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Volumn 1313, Issue , 2015, Pages 21-40

Fusion in cancer: An explanatory model for aneuploidy, metastasis formation, and drug resistance

Author keywords

Aneuploidy; Cancer; Cell fusion; Drug resistance; Hybrid cells; Inflammation; Metastasis

Indexed keywords

ANEUPLOIDY; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER RESISTANCE; CELL FATE; CELL FUSION; CHRONIC INFLAMMATION; HUMAN; METASTASIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; VIRUS INFECTION; CANCER STEM CELL; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; HYBRID CELL; INFLAMMATION; METABOLISM; NEOPLASMS; PATHOLOGY;

EID: 84929008072     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-2703-6_2     Document Type: Article
Times cited : (22)

References (140)
  • 3
    • 79960927324 scopus 로고    scopus 로고
    • The fusion between the oocyte and the perm
    • Dittmar T, Zanker KS (2011) The fusion between the oocyte and the perm. Adv Exp Med Biol 713:1
    • (2011) Adv Exp Med Biol , vol.713 , pp. 1
    • Dittmar, T.1    Zanker, K.S.2
  • 4
    • 0026320514 scopus 로고
    • The evolution of placental mammals
    • Harris JR (1991) The evolution of placental mammals. FEBS Lett 295:3
    • (1991) FEBS Lett , vol.295 , pp. 3
    • Harris, J.R.1
  • 5
    • 84928985606 scopus 로고    scopus 로고
    • Cell fusion in health and disease
    • 161–175
    • Dittmar T, Zaenker KS (eds) (2011) Cell fusion in health and disease, vol 1. Cell fusion in health, Springer Netherlands 161–175 p 189
    • (2011) Springer Netherlands , vol.1 , pp. 189
    • Dittmar, T.1    Zaenker, K.S.2
  • 6
    • 8844287588 scopus 로고    scopus 로고
    • Syncytin: The major regulator of trophoblast fusion? Recent developments and hypotheses on its action
    • Potgens AJ, Drewlo S, Kokozidou M, Kaufmann P (2004) Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its action. Hum Reprod Update 10:487
    • (2004) Hum Reprod Update , vol.10 , pp. 487
    • Potgens, A.J.1    Drewlo, S.2    Kokozidou, M.3    Kaufmann, P.4
  • 7
  • 8
    • 0342737671 scopus 로고
    • Über Zellverschmelzung mit quantitativ abnormer Chromosomenvert-eilung als Ursache der Geschwulstbildung
    • In: Roux W, Wilhelm Engelmann, Leipzig, Germany
    • Aichel O (1911) Über Zellverschmelzung mit quantitativ abnormer Chromosomenvert-eilung als Ursache der Geschwulstbildung. In: Roux W (ed) Vorträge und Aufsätze über Entwicklungsmechanik der Organismen. Wilhelm Engelmann, Leipzig, Germany, pp 1–115
    • (1911) Vorträge Und Aufsätze über Entwicklungsmechanik Der Organismen , pp. 1-115
    • Aichel, O.1
  • 9
    • 0000306454 scopus 로고    scopus 로고
    • Cornefert F (1961) “Hybrid” type cells in combined cultures of two different mammalian cell strains
    • Barski G, Sorieul S, Cornefert F (1961) “Hybrid” type cells in combined cultures of two different mammalian cell strains. J Natl Cancer Inst 26:1269
    • J Natl Cancer Inst , vol.26 , pp. 1269
    • Barski, G.1    Sorieul, S.2
  • 10
    • 0000258464 scopus 로고
    • Characteristics of “hybrid”-type clonal cell lines obtained from mixed cultures in vitro
    • Barski G, Cornefert F (1962) Characteristics of “hybrid”-type clonal cell lines obtained from mixed cultures in vitro. J Natl Cancer Inst 28:801
    • (1962) J Natl Cancer Inst , vol.28 , pp. 801
    • Barski, G.1    Cornefert, F.2
  • 11
    • 84873772990 scopus 로고
    • Cornefert F (1960) [Production of cells of a “hybrid” nature in cultures in vitro of 2 cellular strains in combination]
    • Barski G, Sorieul S, Cornefert F (1960) [Production of cells of a “hybrid” nature in cultures in vitro of 2 cellular strains in combination]. C R Hebd Seances Acad Sci 251:1825
    • (1825) C R Hebd Seances Acad Sci , pp. 251
    • Barski, G.1    Sorieul, S.2
  • 12
    • 0014336985 scopus 로고
    • On the ‘human’ nature of highly malignant hetero-transplantable tumors of human origin
    • Götz H, Goldenberg DM (1968) On the ‘human’ nature of highly malignant hetero-transplantable tumors of human origin. Eur J Cancer 4(5):547
    • (1968) Eur J Cancer , vol.4 , Issue.5 , pp. 547
    • Götz, H.1    Goldenberg, D.M.2
  • 13
    • 0014418006 scopus 로고
    • Antigenic characterization of a heterotransplanted human tumour, GW-127
    • Goldenberg DM, Götz H (1968) Antigenic characterization of a heterotransplanted human tumour, GW-127. Experientia 24(9): 957
    • (1968) Experientia , vol.24 , Issue.9 , pp. 957
    • Goldenberg, D.M.1    Götz, H.2
  • 14
    • 0014993802 scopus 로고
    • [Transformation of a normal differentiated cell of an adult organism, induced by the fusion of this cell with another normal cell of the same organism but with different organ or tissue specifi city]
    • Mekler LB, Drize OB, Osechinskii IV, Shliankevich MA (1971) [Transformation of a normal differentiated cell of an adult organism, induced by the fusion of this cell with another normal cell of the same organism but with different organ or tissue specifi city]. Vestn Akad Med Nauk SSSR 26:75
    • (1971) Vestn Akad Med Nauk SSSR , vol.26 , pp. 75
    • Mekler, L.B.1    Drize, O.B.2    Osechinskii, I.V.3    Shliankevich, M.A.4
  • 16
    • 0031860327 scopus 로고    scopus 로고
    • Melanoma x mac-rophage hybrids with enhanced metastatic potential
    • Rachkovsky M et al (1998) Melanoma x mac-rophage hybrids with enhanced metastatic potential. Clin Exp Metastasis 16:299
    • (1998) Clin Exp Metastasis , vol.16 , pp. 299
    • Rachkovsky, M.1
  • 17
    • 84861420078 scopus 로고    scopus 로고
    • Horizontal transmission of malignancy by cell-cell fusion
    • Goldenberg DM (2012) Horizontal transmission of malignancy by cell-cell fusion. Expert Opin Biol Ther 12(Suppl 1):S133
    • (2012) Expert Opin Biol Ther , vol.12 , pp. S133
    • Goldenberg, D.M.1
  • 18
    • 0342545919 scopus 로고    scopus 로고
    • Syncytin is a captive retrovi-ral envelope protein involved in human pla-cental morphogenesis
    • Mi S et al (2000) Syncytin is a captive retrovi-ral envelope protein involved in human pla-cental morphogenesis. Nature 403:785
    • (2000) Nature , vol.403 , pp. 785
    • Mi, S.1
  • 19
    • 84904739987 scopus 로고    scopus 로고
    • Syncytin-1 in differentiating human myoblasts: Relationship to caveo-lin- 3 and myogenin
    • Bjerregard B, Ziomkiewicz I, Schulz A, Larsson LI (2014) Syncytin-1 in differentiating human myoblasts: relationship to caveo-lin- 3 and myogenin. Cell Tissue Res 357(1): 355–362
    • (2014) Cell Tissue Res , vol.357 , Issue.1 , pp. 355-362
    • Bjerregard, B.1    Ziomkiewicz, I.2    Schulz, A.3    Larsson, L.I.4
  • 20
    • 79952702740 scopus 로고    scopus 로고
    • Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion
    • Soe K et al (2011) Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion. Bone 48:837
    • (2011) Bone , vol.48 , pp. 837
    • Soe, K.1
  • 22
    • 33751506588 scopus 로고    scopus 로고
    • Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction
    • Lundberg P et al (2007) Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction. Biochem Biophys Res Commun 352:444
    • (2007) Biochem Biophys Res Commun , vol.352 , pp. 444
    • Lundberg, P.1
  • 23
    • 5444229284 scopus 로고    scopus 로고
    • RANKL-induced DC-STAMP is essential for osteoclastogene-sis
    • Kukita T et al (2004) RANKL-induced DC-STAMP is essential for osteoclastogene-sis. J Exp Med 200:941
    • (2004) J Exp Med , vol.200 , pp. 941
    • Kukita, T.1
  • 24
    • 57149130418 scopus 로고    scopus 로고
    • Gap junctional communication in human osteoclasts in vitro and in vivo
    • Schilling AF et al (2008) Gap junctional communication in human osteoclasts in vitro and in vivo. J Cell Mol Med 12:2497
    • (2008) J Cell Mol Med , vol.12 , pp. 2497
    • Schilling, A.F.1
  • 26
    • 84902361871 scopus 로고    scopus 로고
    • Osteoclast fusion is based on heterogeneity between fusion partners
    • Hobolt-Pedersen AS, Delaisse JM, Soe K (2014) Osteoclast fusion is based on heterogeneity between fusion partners. Calcif Tissue Int 95:73
    • (2014) Calcif Tissue Int , vol.95 , pp. 73
    • Hobolt-Pedersen, A.S.1    Delaisse, J.M.2    Soe, K.3
  • 27
    • 79960937293 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of mammalian cell fusion
    • Zhou X, Platt JL (2011) Molecular and cellular mechanisms of mammalian cell fusion. Adv Exp Med Biol 713:33
    • (2011) Adv Exp Med Biol , vol.713 , pp. 33
    • Zhou, X.1    Platt, J.L.2
  • 28
    • 40849119785 scopus 로고    scopus 로고
    • Myoblasts and macrophages share molecular components that contribute to cell-cell fusion
    • Pajcini KV, Pomerantz JH, Alkan O, Doyonnas R, Blau HM (2008) Myoblasts and macrophages share molecular components that contribute to cell-cell fusion. J Cell Biol 180:1005
    • (2008) J Cell Biol , vol.180 , pp. 1005
    • Pajcini, K.V.1    Pomerantz, J.H.2    Alkan, O.3    Doyonnas, R.4    Blau, H.M.5
  • 29
    • 68449085032 scopus 로고    scopus 로고
    • Inflammation and proliferation act together to mediate intestinal cell fusion
    • Davies PS, Powell AE, Swain JR, Wong MH (2009) Inflammation and proliferation act together to mediate intestinal cell fusion. PLoS One 4:e6530
    • (2009) Plos One , vol.4
    • Davies, P.S.1    Powell, A.E.2    Swain, J.R.3    Wong, M.H.4
  • 30
    • 43049100770 scopus 로고    scopus 로고
    • Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic Inflammation
    • Johansson CB et al (2008) Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic Inflammation. Nat Cell Biol 10:575
    • (2008) Nat Cell Biol , vol.10 , pp. 575
    • Johansson, C.B.1
  • 31
    • 43049091554 scopus 로고    scopus 로고
    • Myeloid and lym-phoid contribution to non-haematopoietic lineages through irradiation-induced hetero-typic cell fusion
    • Nygren JM et al (2008) Myeloid and lym-phoid contribution to non-haematopoietic lineages through irradiation-induced hetero-typic cell fusion. Nat Cell Biol 10:584
    • (2008) Nat Cell Biol , vol.10 , pp. 584
    • Nygren, J.M.1
  • 32
    • 0242584006 scopus 로고    scopus 로고
    • Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
    • Alvarez-Dolado M et al (2003) Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425:968
    • (2003) Nature , vol.425 , pp. 968
    • Alvarez-Dolado, M.1
  • 33
    • 85047690939 scopus 로고    scopus 로고
    • Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners
    • Camargo FD, Finegold M, Goodell MA (2004) Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. J Clin Invest 113:1266
    • (2004) J Clin Invest , vol.113 , pp. 1266
    • Camargo, F.D.1    Finegold, M.2    Goodell, M.A.3
  • 34
    • 0037464545 scopus 로고    scopus 로고
    • Transplanted bone marrow regenerates liver by cell fusion
    • Vassilopoulos G, Wang PR, Russell DW (2003) Transplanted bone marrow regenerates liver by cell fusion. Nature 422:901
    • (2003) Nature , vol.422 , pp. 901
    • Vassilopoulos, G.1    Wang, P.R.2    Russell, D.W.3
  • 35
    • 0037464574 scopus 로고    scopus 로고
    • Cell fusion is the principal source of bone-marrow-derived hepato-cytes
    • Wang X et al (2003) Cell fusion is the principal source of bone-marrow-derived hepato-cytes. Nature 422:897
    • (2003) Nature , vol.422 , pp. 897
    • Wang, X.1
  • 36
    • 3142734226 scopus 로고    scopus 로고
    • Myelomonocytic cells are suffi cient for therapeutic cell fusion in liver
    • Willenbring H et al (2004) Myelomonocytic cells are suffi cient for therapeutic cell fusion in liver. Nat Med 10:744
    • (2004) Nat Med , vol.10 , pp. 744
    • Willenbring, H.1
  • 37
    • 79955876154 scopus 로고    scopus 로고
    • Human bone marrow-derived stem cells acquire epithelial characteristics through fusion with gastrointestinal epithelial cells
    • Ferrand J et al (2011) Human bone marrow-derived stem cells acquire epithelial characteristics through fusion with gastrointestinal epithelial cells. PLoS One 6:e19569
    • (2011) Plos One , vol.6
    • Ferrand, J.1
  • 38
    • 26944431659 scopus 로고    scopus 로고
    • Proliferation of bone marrow-derived cells contributes to regeneration after folic acid-induced acute tubular injury
    • Fang TC et al (2005) Proliferation of bone marrow-derived cells contributes to regeneration after folic acid-induced acute tubular injury. J Am Soc Nephrol 16:1723
    • (2005) J am Soc Nephrol , vol.16 , pp. 1723
    • Fang, T.C.1
  • 39
    • 33746069082 scopus 로고    scopus 로고
    • In memoriam of Rudolf Virchow: A historical retrospective including aspects of Inflammation, infection and neoplasia
    • Schmidt A, Weber OF (2006) In memoriam of Rudolf Virchow: a historical retrospective including aspects of Inflammation, infection and neoplasia. Contrib Microbiol 13:1
    • (2006) Contrib Microbiol , vol.13 , pp. 1
    • Schmidt, A.1    Weber, O.F.2
  • 40
    • 79951825045 scopus 로고    scopus 로고
    • Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogram-ming
    • Powell AE et al (2011) Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogram-ming. Cancer Res 71:1497
    • (2011) Cancer Res , vol.71 , pp. 1497
    • Powell, A.E.1
  • 41
    • 33646556733 scopus 로고    scopus 로고
    • Bone marrow-derived cells fuse with normal and transformed intestinal stem cells
    • Rizvi AZ et al (2006) Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. Proc Natl Acad Sci U S A 103:6321
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 6321
    • Rizvi, A.Z.1
  • 42
    • 36448937162 scopus 로고    scopus 로고
    • Cell-to-cell fusion as a link between viruses and cancer
    • Duelli D, Lazebnik Y (2007) Cell-to-cell fusion as a link between viruses and cancer. Nat Rev Cancer 7:968
    • (2007) Nat Rev Cancer , vol.7 , pp. 968
    • Duelli, D.1    Lazebnik, Y.2
  • 45
    • 70349904854 scopus 로고    scopus 로고
    • The search for infectious causes of human cancers: Where and why (Nobel lecture)
    • zur Hausen H (2009) The search for infectious causes of human cancers: where and why (Nobel lecture). Angew Chem Int Ed Engl 48:5798
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 5798
    • Zur Hausen, H.1
  • 46
    • 47749155653 scopus 로고    scopus 로고
    • Cancer related Inflammation: The macrophage connection
    • Sica A, Allavena P, Mantovani A (2008) Cancer related Inflammation: the macrophage connection. Cancer Lett 267:204
    • (2008) Cancer Lett , vol.267 , pp. 204
    • Sica, A.1    Allavena, P.2    Mantovani, A.3
  • 47
    • 84864208657 scopus 로고    scopus 로고
    • Systems analysis of eleven rodent disease models reveals an infl ammatome signature and key drivers
    • Wang IM et al (2012) Systems analysis of eleven rodent disease models reveals an infl ammatome signature and key drivers. Mol Syst Biol 8:594
    • (2012) Mol Syst Biol , vol.8 , pp. 594
    • Wang, I.M.1
  • 48
  • 49
    • 0027600180 scopus 로고
    • The binucleate squa-mous cell: Histologic spectrum and relationship to low-grade squamous intraepithelial lesions
    • Prasad CJ, Sheets E, Selig AM, McArthur MC, Crum CP (1993) The binucleate squa-mous cell: histologic spectrum and relationship to low-grade squamous intraepithelial lesions. Mod Pathol 6(313)
    • (1993) Mod Pathol , vol.6 , Issue.313
    • Prasad, C.J.1    Sheets, E.2    Selig, A.M.3    McArthur, M.C.4    Crum, C.P.5
  • 50
    • 84861580867 scopus 로고    scopus 로고
    • Spontaneous formation of tumorigenic hybrids between breast cancer and multipo-tent stromal cells is a source of tumor heterogeneity
    • Rappa G, Mercapide J, Lorico A (2012) Spontaneous formation of tumorigenic hybrids between breast cancer and multipo-tent stromal cells is a source of tumor heterogeneity. Am J Pathol 180:2504
    • (2012) Am J Pathol , vol.180 , pp. 2504
    • Rappa, G.1    Mercapide, J.2    Lorico, A.3
  • 51
    • 79951673159 scopus 로고    scopus 로고
    • Characterization of hybrid cells derived from spontaneous fusion events between breast epithelial cells exhibiting stem-like characteristics and breast cancer cells
    • Dittmar T et al (2011) Characterization of hybrid cells derived from spontaneous fusion events between breast epithelial cells exhibiting stem-like characteristics and breast cancer cells. Clin Exp Metastasis 28:75
    • (2011) Clin Exp Metastasis , vol.28 , pp. 75
    • Dittmar, T.1
  • 52
    • 5444266827 scopus 로고    scopus 로고
    • Infectious agents and cancer: Criteria for a causal relation
    • Pagano JS et al (2004) Infectious agents and cancer: criteria for a causal relation. Semin Cancer Biol 14:453
    • (2004) Semin Cancer Biol , vol.14 , pp. 453
    • Pagano, J.S.1
  • 53
    • 0141645604 scopus 로고    scopus 로고
    • Co-overexpression of p53 and bcl-2 proteins in HPV-induced squamous cell carcinoma of the uterine cervix
    • Grace VM, Shalini JV, Lekha TT, Devaraj SN, Devaraj H (2003) Co-overexpression of p53 and bcl-2 proteins in HPV-induced squamous cell carcinoma of the uterine cervix. Gynecol Oncol 91(51)
    • (2003) Gynecol Oncol , vol.91 , Issue.51
    • Grace, V.M.1    Shalini, J.V.2    Lekha, T.T.3    Devaraj, S.N.4    Devaraj, H.5
  • 54
    • 7044271111 scopus 로고    scopus 로고
    • Chromosomal aberrations accumulate in polyploid cells of high-grade squamous intraepithelial lesions (HSIL)
    • Mehes G, Speich N, Bollmann M, Bollmann R (2004) Chromosomal aberrations accumulate in polyploid cells of high-grade squamous intraepithelial lesions (HSIL). Pathol Oncol Res 10:142
    • (2004) Pathol Oncol Res , vol.10 , pp. 142
    • Mehes, G.1    Speich, N.2    Bollmann, M.3    Bollmann, R.4
  • 55
    • 84860223175 scopus 로고    scopus 로고
    • Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo
    • Goldenberg DM et al (2012) Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo. Int J Cancer 131:49
    • (2012) Int J Cancer , vol.131 , pp. 49
    • Goldenberg, D.M.1
  • 56
    • 84882696526 scopus 로고    scopus 로고
    • Lentiviral gene transfer of TCIRG1 into peripheral blood CD34(+) cells restores osteoclast function in infantile malignant osteopetrosis
    • Moscatelli I et al (2013) Lentiviral gene transfer of TCIRG1 into peripheral blood CD34(+) cells restores osteoclast function in infantile malignant osteopetrosis. Bone 57:1
    • (2013) Bone , vol.57 , pp. 1
    • Moscatelli, I.1
  • 57
    • 0030825508 scopus 로고    scopus 로고
    • Chromosomal imbalance maps of malignant solid tumors: A cytogenetic survey of 3185 neoplasms
    • Mertens F, Johansson B, Hoglund M, Mitelman F (1997) Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms. Cancer Res 57:2765
    • (1997) Cancer Res , vol.57 , pp. 2765
    • Mertens, F.1    Johansson, B.2    Hoglund, M.3    Mitelman, F.4
  • 58
    • 0842320021 scopus 로고    scopus 로고
    • Cell fusion: A hidden enemy?
    • Duelli D, Lazebnik Y (2003) Cell fusion: a hidden enemy? Cancer Cell 3:445
    • (2003) Cancer Cell , vol.3 , pp. 445
    • Duelli, D.1    Lazebnik, Y.2
  • 60
    • 59349098193 scopus 로고    scopus 로고
    • The consequences of tetraploidy and aneuploidy
    • Storchova Z, Kuffer C (2008) The consequences of tetraploidy and aneuploidy. J Cell Sci 121:3859
    • (2008) J Cell Sci , vol.121 , pp. 3859
    • Storchova, Z.1    Kuffer, C.2
  • 61
    • 84864540104 scopus 로고    scopus 로고
    • Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells
    • Lv L et al (2012) Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells. Cell Cycle 11:2864
    • (2012) Cell Cycle , vol.11 , pp. 2864
    • Lv, L.1
  • 62
    • 80051766304 scopus 로고    scopus 로고
    • Illicit survival of cancer cells during polyploidization and depoly-ploidization
    • Vitale I et al (2011) Illicit survival of cancer cells during polyploidization and depoly-ploidization. Cell Death Differ 18:1403
    • (2011) Cell Death Differ , vol.18 , pp. 1403
    • Vitale, I.1
  • 63
    • 84862127178 scopus 로고    scopus 로고
    • Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
    • Davoli T, de Lange T (2012) Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells. Cancer Cell 21:765
    • (2012) Cancer Cell , vol.21 , pp. 765
    • Davoli, T.1    De Lange, T.2
  • 64
    • 61449093808 scopus 로고    scopus 로고
    • Ploidy reductions in murine fusion-derived hepatocytes
    • Duncan AW et al (2009) Ploidy reductions in murine fusion-derived hepatocytes. PLoS Genet 5:e1000385
    • (2009) Plos Genet , vol.5
    • Duncan, A.W.1
  • 66
    • 0035893556 scopus 로고    scopus 로고
    • Derivation of human tumor cells in vitro without widespread genomic instability
    • Zimonjic D, Brooks MW, Popescu N, Weinberg RA, Hahn WC (2001) Derivation of human tumor cells in vitro without widespread genomic instability. Cancer Res 61:8838
    • (2001) Cancer Res , vol.61 , pp. 8838
    • Zimonjic, D.1    Brooks, M.W.2    Popescu, N.3    Weinberg, R.A.4    Hahn, W.C.5
  • 67
    • 0032506125 scopus 로고    scopus 로고
    • Genetic instability of cancer cells is proportional to their degree of aneuploidy
    • Duesberg P, Rausch C, Rasnick D, Hehlmann R (1998) Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc Natl Acad Sci U S A 95:13692
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13692
    • Duesberg, P.1    Rausch, C.2    Rasnick, D.3    Hehlmann, R.4
  • 68
    • 84861853732 scopus 로고    scopus 로고
    • Losing balance: The origin and impact of aneuploidy in cancer
    • Holland AJ, Cleveland DW (2012) Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep 13:501
    • (2012) EMBO Rep , vol.13 , pp. 501
    • Holland, A.J.1    Cleveland, D.W.2
  • 69
    • 0034724312 scopus 로고    scopus 로고
    • Aneuploidy vs. Gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy
    • Li R, Sonik A, Stindl R, Rasnick D, Duesberg P (2000) Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy. Proc Natl Acad Sci U S A 97:3236
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 3236
    • Li, R.1    Sonik, A.2    Stindl, R.3    Rasnick, D.4    Duesberg, P.5
  • 70
    • 0033603632 scopus 로고    scopus 로고
    • Are centrosomes or aneu-ploidy the key to cancer?
    • Duesberg P (1999) Are centrosomes or aneu-ploidy the key to cancer? Science 284:2091
    • (1999) Science , vol.284 , pp. 2091
    • Duesberg, P.1
  • 71
    • 0033564230 scopus 로고    scopus 로고
    • How aneu-ploidy affects metabolic control and causes cancer
    • Rasnick D, Duesberg PH (1999) How aneu-ploidy affects metabolic control and causes cancer. Biochem J 340(Pt 3):621
    • (1999) Biochem J , vol.340 , pp. 621
    • Rasnick, D.1    Duesberg, P.H.2
  • 72
    • 80051871652 scopus 로고    scopus 로고
    • Aneuploidy drives genomic instability in yeast
    • Sheltzer JM et al (2011) Aneuploidy drives genomic instability in yeast. Science 333:1026
    • (2011) Science , vol.333 , pp. 1026
    • Sheltzer, J.M.1
  • 73
    • 33751306051 scopus 로고    scopus 로고
    • Growth arrest and chromosome instability in aneuploid yeast
    • Niwa O, Tange Y, Kurabayashi A (2006) Growth arrest and chromosome instability in aneuploid yeast. Yeast 23:937
    • (2006) Yeast , vol.23 , pp. 937
    • Niwa, O.1    Tange, Y.2    Kurabayashi, A.3
  • 74
    • 0015957618 scopus 로고
    • Studies on Down’s syndrome in tissue culture. I. Growth rates and protein contents of fi broblast cultures
    • Segal DJ, McCoy EE (1974) Studies on Down’s syndrome in tissue culture. I. Growth rates and protein contents of fi broblast cultures. J Cell Physiol 83:85
    • (1974) J Cell Physiol , vol.83 , pp. 85
    • Segal, D.J.1    McCoy, E.E.2
  • 75
    • 84877108757 scopus 로고    scopus 로고
    • Aneuploid yeast strains exhibit defects in cell growth and passage through START
    • Thorburn RR et al (2013) Aneuploid yeast strains exhibit defects in cell growth and passage through START. Mol Biol Cell 24:1274
    • (2013) Mol Biol Cell , vol.24 , pp. 1274
    • Thorburn, R.R.1
  • 76
    • 34548131710 scopus 로고    scopus 로고
    • Effects of aneuploidy on cellular physiology and cell division in hap-loid yeast
    • Torres EM et al (2007) Effects of aneuploidy on cellular physiology and cell division in hap-loid yeast. Science 317:916
    • (2007) Science , vol.317 , pp. 916
    • Torres, E.M.1
  • 77
    • 84887040158 scopus 로고    scopus 로고
    • Chromosome missegre-gation rate predicts whether aneuploidy will promote or suppress tumors
    • Silk AD et al (2013) Chromosome missegre-gation rate predicts whether aneuploidy will promote or suppress tumors. Proc Natl Acad Sci U S A 110:E4134
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. E4134
    • Silk, A.D.1
  • 78
    • 0015061003 scopus 로고
    • The analysis of malignancy by cell fusion. I. Hybrids between tumour cells and L cell derivatives
    • Klein G, Bregula U, Wiener F, Harris H (1971) The analysis of malignancy by cell fusion. I. Hybrids between tumour cells and L cell derivatives. J Cell Sci 8:659
    • (1971) J Cell Sci , vol.8 , pp. 659
    • Klein, G.1    Bregula, U.2    Wiener, F.3    Harris, H.4
  • 79
    • 0015062490 scopus 로고
    • The analysis of malignancy by cell fusion. II. Hybrids between Ehrlich cells and normal diploid cells
    • Harris H, Bregula U, Klein G (1971) The analysis of malignancy by cell fusion. II. Hybrids between Ehrlich cells and normal diploid cells. J Cell Sci 8:673
    • (1971) J Cell Sci , vol.8 , pp. 673
    • Harris, H.1    Bregula, U.2    Klein, G.3
  • 80
    • 0015060241 scopus 로고
    • The analysis of malignancy by cell fusion. 3. Hybrids between diploid fi broblasts and other tumour cells
    • Harris H, Wiener F, Klein G (1971) The analysis of malignancy by cell fusion. 3. Hybrids between diploid fi broblasts and other tumour cells. J Cell Sci 8:681
    • (1971) J Cell Sci , vol.8 , pp. 681
    • Harris, H.1    Wiener, F.2    Klein, G.3
  • 82
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481:306
    • (2012) Nature , vol.481 , pp. 306
    • Greaves, M.1    Maley, C.C.2
  • 83
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by mul-tiregion sequencing
    • Gerlinger M et al (2012) Intratumor heterogeneity and branched evolution revealed by mul-tiregion sequencing. N Engl J Med 366:883
    • (2012) N Engl J Med , vol.366 , pp. 883
    • Gerlinger, M.1
  • 84
    • 57149118627 scopus 로고    scopus 로고
    • Genomic analysis of the clonal origins of relapsed acute lym-phoblastic leukemia
    • Mullighan CG et al (2008) Genomic analysis of the clonal origins of relapsed acute lym-phoblastic leukemia. Science 322:1377
    • (2008) Science , vol.322 , pp. 1377
    • Mullighan, C.G.1
  • 85
    • 84862776537 scopus 로고    scopus 로고
    • Clonal selection drives genetic divergence of metastatic medulloblas-toma
    • Wu X et al (2012) Clonal selection drives genetic divergence of metastatic medulloblas-toma. Nature 482:529
    • (2012) Nature , vol.482 , pp. 529
    • Wu, X.1
  • 86
    • 33748087454 scopus 로고    scopus 로고
    • Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium
    • Jacobsen BM et al (2006) Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium. Cancer Res 66:8274
    • (2006) Cancer Res , vol.66 , pp. 8274
    • Jacobsen, B.M.1
  • 87
    • 69249222535 scopus 로고    scopus 로고
    • Recurrence cancer stem cells–made by cell fusion?
    • Dittmar T et al (2009) Recurrence cancer stem cells–made by cell fusion? Med Hypotheses 73:542
    • (2009) Med Hypotheses , vol.73 , pp. 542
    • Dittmar, T.1
  • 88
    • 79959613246 scopus 로고    scopus 로고
    • Co-cultivation of murine BMDCs with 67NR mouse mammary carcinoma cells give rise to highly drug resistant cells
    • Nagler C, Hardt C, Zanker KS, Dittmar T (2011) Co-cultivation of murine BMDCs with 67NR mouse mammary carcinoma cells give rise to highly drug resistant cells. Cancer Cell Int 11:21
    • (2011) Cancer Cell Int , vol.11 , pp. 21
    • Nagler, C.1    Hardt, C.2    Zanker, K.S.3    Dittmar, T.4
  • 89
    • 77958004840 scopus 로고    scopus 로고
    • The ploidy conveyor of mature hepatocytes as a source of genetic variation
    • Duncan AW et al (2010) The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature 467:707
    • (2010) Nature , vol.467 , pp. 707
    • Duncan, A.W.1
  • 90
    • 0016139097 scopus 로고
    • In vivo hybridisation of human tumour and normal hamster cells
    • Goldenberg DM, Pavia RA, Tsao MC (1974) In vivo hybridisation of human tumour and normal hamster cells. Nature 250:649
    • (1974) Nature , vol.250 , pp. 649
    • Goldenberg, D.M.1    Pavia, R.A.2    Tsao, M.C.3
  • 91
    • 33846201640 scopus 로고    scopus 로고
    • Osteoclast nuclei of myeloma patients show chromosome translo-cations specifi c for the myeloma cell clone: A new type of cancer-host partnership?
    • Andersen TL et al (2007) Osteoclast nuclei of myeloma patients show chromosome translo-cations specifi c for the myeloma cell clone: a new type of cancer-host partnership? J Pathol 211:10
    • (2007) J Pathol , vol.211 , pp. 10
    • Andersen, T.L.1
  • 92
    • 67249120052 scopus 로고    scopus 로고
    • Effi cient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants
    • Lu X, Kang Y (2009) Effi cient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants. Proc Natl Acad Sci U S A 106:9385
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9385
    • Lu, X.1    Kang, Y.2
  • 93
    • 34248594553 scopus 로고    scopus 로고
    • Metastasis: Recent discoveries and novel treatment strategies
    • Eccles SA, Welch DR (2007) Metastasis: recent discoveries and novel treatment strategies. Lancet 369:1742
    • (2007) Lancet , vol.369 , pp. 1742
    • Eccles, S.A.1    Welch, D.R.2
  • 94
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The ‘seed and soil’ hypothesis revisited
    • Fidler IJ (2003) The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer 3:453
    • (2003) Nat Rev Cancer , vol.3 , pp. 453
    • Fidler, I.J.1
  • 95
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AC, MacDonald IC (2002) Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2:563
    • (2002) Nat Rev Cancer , vol.2 , pp. 563
    • Chambers, A.F.1    Groom, A.C.2    Macdonald, I.C.3
  • 96
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9:265
    • (2009) Nat Rev Cancer , vol.9 , pp. 265
    • Polyak, K.1    Weinberg, R.A.2
  • 97
    • 38849093994 scopus 로고    scopus 로고
    • Direct evidence for epithelial-mesenchymal transitions in breast cancer
    • Trimboli AJ et al (2008) Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res 68:937
    • (2008) Cancer Res , vol.68 , pp. 937
    • Trimboli, A.J.1
  • 98
    • 0037102190 scopus 로고    scopus 로고
    • MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition
    • Pinkas J, Leder P (2002) MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition. Cancer Res 62:4781
    • (2002) Cancer Res , vol.62 , pp. 4781
    • Pinkas, J.1    Leder, P.2
  • 99
    • 22244473343 scopus 로고    scopus 로고
    • The fallacy of epithelial mesenchymal transition in neoplasia
    • Tarin D, Thompson EW, Newgreen DF (2005) The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res 65:5996
    • (2005) Cancer Res , vol.65 , pp. 5996
    • Tarin, D.1    Thompson, E.W.2    Newgreen, D.F.3
  • 100
    • 42549167207 scopus 로고    scopus 로고
    • Fusion of tumour cells with bone marrow-derived cells: A unifying explanation for metastasis
    • Pawelek JM, Chakraborty AK (2008) Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis. Nat Rev Cancer 8:377
    • (2008) Nat Rev Cancer , vol.8 , pp. 377
    • Pawelek, J.M.1    Chakraborty, A.K.2
  • 101
    • 56849131881 scopus 로고    scopus 로고
    • The cancer cell–leukocyte fusion theory of metastasis
    • Pawelek JM, Chakraborty AK (2008) The cancer cell–leukocyte fusion theory of metastasis. Adv Cancer Res 101:397
    • (2008) Adv Cancer Res , vol.101 , pp. 397
    • Pawelek, J.M.1    Chakraborty, A.K.2
  • 102
    • 0035700537 scopus 로고    scopus 로고
    • Fusion hybrids with macrophage and melanoma cells up-regulate N-acetylglucosaminyltransferase V, beta1-6 branching, and metastasis
    • Chakraborty AK et al (2001) Fusion hybrids with macrophage and melanoma cells up-regulate N-acetylglucosaminyltransferase V, beta1-6 branching, and metastasis. Cell Growth Differ 12:623
    • (2001) Cell Growth Differ , vol.12 , pp. 623
    • Chakraborty, A.K.1
  • 103
    • 84869187934 scopus 로고    scopus 로고
    • Spontaneous cell fusion of acute leukemia cells and macro-phages observed in cells with leukemic potential
    • Martin-Padura I et al (2012) Spontaneous cell fusion of acute leukemia cells and macro-phages observed in cells with leukemic potential. Neoplasia 14:1057
    • (2012) Neoplasia , vol.14 , pp. 1057
    • Martin-Padura, I.1
  • 104
    • 0032177482 scopus 로고    scopus 로고
    • Melanoma x macro-phage fusion hybrids acquire increased mela-nogenesis and metastatic potential: Altered N-glycosylation as an underlying mechanism
    • Sodi SA et al (1998) Melanoma x macro-phage fusion hybrids acquire increased mela-nogenesis and metastatic potential: altered N-glycosylation as an underlying mechanism. Pigment Cell Res 11:299
    • (1998) Pigment Cell Res , vol.11 , pp. 299
    • Sodi, S.A.1
  • 105
    • 0034194240 scopus 로고    scopus 로고
    • A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids
    • Chakraborty AK et al (2000) A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids. Cancer Res 60:2512
    • (2000) Cancer Res , vol.60 , pp. 2512
    • Chakraborty, A.K.1
  • 106
    • 0141443427 scopus 로고    scopus 로고
    • Altered N-glycosylation in macrophage x melanoma fusion hybrids
    • Pawelek JM et al (1999) Altered N-glycosylation in macrophage x melanoma fusion hybrids. Cell Mol Biol 45:1011
    • (1999) Cell Mol Biol , vol.45 , pp. 1011
    • Pawelek, J.M.1
  • 107
    • 0032764342 scopus 로고    scopus 로고
    • Acquired melanocyte stimulating hormone-inducible chemotaxis following macrophage fusion with Cloudman S91 melanoma cells
    • Rachkovsky M, Pawelek J (1999) Acquired melanocyte stimulating hormone-inducible chemotaxis following macrophage fusion with Cloudman S91 melanoma cells. Cell Growth Differ 10:517
    • (1999) Cell Growth Differ , vol.10 , pp. 517
    • Rachkovsky, M.1    Pawelek, J.2
  • 108
    • 84881361029 scopus 로고    scopus 로고
    • The dark side of stem cells: Triggering cancer progression by cell fusion
    • Dittmar T, Nagler C, Niggemann B, Zanker KS (2013) The dark side of stem cells: triggering cancer progression by cell fusion. Curr Mol Med 13:735
    • (2013) Curr Mol Med , vol.13 , pp. 735
    • Dittmar, T.1    Nagler, C.2    Niggemann, B.3    Zanker, K.S.4
  • 109
    • 84877153497 scopus 로고    scopus 로고
    • Fusion of CCL21 non-migratory active breast epithelial and breast cancer cells give rise to CCL21 migratory active tumor hybrid cell lines
    • Berndt B et al (2013) Fusion of CCL21 non-migratory active breast epithelial and breast cancer cells give rise to CCL21 migratory active tumor hybrid cell lines. PLoS One 8:e63711
    • (2013) Plos One , vol.8
    • Berndt, B.1
  • 110
    • 84873531459 scopus 로고    scopus 로고
    • Horizontal transmission of malignancy: In-vivo fusion of human lymphomas with hamster stroma produces tumors retaining human genes and lymphoid pathology
    • Goldenberg DM et al (2013) Horizontal transmission of malignancy: in-vivo fusion of human lymphomas with hamster stroma produces tumors retaining human genes and lymphoid pathology. PLoS One 8: e55324
    • (2013) Plos One , vol.8
    • Goldenberg, D.M.1
  • 111
    • 84903190875 scopus 로고    scopus 로고
    • Fusion of HepG2 cells with mesenchymal stem cells increases cancer associated and malignant properties: An in vivo metastasis model
    • Li H et al (2014) Fusion of HepG2 cells with mesenchymal stem cells increases cancer associated and malignant properties: an in vivo metastasis model. Oncol Rep 32(2): 539–547
    • (2014) Oncol Rep , vol.32 , Issue.2 , pp. 539-547
    • Li, H.1
  • 112
    • 79951818699 scopus 로고    scopus 로고
    • Aldehyde dehydroge-nase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis
    • Marcato P et al (2011) Aldehyde dehydroge-nase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis. Stem Cells 29:32
    • (2011) Stem Cells , vol.29 , pp. 32
    • Marcato, P.1
  • 113
    • 47949132157 scopus 로고    scopus 로고
    • The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host
    • Podhajcer OL et al (2008) The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host. Cancer Metastasis Rev 27:691
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 691
    • Podhajcer, O.L.1
  • 114
    • 84879469812 scopus 로고    scopus 로고
    • A melanoma brain metastasis with a donor-patient hybrid genome following bone marrow transplantation: Fi rst evidence for fusion in human cancer
    • Lazova R et al (2013) A melanoma brain metastasis with a donor-patient hybrid genome following bone marrow transplantation: fi rst evidence for fusion in human cancer. PLoS One 8:e66731
    • (2013) Plos One , vol.8
    • Lazova, R.1
  • 115
    • 0024311905 scopus 로고
    • Production of a more aggressive tumor cell variant by spontaneous fusion of two mouse tumor subpopulations
    • Miller FR, Mohamed AN, McEachern D (1989) Production of a more aggressive tumor cell variant by spontaneous fusion of two mouse tumor subpopulations. Cancer Res 49:4316
    • (1989) Cancer Res , vol.49 , pp. 4316
    • Miller, F.R.1    Mohamed, A.N.2    McEachern, D.3
  • 116
    • 77954765542 scopus 로고    scopus 로고
    • Kim JW (2010) p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: Correlations with cell fusion and doxorubicin resistance
    • Yang JY, Ha SA, Yang YS, Kim JW (2010) p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. BMC Cancer 10:388
    • BMC Cancer , vol.10 , pp. 388
    • Yang, J.Y.1    Ha, S.A.2    Yang, Y.S.3
  • 117
    • 0344012471 scopus 로고    scopus 로고
    • Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter
    • Frank NY et al (2003) Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem 278:47156
    • (2003) J Biol Chem , vol.278 , pp. 47156
    • Frank, N.Y.1
  • 118
    • 57649188662 scopus 로고    scopus 로고
    • Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance
    • Hembruff SL et al (2008) Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance. BMC Cancer 8:318
    • (2008) BMC Cancer , vol.8 , pp. 318
    • Hembruff, S.L.1
  • 119
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells– perspectives on current status and future directions: AACR Workshop on cancer stem cells
    • Clarke MF et al (2006) Cancer stem cells– perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 66:9339
    • (2006) Cancer Res , vol.66 , pp. 9339
    • Clarke, M.F.1
  • 121
    • 33846239456 scopus 로고    scopus 로고
    • Beyond tumorigenesis: Cancer stem cells in metastasis
    • Li F, Tiede B, Massague J, Kang Y (2007) Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 17:3
    • (2007) Cell Res , vol.17 , pp. 3
    • Li, F.1    Tiede, B.2    Massague, J.3    Kang, Y.4
  • 122
    • 42349093952 scopus 로고    scopus 로고
    • Cancer stem cells: Implications for the progression and treatment of metastatic disease
    • Croker AK, Allan AL (2008) Cancer stem cells: implications for the progression and treatment of metastatic disease. J Cell Mol Med 12:374
    • (2008) J Cell Mol Med , vol.12 , pp. 374
    • Croker, A.K.1    Allan, A.L.2
  • 123
    • 72949118673 scopus 로고    scopus 로고
    • High aldehyde dehy-drogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability
    • Croker AK et al (2009) High aldehyde dehy-drogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability. J Cell Mol Med 13:2236
    • (2009) J Cell Mol Med , vol.13 , pp. 2236
    • Croker, A.K.1
  • 124
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann PC et al (2007) Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1:313
    • (2007) Cell Stem Cell , vol.1 , pp. 313
    • Hermann, P.C.1
  • 125
    • 79960900961 scopus 로고    scopus 로고
    • Cell fusion, drug resistance and recurrence CSCs
    • Nagler C, Zanker KS, Dittmar T (2011) Cell fusion, drug resistance and recurrence CSCs. Adv Exp Med Biol 714:173
    • (2011) Adv Exp Med Biol , vol.714 , pp. 173
    • Nagler, C.1    Zanker, K.S.2    Dittmar, T.3
  • 126
    • 45549093647 scopus 로고    scopus 로고
    • Survival of the fi t-test: Cancer stem cells in therapeutic resistance and angiogenesis
    • Eyler CE, Rich JN (2008) Survival of the fi t-test: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol 26:2839
    • (2008) J Clin Oncol , vol.26 , pp. 2839
    • Eyler, C.E.1    Rich, J.N.2
  • 127
    • 35148888629 scopus 로고    scopus 로고
    • Cancer stem cells in radiation resistance
    • Rich JN (2007) Cancer stem cells in radiation resistance. Cancer Res 67:8980
    • (2007) Cancer Res , vol.67 , pp. 8980
    • Rich, J.N.1
  • 128
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M, Fojo T, Bates S (2005) Tumour stem cells and drug resistance. Nat Rev Cancer 5:275
    • (2005) Nat Rev Cancer , vol.5 , pp. 275
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 129
    • 45949101159 scopus 로고    scopus 로고
    • Expression of multidrug resistance genes in normal and cancer stem cells
    • Shervington A, Lu C (2008) Expression of multidrug resistance genes in normal and cancer stem cells. Cancer Invest 26:535
    • (2008) Cancer Invest , vol.26 , pp. 535
    • Shervington, A.1    Lu, C.2
  • 131
    • 33847052127 scopus 로고    scopus 로고
    • Identifi cation of pancreatic cancer stem cells
    • Li C et al (2007) Identifi cation of pancreatic cancer stem cells. Cancer Res 67:1030
    • (2007) Cancer Res , vol.67 , pp. 1030
    • Li, C.1
  • 132
    • 0043240184 scopus 로고    scopus 로고
    • Curing meta-static cancer: Lessons from testicular germ-cell tumours
    • Masters JR, Koberle B (2003) Curing meta-static cancer: lessons from testicular germ-cell tumours. Nat Rev Cancer 3:517
    • (2003) Nat Rev Cancer , vol.3 , pp. 517
    • Masters, J.R.1    Koberle, B.2
  • 133
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • Shackleton M, Quintana E, Fearon ER, Morrison SJ (2009) Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138:822
    • (2009) Cell , vol.138 , pp. 822
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 134
    • 0015111747 scopus 로고    scopus 로고
    • Pavia RA (1971) In vivo human-hamster somatic cell fusion indicated by glucose 6-phosphate dehydroge-nase and lactate dehydrogenase profi les
    • Goldenberg DM, Bhan RD, Pavia RA (1971) In vivo human-hamster somatic cell fusion indicated by glucose 6-phosphate dehydroge-nase and lactate dehydrogenase profi les. Cancer Res 31:1148
    • Cancer Res , vol.31 , pp. 1148
    • Goldenberg, D.M.1    Bhan, R.D.2
  • 135
    • 0036681286 scopus 로고    scopus 로고
    • Spontaneously formed tumorigenic hybrids of Meth A sarcoma and macrophages grow faster and are better vascularized than the parental tumor
    • Busund LT, Killie MK, Bartnes K, Seljelid R (2002) Spontaneously formed tumorigenic hybrids of Meth A sarcoma and macrophages grow faster and are better vascularized than the parental tumor. Int J Cancer 100:407
    • (2002) Int J Cancer , vol.100 , pp. 407
    • Busund, L.T.1    Killie, M.K.2    Bartnes, K.3    Seljelid, R.4
  • 136
    • 0033769681 scopus 로고    scopus 로고
    • Primary cells suppress oncogene-dependent apoptosis
    • Duelli DM, Lazebnik YA (2000) Primary cells suppress oncogene-dependent apoptosis. Nat Cell Biol 2:859
    • (2000) Nat Cell Biol , vol.2 , pp. 859
    • Duelli, D.M.1    Lazebnik, Y.A.2
  • 137
    • 84928998251 scopus 로고    scopus 로고
    • Murine breast-cancer-cell/mesenchymal-stem- cell hybrids exhibit enhanced drug resistance to different cytostatic drugs
    • Nagler C, Zänker KS, Dittmar T (2010) Murine breast-cancer-cell/mesenchymal-stem- cell hybrids exhibit enhanced drug resistance to different cytostatic drugs. J Stem Cells Regen Med 6:133
    • (2010) J Stem Cells Regen Med , vol.6 , pp. 133
    • Nagler, C.1    Zänker, K.S.2    Dittmar, T.3
  • 138
    • 29244479554 scopus 로고    scopus 로고
    • Why therapeutic response may not prolong the life of a cancer patient: Selection for oncogenic resistance
    • Blagosklonny MV (2005) Why therapeutic response may not prolong the life of a cancer patient: selection for oncogenic resistance. Cell Cycle 4:1693
    • (2005) Cell Cycle , vol.4 , pp. 1693
    • Blagosklonny, M.V.1
  • 139
    • 44849143103 scopus 로고    scopus 로고
    • Cancer stem cells contribute to cisplatin resistance in Brca1/ p53-mediated mouse mammary tumors
    • Shafee N et al (2008) Cancer stem cells contribute to cisplatin resistance in Brca1/ p53-mediated mouse mammary tumors. Cancer Res 68:3243
    • (2008) Cancer Res , vol.68 , pp. 3243
    • Shafee, N.1
  • 140
    • 84864359517 scopus 로고    scopus 로고
    • Tumor associated macrophage x cancer cell hybrids may acquire cancer stem cell properties in breast cancer
    • Ding J, Jin W, Chen C, Shao Z, Wu J (2012) Tumor associated macrophage x cancer cell hybrids may acquire cancer stem cell properties in breast cancer. PLoS One 7:e41942
    • (2012) Plos One , vol.7
    • Ding, J.1    Jin, W.2    Chen, C.3    Shao, Z.4    Wu, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.