Co-overexpression of p53 and bcl-2 proteins in HPV-induced squamous cell carcinoma of the uterine cervix

Gynecologic Oncology

Volumn 91, Issue 1, 2003, Pages 51-58

  Grace, V M Berlin ^a,b   Shalini, J Veronica ^b   Lekha, T T Sree ^c   Devaraj, S Niranjali ^b   Devaraj, Halagowder ^b  

^a GOVERNMENT COLLEGE OF TECHNOLOGY   (India)

^b UNIVERSITY OF MADRAS   (India)

^c REGIONAL CANCER CENTRE   (India)

Author keywords

Aberrant immunoreactivity; Anti apoptotic protein bcl 2; HPV infection; SCC of the uterine cervix; Tumor supressor p53

Indexed keywords

BIOTIN; PROTEIN BCL 2; PROTEIN P53; STREPTAVIDIN;

ADULT; AGED; ANALYTIC METHOD; APOPTOSIS; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; STATISTICAL ANALYSIS; UTERINE CERVIX CARCINOMA; UTERINE CERVIX EPITHELIUM; VERRUCA VULGARIS; WART VIRUS;

EID: 0141645604     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-8258(03)00439-6     Document Type: Article

References (37)

1. Dimitrakakis C., Kymionis G., Diakomanolis E., Papaspyrou I., Rodolakis A., Arzimanoglou I., Leandros E., Michales S. The possible role of p53 and bcl-2 expression in cervical carcinomas and their premalignant lesions. Gynecol Oncol. 77:2000;129-136.
2. Kerr J.F.R., Winterford C.M., Harmon B.V. Apoptosis its significance in cancer and cancer therapy . Cancer. 73:1994;2013-2026.
3. Popescu R.A., Lohri A., de Kant E., Thiede C., Reuter J., Hermann R., Rochlitz C.F. Bcl-2 expression is reciprocal to p53 and c-myc expression in metastatic human colorectal cancer. Eur J Cancer. 34:1998;1268-1273.
4. Skomedal H., Kristensen G.B., Lie A.K., Holm R. Aberrant expression of the cell cycle associated proteins TP 53, MDM 2, p21, p27, CdK4, Cyclin D, RB and EGFR in cervical carcinomas. Gynecol Oncol. 73:1999;223-228.
5. Ravi D., Panikkar K.R., Krishnan Nair M., Radhakrishna Pillai M. Apoptosis future directions in cancer therapy . Natl Med J India. 13:2000;71-78.
6. Pradip Nair, Krishnan Nair M., Jayaprakash P.G., Radhakrishna Pillai M. Decreased programmed cell death in the uterine cervix associated with high risk human papilloma virus infection. Pathol Oncol Res. 5:1999;95-103.
7. Giannoudis A., Evans M.F., Southern S.A., Herrington C.S. Basal keratinocyte tetrasomy in low-grade squamous intra-epithelia lesions of the cervix is restricted to high and intermediate risk HPV infection but is not type-specific. Br J Cancer. 2:2000;424-428.
8. Helland A., Holm R., Kristensen G., Kaern J., Karlsen F., Trope C., Nesland J.M., Borresen A.L. Genetic alterations of the TP53 gene, p53 protein expression and HPV infection in primary cervical carcinomas. J Pathol. 171:1993;105-114.
9. Radhakrishna Pillai M., Jayaprakash P.G., Krishnan Nair M. Bcl-2 immunoreactivity but not p53 accumulation associated with tumour response to radiotherapy in cervical carcinoma. J Cancer Res Clin Oncol. 125:1999;55-60.
10. Pradip Nair, Gangadevi T., Jayaprakash P.G., Balaraman Nair M., Krishnan Nair M., Radhakrishna Pillai M. Increased angiogenesis in the uterine cervix associated with human papilloma virus infection. Pathol Res Pract. 195:1999;163-169.
11. Miyashita T., Krajewski S., Krajewska M., Wang H.G., Lin H.K., Liebermann D.A., Hoffman B., Reed J.C. Tumour suppressor p53 is a regulator of bcl-2 and base gene expression in vitro and in vivo. Oncogene. 9:1994;1799-1805.
12. Waga S., Hannon G.J., Beach D., Stillman B. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature. 369:1994;574-578.
13. Haldar S., Negrini M., Monne M., Sabbioni S., Croce C.M. Down regulation of bcl-2 by p53 in breast cancer cells. Cancer Res. 54:1994;2095-2097.
14. Henriksen R, Wilander E, Oberg. Expression and prognostic significance of bcl-2 in ovarian tumours. Br J Cancer 1995; 72:1324-9.
15. Nguyen P.L., Zukerberg L.R., Benedict W.F., Harris N.L. Immunohistochemical detection of p53, bcl-2 and retinoblastoma proteins in follicular lymphoma. Am J Clin Pathol. 105:1996;538-543.
16. Tjalma W.A., Weyler J.J., Bogers J.J., Pollefliet C., Baay M., Goovaerts G.C., Vermorken J.B., Van Dam P.A., Van Marck E.A., Buytaert P.M. The importance of biological factors (bcl-2, bax, p53, PCNA, MI, HPV and angiogenesis) in invasive cervical cancer. Eur J Obstet Gynecol Reprod Biol. 97:2001;223-230.
17. Clarke B., Chetty R. Cell cycle aberrations in the pathogenesis of squamous cell carcinoma of the uterine cervix. Gynecol Oncol. 82:2001;238-246.
18. Yang E., Korsmeyer S.J. Molecular thanatopsis a discourse on the bcl-2 family and cell death . Blood. 88:1996;386-401.
19. Rajkumar T., Rajan S., Baruah R.K., Majhi V., Selvalukmi G., Vasanthan A. Prognostic significance of bcl-2 and p53 protein expression in stage IIA and IIB squamous cell carcinoma of the cervix. Eur J Gynecol Oncol. 19:1998;556-560.
20. Wang Y.S., Szekely L., Okan I., Klein G., Wiman G., Wiman K.L. Wild-type p53- triggered apoptosis is inhibited by bcl-2 in a V-myc-induced T-cell lymphoma line. Oncogene. 8:1993;3427-3431.
21. Morrison E.A.B., HO G.Y.F., Vermund S.H., Goldberd G.L., Kadish A.S., Kelley K.F., Burk R.D. Human papilloma virus infection and other risk factors for cervical neoplasia a case control study . Int J Cancer. 49:1991;6-13.
22. Chan M.K.M., Lau K.M., Tsui Y., Wong F.W.S., Huang D.P. Human papilloma virus infection in Hong Kong Chinese women with normal and abnormal cervix-detection by polymerase chain reaction method on cervical scrapes. Gynecol Oncol. 60:1996;217-223.
23. Cotter T.G., Samali A. Oncogenes, apoptosis and cancer forum trends. Exp Clin Med. 7:1997;4-17.
24. Vassallo J., Derchain S.F.M., Pinto G.A., Martinez E.Z., Syranen K.J., Andrade L.A.L. High risk HPV and p53 protein expression in cervical intraepithelial neoplasia. Int J Gynecol Obstet. 71:2000;45-48.
25. Koshida Y., Saegusa M., Okayasu I. Apoptosis, cell proliferation and expression of bcl-2 and bax in gastric carcinomas immunohistochemical and clinicopathological study . Br J Cancer. 75:1997;367-373.
26. Ku J.L., Kim W.H., Park H.S., Kang S.B., Park J.G. Establishment and characterization of 12 uterine cervical carcinoma cell-lines common sequence variation in the E7 gene of HPV 16-positive cell lines . Int J Cancer. 72:1997;313-320.
27. Thomas M., Pim D., Banks L. The role of the E6-p53 interaction in the molecular pathogenesis of HPV. Oncogene. 15:1999;7690-7700.
28. Herrington C.S., McGee J.o'D. Neoplasia interphase cytogenetics and tumour pathology . McGee J.O.'D., Isaacson P.G., Wright N.A. Oxford text book of pathology. Vol 1:1992;590-592 Oxford Univ. Press, Oxford.
29. Paquette R.L., Lee Y.Y., Wilczynski S.P., Karmakar A., Kizaki M., Miller C.W., Koeffler H.P. Mutations of p53 and human papilloma virus infection in cervical carcinoma. Cancer. 72:1993;1272-1280.
30. Crook T., Fisher C., Masterson P.J., Vousden K.H. Modulation of transcriptional regulatory properties of p53 by HPV E6. Oncogene. 9:1994;1225-1230.
31. Kurvinen K., Syrjanen K., Syrjanen S. p53 and bcl-2 proteins as prognostic markers in human papilloma virus associated cervical lesions. J Clin Oncol. 14:1996;2120-2130.
32. Liang X.H., Mungal S., Ayscue A., Meissner J.D., Wodnicki P., Hockenbery D., Lockett S., Herman B. Bcl-2 protooncogene expression in cervical carcinoma cell lines containing inactive p53. J Cell Biochem. 57:1995;509-521.
33. Crawford R.A.F., Caldwell C., Iles R.K., Lowe D., Shepherd J.H., Chard T. Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer. Br J Cancer. 78:1998;210-214.
34. Radhakrishna Pillai M., Halabi S., Mckalip A., Jayaprakash P.G., Rajalakshmi T.N., Krishnan Nair M.R., Herman B. The presence of human papilloma virus-16/18 E6, p53 and bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer. Cancer Epidemiol Biomark Prev. 5:1996;329-335.
35. Brychtova S., Brychta T., Kotrsova L., Pilka R., Tichy M., Ticha V., Kolar Z. Expression of bcl-2 in dysplastic and neoplastic cervical lesions in relation to cell proliferation and HPV infection. Neoplasma. 47:2000;143-147.
36. Oltvai Z.N., Korsmeyer S.J. Checkpoints of dueling dimers foil death wishes. Cell. 79:1994;189-192.
37. Sidransky D., Hollstein M. Clinical implications of the p53 gene. Annu Rev Med. 47:1996;285-301.