IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursors and mature CD8αα+ IELs in the intestine

Journal of Immunology

Volumn 180, Issue 6, 2008, Pages 3757-3765

  Lai, Yein Gei ^a,b   Hou, Mau Sheng ^b   Hsu, Yaw Wen ^b   Chang, Chin Ling ^a,b   Liou, Yae Huei ^b   Tsai, Ming Han ^b   Lee, Fan ^c   Liao, Nan Shih ^a,b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CD8ALPHA ANTIGEN; INTERLEUKIN 15 RECEPTOR ALPHA; CD8 ANTIGEN; CD8 ANTIGEN, ALPHA CHAIN; INTERLEUKIN 15;

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; EPITHELIUM CELL; HOMEOSTASIS; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; THYMUS; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; GENETICS; IMMUNOLOGY; INTESTINE MUCOSA; LYMPHOCYTE SUBPOPULATION; METABOLISM; MOUSE MUTANT; NUDE MOUSE; PHYSIOLOGY; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD8; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; EPITHELIAL CELLS; HOMEOSTASIS; INTERLEUKIN-15; INTESTINAL MUCOSA; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; MICE, TRANSGENIC; STEM CELLS; THYMUS GLAND;

EID: 44849096173     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.6.3757     Document Type: Article

References (37)

1. Grabstein, K. H., J. Eisenman, K. Shanebeck, C. Rauch, S. Srinivasan, V. Fung, C. Beers, J. Richardson, M. A. Schoenborn, M. Ahdieh, et al. 1994. Cloning of a T cell growth factor that interacts with the b chain of the interleukin-2 receptor. Science 264: 965-968.
2. Giri, J. G., S. Kumaki, M. Ahdieh, D. J. Friend, A. Loomis, K. Shanebeck, R. DuBose, D. Cosman, L. S. Park, and D. M. Anderson. 1995. Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor. EMBO J. 14: 3654-3663.
3. Dubois, S., J. Mariner, T. Waldmann, and Y. Tagaya. 2002. IL-15Rα recycles and presents IL-15 in trans to neighboring cells. Immunity 17: 537-547.
4. Ma, A., R. Koka, and P. Burkett. 2006. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu. Rev. Immunol. 24: 657-679.
5. Kennedy, M., M. Glaccum, S. Brown, E. Butz, J. Viney, M. Embers, N. Matsuki, K. Charrier, L. Sedger, C. Willis, et al. 2000. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191: 771-780.
6. Lodolce, J. P., D. L. Boone, S. Chai, R. E. Swain, T. Dassopoulos, S. Trettin, and A. Ma. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9: 669-676.
7. Suzuki, H., G. Duncan, H. Takimoto, and T. Mak. 1997. Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor β chain. J. Exp. Med. 185: 499-505.
8. Schluns, K., E. Nowak, A. Cabrera-Hernandez, L. Puddington, L. Lefrancois, and H. Aguila. 2004. Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor α expression. Proc. Natl. Acad. Sci. USA 101: 5616-5621.
9. Bandeira, A., S. Itohara, M. Bonneville, O. Burlen-Defranoux, T. Mota-Santos, A. Coutinho, and S. Tonegawa. 1991. Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor γ δ. Proc. Natl. Acad. Sci. USA 88: 43-47.
10. Lin, T., G. Matsuzaki, H. Kenai, T. Nakamura, and K. Nomoto. 1993. Thymus influences the development of extrathymically derived intestinal intraepithelial lymphocytes. Eur. J. Immunol. 23: 1968-1974.
11. +αα intestinal intraepithelial lymphocytes early in ontogeny. Eur. J. Immunol. 24: 1785-1791.
12. + intraepithelial lymphocyte precursors in the thymus. Immunity 25: 631-641.
13. + T cells are positively selected in the thymus by agonist selfpeptides. Immunity 16: 355-364.
14. + cells. Science 305: 248-251.
15. Lambolez, F., M. Arcangeli, A. Joret, V. Pasqualetto, C. Cordier, J. Di Santo, B. Rocha, and S. Ezine. 2006. The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs. Nat. Immunol. 7: 76-82.
16. LecLercq, G., V. Debacker, M. De Smedt, and J. Plum. 1996. Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells. J. Exp. Med. 184: 325-336.
17. + lympho-hemopoietic progenitors develop. J. Exp. Med. 184: 1449-1459.
18. Saito, H., Y. Kanamori, T. Takemori, H. Nariuchi, E. Kubota, H. Takahashi-Iwanaga, T. Iwanaga, and H. Ishikawa. 1998. Generation of intestinal T cells from progenitors residing in gut cryptopatches. Science 280: 275-278.
19. Lambolez, F., O. Azogui, A. Joret, C. Garcia, H. von Boehmer, J. Di Santo, S. Ezine, and B. Rocha. 2002. Characterization of T cell differentiation in the murine gut. J. Exp. Med. 195: 437-449.
20. Pabst, O., H. Herbrand, T. Worbs, M. Friedrichsen, S. Yan, M. Hoffmann, H. Körner, G. Bernhardt, R. Pabst, and R. Förster. 2005. Cryptopatches and isolated lymphoid follicles: dynamic lymphoid tissues dispensable for the generation of intraepithelial lymphocytes. Eur. J. Immunol. 35: 98-107.
21. + lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J. Exp. Med. 173: 471-481.
22. Inakaki-Ohara, K., H. Nishimura, A. Mitani, and Y. Yoshikai. 1997. Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice. Eur. J. Immunol. 27: 2885-2891.
23. + intestinal intraepithelial lymphocytes. J. Immunol. 163: 5843-5850.
24. Nakazato, K., H. Yamada, T. Yajima, Y. Kagimoto, H. Kuwano, and Y. Yoshikai. 2007. Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRγδ intestinal intraepithelial T lymphocytes in IL-15-deficient mice. J. Immunol. 178: 757-764.
25. + T cell deficient in the IL-15 receptor α-chain. J. Immunol. 168: 705-712.
26. Reeves, J., P. Reeves, and L. Thomas Chin. 1991. Survival surgery: removal of the spleen and thymus. In Current Protocols in Immunology. J. Coligan, A. Kruisbeek, D. Margulies, E. Shevach, and W. Strober, eds. John Wiley & Sons, Hoboken, NJ, pp. 1.10.11-11.10.11.
27. Donovan, J., R. Rorer, and P. Brown. 1998. Anesthesia. In Current Protocols in Immunology. J. Coligan, A. Kruisbeek, D. Margulies, E. Shevach, and W. Strober, eds. John Wiley & Sons, Hoboken, NJ, pp. 1.4.1-1.4.5.
28. Terszowski, G., S. Muller, C. Bleul, C. Blum, R. Schirmbeck, J. Reimann, L. Pasquier, T. Amagai, T. Boehm, and H. Rodewald. 2006. Evidence for a functional second thymus in mice. Science 312: 284-287.
29. + intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL. Eur. J. Immunol. 24: 1080.
30. Johnston, J., C. Bacon, D. Finbloom, R. Ree, D. Kaplan, K. Shibuya, J. Ortaldo, S. Gupta, Y. Chen, J. Giri, and J. O'Shea. 1995. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc. Natl. Acad. Sci. USA 92: 8705-8709.
31. Zhao, H., H. Nguyen, and J. Kang. 2005. Interleukin 15 controls the generation of the restricted T cell receptor repertoire of γ δ intestinal intraepithelial lymphocytes. Nat. Immunol. 6: 1263-1271.
32. Page, S., N. van Oers, R. Perlmutter, A. Weiss, and A. Pullen. 1997. Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development. Eur. J. Immunol. 27: 554-562.
33. Page, S., L. Bogatzki, J. Hamerman, C. Sweenie, P. Hogarth, M. Malissen, R. Perlmutter, and A. Pullen. 1998. Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor α β lineage. Proc. Natl. Acad. Sci. USA 95: 9459-9464.
34. Koka, R., P. R. Burkett, M. Chien, S. Chai, F. Chan, J. P. Lodolce, and D. L. M. Boone, A. 2003. Interleukin (IL)-15Rα-deficient natural killer cells survive in normal but not IL-15Rα-deficient mice. J. Exp. Med. 197: 977-984.
35. + T cells is dispensable for T cell memory. Proc. Natl. Acad. Sci. USA 100: 4724-4729.
36. Sandau, M. M., K. S. Schluns, L. Lefrançois, and S. C. Jameson. 2004. Transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15Rα by the same cells. J. Immunol. 173: 6537-6541.
37. + T cell homeostasis. J. Exp. Med. 200: 825-834.