Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo

International Journal of Cancer

Volumn 131, Issue 1, 2012, Pages 49-58

  Goldenberg, David M ^a   Zagzag, David ^b   Heselmeyer Haddad, Kerstin M ^c   Berroa Garcia, Lissa Y ^c   Ried, Thomas ^c   Loo, Meiyu ^d   Chang, Chien Hsing ^d   Gold, David V ^a  

^a CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d IMMUNOMEDICS INC   (United States)

Author keywords

cancer stroma; cell fusion; gene transfer; glioblastoma; metastasis

Indexed keywords

CD74 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; GENOMIC DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER MORPHOLOGY; CASE REPORT; CD74 GENE; CELL FUSION; CONTROLLED STUDY; CXCR4 GENE; DISEASE TRANSMISSION; DNA HYBRIDIZATION; EGFR GENE; FEMALE; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE PRODUCT; GENETIC REGULATION; GFAP GENE; GLIOBLASTOMA; HAMSTER; HORIZONTAL GENE TRANSFER; HOST CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO PROPAGATION; IN VIVO STUDY; MALE; NONHUMAN; ONCOGENE; PLAGL2 GENE; PRIORITY JOURNAL; RNA TRANSLATION; TP53 GENE; VIM GENE; XENOGRAFT;

ANIMALS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; CELL FUSION; CELL LINE, TUMOR; CHIMERA; CRICETINAE; DISEASE PROGRESSION; DNA-BINDING PROTEINS; GLIOBLASTOMA; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; HYBRID CELLS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; RECEPTORS, CXCR4; RNA-BINDING PROTEINS; STROMAL CELLS; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 84860223175     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26327     Document Type: Article

References (50)

1. Goldenberg DM,. Über die Progression der Malignität: Eine Hypothese [On the progression of malignancy: A hypothesis]. Klin Wochenschr 1968; 46: 898-99.
2. Goldenberg DM,. Stathmokinetic effect of colcemid on a presumptive human-hamster hybrid tumor, GW-478. Exp Mol Pathol 1971; 14: 134-7.
3. Goldenberg DM, Götz H,. On the 'human' nature of highly malignant heterotransplantable tumors of human origin. Eur J Cancer 1968; 4: 547-8.
4. Götz H, Goldenberg DM,. Antigenic characterization of a heterotransplanted human tumor, GW-127. Experientia 1968; 24: 957-8.
5. Goldenberg DM, Bhan RD, Pavia RA,. In vivo human-hamster somatic cell fusion by glucose-6-phosphate dehydrogenase and lactate dehydrogenase profiles. Cancer Res 1971; 31: 1148-52.
6. Goldenberg DM, Pavia RA, Tsao MC,. In vivo hybridisation of human tumour and normal hamster cells. Nature 1974; 250: 649-51.
7. Goldenberg DM, Pavia RA,. Horizontal transmission of malignant conditions rediscovered. N Engl J Med 1981; 305: 283-4.
8. Aichel O,. Über Zellverschmelzung mit qualitative abnormer Chromosomenverteilung als Ursache der Geschwulstbildung [On cell fusion with qualitative abnormal chromosome distribution as the cause of tumor formation]. In:, Roux W, ed. Vorträge und Aufsätze über Entwicklungsmechanik der Organismen, Vol. 13, Leizig: Wilhelm Engelmann; 1911.
9. Chakraborty A, Sodi S, Rachkovsky M, Kolesnikova N, Platt JT, Bolognia JL, Pawelek JM,. A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids. Cancer Res 2000; 60: 2512-19.
10. DeBaetselier P, Roos E, Brys L, Remels L, Gobert M, Dekegel D, Segal S, Feldman M,. Nonmetastatic tumor cells acquire metastatic properties following somatic hybridization with normal cells. Cancer Metastasis Rev 1984; 3: 5-24.
11. Larizza L, Schirrmacher V,. Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants. Cancer Metastasis Rev 1984; 3: 193-222.
12. Lagarde AE, Kerbel RS,. Somatic cell hybridization in vivo and in vitro in relation to the metastatic phenotype. Biochim Biophys Acta 1985; 823: 81-110.
13. Miller FR, Mohamed AN, McEachern D,. Production of more aggressive tumor cell variant by spontaneous fusion of two mouse tumor subpopulations. Cancer Res 1989; 49: 4316-21.
14. Jacobsen BM, Harrell JC, Jedlicka P, Borges, Varella-Garcia M, Horwitz KB,. Sponteneous fusion with and transformation of mouse stroma by malignant human breast cancer epithelium. Cancer Res 2006; 66: 8274-79.
15. Pawelek JM, Chakrabarty AK,. Fusion of tumor cells with bone marrow-derived cells: a unifying explanation of metastasis. Nat Rev Cancer 2008; 8: 377-86.
16. Yilmaz Y, Lazova R, Qumsiyeh M, Cooper D, Pawelek J,. Donor Y chromosome in renal carcinoma cells of a female BMT recipient: visualization of putative BMT-tumor hybrids by FISH. Bone Marrow Transplant 2005; 35: 1021-4.
17. Ogle BM, Cascalho M, Platt JL,. Biological implications of cell fusion. Nat Rev Mol Cell Biol 2005; 6: 567-75.
18. Vignery A,. Macrophage fusion: are somatic and cancer cells possible partners? Trends Cell Biol 2005; 15: 188-93.
19. Duelli D, Lazebnik,. Cell-to-cell fusion as a link between viruses and cancer. Nat Rev Cancer 2007; 7: 968-76.
20. Larsson L-I, Bjerregaard B, Talts JF,. Cell fusions in mammals. Histochem Cell Biol 2008; 129: 551-61.
21. Chen EH, Olson EN,. Unveiling the mechanisms of cell-cell fusion. Science 2005; 308: 369-73.
22. Dittmar T, Nagler C, Schwitalla S, Reith G, Niggemann B, Zänker KS,. Recurrence cancer stem cells-made by cell fusion? Med Hypotheses 2009; 73: 542-7.
23. Harris H,. The analysis of malignancy by cell fusion: the position in 1988. Cancer Res 1988; 48: 3302-6.
24. Powell AE, Anderson EC, Davies PS, Silk AD, Pelz C, Impey S, Wong MH,. Fusion between intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming. Cancer Res 2011; 71: 1497-505.
25. Goldenberg DM, Pavia RA,. Oncogenesis by interspecific interaction of malignant murine and non-malignant hamster cells in vitro. Int J Cancer 1975; 15: 282-300.
26. Goldenberg DM, Pavia RA, Smith L,. Karyology of a human colonic carcinoma (GW-39) serially xenografted in hamsters and nude mice. Cancer Lett 1977; 2: 195-200.
27. Tlsty TD,. Stromal cells can contribute oncogenic signals. Cancer Biol 2001; 11: 97-104.
28. Mueller MM, Fusenig NE,. Friends or foe-biopolar effects of the tumor stroma in cancer. Nat Rev Cancer 2004; 4: 839-49.
29. Proia DA, Kuperwasser C,. Stroma tumor agonist or antagonist. Cell Cycle 2005; 4: 1022-5.
30. Joyce JA, Pollard JW,. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009; 9: 239-52.
31. Stein R, Mattes MJ, Cardillo TM, Hansen HJ, Chang CH, Burton J, Govindan S, Goldenberg DM,. CD74: a new candidate target for the immunotherapy of B-cell neoplasms. Clin Cancer Res 2000; 23 (Suppl): 5556s-5563s.
32. Schwartz V, Lue H, Kraemer S, Korbiel J, Krohn R, Ohl K, Bucala R, Weber C, Bernhagen J,. A functional heteromeric MIF receptor formed by CD74 and CXCR4. FEBS Lett 2009; 583: 2749-57.
33. Ehtesham M, Winston JA, Kabos P, Thompson RC,. CXCR4 expression mediates glioma cell invasiveness. Oncogene 2006; 25: 2801-6.
34. Rempel SA, Dudas S, Ge S, Gutiérrez JA,. Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 2000; 6: 102-11.
35. Sehgal A, Ricks S, Boynton AL, Warrick J, Murphy GP,. Molecular characterization of CXCR-4: a potential brain tumor-associated gene. J Surg Oncol 1998; 69: 239-48.
36. Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, et al,. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 2010; 17: 497-509.
37. Gupta V, Rajaraman S, Gadson P, Costanzi JJ,. Primary transfection as a mechanism for transformation of host cells by human tumor cells implanted in nude mice. Cancer Res 1987; 47: 5194-201.
38. Lu X, Kang Y,. Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants. Proc Natl Acad Sci USA 2009; 106: 9385-90.
39. Duelli DM, Padilla-Nash HM, Berman D, Murphy KM, Ried T, Lazebnik Y,. A virus causes cancer by inducing massive chromosomal instability through cell fusion. Current Biol 2007; 17: 431-7.
40. Pelham RJ, Rodgers L, Hall I, Lucito R, Nguyen KC, Navin N, Hicks J, Mu D, Powers S, Wigler M, Botstein D,. Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proc Natl Acad Sci USA 2006; 103: 19848-53.
41. Monifer F, Man YG, Arnould L, Bratthauer GL, Ratschek M, Tavassoli FA,. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res 2000; 60: 2562-6.
42. Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK,. Malignant cells facilitate lung metastasis by bringing their own soil. Proc Natl Acad Sci USA 2010; 107: 21677-82.
43. Goldenberg DM, Pavia RA,. Malignant potential of murine stromal cells after transplantation of human tumors into nude mice. Science 1981; 212: 65-67.
44. Goldenberg DM, Pavia RA,. In vivo horizontal oncogenesis by a human tumor in nude mice. Proc Natl Acad Sci USA 1982; 79: 2389-92.
45. Beattie GM, Knowles AF, Jensen FC, Baird SM, Kaplan NO,. Induction of sarcomas in athymic mice. Proc Natl Acad Sci USA 1982; 79: 3033-6.
46. Ehrlich P, Apolant H,. Beobachtungen über maligne Mäusetumoren [Observations on malignant murine tumors]. Berl Klin Wochenschr 1905; 42: 871-4.
47. Holmgren L, Bergsmedh A, Spetz AL,. Horizontal transfer of DNA by uptake of apoptotic bodies. Vox Sang 2002; 83 (Suppl 1): S305-S306.
48. Garcia-Olmo DC, Domínguez C, García-Arranz M, Anker P, Stroun M, García-Verdugo JM, Garcia-Olmo D,. Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells. Cancer Res 2010; 70: 560-7.
49. Stoecklin NH, Klein CA,. Genetic disparity between primary tumors, disseminated tumor cells, and manifest metastasis. Int J Cancer 2010; 126: 589-98.
50. Davies PS, Powell AE, Swain JR, Wong MH,. Inflammation and proliferation act together to mediate intestinal cell fusion. PLoS ONE 2009; 4: e6530 doi:10.1371/journal.pone.0006530.