Commensal microflora and interferon-γ promote steady-state interleukin-7 production in vivo

European Journal of Immunology

Volumn 40, Issue 9, 2010, Pages 2391-2400

  Shalapour, Shabnam ^a   Deiser, Katrin ^a   Sercan, Özen ^a,b   Tuckermann, Jan ^c   Minnich, Kerstin ^c   Willimsky, Gerald ^a,d   Blankenstein, Thomas ^a,d   Hämmerling, Günter J ^b   Arnold, Bernd ^b   Schüler, Thomas ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c FRITZ LIPMANN INSTITUTE   (Germany)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Commensal microflora; IFN c ; IL 7; Intestinal epithelial cells

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 7; ANTIINFECTIVE AGENT; PHOTOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; COMMENSAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE ACTIVITY; GENE CONTROL; GENE INACTIVATION; IN VIVO STUDY; INTESTINE; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SIGNAL TRANSDUCTION; SKIN; STEADY STATE; T LYMPHOCYTE; THYMUS; ANIMAL; BACTERIAL ARTIFICIAL CHROMOSOME; DRUG EFFECTS; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INTESTINE MUCOSA; METABOLISM; METAGENOME; MICROBIOLOGY; PATHOLOGY; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; ANTI-BACTERIAL AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CHROMOSOMES, ARTIFICIAL, BACTERIAL; DEXAMETHASONE; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION; INTERFERON-GAMMA; INTERLEUKIN-7; INTESTINAL MUCOSA; INTESTINES; LUMINESCENT PROTEINS; METAGENOME; MICE; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 77956478866     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040441     Document Type: Article

References (32)

1. von Freeden-Jeffry, U., Vieira, P., Lucian, L. A., McNeil, T., Burdach, S. E. and Murray, R., Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 1995. 181: 1519-1526.
2. Kieper, W. C., Tan, J. T., Bondi-Boyd, B., Gapin, L., Sprent, J., Ceredig, R. and Surh, C. D., Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J. Exp. Med. 2002. 195: 1533-1539.
3. Sawa, S., Kamimura, D., Jin, G. H., Morikawa, H., Kamon, H., Nishihara, M., Ishihara, K. et al., Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J. Exp. Med. 2006. 203: 1459-1470.
4. Watanabe, M., Ueno, Y., Yajima, T., Okamoto, S., Hayashi, T., Yamazaki, M., Iwao, Y. et al., Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J. Exp. Med. 1998. 187: 389-402.
5. Weitzmann, M. N., Roggia, C., Toraldo, G., Weitzmann, L. and Pacifici, R., Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J. Clin. Invest. 2002. 110: 1643-1650.
6. Fry, T. J. and Mackall, C. L., The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J. Immunol. 2005. 174: 6571-6576.
7. Mazzucchelli, R. and Durum, S. K., Interleukin-7 receptor expression: intelligent design. Nat. Rev. Immunol. 2007. 7: 144-154.
8. Sawa, Y., Arima, Y., Ogura, H., Kitabayashi, C., Jiang, J. J., Fukushima, T., Kamimura, D. et al., Hepatic interleukin-7 expression regulates T cell responses. Immunity 2009. 30: 447-457.
9. Guimond, M., Veenstra, R. G., Grindler, D. J., Zhang, H., Cui, Y., Murphy, R. D., Kim, S. Y. et al., Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat. Immunol. 2009. 10: 149-157.
10. Zamisch, M., Moore-Scott, B., Su, D. M., Lucas, P. J., Manley, N. and Richie, E. R., Ontogeny and regulation of IL-7-expressing thymic epithelial cells. J. Immunol. 2005. 174: 60-67.
11. Mazzucchelli, R. I., Warming, S., Lawrence, S. M., Ishii, M., Abshari, M., Washington, A. V., Feigenbaum, L. et al., Visualization and identification of IL-7 producing cells in reporter mice. PLoS One 2009. 4: e7637.
12. Colin, M., Moritz, S., Schneider, H., Capeau, J., Coutelle, C. and Brahimi-Horn, M. C., Haemoglobin interferes with the ex vivo luciferase luminescence assay: consequence for detection of luciferase reporter gene expression in vivo. Gene Ther. 2000. 7: 1333-1336.
13. Watanabe, M., Ueno, Y., Yajima, T., Iwao, Y., Tsuchiya, M., Ishikawa, H., Aiso, S. et al., Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J. Clin. Invest. 1995. 95: 2945-2953.
14. Constien, R., Forde, A., Liliensiek, B., Grone, H. J., Nawroth, P., Hammerling, G. and Arnold, B., Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line. Genesis 2001. 30: 36-44.
15. Oshima, S., Nakamura, T., Namiki, S., Okada, E., Tsuchiya, K., Okamoto, R., Yamazaki, M. et al., Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol. Cell. Biol. 2004. 24: 6298-6310.
16. Keilbaugh, S. A., Shin, M. E., Banchereau, R. F., McVay, L. D., Boyko, N., Artis, D., Cebra, J. J. and Wu, G. D., Activation of RegIIIbeta/gamma and interferon gamma expression in the intestinal tract of SCID mice: an innate response to bacterial colonisation of the gut. Gut 2005. 54: 623-629.
17. Niess, J. H., Leithauser, F., Adler, G. and Reimann, J., Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions. J. Immunol. 2008. 180: 559-568.
18. Park, J. H., Adoro, S., Lucas, P. J., Sarafova, S. D., Alag, A. S., Doan, L. L., Erman, B. et al., "Coreceptor tuning": cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat. Immunol. 2007. 8: 1049-1059.
19. Hu, X., Li, W. P., Meng, C. and Ivashkiv, L. B., Inhibition of IFN-gamma signaling by glucocorticoids. J. Immunol. 2003. 170: 4833-4839.
20. Tronche, F., Kellendonk, C., Kretz, O., Gass, P., Anlag, K., Orban, P. C., Bock, R. et al., Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat. Genet. 1999. 23: 99-103.
21. Alves, N. L., Goff, O. R., Huntington, N. D., Sousa, A. P., Ribeiro, V. S., Bordack, A., Vives, F. L. et al., Characterization of the thymic IL-7 niche in vivo. Proc. Natl. Acad. Sci. USA 2009. 106: 1512-1517.
22. Repass, J. F., Laurent, M. N., Carter, C., Reizis, B., Bedford, M. T., Cardenas, K., Narang, P. et al., IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: New tools for analysis of IL-7 expressing cells. Genesis 2009. 47: 281-287.
23. Gaboriau-Routhiau, V., Rakotobe, S., Lécuyer, E., Mulder, I., Lan, A., Bridonneau, C., Rochet, V. et al., The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 2009. 31: 677-689.
24. Laky, K., Lefrancois, L., Lingenheld, E. G., Ishikawa, H., Lewis, J. M., Olson, S., Suzuki, K. et al., Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches. J. Exp. Med. 2000. 191: 1569-1580.
25. Sercan, O., Hämmerling, G. J., Arnold, B. and Schüler, T., Innate immune cells contribute to the IFN-gamma-dependent regulation of antigen-specific CD8+ T cell homeostasis. J. Immunol. 2006. 176: 735-739.
26. Sercan, O., Stoycheva, D., Hämmerling, G. J., Arnold, B. and Schüler, T., IFN-{gamma} receptor signaling regulates memory CD8+ T cell differentiation. J. Immunol. 2010. 184: 2855-2862.
27. Finkelman, F. D. and Morris, S. C., Development of an assay to measure in vivo cytokine production in the mouse. Int. Immunol. 1999. 11: 1811-1818.
28. Kaech, S. M., Hemby, S., Kersh, E. and Ahmed, R., Molecular and functional profiling of memory CD8 T cell differentiation. Cell 2002. 111: 837-851.
29. Stetson, D. B., Mohrs, M., Reinhardt, R. L., Baron, J. L.,Wang, Z. E., Gapin, L., Kronenberg, M. and Locksley, R. M., Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J. Exp. Med. 2003. 198: 1069-1076.
30. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. and Medzhitov, R., Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004. 118: 229-241.
31. Szymczak, A. L., Workman, C. J., Wang, Y., Vignali, K. M., Dilioglou, S., Vanin, E. F. and Vignali, D. A., Correction of multi-gene deficiency in vivo using a single "self-cleaving" 2A peptide-based retroviral vector. Nat. Biotechnol. 2004. 22: 589-594.
32. Lee, E. C., Yu, D., Martinez de Velasco, J., Tessarollo, L., Swing, D. A., Court, D. L., Jenkins, N. A. and Copeland, N. G., A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 2001. 73: 56-65.