IL-15 modulates the balance between Bcl-2 and Bim via a Jak3/1-PI3K-Akt-ERK pathway to promote CD8αα+ intestinal intraepithelial lymphocyte survival

European Journal of Immunology

Volumn 43, Issue 9, 2013, Pages 2305-2316

  Lai, Yein Gei ^a,b   Hou, Mau Sheng ^a,c   Lo, Albert ^a   Huang, Shih Ting ^a   Huang, Yen Wen ^a   Yang Yen, Hsin Fang ^a   Liao, Nan Shih ^a,b  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c ACADEMIA SINICA   (Taiwan)

Author keywords

Bcl 2; Bim; CD8 + intestinal intraepithelial lymphocytes (iIELs); IL 15

Indexed keywords

BIM PROTEIN; CD8ALPHA ANTIGEN; CD8ALPHAALPHA ANTIGEN; INTERLEUKIN 15; JANUS KINASE 1; JANUS KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN MCL 1; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SURVIVAL; CELL TRANSFER; DISSOCIATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; IN VITRO STUDY; INTESTINAL INTRAEPITHELIAL LYMPHOCYTE; INTESTINE EPITHELIUM CELL; INTRACELLULAR SIGNALING; LYMPHOCYTE; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SURVIVAL FACTOR; UPREGULATION;

BCL-2; BIM; CD8ΑΑ+ INTESTINAL INTRAEPITHELIAL LYMPHOCYTES (IIELS); IL-15;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD8; APOPTOSIS REGULATORY PROTEINS; CELL SURVIVAL; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INTERLEUKIN-15; INTESTINES; JANUS KINASE 3; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, INTERLEUKIN-15; T-LYMPHOCYTE SUBSETS;

EID: 84883506107     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201243026     Document Type: Article

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