunol , vol.205 , pp. 62-71
    • Wang, T.1    Alam, R.2    Langley, K.E.3    Klimpel, G.R.4
  • 124
    • 84881628352 scopus 로고    scopus 로고
    • Tissue-resident memory T cells
    • Shin, H., Iwasaki, A. (2013) Tissue-resident memory T cells. Immunol. Rev. 255, 165–181.
    • (2013) Immunol. Rev , vol.255 , pp. 165-181
    • Shin, H.1    Iwasaki, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.