Mucosal T cells bearing TCRγδ play a protective role in intestinal inflammation

Journal of Immunology

Volumn 173, Issue 2, 2004, Pages 1390-1398

  Inagaki Ohara, Kyoko ^a,b   Chinen, Takatoshi ^b   Matsuzaki, Goro ^c   Sasaki, Atsuo ^b   Sakamoto, Yukiko ^a   Hiromatsu, Kenji ^a   Nakamura Uchiyama, Fukumi ^a   Nawa, Yukifumi ^a   Yoshimura, Akihiko ^b  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TRANSFORMING GROWTH FACTOR BETA; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL FUNCTION; COLITIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; ENTERITIS; GEL; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL;

EID: 3142686026     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.2.1390     Document Type: Article

References (44)

1. Janeway, C. A., Jr., B. Jones, and A. Hayday. 1988. Specificity and function of T cells bearing γδ receptors. Immunol. Today 9:73.
2. Panja, A., R. S. Blumberg, S. P. Balk, and L. Mayer. 1993. CDld is involved in T cell-intestinal epithelial cell interactions. J. Exp. Med. 178:1115.
3. Targan, S. R., R. L. Deem, M. Liu, S. Wang, and A. Nel. 1995. Definition of a lamina propria T cell responsive state: enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J. Immunol. 154:664.
4. + lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J. Exp. Med. 173:471.
5. Allison, J. P., and W. L. Havran. 1991. The immunobiology of T cells with invariant γδ antigen receptors. Annu. Rev. Immunol. 9:679.
6. Kaufmann, S. H. 1996. γδ and other unconventional T lymphocytes: what do they see and what do they do? Proc. Natl. Acad. Sci. USA 93:2272.
7. Boismenu, R., and W. L. Havran. 1994. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 266:1253.
8. Komano, H., Y. Fujiura, M. Kawaguchi, S. Matsumoto, Y. Hashimoto, S. Obana, P. Mombaerts, S. Tonegawa, H. Yamamoto, S. Itohara, et al. 1995. Homeostatic regulation of intestinal epithelia by intraepithelial γδ T cells. Proc. Natl. Acad. Sci. USA 92:6147.
9. + T cells provide B cell help. J. Exp. Med. 175:695.
10. Ke, Y., K. Pearce, J. P. Lake, H. K. Ziegler, and J. A. Kapp. 1997. γδ T lymphocytes regulate the induction and maintenance of oral tolerance. J. Immunol. 158:3610.
11. + T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 179:589.
12. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295.
13. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166:3008.
14. Hoffmann, J. C., K. Peters, S. Henschke, B. Herrmann, K. Pfister, J. Westermann, and M. Zeitz. 2001. Role of T lymphocytes in rat 2,4,6-trinitrobenzene sulphonic acid (TNBS) induced colitis: increased mortality after γδ T cell depletion and no effect of αβ T cell depletion. Gut 48:489.
15. Chen, Y., K. Chou, E. Fuchs, W. L. Havran, and R. Boismenu. 2002. Protection of the intestinal mucosa by intraepithelial γδ T cells. Proc. Natl. Acad. Sci. USA 99:14338.
16. Dohi, T., K. Fujihashi, H. Kiyono, C. O. Elson, and A. R. McGhee. 2000. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119:724.
17. + lamina propria T-cell lines: phenotypic and functional characterization. Immunology 75:66.
18. Inagaki-Ohara, K., H. Nishimura, A. Mitani, and Y. Yoshikai. 1997. Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice. Eur. J. Immunol. 27:2885.
19. Evans, G. S., N. Flint, A. S. Somers, B. Eyden, and C. S. Potten. 1992. The development of a method for the preparation of rat intestinal epithelial cell primary cultures. J. Cell Sci. 101:219.
20. Sasaki, A., H. Yasukawa, A. Suzuki, S. Kamizono, T. Syoda, I. Kinjyo, M. Sasaki, J. A. Johnston, and A. Yoshimura. 1999. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells 4:339.
21. Cummings, J. H., G. T. Macfarlane, and S. Macfarlane. 2003. Intestinal bacteria and ulcerative colitis. Curr. Issues Intest. Microbiol. 4:9.
22. Yamamoto, M., K. Fujihashi, K. Kawabata, J. R. McGhee, and H. Kiyono. 1998. A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J. Immunol. 160:2188.
23. Giri, J. G., M. Ahdieh, J. Eisenman, K. Shanebeck, K. Grabstein, S. Kumaki, A. Namen, L. S. Park, D. Cosman, and D. Anderson. 1994. Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13:2822.
24. Marks-Konczalik, J., S. Dubois, J. M. Losi, H. Sabzevari, N. Yamada, L. Feigenbaum, T. A. Waldmann, and Y. Tagaya. 2000. IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proc. Natl. Acad. Sci. USA 97:11445.
25. + memory T cells by opposing cytokines. Science 288:675.
26. Kirman, I., and O. H. Nielsen. 1996. Increased numbers of interleukin-15-expressing cells in active ulcerative colitis. Am. J. Gastroenterol. 91:1789.
27. Vainer, B., O. H. Nielsen, J. Hendel, T. Horn, and I. Kirman. 2000. Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease. Cytokine 12:1531.
28. + B cells regardless of the method of B cell activation. J. Immunol. 148:3830.
29. Poussier, P., T. Ning, D. Banerjee, and M. Julius. 2002. A unique subset of self-specific intraintestinal T cells maintains gut integrity. J. Exp. Med. 195:1491.
30. Peng, S. L., J. M. McNiff, M. P. Madaio, J. Ma, M. J. Owen, R. A. Flavell, A. C. Hayday, and J. Craft. 1997. αβ T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. J. Immunol. 158:2464.
31. Fukushima, K., T. Masuda, H. Ohtani, I. Sasaki, Y. Funayama, S. Matsuno, and H. Nagara. 1991. Immunohistochemical characterization, distribution, and ultrastructure of lymphocytes bearing T-cell receptor γ/δ in inflammatory bowel disease. Gastroenterology 101:670.
32. Elsaghier, A., C. Prantera, C. Moreno, and J. Ivanyi. 1992. Antibodies to Mycobacterium paratuberculosis-specific protein antigens in Crohn's disease. Clin. Exp. Immunol. 90:503.
33. Darfeuille-Michaud, A., C. Neut, N. Barnich, E. Lederman, P. Di Martino, P. Desreumaux, L. Gambiez, B. Joly, A. Cortot, and J. F. Colombel. 1998. Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease. Gastroenterology 115:1405.
34. Fagarasan, S., M. Muramatsu, K. Suzuki, H. Nagaoka, H. Hiai, and T. Honjo. 2002. Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298:1424.
35. Reinecker, H. C., R. P. MacDermott, S. Mirau, A. Dignass, and D. K. Podolsky. 1996. Intestinal epithelial cells both express and respond to interleukin 15. Gastroenterology 111:1706.
36. McInnes, I. B., J. al-Mughales, M. Field, B. P. Leung, F. P. Huang, R. Dixon, R. D. Sturrock, P. C. Wilkinson, and F. Y. Liew. 1996. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat. Med. 2:175.
37. McInnes, I. B., B. P. Leung, R. D. Sturrock, M. Field, and F. Y. Liew. 1997. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis. Nat. Med. 3:189.
38. + T cells for the development of small intestinal inflammation. J. Immunol. 169:460.
39. Campbell, N., X. Y. Yio, L. P. So, Y. Li, and L. Mayer. 1999. The intestinal epithelial cell: processing and presentation of antigen to the mucosal immune system. Immunol. Rev. 172:315.
40. O'Neil, D. A., E. M. Porter, D. Elewaut, G. M. Anderson, L. Eckmann, T. Ganz, and M. F. Kagnoff. 1999. Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium. J. Immunol. 163:6718.
41. +CD8 αα T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease. Proc. Natl. Acad. Sci. USA 100:5324.
42. Saubermann, L. J., P. Beck, Y. P. De Jong, R. S. Pitman, M. S. Ryan, H. S. Kim, M. Exley, S. Snapper, S. P. Balk, S. J. Hagen, et al. 2000. Activation of natural killer T cells by α-galactosylceramide in the presence of CD1d provides protection against colitis in mice. Gastroenterology 119:119.
43. Takeuchi, M., H. Miyazaki, K. Mirokawa, T. Yokokura, and Y. Yoshikai. 1993. Age-related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice. Eur. J. Immunol. 23:1409.
44. Nakamura, T., G. Matsuzaki, H. Takimoto, and K. Nomoto. 1995. Age-associated changes in the proliferative response of rat intestinal intraepithelial leukocytes to bacterial antigens. Gastroenterology 109:748.