Differential effects of IL-2 and IL-15 on the death and survival of activated TCRγδ+ intestinal intraepithelial lymphocytes

Journal of Immunology

Volumn 162, Issue 4, 1999, Pages 1896-1903

  Chu, Ching Liang ^a,b   Chen, Shih Shun ^a,b   Wu, Tzong Shoon ^b   Kuo, Szu Cheng ^b   Liao, Nan Shih ^a,b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE RESPONSE; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; INTERLEUKIN-15; INTERLEUKIN-2; INTESTINAL MUCOSA; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, INTERLEUKIN-15; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTE SUBSETS;

EID: 0033558129     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Beagley, K. W., and A. J. Husband. 1998. Intraepithelial lymphocytes: origin, distribution, and function. Crit. Rev. Immunol. 18:237.
2. + intraepithelial lymphocytes. Nature 333:855.
3. + lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J. Exp. Med. 173:471.
4. + T cells produce IFN-γ and IL-5. J. Immunol. 147:3736.
5. Bandeira, A., S. Itohara, M. Bonneville, O. Burlen-Defranoux, T. Mota-Santos, A. Coutinho, and S. Tonegawa. 1991. Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor γδ. Proc. Natl. Acad. Sci. USA 88:43.
6. Qian, D., A. I. Sperling, D. W. Lancki, Y. Tatsumi, T. A. Barrett, J. A. Bluestone, and F. W. Fitch. 1993. The γ chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in γδ T lymphocytes. Proc. Natl. Acad. Sci. USA 90:11875.
7. Guy-Grand, D., B. Rocha, P. Mintz, M. Malassis-Seris, F. Selz, B. Malissen, and P. Vassalli. 1994. Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation. J. Exp. Med. 180:673.
8. Ohno, H., S. Ono, N. Hirayama, S. Shimada, and T. Saito. 1994. Preferential usage of the Fc receptor γ chain in the T cell antigen receptor complex by γ/δ T cells localized in epithelia. J. Exp. Med. 179:365.
9. Findly, R. C., R. S.J., and A. C. Hayday. 1993. Dynamic response of murine gut intraepithelial T cells after infection by the coccidian parasite Eimeria. Eur. J. Immunol. 23:2557.
10. Yamamoto, S., F. Russ, H. C. Teixeira, P. Conradt, and S. H. Kaufmann. 1993. Listeria monocytogenes-induced γ interferon secretion by intestinal intraepithelial γ/δ T lymphocytes. Infect. Immun. 61:2154.
11. Komano, H., Y. Fujiura, M. Kawaguchi, S. Matsumoto, Y. Hashimoto, S. Obana, P. Mombaerts, S. Tonegawa, H. Yamamoto, S. Itohara et al. 1995. Homeostatic regulation of intestinal epithelia by intraepithelial γδ T cells. Proc. Natl. Acad. Sci. USA 92:6147.
12. Fujihashi, K., J. R. McGhee, M.-N. Kweon, M. D. Cooper, S. Tonegawa, I. Takahashi, T. Hiroi, J. Mestecky, and H. Kiyono. 1996. γ/δ T cell-deficient mice have impaired mucosal immunoglobulin A responses. J. Exp. Med. 183: 1929.
13. + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc. Natl. Acad. Sci. USA 93:11774.
14. Grabstein, K. H., J. Eisenman, K. Shanebeck, C. Rauch, S. Srinivasan, V. Fung, C. Beers, J. Richardson, M. A. Schoenborn, M. Ahdieh, et al. 1994. Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264:965.
15. Giri, J. G., M. Ahdieh, J. Eisenman, K. Shanebeck, K. H. Grabstein, S. Kumaki, A. Namen, L. S. Park, D. Cosman, and D. M. Anderson. 1994. Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13:2822.
16. Carson, W. E., J. G. Giri, M. J. Lindemann, M. L. Linett, M. Ahdieh, R. Paxton, D. Anderson, J. Eisenmann, K. Grabstein, and M. A. Caligiuri. 1994. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180:1395.
17. Giri, J. G., S. Kumaki, M. Ahdieh, D. J. Friend, A. Loomis, K. Shanebeck, R. DuBose, D. Cosman, L. S. Park, and D. M. Anderson. 1995. Identification and cloning of a novel IL-15 binding protein that is structurally related to the a chain of the IL-2 receptor. EMBO J. 14:3654.
18. Inakaki-Ohara, K., H. Nishimura, A. Mitani, and Y. Yoshikai. 1997. Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice. Eur. J. Immunol. 27:2885.
19. Reinecker, H-C., R. P. MacDermott, S. Mirau, A. Dignass, and D. K. Podolsky. 1996. Intestinal epithelial cells both express and respond to interleukin 15. Gastroenterology 111:1706.
20. c-chains of the IL-2 receptor. J. Invest. Dermatol. 105:837.
21. Van Parijs, L., and A. K. Abbas. 1998. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 280:243.
22. Fuse, Y., H. Nishimura, K. Maeda, and Y. Yoshikai. 1997. CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria in murine Hsteriosis. Infect. Immun. 65:1883.
23. Lenardo, M. J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 858.
24. Refaeli, Y., L. Van Parijs, C. A. London, J. Tschopp, and A. Abbas. 1998 Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8:615.
25. Kneitz, B., T. Herrmann, S. Yonehara, and A. Schimpl. 1995. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 25:2572.
26. Goodman, T., and L. Lefrancois. 1989 Intraepithelial lymphocytes. Anatomical sites, not T cell recptor form, dictates phenotype and function. J. Exp. Med. 170:1569.
27. Kubo, R. B., J. W. Kappler, P. Marrack, and M. Pigeon. 1989. Characterization of a monoclonal antibody which detects all murine αβ T cell receptors. J. Immunol. 142:2736.
28. Mosmann, T. H., M. Cherwinski, M. Bond, M. Giedlin, and R. Coffman. 1986. Two types of murine T helper clone. 1. Definition according to profile of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
29. Mosley, R. L., and J. R. Klein. 1992. A rapid method for isolating murine intestine intraepithelial lymphocytes with high yield and purity. J. Immunol. Methods 156:19.
30. Nicoletti, L. G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry J. Immunol. Methods 139:271.
31. White, E. 1996. Life, death, and the pursuit of apoptosis. Genes Dev. 10:1.
32. Beagley, K. W., K. Fjuihashi, C. A. Black, A. S. Lagoo, M. Yamamoto, J. R. McGhee, and H. Kiyono. 1993. The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes. Eur. J. Immunol. 23:2049.
33. Emoto, M., O. Neuhaus, Y. Emoto, and S. H. E. Kaufmann. 1996. Influence of b2-microglobulin expression on γ interferon secretion and target cell lysis by intraepithelial lymphocytes during intestinal Listeria monocytogenes infection. Infect. Immun. 64:569.
34. Groh, V., A. Steinle, S. Bauer, and T. Spies. 1998. Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 279:1737.
35. + T cells for helper activity. Int. Immunol. 5:1473.
36. + intestinal intraepithelial lymphocyte subsets and lymph node cells. J. Immunol. 155:76.
37. Bulfone-Paus, S., D. Ungureanu, T. Pohl, G. Lindner, R. Paus, R. Rockert, H. Krause, and U. Kunzendorf. 1997. Interleukin-15 protects fom lethal apoptosis in vivo. Nat. Med. 3:1124.
38. Carson, W. E., T. A. Fehniger, S. Haldar, K. Eckhert, M. J. Lindemann, C.-F. Lai, C. M. Croce, H. Baumann, and M. A. Caligiuri. 1997. A potential role for interleukin-15 in the regulation of human natural killer cell survival. J. Clin. Invest. 99:937.
39. Girard, D., M.-E. Paquet, R. Paquin, and A. D. Beaulieu. 1996. Differential effects of interleukin-15 and IL-2 on human neutrophils: modulation of phagocytosis, cytoskeleton rearrangement, gene expression, and apoptosis by IL-15. Blood 88:3176.
40. Contractor, N. C., H. Bassiri, T. Reya, A. Y. Park, D. C. Baumgart, M. A. Wasik, S. G. Emerson, and S. R. Carding. 1998. Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice J. Immunol. 160:385.
41. + T cells. J. Immunol. 146:35.
42. Li, B., H. Bassiri, M. D. Rossman, P. Kramer, A. F.-O. Eyuboglu, M. Torres, E. Sada, T. Imir, and S. Carding. 1998. Involvement of the Fas/Fas ligand pathway in activation-induced cell death of Mycobacteria-reactive human γδ T cells: a mechanism for the loss of γδ T cells in patients with pulmonary tuberculosis. J. Immunol. 161:1558.
43. Giri, J. G., D. M. Anderson, S. Kumaki, L. S. Park, K. H. Grabstein, and D. Cosman. 1995 IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2. J. Leukocyte Biol. 57:763.
44. Anderson, D. M., S. Kumaki, M. Ahdieh, J. Bertles, M. Tometsko, A. Loomis, J. Giri, N. G. Copeland, D. J. Gilbert, N. A. Jenkins et al. 1995. Functional characterization of the human interleukin-15 receptor α chain and close linkage of IL15Rα and IL2Rα genes. J. Biol. Chem. 270:29862.
45. c subunits. J. Immunol. 156:1339.
46. + T cells responding to a bacterial superantigen. J. Immunol. 154:4302.
47. Rovere, P., E. Clementi, M. Ferrarini, S. Heltai, C. Sciorai, M. G. Sabbadini, C. Rugarli, and A. A. Manfredi. 1996. CD95 engagement releases calcium from intracellular stores of long term activated, apoptosis-prone γδ T cells. J. Immunol. 156:4631.
48. 2 by intestinal intraepithelial lymphocytes: resistance to apoptosis by glucocorticoids and irradiation. Int. Immunol. 9:945.
49. L can inhibit apoptosis in cells that have undergone Fas-induced protease activation. Proc. Natl. Acad. Sci. USA 94: 3759.
50. L regulates the membrane potential and volumn homeostasis of mitochondria. Cell 91:627.
51. Yang, J., X. Liu, K. Bhalla, C. N. Kim, A. M. Ibrado, J. Cai, T.-I. Peng, D. P. Jones, and X. Wang. 1997. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129.
52. Nakayama, K.-I., K. Nakayama, I. Negishi, K. Kuida, Y. Shinkai, M. Loiuie, L. Fields, P. Lucas, V. Stewart, F. Alt, and D. Loh. 1993. Disappearance of the lymphoid system in bcl-2 homozygous mutant chimeric mice. Science 261:1584.
53. Strasser, A., A. W. Harris, D. C. S. Huang, P. H. Krammer, and S. Cory. 1995. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14:6136.
54. Van Parijs, L., A. Biuckians, and A. K. Abbas. 1998. Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes. J. Immunol. 160:2065.
55. L. Immunity 3:87.
56. Van Parijs, L., A. Ibraghimov, and A. K. Abbas. 1996. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity 4:321.
57. Memon, S. A., M. B. Moreno, D. Petrak, and C. M. Zacharchuk. 1995. Bcl-2 blocks glucocorticoid-but not Fas- or activation-induced apoptosis in a T cell hybridoma. J. Immunol. 155:4644.
58. Miyazaki, T., Z.-J. Liu, A. Kawahara, Y. Minami, K. yamada, Y. Tsujimoto, E. L. Barsoumian, R. M. Perlmutter, and T. Taniguchi. 1995. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81:223.