Effects of intraepithelial lymphocyte-derived cytokines on intestinal mucosal barrier function

Journal of Interferon and Cytokine Research

Volumn 33, Issue 10, 2013, Pages 551-562

  Qiu, Yuan ^a   Yang, Hua ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTRAEPITHELIAL LYMPHOCYTE DERIVED CYTOKINE; KERATINOCYTE GROWTH FACTOR; MUCIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

BLOOD; CELL COMPONENT; CELL FUNCTION; CELL JUNCTION; CELL TYPE; CYTOKINE PRODUCTION; DESMOSOME; ENTERITIS; ENTEROPATHY; EPITHELIUM; EPITHELIUM CELL; GAP JUNCTION; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL TRACT; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; INFLAMMATION; INTESTINE EPITHELIUM; LYMPHOCYTE; MICROORGANISM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SPLEEN; T LYMPHOCYTE; TH2 CELL;

ANIMALS; CYTOKINES; HUMANS; INTESTINAL MUCOSA; LYMPHOCYTE SUBSETS;

EID: 84885626972     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2012.0162     Document Type: Review

References (127)

1. Alattia JR, Kurokawa H, Ikura M. 1999. Structural view of cadherin-mediated cell-cell adhesion. Cell Mol Life Sci 55(3): 359-367. (Pubitemid 29178879)
2. Anderson JM, Fanning AS, Lapierre L, Van Itallie CM. 1995. Zonula occludens (ZO)-1 and ZO-2: membrane-associated guanylate kinase homologues (MAGuKs) of the tight junction. Biochem Soc Trans 23(3):470-475.
3. Ashida H, Ogawa M, Kim M, Mimuro H, Sasakawa C. 2012. Bacteria and host interactions in the gut epithelial barrier. Nat Chem Biol 8(1):36-45.
4. Baker K, Chong G, Foulkes WD, Jass JR. 2006. Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes. Histopathology 49(4):371-380. (Pubitemid 44401544)
5. Beatch M, Jesaitis LA, Gallin WJ, Goodenough DA, Stevenson BR. 1996. The tight junction protein ZO-2 contains three PDZ (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced region. J Biol Chem 271(42):25723-25726. (Pubitemid 26347394)
6. Beharka AA, Paiva S, Leka LS, Ribaya-Mercado JD, Russell RM, Nibkin Meydani S. 2001. Effect of age on the gastrointestinalassociated mucosal immune response of humans. J Gerontol A Biol Sci Med Sci 56(5):B218-B223. (Pubitemid 32381800)
7. Bek S, Kemler R. 2002. Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. J Cell Sci 115(Pt 24):4743-4753. (Pubitemid 36054629)
8. Bevins CL, Salzman NH. 2011. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 9(5):356-368.
9. Bonneville M, Janeway CA, Jr., Ito K, Haser W, Ishida I, Nakanishi N, Tonegawa S. 1988. Intestinal intraepithelial lymphocytes are a distinct set of gamma delta T cells. Nature 336(6198):479-481.
10. Bowie RV, Donatello S, Lyes C, Owens MB, Babina IS, Hudson L, Walsh SV, O'Donoghue DP, Amu S, Barry SP, Fallon PG, Hopkins AM. 2012. Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier. Am J Physiol Gastrointest Liver Physiol 302(8):G781-G793.
11. Brooke MA, Nitoiu D, Kelsell DP. 2012. Cell-cell connectivity: desmosomes and disease. J Pathol 226(2):158-171.
12. Bruewer M, Luegering A, Kucharzik T, Parkos CA, Madara JL, Hopkins AM, Nusrat A. 2003. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol 171(11):6164-6172. (Pubitemid 37467239)
13. Bruewer M, Utech M, Ivanov AI, Hopkins AM, Parkos CA, Nusrat A. 2005. Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J 19(8):923-933. (Pubitemid 40827713)
14. Cai Y, Wang W, Liang H, Sun L, Teitelbaum DH, Yang H. 2012a. Keratinocyte growth factor improves epithelial structure and function in a mouse model of intestinal ischemia/reperfusion. PLoS One 7(9):e44772.
15. Cai YJ, Wang WS, Liang HY, Sun LH, Teitelbaum DH, Yang H. 2012b. Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo. Int J Clin Exp Pathol 5(6):569-580.
16. Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, Rimm DL, Brenner MB. 1994. Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature 372(6502):190-193.
17. Chen HQ, Yang J, Zhang M, Zhou YK, Shen TY, Chu ZX, Hang XM, Jiang YQ, Qin HL. 2010. Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout mice. Am J Physiol Gastrointest Liver Physiol 299(6):G1287-G1297.
18. Chen Y, Chou K, Fuchs E, Havran WL, Boismenu R. 2002. Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci USA 99(22):14338-14343. (Pubitemid 35257673)
19. Cheroutre H, Lambolez F. 2008. Doubting the TCR coreceptor function of CD8alphaalpha. Immunity 28(2):149-159. (Pubitemid 351215236)
20. Cheroutre H, Lambolez F, Mucida D. 2011. The light and dark sides of intestinal intraepithelial lymphocytes. Nat Rev Immunol 11(7):445-456.
21. Cummins PM. 2012. Occludin: one protein, many forms. Mol Cell Biol 32(2):242-250.
22. Denning TL, Granger SW, Mucida D, Graddy R, Leclercq G, Zhang W, Honey K, Rasmussen JP, Cheroutre H, Rudensky AY, KronenbergM. 2007. Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. J Immunol 178(7):4230-4239. (Pubitemid 46492373)
23. Dharmani P, Leung P, Chadee K. 2011. Tumor necrosis factoralpha and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis. PLoS One 6(9):e25058.
24. Di Leo V, Yang PC, Berin MC, Perdue MH. 2002. Factors regulating the effect of IL-4 on intestinal epithelial barrier function. Int Arch Allergy Immunol 129(3):219-227. (Pubitemid 35365362)
25. Ebert EC. 1998. Tumour necrosis factor-alpha enhances intraepithelial lymphocyte proliferation and migration. Gut 42(5):650-655. (Pubitemid 28261050)
26. Ebert EC. 1999. Inhibitory effects of transforming growth factorbeta (TGF-beta) on certain functions of intraepithelial lymphocytes. Clin Exp Immunol 115(3):415-420. (Pubitemid 29130354)
27. Ebert EC. 2005. IL-15 converts human intestinal intraepithelial lymphocytes to CD94 producers of IFN-gamma and IL-10, the latter promoting Fas ligand-mediated cytotoxicity. Immunology 115(1):118-126. (Pubitemid 40593298)
28. Ebert EC, Mehta V. 2006. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell Immunol 241(1): 7-13. (Pubitemid 44441163)
29. Ebert EC, Panja A, Praveen R. 2009. Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction. Am J Physiol Gastrointest Liver Physiol 296(3):G671-G677.
30. Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. 2012. Dynamic migration of gammadelta intraepithelial lymphocytes requires occludin. Proc Natl Acad Sci USA 109(18): 7097-7102.
31. Fernandez-Estivariz C, Gu LH, Gu L, Jonas CR, Wallace TM, Pascal RR, Devaney KL, Farrell CL, Jones DP, Podolsky DK, Ziegler TR. 2003. Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting-refeeding. Am J Physiol Regul Integr Comp Physiol 284(2):R564-R573. (Pubitemid 36120176)
32. Ferrier L, Mazelin L, Cenac N, Desreumaux P, Janin A, Emilie D, Colombel JF, Garcia-Villar R, Fioramonti J, Bueno L. 2003. Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice. Gastroenterology 125(3):795-804. (Pubitemid 37070697)
33. Fidan I, Kalkanci A, Yesilyurt E, Yalcin B, Erdal B, Kustimur S, Imir T. 2009. Effects of Saccharomyces boulardii on cytokine secretion from intraepithelial lymphocytes infected by Escherichia coli and Candida albicans. Mycoses 52(1):29-34.
34. Forsberg G, Hernell O, Hammarstrom S, Hammarstrom ML. 2007. Concomitant increase of IL-10 and pro-inflammatory cytokines in intraepithelial lymphocyte subsets in celiac disease. Int Immunol 19(8):993-1001. (Pubitemid 47386924)
35. Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S. 1993. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 123(6 Pt 2):1777-1788. (Pubitemid 24012933)
36. Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M. 2009. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15(2):103-113.
37. Grunwald GB. 1993. The structural and functional analysis of cadherin calcium-dependent cell adhesion molecules. Curr Opin Cell Biol 5(5):797-805.
38. Gumbiner BM. 1996. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 84(3):345-357. (Pubitemid 26058560)
39. Guy-Grand D, Cuenod-Jabri B, Malassis-Seris M, Selz F, Vassalli P. 1996. Complexity of the mouse gut T cell immune system: identification of two distinct natural killer T cell intraepithelial lineages. Eur J Immunol 26(9):2248-2256. (Pubitemid 26297529)
40. Guy-Grand D, DiSanto JP, Henchoz P, Malassis-Seris M, Vassalli P. 1998. Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal. Eur J Immunol 28(2):730-744. (Pubitemid 28101750)
41. Hansson GC, Johansson ME. 2010. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Gut Microbes 1(1):51-54.
42. Haskins J, Gu L, Wittchen ES, Hibbard J, Stevenson BR. 1998. ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. J Cell Biol 141(1):199-208. (Pubitemid 28182652)
43. Hasnain SZ, Tauro S, Das I, Tong H, Chen AC, Jeffery PL, McDonald V, Florin TH, McGuckin MA. 2012. IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology pii:S0016-5085(12):01601-0.
44. Hayday A, Theodoridis E, Ramsburg E, Shires J. 2001. Intraepithelial lymphocytes: exploring the Third Way in immunology. Nat Immunol 2(11):997-1003. (Pubitemid 33069493)
45. Hering NA, Andres S, Fromm A, van Tol EA, Amasheh M, Mankertz J, Fromm M, Schulzke JD. 2011. Transforming growth factor-beta, a whey protein component, strengthens the intestinal barrier by upregulating claudin-4 in HT-29/B6 cells. J Nutr 141(5):783-789.
46. Hooper LV, Macpherson AJ. 2010. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol 10(3):159-169.
47. Inagaki-Ohara K, Chinen T, Matsuzaki G, Sasaki A, Sakamoto Y, Hiromatsu K, Nakamura-Uchiyama F, Nawa Y, Yoshimura A. 2004. Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation. J Immunol 173(2):1390-1398. (Pubitemid 38924320)
48. Inagaki-Ohara K, Dewi FN, Hisaeda H, Smith AL, Jimi F, Miyahira M, Abdel-Aleem AS, Horii Y, Nawa Y. 2006. Intestinal intraepithelial lymphocytes sustain the epithelial barrier function against Eimeria vermiformis infection. Infect Immun 74(9):5292-5301. (Pubitemid 44300448)
49. Itoh M, Nagafuchi A, Yonemura S, Kitani-Yasuda T, Tsukita S. 1993. The 220-kD protein colocalizing with cadherins in nonepithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J Cell Biol 121(3):491-502. (Pubitemid 23131262)
50. Kanoh A, Takeuchi H, Kato K, Waki M, Usami K, Irimura T. 2008. Interleukin-4 induces specific pp-GalNAc-T expression and alterations in mucin O-glycosylation in colonic epithelial cells. Biochim Biophys Acta 1780(3):577-584. (Pubitemid 351395303)
51. Katsuno T, Umeda K, Matsui T, Hata M, Tamura A, Itoh M, Takeuchi K, Fujimori T, Nabeshima Y, Noda T, Tsukita S. 2008. Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells.Mol Biol Cell 19(6):2465-2475.
52. Kim YS, Ho SB. 2010. Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr Gastroenterol Rep 12(5):319-330.
53. Kimizuka K, Nakao A, Nalesnik MA, Demetris AJ, Uchiyama T, Ruppert K, Fink MP, Stolz DB, Murase N. 2004. Exogenous IL-6 inhibits acute inflammatory responses and prevents ischemia/reperfusion injury after intestinal transplantation. Am J Transplant 4(4):482-494. (Pubitemid 38523571)
54. Kinugasa T, Sakaguchi T, Gu X, Reinecker HC. 2000. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 118(6):1001-1011. (Pubitemid 30346975)
55. Klein JR. 1986. Ontogeny of the Thy-1-, Lyt-2 + murine intestinal intraepithelial lymphocyte. Characterization of a unique population of thymus-independent cytotoxic effector cells in the intestinal mucosa. J Exp Med 164(1):309-314. (Pubitemid 16069241)
56. Kolkowski EC, Fernandez MA, Pujol-Borrell R, Jaraquemada D. 2006. Human intestinal alphabeta IEL clones in celiac disease show reduced IL-10 synthesis and enhanced IL-2 production. Cell Immunol 244(1):1-9. (Pubitemid 46659713)
57. Kunisawa J, Takahashi I, Kiyono H. 2007. Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine. Immunol Rev 215: 136-153. (Pubitemid 46212236)
58. Lee WY, Hu YM, Ko TL, Yeh SL, Yeh CL. 2012. Glutamine modulates sepsis-induced changes to intestinal intraepithelial gammadeltaT lymphocyte expression in mice. Shock 38(3): 288-293.
59. Lefrancois L. 1991. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J Immunol 147(6):1746-1751.
60. Lim SP, Leung E, Krissansen GW. 1998. The beta7 integrin gene (Itgb-7) promoter is responsive to TGF-beta1: defining control regions. Immunogenetics 48(3):184-195. (Pubitemid 28352184)
61. Lugering N, Kucharzik T, Kraft M, Winde G, Sorg C, Stoll R, Domschke W. 1999. Interleukin (IL)-13 and IL-4 are potent inhibitors of IL-8 secretion by human intestinal epithelial cells. Dig Dis Sci 44(3):649-655. (Pubitemid 29137981)
62. Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P. 2008. The immune geography of IgA induction and function. Mucosal Immunol 1(1):11-22.
63. Marques R, Boneca IG. 2011. Expression and functional importance of innate immune receptors by intestinal epithelial cells. Cell Mol Life Sci 68(22):3661-3673.
64. McGuckin MA, Linden SK, Sutton P, Florin TH. 2011. Mucin dynamics and enteric pathogens. Nat Rev Microbiol 9(4):265-278.
65. McKaig BC, Makh SS, Hawkey CJ, Podolsky DK, Mahida YR. 1999. Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-beta3. Am J Physiol 276(5 Pt 1):G1087-G1093. (Pubitemid 29251906)
66. McKay DM, Watson JL, Wang A, Caldwell J, Prescott D, Ceponis PM, Di Leo V, Lu J. 2007. Phosphatidylinositol 3¢-kinase is a critical mediator of interferon-gamma-induced increases in enteric epithelial permeability. J Pharmacol Exp Ther 320(3):1013-1022. (Pubitemid 46294056)
67. Merger M, Viney JL, Borojevic R, Steele-Norwood D, Zhou P, Clark DA, Riddell R, Maric R, Podack ER, Croitoru K. 2002. Defining the roles of perforin, Fas/FasL, and tumour necrosis factor alpha in T cell induced mucosal damage in the mouse intestine. Gut 51(2):155-163. (Pubitemid 34791439)
68. Mochizuki T, Satsu H, Totsuka M, Shimizu M. 2009. Transepithelial transport of macromolecular substances in IL-4 treated human intestinal T84 cell monolayers. Biosci Biotechnol Biochem 73(11):2422-2426.
69. Monteleone I, Sarra M, Del Vecchio Blanco G, Paoluzi OA, Franze E, Fina D, Fabrizi A, MacDonald TT, Pallone F, Monteleone G. 2010. Characterization of IL-17A-producing cells in celiac disease mucosa. J Immunol 184(4):2211-2218.
70. Montufar-Solis D, Garza T, Klein JR. 2005. Selective upregulation of immune regulatory and effector cytokine synthesis by intestinal intraepithelial lymphocytes following CD43 costimulation. Biochem Biophys Res Commun 338(2):1158-1163. (Pubitemid 41597758)
71. Montufar-Solis D, Garza T, Klein JR. 2007. T-cell activation in the intestinal mucosa. Immunol Rev 215:189-201. (Pubitemid 46212240)
72. Nussler NC, O'Brien J, Stange B, Platz KP, Neuhaus P, Muller AR. 2000. IL-2 promotes the subset restoration of in-traepithelial lymphocytes after ischemia/reperfusion injury. Transplant Proc 32(6):1305-1306.
73. Ohteki T, MacDonald HR. 1993. Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness. Eur J Immunol 23(6):1251-1255. (Pubitemid 23165686)
74. Park SG, Mathur R, Long M, Hosh N, Hao L, Hayden MS, Ghosh S. 2010. T regulatory cells maintain intestinal homeostasis by suppressing gammadelta T cells. Immunity 33(5): 791-803.
75. Perez-Moreno M, Fuchs E. 2006. Catenins: keeping cells from getting their signals crossed. Dev Cell 11(5):601-612. (Pubitemid 44644972)
76. Popoff MR, Geny B. 2009. Multifaceted role of Rho, Rac, Cdc42 and Ras in intercellular junctions, lessons from toxins. Biochim Biophys Acta 1788(4):797-812.
77. Potten CS, O'Shea JA, Farrell CL, Rex K, Booth C. 2001. The effects of repeated doses of keratinocyte growth factor on cell proliferation in the cellular hierarchy of the crypts of the murine small intestine. Cell Growth Differ 12(5):265-275. (Pubitemid 32678229)
78. Rao R. 2009. Occludin phosphorylation in regulation of epithelial tight junctions. Ann N Y Acad Sci 1165:62-68.
79. Rao RK, Basuroy S, Rao VU, Karnaky Jr KJ, Gupta A. 2002. Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress. Biochem J 368(Pt 2):471-481. (Pubitemid 35454525)
80. Reynolds JM, Martinez GJ, Nallaparaju KC, Chang SH, Wang YH, Dong C. 2012. Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C. J Immunol 189(9): 4226-4230.
81. Rollwagen FM, Madhavan S, Singh A, Li YY, Wolcott K, Maheshwari R. 2006. IL-6 protects enterocytes from hypoxiainduced apoptosis by induction of bcl-2 mRNA and reduction of fas mRNA. Biochem Biophys Res Commun 347(4):1094-1098. (Pubitemid 44118226)
82. Saitou M, Furuse M, Sasaki H, Schulzke JD, Fromm M, Takano H, Noda T, Tsukita S. 2000. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell 11(12):4131-4142.
83. Sakakibara A, Furuse M, Saitou M, Ando-Akatsuka Y, Tsukita S. 1997. Possible involvement of phosphorylation of occludin in tight junction formation. J Cell Biol 137(6):1393-1401. (Pubitemid 27265950)
84. Saurer L, Mueller C. 2009. T cell-mediated immunoregulation in the gastrointestinal tract. Allergy 64(4):505-519.
85. Schmit A, Van Gossum A, Carol M, Houben JJ, Mascart F. 2000. Diversion of intestinal flow decreases the numbers of interleukin 4 secreting and interferon gamma secreting T lymphocytes in small bowel mucosa. Gut 46(1):40-45. (Pubitemid 30307675)
86. Seth A, Sheth P, Elias BC, Rao R. 2007. Protein phosphatases 2A and 1 interact with occludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayer. J Biol Chem 282(15):11487-11498. (Pubitemid 47100808)
87. Shapiro L, Weis WI. 2009. Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol 1(3): a003053.
88. Shen L. 2012. Tight junctions on the move: molecular mechanisms for epithelial barrier regulation. Ann N Y Acad Sci 1258: 9-18.
89. Shires J, Theodoridis E, Hayday AC. 2001. Biological insights into TCRgammadelta + and TCRalphabeta + intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity 15(3):419-434. (Pubitemid 32907389)
90. Smyth D, Leung G, Fernando M, McKay DM. 2012. Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent. PLoS One 7(6): e38441.
91. Sperber K, Silverstein L, Brusco C, Yoon C, Mullin GE, Mayer L. 1995. Cytokine secretion induced by superantigens in peripheral blood mononuclear cells, lamina propria lymphocytes, and intraepithelial lymphocytes. Clin Diagn Lab Immunol 2(4):473-477.
92. Sun X, Yang H, Nose K, Nose S, Haxhija EQ, Koga H, Feng Y, Teitelbaum DH. 2008. Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 294(1):G139-G147. (Pubitemid 351164859)
93. Sund M, Xu LL, Rahman A, Qian BF, Hammarstrom ML, Danielsson A. 2005. Reduced susceptibility to dextran sulphate sodium-induced colitis in the interleukin-2 heterozygous (IL-2) mouse. Immunology 114(4):554-564. (Pubitemid 40478149)
94. Suzuki M, Hisamatsu T, Podolsky DK. 2003. Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex. Infect Immun 71(6):3503-3511. (Pubitemid 36637579)
95. Suzuki T, Yoshinaga N, Tanabe S. 2011. Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem 286(36):31263-31271.
96. Sveinbjornsson B, Rushfeldt C, Olsen R, Smedsrod B, Seljelid R. 1997. Cytotoxic effect of cytokines on murine colon carcinoma cells involves TNF-mediated apoptosis. Biochem Biophys Res Commun 233(1):270-275. (Pubitemid 27215949)
97. Takagaki K, Osawa S, Horio Y, Yamada T, Hamaya Y, Takayanagi Y, Furuta T, Hishida A, Ikuma M. 2009. Cytokine responses of intraepithelial lymphocytes are regulated by histamine H(2) receptor. J Gastroenterol 44(4):285-296.
98. Takayanagi Y, Osawa S, Ikuma M, Takagaki K, Zhang J, Hamaya Y, Yamada T, Sugimoto M, Furuta T, Miyajima H, Sugimoto K. 2012. Norepinephrine suppresses IFN-gamma and TNF-alpha production by murine intestinal intraepithelial lymphocytes via the beta(1) adrenoceptor. J Neuroimmunol 245(1-2):66-74.
99. Ten Elshof AE, Brittenham GM, Chorney KA, Page MJ, Gerhard G, Cable EE, Chorney MJ. 1999. Gamma delta intraepithelial lymphocytes drive tumor necrosis factor-alpha responsiveness to intestinal iron challenge: relevance to hemochromatosis. Immunol Rev 167:223-232. (Pubitemid 29178984)
100. Thomason HA, Scothern A, McHarg S, Garrod DR. 2010. Desmosomes: adhesive strength and signalling in health and disease. Biochem J 429(3):419-433.
101. Unger BL, McGee DW. 2011. Hepatocyte growth factor and keratinocyte growth factor enhance IL-1-induced IL-8 secretion through different mechanisms in Caco-2 epithelial cells. In Vitro Cell Dev Biol Anim 47(2):173-181.
102. Van Houten N,Mixter PF, Wolfe J, Budd RC. 1993. CD2 expression on murine intestinal intraepithelial lymphocytes is bimodal and defines proliferative capacity. Int Immunol 5(6):665-672. (Pubitemid 23209421)
103. Van Itallie CM, Anderson JM. 2006. Claudins and epithelial paracellular transport. Annu Rev Physiol 68:403-429.
104. Viney JL, Kilshaw PJ, MacDonald TT. 1990. Cytotoxic alpha/beta + and gamma/delta + T cells in murine intestinal epithelium. Eur J Immunol 20(7):1623-1626. (Pubitemid 20233804)
105. Wang J, Zhang H, Ma H, Lu B, Li Y, Li J. 2008. Inhibitory effect of dietary n-3 polyunsaturated fatty acids to intestinal IL-15 expression is associated with reduction of TCRalphabeta + CD8alpha + CD8beta-intestinal intraepithelial lymphocytes. J Nutr Biochem 19(7):475-481. (Pubitemid 351783408)
106. Wang L, Walia B, Evans J, Gewirtz AT, Merlin D, Sitaraman SV. 2003. IL-6 induces NF-kappa B activation in the intestinal epithelia. J Immunol 171(6):3194-3201. (Pubitemid 37093545)
107. Wang T, Alam R, Langley KE, Klimpel GR. 2000. Stem cell factor and IL-2 act synergistically in inducing intraepithelial lymphocyte proliferation and cytokine production: upregulation of the IL-2 receptor gamma-chain and signaling via JAK-3. Cell Immunol 205(1):62-71.
108. Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. 2010. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem 285(16):12037-12046.
109. Wheelock MJ, Jensen PJ. 1992. Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherin. J Cell Biol 117(2):415-425.
110. Wildhaber BE, Yang H, Haxhija EQ, Spencer AU, Teitelbaum DH. 2005a. Intestinal intraepithelial lymphocyte derived angiotensin converting enzyme modulates epithelial cell apoptosis. Apoptosis 10(6):1305-1315. (Pubitemid 43118372)
111. Wildhaber BE, Yang H, Spencer AU, Drongowski RA, Teitelbaum DH. 2005b. Lack of enteral nutrition-effects on the intestinal immune system. J Surg Res 123(1):8-16. (Pubitemid 40094639)
112. Wildhaber BE, Yang H, Teitelbaum DH. 2003. Total parenteral nutrition-induced apoptosis in mouse intestinal epithelium: modulation by keratinocyte growth factor. J Surg Res 112(2): 144-151. (Pubitemid 36904039)
113. Wisner DM, Harris LR, 3rd, Green CL, Poritz LS. 2008. Opposing regulation of the tight junction protein claudin-2 by interferon-gamma and interleukin-4. J Surg Res 144(1):1-7. (Pubitemid 350234959)
114. Wyatt CR, Barrett WJ, Brackett EJ, Schaefer DA, Riggs MW. 2002. Association of IL-10 expression by mucosal lymphocytes with increased expression of Cryptosporidium parvum epitopes in infected epithelium. J Parasitol 88(2):281-286. (Pubitemid 34493393)
115. Xu J, Kausalya PJ, Phua DC, Ali SM, Hossain Z, Hunziker W. 2008. Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development. Mol Cell Biol 28(5):1669-1678.
116. Yamada K, Kimura Y, Nishimura H, Namii Y, Murase M, Yoshikai Y. 1999. Characterization of CD4+ CD8alphaalpha + and CD4-CD8alphaalpha + intestinal intraepithelial lymphocytes in rats. Int Immunol 11(1):21-28. (Pubitemid 29037585)
117. Yang H, Antony PA, Wildhaber BE, Teitelbaum DH. 2004. Intestinal intraepithelial lymphocyte gamma delta-T cellderived keratinocyte growth factor modulates epithelial growth in the mouse. J Immunol 172(7):4151-4158. (Pubitemid 38375227)
118. Yang H, Fan Y, Teitelbaum DH. 2003. Intraepithelial lymphocyte-derived interferon-gamma evokes enterocyte apoptosis with parenteral nutrition in mice. Am J Physiol Gastrointest Liver Physiol 284(4):G629-G637. (Pubitemid 36343212)
119. Yang H, Kiristioglu I, Fan Y, Forbush B, Bishop DK, Antony PA, Zhou H, Teitelbaum DH. 2002. Interferon-gamma expression by intraepithelial lymphocytes results in a loss of epithelial barrier function in a mouse model of total parenteral nutrition. Ann Surg 236(2):226-234. (Pubitemid 34809542)
120. Yang H, Spencer AU, Teitelbaum DH. 2005. Interleukin-7 administration alters intestinal intraepithelial lymphocyte phenotype and function in vivo. Cytokine 31(6):419-428. (Pubitemid 41242766)
121. Yap AS, Crampton MS, Hardin J. 2007. Making and breaking contacts: the cellular biology of cadherin regulation. Curr Opin Cell Biol 19(5):508-514. (Pubitemid 350016859)
122. Ye D, Ma I, Ma TY. 2006. Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol 290(3):G496-G504.
123. Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B, Kleinschek MA, Owyang A, Mattson J, Blumenschein W, Murphy E, Sathe M, Cua DJ, Kastelein RA, Rennick D. 2006. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116(5):1310-1316.
124. Youakim A, Ahdieh M. 1999. Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Am J Physiol 276(5 Pt 1):G1279-G1288. (Pubitemid 29251928)
125. Yu S, Bruce D, Froicu M, Weaver V, Cantorna MT. 2008. Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice. Proc Natl Acad Sci USA 105(52):20834-20839.
126. Zeissig S, Burgel N, Gunzel D, Richter J, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD. 2007. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56(1):61-72. (Pubitemid 46044890)
127. Zufferey C, Erhart D, Saurer L, Mueller C. 2009. Production of interferon-gamma by activated T-cell receptor-alphabeta CD8alphabeta intestinal intraepithelial lymphocytes is required and sufficient for disruption of the intestinal barrier integrity. Immunology 128(3):351-359.