Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

Nature

Volumn 425, Issue 6961, 2003, Pages 968-973

  Alvarez Dolado, Manuel ^a   Pardal, Ricardo ^b   Garcia Verdugo, Jose M ^c   Fike, John R ^a   Lee, Hyun O ^b   Pfeffer, Klaus ^d   Lois, Carlos ^e   Morrison, Sean J ^b   Alvarez Bullia, Arturo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF VALENCIA   (Spain)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CARDIOLOGY; NEUROLOGY; TISSUE;

PURKINJE NEURONS;

CELLS;

ADOLESCENT; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL FUSION; CELL MATURATION; CRE GENE; GENE; GENETIC RECOMBINATION; HEART MUSCLE CELL; KNOCKOUT MOUSE; LIVER CELL; LOX GENE; MOUSE; MULTINUCLEAR CELL; NERVE CELL; NERVE CELL PLASTICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELL FUSION; GIANT CELLS; HEPATOCYTES; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MYOCYTES, CARDIAC; PURKINJE CELLS; STEM CELLS;

ANIMALIA; MUS MUSCULUS;

EID: 0242584006     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02069     Document Type: Article

References (30)

1. Morrison, S. J. Stem cell potential: can anything make anything? Curr. Biol. 11, R7-R9 (2001).
2. Orkin, S. H. & Zon, L. I. Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. Nature Immunol. 3, 323-328 (2002).
3. Krause, D. S. et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105, 369-377 (2001).
4. Orlic, D. et al. Bone marrow cells regenerate infarcted myocardium. Nature 410, 701-705 (2001).
5. Priller, J. et al. Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo. J. Cell Biol. 155, 733-738 (2001).
6. Terada, N. et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 416, 542-545 (2002).
7. Ying, Q. L., Nichols, J., Evans, E. P. & Smith, A. G. Changing potency by spontaneous fusion. Nature. 416, 545-548 (2002).
8. Vassilopoulos, G., Wang, P. R. & Russell, D. W. Transplanted bone marrow regenerates liver by cell fusion. Nature 422, 901-904 (2003).
9. Wang, X. et al. Cell fusion mice principal source of bone-marrow-derived hepatocyte. Nature 422, 897-901 (2003).
10. Sauer, B. Inducible gene targeting in mice using the Cre/Iox system. Methods 14, 381-392 (1998).
11. Lewandoski, M., Meyers, E. N. & Martin, G. R. Analysis of Fgf8 gene function in vertebrate development. Cold Spring Harb. Symp. Quant. Biol. 62, 159-168 (1997)
12. Mao, X., Fujiwara, Y. & Orkin, S. H. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc. Natl Acad. Sci. USA 96, 5037-5042 (1999).
13. Ianus, A., Holz, G. G., Theise, N. D. & Hussain, M. A. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest. 111, 843-850 (2003).
14. Weiss, S. et al. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J. Neurosci. 16, 7599-7609 (1996).
15. Palay, L. P. & Chan-Palay, V. Cerebellar Cortex 15-25 (Springer, Berlin. 1974).
16. Weimman, J. M., Charlton, C. A., Brazelton, T. R., Hackman, R. C. & Blau, H. M. Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains. Proc. Natl Acad. Sci. USA 100, 2088-2093 (2003).
17. Wagers, A. J., Sherwood, R. I., Christensen, J. L. & Weissman, I. L. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 297, 2256-2259 (2002).
18. Ledbetter, J. A. & Herzenberg, L. A. Xenogeneic monodonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47, 63-90 (1979).
19. van Ewijk, W., van Soest, P. L. & van den Engh, G. J. Fluorescence analysis and anatomic distribution of mouse T lymphocyte subsets defined by monoclonal antibodies to the antigens Thy-1, Lyt-1, Lyt-2, and T-200. J. Immunol. 127, 2594-2604 (1981).
20. Ling, E. A. & Wong, W. C. The origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia 7, 9-18 (1993).
21. Gehrmann, J., Matsumoto, Y. & Kreutzberg, G. W. Microglia: intrinsic immuneffector cell of the brain. Brain Res. Brain Res. Rev. 20, 269-287 (1995).
22. Arias, I. M., et al. The Liver Biology and Pathobiology (Lippincott Williams and Wilkins, Philadelphia, 2001).
23. Anderson, J. M. Multinucleated giant cells. Curr. Opin. Hematol. 7, 40-47 (2000).
24. Piper, H. M. & Isenberg, I. Isolated Adult Cardiomyocytes (CRC, Boca Raton, 1989).
25. Lapham, L. W. Tetraploid DNA content of Purkinje neurons of human cerebellar cortex. Science 159, 310-312 (1968).
26. Mates, V., Lodin, Z. & Sacha, J. A cytochemical and autoradiographic study of nuclear DNA in mouse Purkinje cells. Brain Res. 53, 273-289 (1973).
27. Doetsch, F., Caille, I., Lim, D. A., Garcia-Verdugo, J. M. & Alvarez-Buylla, A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97, 703-716 (1999).
28. Spector, D. L., Goldman, R. D. & Leinwand, L. A. Cells: a Laboratory Manual 4.1-4.7 (Cold Spring Harbor Laboratory Press, New York, 1998).
29. Hadjantonakis, A. K., Gertsenstein, M., Ikawa, M., Okabe, M. & Nagy, A. Generating green fluorescent mice by germline transmission of green fluorescent ES cells. Mech. Dev. 76, 79-90 (1998).
30. Christensen, J. L. & Weissman, I. L. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc. Natl Acad. Sci. USA 98, 14541-14546 (2001).