Myelomonocytic cells are sufficient for therapeutic cell fusion in liver

Nature Medicine

Volumn 10, Issue 7, 2004, Pages 744-748

  Willenbring, Holger ^a   Bailey, Alexis S ^a   Foster, Mark ^a   Akkari, Yassmine ^a   Dorrell, Craig ^a   Olson, Susan ^a   Finegold, Milton ^b   Fleming, William H ^a   Grompe, Markus ^a,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL FUSION; CONTROLLED STUDY; ENZYME DEFICIENCY; EPITHELIUM CELL; FEMALE; FUMARYLACETOACETATE HYDROLASE DEFICIENCY; GRANULOCYTE; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; LIVER; LIVER CELL; MACROPHAGE; MALE; MONOCYTE; MOUSE; MYELOMONOCYTE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL FUSION; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEPATOCYTES; HYDROLASES; LIVER REGENERATION; MACROPHAGES; MICE; MICE, INBRED C57BL;

ANIMALIA;

EID: 3142734226     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1062     Document Type: Article

References (30)

1. Lagasse, E. et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 6, 1229-1234 (2000).
2. Wang, X. et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422, 897-901 (2003).
3. Ferrari, G. et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279, 1528-1530 (1998).
4. Jackson, K.A. et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J. Clin. Invest. 107, 1395-402 (2001).
5. Mezey, E., Chandross, K.J., Harta, G., Maki, R.A. & McKercher, S.R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290, 1779-1782 (2000).
6. Petersen, B.E. et al. Bone marrow as a potential source of hepatic oval cells. Science 284, 1168-1170 (1999).
7. Alison, M.R. et al. Hepatocytes from non-hepatic adult stem cells. Nature 406, 257 (2000).
8. Krause, D.S. et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105, 369-377 (2001).
9. Vassilopoulos, G., Wang, P.R. & Russell, D.W. Transplanted bone marrow regenerates liver by cell fusion. Nature 422, 901-904 (2003).
10. Alvarez-Dolado, M. et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425, 968-973 (2003).
11. Nygren, J.M. et al. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat. Med. 10, 494-501 (2004).
12. Weimann, J.M., Johansson, C.B., Trejo, A. & Blau, H.M. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat. Cell Biol. 5, 959-966 (2003).
13. Overturf, K. et al. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nat. Genet. 12, 266-273 (1996).
14. Mombaerts, P. et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-77 (1992).
15. Bailey, A.S. et al. Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells. Blood 103, 13-19 (2004).
16. Wang, X. et al. Kinetics of liver repopulation after bone marrow transplantation. Am. J. Pathol. 161, 565-574 (2002).
17. Akashi, K., Traver, D., Miyamoto, T. & Weissman, I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193-197 (2000).
18. Na Nakorn, T., Traver, D., Weissman, I.L. & Akashi, K. Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S. J. Clin. Invest. 109, 1579-1585 (2002).
19. BitMansour, A. et al. Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation. Blood 100, 4660-4667 (2002).
20. Kondo, M., Weissman, I.L. & Akashi, K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661-672 (1997).
21. Cozzio, A. et al. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 17, 3029-3035 (2003).
22. Friedrich, G. & Soriano, P. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5, 1513-1523 (1991).
23. Kennedy, D.W. & Abkowitz, J.L. Mature monocytic cells enter tissues and engraft. Proc. Natl. Acad. Sci. USA 95, 14944-14949 (1998).
24. Freeman, B.J. et al. Behavior and therapeutic efficacy of β-glucuronidase-positive mononuclear phagocytes in a murine model of mucopolysaccharidosis type VII. Blood 94, 2142-2150 (1999).
25. Geissmann, F., Jung, S. & Littman, D.R. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19, 71-82 (2003).
26. Van Rooijen, N. & Sanders, A. Kupffer cell depletion by liposome-delivered drugs: comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid. Hepatology 23, 1239-1243 (1996).
27. Camargo, F.D., Green, R., Capetenaki, Y., Jackson, K.A. & Goodell, M.A. Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates. Nat. Med. 9, 1520-1527 (2003).
28. Jorquera, R. & Tanguay, R.M. Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability. Hum. Mol. Genet. 10, 1741-1752 (2001).
29. van de Rijn, M., Heimfeld, S., Spangrude, G.J. & Weissman, I.L. Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family. Proc. Natl. Acad. Sci. USA 86, 4634-4638 (1989).
30. Grompe, M. et al. Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice. Genes Dev. 7, 2298-2307 (1993).