The V-J recombination of T cell receptor-γ genes is blocked in interleukin-7 receptor-deficient mice

Journal of Experimental Medicine

Volumn 184, Issue 6, 1996, Pages 2423-2427

  Maki, Kazushige ^a   Sunaga, Shinji ^a   Ikuta, Koichi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; INTERLEUKIN 7 RECEPTOR; MESSENGER RNA; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE REARRANGEMENT; GENETIC RECOMBINATION; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE RECEPTOR GENE; THYMOCYTE;

ANIMALS; ANTIGENS, CD; DNA PRIMERS; DNA-BINDING PROTEINS; EXONS; GENE REARRANGEMENT, GAMMA-CHAIN T-CELL ANTIGEN RECEPTOR; HETEROZYGOTE; HOMEODOMAIN PROTEINS; HOMOZYGOTE; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, TRANSGENIC; PHOSPHOGLYCERATE KINASE; POLYMERASE CHAIN REACTION; PROTEIN BIOSYNTHESIS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-7; RECOMBINATION, GENETIC; T-LYMPHOCYTES;

EID: 0030442579     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.6.2423     Document Type: Article

References (31)

1. Muegge, K., M.P. Vila, and S.K. Durum. 1993. Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor β gene. Science (Wash. DC). 261:93-95.
2. Appasamy, P.M., T.J. Kenniston, Y. Weng, E.C. Holt, J. Kost, and W.H. Chambers. 1993. Interleukin-7-induced expression of specific T cell receptor γ variable region genes in murine fetal liver cultures. J. Exp. Med. 178:2201-2206.
3. Grabstein, K.H., T.J. Waidschmidt, F.D. Finkelman, B.W. Hess, A.R. Alpert, N.E. Boiani, A.E. Namen, and P.J. Morrissey. 1993. Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin-7 monoclonal antibody. J. Exp. Med. 178:257-264.
4. Sudo, T., S. Nishikawa, N. Ohno, N. Akiyama, M. Tamakoshi, H. Yoshida, and S. Nishikawa. 1993. Expression and function of the interleukin-7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. USA. 90:9125-9129.
5. von Freeden-Jeffry, U., P. Vieira, L.A. Lucian, T. McNeil, S.E. Burdach, and R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundantcytokine. J. Exp. Med. 181:1519-1526.
6. Peschon, J.J., P.J. Morrissey, K.H. Grabstein, F.J. Ramsdell, E. Maraskovsky, B.C. Gliniak, L.S. Park, S.F. Ziegler, D.E. Williams, C.B. Ware, J.D. Meyer, and B.L. Davison. 1994. Early lymphocyte expansion is severely impaired in interleukin-7 receptor-deficient mice. J. Exp. Med. 180:1955-1960.
7. Ikuta, K., N. Uchida, J. Friedman, and I.L. Weissman. 1992. Lymphocyte development from stem cells. Annu. Rev. Immunol. 10:759-783.
8. Haas, W., P. Pereira, and S. Tonegawa. 1993. Gamma/delta cells. Annu. Rev. Immunol. 11:637-685.
9. Watanabe, Y., T. Sudo, N. Minato, A. Ohnishi, and Y. Katsura. 1991. Interleukin 7 preferentially supports the growth of γδ T cell receptor-bearing T cells from fetal thymocytes in vitro. Int. Immunol. 3:1067-1075.
10. Matsue, H., P.R. Bergstresser, and A. Takashima. 1993. Keratinocyte-derived IL-7 serves as a growth factor for dendritic epidermal T cells in mice. J. Immunol. 151:6012-6019.
11. Watanabe, M., Y. Ueno, T. Yajima, Y. Iwao, M. Tsuchiya, H. Ishikawa, S. Aiso, T. Hibi, and H. Ishii. 1995. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J. Clin. Invest. 95:2945-2953.
12. Maki, K., S. Sunaga, Y. Komagata, Y. Kodaira, A. Mabuchi, H. Karasuyama, K. Yokomuro, J. Miyazaki, and K. Ikuta. 1996. Interleukin-7 receptor-deficient mice lack γδ T cells. Proc. Natl. Acad. Sci. USA. 93:7172-7177.
13. Cao, X., E.W. Shores, L.J. Hu, M.R. Anver, B.L. Kelsall, S.M. Russell, J. Drago, M. Noguchi, A. Grinberg, E.T. Bloom, W.E. Paul, S.I. Katz, P.E. Love, and W.J. Leonard. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. Immunity. 2:223-238.
14. Park, S.Y., K. Saijo, T. Takahashi, M. Osawa, H. Arase, N. Hirayama, K. Miyake, H. Nakauchi, T. Shirasawa, and T. Saito. 1995. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity. 3:771-782.
15. Takagaki, Y., N. Nakanishi, I. Ishida, O. Kanagawa, and S. Tonegawa. 1989. T cell receptor-γ and -δ genes preferentially utilized by adult thymocytes for the surface expression. J. Immunol. 142:2112-2121.
16. Winoto, A., S. Mjolsness, and L. Hood. 1985. Genomic organization of the genes encoding mouse T-cell receptor α-chain. Nature (Lond.). 316:832-836.
17. Takeshita, S., M. Toda, and H. Yamagishi. 1989. Excision products of the T cell receptor gene support a progressive rearrangement model of the α/δ locus. EMBO (Eur. Mol. Biol. Organ.) J. 8:3261-3270.
18. Ikuta, K., M. Hattori, K. Wake, S. Kano, T. Honjo, J. Yodoi, and N. Minato. 1986. Expression and rearrangement of the α, β, and γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines: no correlation with the cytotoxic spectrum. J. Exp. Med. 164:428-442.
19. Oettinger, M.A., D.G. Schatz, C. Gorka, and D. Baltimore. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science (Wash. DC). 248:1517-1523.
20. Itohara, S., P. Mombaerts, J. Lafaille, J. Iacomini, A. Nelson, A.R. Clarke, M.L. Hooper, A. Farr, and S. Tonegawa. 1993. T cell receptor δ gene mutant mice: independent generation of αβ T cells and programmed rearrangements of γδ TCR genes. Cell. 72:337-348.
21. Palacios, R., and J. Samaridis. 1993. Bone marrow clones representing an intermediate stage of development between hematopoietic stem cells and pro-T-lymphocyte or proB-lymphocyte progenitors. Blood. 81:1222-1238.
22. lck in thymopoiesis. EMBO (Eur. Mol. Biol. Organ.) J. 12:1671-1680.
23. lck. EMBO (Eur. Mol. Biol. Organ.) J. 11:4877-4886.
24. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
25. Koiwai, O., T. Yokota, T. Kageyama, T. Hirose, S. Yoshida, and K. Arai. 1986. Isolation and characterization of bovine and mouse terminal deoxynucleotidyltransferase cDNAs expressible in mammalian cells. Nucleic Acids Res. 14:5777-5792.
26. Tsuda, S., S. Rieke, Y. Hashimoto, H. Nakauchi, and Y. Takahama. 1996. IL-7 supports D-J but not V-DJ rearrangement of TCR-β gene in fetal liver progenitor cells. J. Immunol. 156:3233-3242.
27. Lin, W.C., and S. Desiderio. 1995. V(D)J recombination and the cell cycle. Immunol. Today. 16:279-289.
28. Heilig, J.S., and S. Tonegawa. 1987. T-cell γ gene is allelically but not isotypically excluded and is not required in known functional T-cell subsets. Proc. Natl. Acad. Sci. USA. 84:8070-8074.
29. Foxwell, B.M., C. Beadling, D. Guschin, I. Kerr, and D. Cantrell. 1995. Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells. Eur. J. Immunol. 25:3041-3046.
30. Vernooij, B.T., J.A. Lenstra, K. Wang, and L. Hood. 1993. Organization of the murine T-cell receptor γ locus. Genomics. 17:566-574.
31. Ihle, J.N. 1996. STATs: signal transducers and activators of transcription. Cell. 84:331-334.