메뉴 건너뛰기




Volumn 2014, Issue , 2014, Pages

Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; AGE RELATED MACULAR DEGENERATION; CELL SURVIVAL; CHOROID CAPILLARY LAYER; COMPLEMENT ACTIVATION; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT SYSTEM; CYTOLYSIS; EYE PROTECTION; GENE MUTATION; HUMAN; HUMORAL IMMUNITY; META ANALYSIS (TOPIC); MULTICENTER STUDY (TOPIC); NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PIGMENT EPITHELIUM; PROTECTION; RETINA; RETINA DEGENERATION; RETINA MACULOPATHY; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; TISSUE DEGENERATION; TISSUE INJURY; TISSUE PROTECTION; BIOLOGICAL MODEL; GENETICS; IMMUNOLOGY; MACULAR DEGENERATION; METABOLISM; MUTATION;

EID: 84928985230     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2014/483960     Document Type: Review
Times cited : (59)

References (112)
  • 1
    • 11144354339 scopus 로고    scopus 로고
    • Prevalence of age-relatedmacular degeneration in theUnited States
    • D. S. Friedman, B. J. O'Colmain, B.Muñoz et al., "Prevalence of age-relatedmacular degeneration in theUnited States, " Archives of Ophthalmology, vol. 122, no. 4, pp. 564-572, 2004.
    • (2004) Archives of Ophthalmology , vol.122 , Issue.4 , pp. 564-572
    • Friedman, D.S.1    O'Colmain, B.J.2    Muñoz, B.3
  • 2
    • 33749440219 scopus 로고    scopus 로고
    • Age-related macular degeneration
    • P. T. V. M. de Jong, "Age-related macular degeneration, " The New England Journal ofMedicine, vol. 355, no. 14, pp. 1474-1485, 2006.
    • (2006) The New England Journal OfMedicine , vol.355 , Issue.14 , pp. 1474-1485
    • De Jong, P.T.V.M.1
  • 3
    • 53149151049 scopus 로고    scopus 로고
    • Prevalence of decreased visual acuity among preschool-aged children in an American urban population: The Baltimore Pediatric Eye Disease Study, methods, and results
    • D. S. Friedman, M. X. Repka, J. Katz et al., "Prevalence of decreased visual acuity among preschool-aged children in an American urban population: the Baltimore Pediatric Eye Disease Study, methods, and results, " Ophthalmology, vol. 115, no. 10, pp. 1786-1795, 2008.
    • (2008) Ophthalmology , vol.115 , Issue.10 , pp. 1786-1795
    • Friedman, D.S.1    Repka, M.X.2    Katz, J.3
  • 4
    • 0031056911 scopus 로고    scopus 로고
    • The fiveyear incidence and progression of age-related maculopathy: The beaver dam eye study
    • R. Klein, B. E. K. Klein, S. C. Jensen, and S. M.Meuer, "The fiveyear incidence and progression of age-related maculopathy: the beaver dam eye study, " Ophthalmology, vol. 104, no. 1, pp. 7-21, 1997.
    • (1997) Ophthalmology , vol.104 , Issue.1 , pp. 7-21
    • Klein, R.1    Klein, B.E.K.2    Jensen, S.C.3    Meuer, S.M.4
  • 5
    • 84863727273 scopus 로고    scopus 로고
    • Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch'smembrane/choriocapillaris complex
    • I. Bhutto and G. Lutty, "Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch'smembrane/choriocapillaris complex, " Molecular Aspects of Medicine, vol. 33, no. 4, pp. 295-317, 2012.
    • (2012) Molecular Aspects of Medicine , vol.33 , Issue.4 , pp. 295-317
    • Bhutto, I.1    Lutty, G.2
  • 6
    • 70350238360 scopus 로고    scopus 로고
    • Unraveling a multifactorial late-onset disease: From genetic susceptibility to disease mechanisms for age-related macular degeneration
    • A. Swaroop, E. Y. Chew, C. B. Rickman, and G. R. Abecasis, "Unraveling a multifactorial late-onset disease: From genetic susceptibility to disease mechanisms for age-related macular degeneration, " Annual Review of Genomics and Human Genetics, vol. 10, pp. 19-43, 2009.
    • (2009) Annual Review of Genomics and Human Genetics , vol.10 , pp. 19-43
    • Swaroop, A.1    Chew, E.Y.2    Rickman, C.B.3    Abecasis, G.R.4
  • 7
    • 84863725676 scopus 로고    scopus 로고
    • Complement dysregulation in AMD: RPE-Bruch's membrane-choroid
    • J. R. Sparrow, K. Ueda, and J. Zhou, "Complement dysregulation in AMD: RPE-Bruch's membrane-choroid, " Molecular Aspects of Medicine, vol. 33, no. 4, pp. 436-445, 2012.
    • (2012) Molecular Aspects of Medicine , vol.33 , Issue.4 , pp. 436-445
    • Sparrow, J.R.1    Ueda, K.2    Zhou, J.3
  • 9
    • 84863716162 scopus 로고    scopus 로고
    • Genetic insights into age-related macular degeneration: Controversies addressing risk, causality, and therapeutics
    • M. B. Gorin, "Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics, " Molecular Aspects of Medicine, vol. 33, no. 4, pp. 467-486, 2012.
    • (2012) Molecular Aspects of Medicine , vol.33 , Issue.4 , pp. 467-486
    • Gorin, M.B.1
  • 11
    • 5144222255 scopus 로고    scopus 로고
    • Complement: A unique innate immune sensor for danger signals
    • P. Gasque, "Complement: a unique innate immune sensor for danger signals, "Molecular Immunology, vol. 41, no. 11, pp. 1089-1098, 2004.
    • (2004) Molecular Immunology , vol.41 , Issue.11 , pp. 1089-1098
    • Gasque, P.1
  • 13
    • 77249147331 scopus 로고    scopus 로고
    • The pivotal role of the complement systemin aging and age-related macular degeneration: Hypothesis re-visited
    • D. H. Anderson, M. J. Radeke, N. B. Gallo et al., "The pivotal role of the complement systemin aging and age-related macular degeneration: hypothesis re-visited, " Progress in Retinal and Eye Research, vol. 29, no. 2, pp. 95-112, 2010.
    • (2010) Progress in Retinal and Eye Research , vol.29 , Issue.2 , pp. 95-112
    • Anderson, D.H.1    Radeke, M.J.2    Gallo, N.B.3
  • 15
    • 0034012166 scopus 로고    scopus 로고
    • Drusen associated with aging and age-relatedmacular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
    • R. F.Mullins, S. R. Russell, D. H. Anderson, and G. S.Hageman, "Drusen associated with aging and age-relatedmacular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease, " FASEB Journal, vol. 14, no. 7, pp.835-846, 2000.
    • (2000) FASEB Journal , vol.14 , Issue.7 , pp. 835-846
    • Mullins, R.F.1    Russell, S.R.2    Anderson, D.H.3    Hageman, G.S.4
  • 16
    • 0035699547 scopus 로고    scopus 로고
    • Complement activation and inflammatory processes in drusen formation and age related macular degeneration
    • L. V. Johnson, W. P. Leitner, M. K. Staples, and D. H. Anderson, "Complement activation and inflammatory processes in drusen formation and age related macular degeneration, " Experimental Eye Research, vol. 73, no. 6, pp. 887-896, 2001.
    • (2001) Experimental Eye Research , vol.73 , Issue.6 , pp. 887-896
    • Johnson, L.V.1    Leitner, W.P.2    Staples, M.K.3    Anderson, D.H.4
  • 18
    • 48649088785 scopus 로고    scopus 로고
    • The aged retinal pigment epithelium/choroid: A potential substratum for the pathogenesis of age-related macular degeneration
    • H. Chen, B. Liu, T. J. Lukas, and A. H. Neufeld, "The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration, " PLoS ONE, vol. 3, no. 6, Article ID e2339, 2008.
    • (2008) PLoS ONE , vol.3 , Issue.6
    • Chen, H.1    Liu, B.2    Lukas, T.J.3    Neufeld, A.H.4
  • 19
    • 65549131634 scopus 로고    scopus 로고
    • Functional annotation of the human retinal pigment epithelium transcriptome
    • J. C. Booij, S. van Soest, S. M. A. Swagemakers et al., "Functional annotation of the human retinal pigment epithelium transcriptome, " BMC Genomics, vol. 10, article 164, 2009.
    • (2009) BMC Genomics , vol.10
    • Booij, J.C.1    Van Soest, S.2    Swagemakers, S.M.A.3
  • 20
    • 56349086505 scopus 로고    scopus 로고
    • Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina
    • M. Chen, E. Muckersie, M. Robertson, J. V. Forrester, and H. Xu, "Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina, " Experimental Eye Research, vol. 87, no. 6, pp. 543-550, 2008.
    • (2008) Experimental Eye Research , vol.87 , Issue.6 , pp. 543-550
    • Chen, M.1    Muckersie, E.2    Robertson, M.3    Forrester, J.V.4    Xu, H.5
  • 21
    • 33947160639 scopus 로고    scopus 로고
    • Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments
    • M. Chen, J. V. Forrester, and H. Xu, "Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments, " Experimental Eye Research, vol. 84, no. 4, pp. 635-645, 2007.
    • (2007) Experimental Eye Research , vol.84 , Issue.4 , pp. 635-645
    • Chen, M.1    Forrester, J.V.2    Xu, H.3
  • 23
    • 77955554198 scopus 로고    scopus 로고
    • Enhanced expression of the complement factor HmRNA in proliferating human RPE cells
    • N. Kociok and A. M. Joussen, "Enhanced expression of the complement factor HmRNA in proliferating human RPE cells, " Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 248, no. 8, pp. 1145-1153, 2010.
    • (2010) Graefe's Archive for Clinical and Experimental Ophthalmology , vol.248 , Issue.8 , pp. 1145-1153
    • Kociok, N.1    Joussen, A.M.2
  • 24
    • 67649958460 scopus 로고    scopus 로고
    • Expression and modulation of RPE cell membrane complement regulatory proteins
    • P. Yang, J. Tyrrell, I. Han, and G. J. Jaffe, "Expression and modulation of RPE cell membrane complement regulatory proteins, " Investigative Ophthalmology and Visual Science, vol. 50, no. 7, pp. 3473-3481, 2009.
    • (2009) Investigative Ophthalmology and Visual Science , vol.50 , Issue.7 , pp. 3473-3481
    • Yang, P.1    Tyrrell, J.2    Han, I.3    Jaffe, G.J.4
  • 25
    • 33846507393 scopus 로고    scopus 로고
    • CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration
    • N. S. Bora, S. Kaliappan, P. Jha et al., "CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration, " The Journal of Immunology, vol. 178, no. 3, pp. 1783-1790, 2007.
    • (2007) The Journal of Immunology , vol.178 , Issue.3 , pp. 1783-1790
    • Bora, N.S.1    Kaliappan, S.2    Jha, P.3
  • 26
    • 0033485393 scopus 로고    scopus 로고
    • Inhibition of oligodendrocyte apoptosis by sublytic C5b-9 is associated with enhanced synthesis of Bcl-2 and mediated by inhibition of caspase-3 activation
    • L. Soane, H. Rus, F. Niculescu, and M. L. Shin, "Inhibition of oligodendrocyte apoptosis by sublytic C5b-9 is associated with enhanced synthesis of Bcl-2 and mediated by inhibition of caspase-3 activation, " Journal of Immunology, vol. 163, no. 11, pp. 6132-6138, 1999.
    • (1999) Journal of Immunology , vol.163 , Issue.11 , pp. 6132-6138
    • Soane, L.1    Rus, H.2    Niculescu, F.3    Shin, M.L.4
  • 27
    • 0034793956 scopus 로고    scopus 로고
    • Sublytic C5b-9-stimulated Schwann cell survival through PI 3-kinase-mediated phosphorylation of BAD
    • S. Hila, L. Soane, and C. L. Koski, "Sublytic C5b-9-stimulated Schwann cell survival through PI 3-kinase-mediated phosphorylation of BAD, " Glia, vol. 36, no. 1, pp. 58-67, 2001.
    • (2001) Glia , vol.36 , Issue.1 , pp. 58-67
    • Hila, S.1    Soane, L.2    Koski, C.L.3
  • 28
    • 0029929039 scopus 로고    scopus 로고
    • Sublytic complement attack induces cell cycle in oligodendrocytes: S phase induction is dependent on c-jun activation
    • H. G. Rus, F. Niculescu, and M. L. Shin, "Sublytic complement attack induces cell cycle in oligodendrocytes: S phase induction is dependent on c-jun activation, " Journal of Immunology, vol. 156, no. 12, pp. 4892-4900, 1996.
    • (1996) Journal of Immunology , vol.156 , Issue.12 , pp. 4892-4900
    • Rus, H.G.1    Niculescu, F.2    Shin, M.L.3
  • 29
    • 33947315191 scopus 로고    scopus 로고
    • Molecular genetics of AMD and current animal models
    • A. O. Edwards and G. Malek, "Molecular genetics of AMD and current animal models, " Angiogenesis, vol. 10, no. 2, pp. 119-132, 2007.
    • (2007) Angiogenesis , vol.10 , Issue.2 , pp. 119-132
    • Edwards, A.O.1    Malek, G.2
  • 30
    • 14944364782 scopus 로고    scopus 로고
    • The US twin study of age-related macular degeneration: Relative roles of genetic and environmental influences
    • J. M. Seddon, J. Cote, W. F. Page, S. H. Aggen, and M. C. Neale, "The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences, " Archives of Ophthalmology, vol. 123, no. 3, pp. 321-327, 2005.
    • (2005) Archives of Ophthalmology , vol.123 , Issue.3 , pp. 321-327
    • Seddon, J.M.1    Cote, J.2    Page, W.F.3    Aggen, S.H.4    Neale, M.C.5
  • 31
    • 80052196120 scopus 로고    scopus 로고
    • Commonvariants near FRK/COL10A1 and VEGFA are associated with advanced agerelated macular degeneration
    • Y.Yu, T. R. Bhangale, J. Fagerness et al., "Commonvariants near FRK/COL10A1 and VEGFA are associated with advanced agerelated macular degeneration, " Human Molecular Genetics, vol. 20, no. 18, pp. 3699-3709, 2011.
    • (2011) Human Molecular Genetics , vol.20 , Issue.18 , pp. 3699-3709
    • Yu, Y.1    Bhangale, T.R.2    Fagerness, J.3
  • 32
    • 84875706378 scopus 로고    scopus 로고
    • Seven new loci associated with age-related macular degeneration
    • L. G. Fritsche, W. Chen, M. Schu et al., "Seven new loci associated with age-related macular degeneration, " Nature Genetics, vol. 45, no. 4, pp. 433-439, 2013.
    • (2013) Nature Genetics , vol.45 , Issue.4 , pp. 433-439
    • Fritsche, L.G.1    Chen, W.2    Schu, M.3
  • 33
    • 70350716559 scopus 로고    scopus 로고
    • CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD
    • H. P. N. Scholl, M. Fleckenstein, L. G. Fritsche et al., "CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD, " PLoS ONE, vol. 4, no. 10, Article IDe7418, 2009.
    • (2009) PLoS ONE , vol.4 , Issue.10
    • Scholl, H.P.N.1    Fleckenstein, M.2    Fritsche, L.G.3
  • 34
    • 33645419787 scopus 로고    scopus 로고
    • Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
    • B. Gold, J. E. Merriam, J. Zernant et al., "Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration, " Nature Genetics, vol. 38, no. 4, pp. 458-462, 2006.
    • (2006) Nature Genetics , vol.38 , Issue.4 , pp. 458-462
    • Gold, B.1    Merriam, J.E.2    Zernant, J.3
  • 35
    • 66249126501 scopus 로고    scopus 로고
    • 3 are associatedwith progression to advanced age related macular degeneration associated with visual loss
    • 3 are associatedwith progression to advanced age related macular degeneration associated with visual loss, " Journal of Medical Genetics, vol. 46, no. 5, pp. 300-307, 2009.
    • (2009) Journal of Medical Genetics , vol.46 , Issue.5 , pp. 300-307
    • Francis, P.J.1    Hamon, S.C.2    Ott, J.3    Weleber, R.G.4    Klein, M.L.5
  • 37
    • 34548406001 scopus 로고    scopus 로고
    • Protective effect of complement factor B and complement component 2 variants in age-relatedmacular degeneration
    • K. L. Spencer, M. A.Hauser, L. M. Olson et al., "Protective effect of complement factor B and complement component 2 variants in age-relatedmacular degeneration, " HumanMolecular Genetics, vol. 16, no. 16, pp. 1986-1992, 2007.
    • (2007) HumanMolecular Genetics , vol.16 , Issue.16 , pp. 1986-1992
    • Spencer, K.L.1    Hauser, M.A.2    Olson, L.M.3
  • 39
    • 75749107535 scopus 로고    scopus 로고
    • The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration
    • I. Kaur, S. Katta, R. K. Reddy et al., "The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration, " Investigative Ophthalmology and Visual Science, vol. 51, no. 1, pp. 59-63, 2010.
    • (2010) Investigative Ophthalmology and Visual Science , vol.51 , Issue.1 , pp. 59-63
    • Kaur, I.1    Katta, S.2    Reddy, R.K.3
  • 40
    • 33748309136 scopus 로고    scopus 로고
    • Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration
    • J. Maller, S. George, S. Purcell et al., "Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration, " Nature Genetics, vol. 38, no. 9, pp. 1055-1059, 2006.
    • (2006) Nature Genetics , vol.38 , Issue.9 , pp. 1055-1059
    • Maller, J.1    George, S.2    Purcell, S.3
  • 41
    • 59449109680 scopus 로고    scopus 로고
    • Analysis of rare variants in the complement component 2 (C2) and factor B (BF) genes refine association for age-related macular degeneration (AMD)
    • A. J. Richardson, F. M. Amirul Islam, R. H. Guymer, and P. N. Baird, "Analysis of rare variants in the complement component 2 (C2) and factor B (BF) genes refine association for age-related macular degeneration (AMD), " Investigative Ophthalmology and Visual Science, vol. 50, no. 2, pp. 540-543, 2009.
    • (2009) Investigative Ophthalmology and Visual Science , vol.50 , Issue.2 , pp. 540-543
    • Richardson, A.J.1    Amirul Islam, F.M.2    Guymer, R.H.3    Baird, P.N.4
  • 42
    • 48249096770 scopus 로고    scopus 로고
    • C2 and CFB genes in Age-related maculopathy and joint action with CFH and LOC387715 genes
    • J. Jakobsdottir, Y. P. Conley, D. E. Weeks, R. E. Ferrell, and M. B. Gorin, "C2 and CFB genes in Age-related maculopathy and joint action with CFH and LOC387715 genes, " PLoS ONE, vol. 3, no. 5, Article ID e2199, 2008.
    • (2008) PLoS ONE , vol.3 , Issue.5
    • Jakobsdottir, J.1    Conley, Y.P.2    Weeks, D.E.3    Ferrell, R.E.4    Gorin, M.B.5
  • 43
    • 81855198945 scopus 로고    scopus 로고
    • Evaluation of new and established age-related macular degeneration susceptibility genes in the Women's Health Initiative Sight Exam (WHI-SE) study
    • I. Peter, G. S. Huggins, J. M. Ordovas, M. Haan, and J. M. Seddon, "Evaluation of new and established age-related macular degeneration susceptibility genes in the Women's Health Initiative Sight Exam (WHI-SE) study, " The American Journal of Ophthalmology, vol. 152, no. 6, pp. 1005-1013, 2011.
    • (2011) The American Journal of Ophthalmology , vol.152 , Issue.6 , pp. 1005-1013
    • Peter, I.1    Huggins, G.S.2    Ordovas, J.M.3    Haan, M.4    Seddon, J.M.5
  • 44
    • 33947661925 scopus 로고    scopus 로고
    • Evidence for association between multiple complement pathway genes and AMD
    • V. Dinu, P. L. Miller, and H. Zhao, "Evidence for association between multiple complement pathway genes and AMD, " Genetic Epidemiology, vol. 31, no. 3, pp. 224-237, 2007.
    • (2007) Genetic Epidemiology , vol.31 , Issue.3 , pp. 224-237
    • Dinu, V.1    Miller, P.L.2    Zhao, H.3
  • 45
    • 17244379811 scopus 로고    scopus 로고
    • Complement factor H polymorphism and age-related macular degeneration
    • A. O. Edwards, R. Ritter III, K. J. Abel, A.Manning, C. Panhuysen, and L.A. Farrer, "Complement factor H polymorphism and age-related macular degeneration, " Science, vol. 308, no. 5720, pp. 421-424, 2005.
    • (2005) Science , vol.308 , Issue.5720 , pp. 421-424
    • Edwards, A.O.1    Ritter, R.2    Abel, K.J.3    Manning, A.4    Panhuysen, C.5    Farrer, L.A.6
  • 46
    • 20244388812 scopus 로고    scopus 로고
    • Complement factor H variant increases the risk of age-related macular degeneration
    • J. L.Haines, M.A.Hauser, S. Schmidt et al., "Complement factor H variant increases the risk of age-related macular degeneration, " Science, vol. 308, no. 5720, pp. 419-421, 2005.
    • (2005) Science , vol.308 , Issue.5720 , pp. 419-421
    • Haines, J.L.1    Hauser, M.A.2    Schmidt, S.3
  • 47
    • 20244380171 scopus 로고    scopus 로고
    • Complement factor H polymorphism in age-related macular degeneration
    • R. J. Klein, C. Zeiss, E. Y. Chew et al., "Complement factor H polymorphism in age-related macular degeneration, " Science, vol. 308, no. 5720, pp. 385-389, 2005.
    • (2005) Science , vol.308 , Issue.5720 , pp. 385-389
    • Klein, R.J.1    Zeiss, C.2    Chew, E.Y.3
  • 48
    • 35148839857 scopus 로고    scopus 로고
    • Haplotypes spanning the complement factor H gene are protective against age-relatedmacular degeneration
    • K. L. Spencer, M. A. Hauser, L. M. Olson et al., "Haplotypes spanning the complement factor H gene are protective against age-relatedmacular degeneration, " Investigative Ophthalmology and Visual Science, vol. 48, no. 9, pp. 4277-4283, 2007.
    • (2007) Investigative Ophthalmology and Visual Science , vol.48 , Issue.9 , pp. 4277-4283
    • Spencer, K.L.1    Hauser, M.A.2    Olson, L.M.3
  • 49
    • 21044453724 scopus 로고    scopus 로고
    • A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    • G. S. Hageman, D. H. Anderson, L. V. Johnson et al., "A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration, " Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 20, pp. 7227-7232, 2005.
    • (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , Issue.20 , pp. 7227-7232
    • Hageman, G.S.1    Anderson, D.H.2    Johnson, L.V.3
  • 50
    • 33644676878 scopus 로고    scopus 로고
    • Complement factor H polymorphisms in Japanese population with age-related macular degeneration
    • H. Okamoto, S.Umeda, M. Obazawa et al., "Complement factor H polymorphisms in Japanese population with age-related macular degeneration, " Molecular Vision, vol. 12, pp. 156-158, 2006.
    • (2006) Molecular Vision , vol.12 , pp. 156-158
    • Okamoto, H.1    Umeda, S.2    Obazawa, M.3
  • 51
    • 78649691414 scopus 로고    scopus 로고
    • Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-relatedmacular degeneration
    • L. J. Kopplin, R. P. Igo, Y. Wang Jr. et al., "Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-relatedmacular degeneration, " Genes and Immunity, vol. 11, no. 8, pp. 609-621, 2010.
    • (2010) Genes and Immunity , vol.11 , Issue.8 , pp. 609-621
    • Kopplin, L.J.1    Igo, R.P.2    Wang, Y.3
  • 52
    • 77952147434 scopus 로고    scopus 로고
    • Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    • W. Chen, D. Stambolian, A. O. Edwards et al., "Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration, " Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 16, pp. 7401-7406, 2010.
    • (2010) Proceedings of the National Academy of Sciences of the United States of America , vol.107 , Issue.16 , pp. 7401-7406
    • Chen, W.1    Stambolian, D.2    Edwards, A.O.3
  • 53
    • 33749123246 scopus 로고    scopus 로고
    • A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration
    • A. E. Hughes, N. Orr, H. Esfandiary, M. Diaz-Torres, T. Goodship, and U. Chakravarthy, "A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration, " Nature Genetics, vol. 38, no. 10, pp. 1173-1177, 2006.
    • (2006) Nature Genetics , vol.38 , Issue.10 , pp. 1173-1177
    • Hughes, A.E.1    Orr, N.2    Esfandiary, H.3    Diaz-Torres, M.4    Goodship, T.5    Chakravarthy, U.6
  • 54
    • 78149270873 scopus 로고    scopus 로고
    • An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)
    • L. G. Fritsche, N. Lauer, A. Hartmann et al., "An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD), " Human Molecular Genetics, vol. 19, no. 23, pp. 4694-4704, 2010.
    • (2010) Human Molecular Genetics , vol.19 , Issue.23 , pp. 4694-4704
    • Fritsche, L.G.1    Lauer, N.2    Hartmann, A.3
  • 55
    • 82255162545 scopus 로고    scopus 로고
    • A rare penetrant mutation in CFH confers high risk of age-related macular degeneration
    • S. Raychaudhuri, O. Iartchouk, K. Chin et al., "A rare penetrant mutation in CFH confers high risk of age-related macular degeneration, " Nature Genetics, vol. 43, no. 12, pp. 1232-1236, 2011.
    • (2011) Nature Genetics , vol.43 , Issue.12 , pp. 1232-1236
    • Raychaudhuri, S.1    Iartchouk, O.2    Chin, K.3
  • 56
    • 65349175762 scopus 로고    scopus 로고
    • Genetic analysis of complement factor H related 5, CFHR5, in patients with age-related macular degeneration
    • U. Narendra, G. J. T. Pauer, and S. A. Hagstrom, "Genetic analysis of complement factor H related 5, CFHR5, in patients with age-related macular degeneration, " Molecular Vision, vol. 15, pp. 731-736, 2009.
    • (2009) Molecular Vision , vol.15 , pp. 731-736
    • Narendra, U.1    Pauer, G.J.T.2    Hagstrom, S.A.3
  • 58
    • 69449090499 scopus 로고    scopus 로고
    • The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity
    • A. Tortajada, T. Montes, R. Martínez-Barricarte, B. P. Morgan, C. L. Harris, and S. R. de Córdoba, "The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity, " Human Molecular Genetics, vol. 18, no. 18, pp. 3452-3461, 2009.
    • (2009) Human Molecular Genetics , vol.18 , Issue.18 , pp. 3452-3461
    • Tortajada, A.1    Montes, T.2    Martínez-Barricarte, R.3    Morgan, B.P.4    Harris, C.L.5    De Córdoba, S.R.6
  • 61
    • 33847153137 scopus 로고    scopus 로고
    • Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: Characterization, ethnic distribution and evolutionary implications
    • G. S. Hageman, L. S. Hancox, A. J. Taiber et al., "Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications, " Annals ofMedicine, vol. 38, no. 8, pp. 592-604, 2006.
    • (2006) Annals OfMedicine , vol.38 , Issue.8 , pp. 592-604
    • Hageman, G.S.1    Hancox, L.S.2    Taiber, A.J.3
  • 62
    • 70349441306 scopus 로고    scopus 로고
    • Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation
    • S. Heinen, A. Hartmann, N. Lauer et al., "Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation, " Blood, vol. 114, no. 12, pp. 2439-2447, 2009.
    • (2009) Blood , vol.114 , Issue.12 , pp. 2439-2447
    • Heinen, S.1    Hartmann, A.2    Lauer, N.3
  • 63
    • 84866039264 scopus 로고    scopus 로고
    • Complement dysregulation and disease: From genes and proteins to diagnostics and drugs
    • S. R. de Cordoba, A. Tortajada, C. L. Harris, and B. P. Morgan, "Complement dysregulation and disease: from genes and proteins to diagnostics and drugs, " Immunobiology, vol. 217, no. 11, pp. 1034-1046, 2012.
    • (2012) Immunobiology , vol.217 , Issue.11 , pp. 1034-1046
    • De Cordoba, S.R.1    Tortajada, A.2    Harris, C.L.3    Morgan, B.P.4
  • 64
    • 79958789920 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: A HuGE review and meta-analysis
    • A. Thakkinstian, G. J. McKay, M. McEvoy et al., "Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: a HuGE review and meta-analysis, " The American Journal of Epidemiology, vol. 173, no. 12, pp. 1365-1379, 2011.
    • (2011) The American Journal of Epidemiology , vol.173 , Issue.12 , pp. 1365-1379
    • Thakkinstian, A.1    McKay, G.J.2    McEvoy, M.3
  • 65
    • 73349112242 scopus 로고    scopus 로고
    • Plasma complement components and activation fragments: Associations with age-relatedmacular degeneration genotypes and phenotypes
    • R. Reynolds, M. E. Hartnett, J. P. Atkinson, P. C. Giclas, B. Rosner, and J. M. Seddon, "Plasma complement components and activation fragments: associations with age-relatedmacular degeneration genotypes and phenotypes, " InvestigativeOphthalmology and Visual Science, vol. 50, no. 12, pp. 5818-5827, 2009.
    • (2009) InvestigativeOphthalmology and Visual Science , vol.50 , Issue.12 , pp. 5818-5827
    • Reynolds, R.1    Hartnett, M.E.2    Atkinson, J.P.3    Giclas, P.C.4    Rosner, B.5    Seddon, J.M.6
  • 66
    • 77649291314 scopus 로고    scopus 로고
    • Genetic control of the alternative pathway of complement in humans and age-related macular degeneration
    • L. A.Hecker, A.O. Edwards, E. Ryu et al., "Genetic control of the alternative pathway of complement in humans and age-related macular degeneration, " Human Molecular Genetics, vol. 19, no. 1, pp. 209-215, 2009.
    • (2009) Human Molecular Genetics , vol.19 , Issue.1 , pp. 209-215
    • Hecker, L.A.1    Edwards, A.O.2    Ryu, E.3
  • 67
    • 49749150467 scopus 로고    scopus 로고
    • Systemic complement activation in age-relatedmacular degeneration
    • H. P.N. Scholl, P.C. Issa, M.Walier et al., "Systemic complement activation in age-relatedmacular degeneration, " PLoS ONE, vol. 3, no. 7, Article ID e2593, 2008.
    • (2008) PLoS ONE , vol.3 , Issue.7
    • Scholl, H.P.N.1    Issa, P.C.2    Walier, M.3
  • 68
    • 20444430102 scopus 로고    scopus 로고
    • Basal deposits and drusen in eyes with age-related maculopathy: Evidence for solid lipid particles
    • C. A. Curcio, J. B. Presley, C. L. Millican, and N. E. Medeiros, "Basal deposits and drusen in eyes with age-related maculopathy: evidence for solid lipid particles, " Experimental Eye Research, vol. 80, no. 6, pp. 761-775, 2005.
    • (2005) Experimental Eye Research , vol.80 , Issue.6 , pp. 761-775
    • Curcio, C.A.1    Presley, J.B.2    Millican, C.L.3    Medeiros, N.E.4
  • 69
    • 23244467801 scopus 로고    scopus 로고
    • Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: Initial characterization
    • C. Li, B. H. Chung, J. B. Presley et al., "Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization, " Investigative Ophthalmology and Visual Science, vol. 46, no. 7, pp. 2576-2586, 2005.
    • (2005) Investigative Ophthalmology and Visual Science , vol.46 , Issue.7 , pp. 2576-2586
    • Li, C.1    Chung, B.H.2    Presley, J.B.3
  • 70
    • 77956402099 scopus 로고    scopus 로고
    • Abundant lipid and protein components of drusen
    • L.Wang, M. E. Clark, D. K. Crossman et al., "Abundant lipid and protein components of drusen, " PLoS ONE, vol. 5, no. 4, Article ID e10329, 2010.
    • (2010) PLoS ONE , vol.5 , Issue.4
    • Wang, L.1    Clark, M.E.2    Crossman, D.K.3
  • 71
    • 27744516278 scopus 로고    scopus 로고
    • Asimplified severity scale for age-related macular degeneration: AREDS report no. 18
    • F. L. Ferris, M.D.Davis, T. E. Clemons et al., "Asimplified severity scale for age-related macular degeneration: AREDS report no. 18, " Archives ofOphthalmology, vol. 123, no. 11, pp. 1570-1574, 2005.
    • (2005) Archives OfOphthalmology , vol.123 , Issue.11 , pp. 1570-1574
    • Ferris, F.L.1    Davis, M.D.2    Clemons, T.E.3
  • 72
    • 0037332052 scopus 로고    scopus 로고
    • Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy
    • G. Malek, C. M. Li, C. Guidry, N. E. Medeiros, and C. A. Curcio, "Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy, " The American Journal of Pathology, vol. 162, no. 2, pp. 413-425, 2003.
    • (2003) The American Journal of Pathology , vol.162 , Issue.2 , pp. 413-425
    • Malek, G.1    Li, C.M.2    Guidry, C.3    Medeiros, N.E.4    Curcio, C.A.5
  • 73
    • 81055130123 scopus 로고    scopus 로고
    • Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration
    • L. V. Johnson, D. L. Forest, C. D. Banna et al., "Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration, " Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 45, pp. 18277-18282, 2011.
    • (2011) Proceedings of the National Academy of Sciences of the United States of America , vol.108 , Issue.45 , pp. 18277-18282
    • Johnson, L.V.1    Forest, D.L.2    Banna, C.D.3
  • 74
    • 0345760069 scopus 로고    scopus 로고
    • Characterization of β amyloid assemblies in drusen: The deposits associated with aging and agerelated macular degeneration
    • D.H.Anderson, K. C. Talaga, A. J.Rivest, E. Barron, G. S.Hageman, and L. V. Johnson, "Characterization of β amyloid assemblies in drusen: the deposits associated with aging and agerelated macular degeneration, " Experimental Eye Research, vol. 78, no. 2, pp. 243-256, 2004.
    • (2004) Experimental Eye Research , vol.78 , Issue.2 , pp. 243-256
    • Anderson, D.H.1    Talaga, K.C.2    Rivest, A.J.3    Barron, E.4    Hageman, G.S.5    Johnson, L.V.6
  • 76
    • 1842478123 scopus 로고    scopus 로고
    • Current concepts in the pathogenesis of agerelated macular degeneration
    • M. A. Zarbin, "Current concepts in the pathogenesis of agerelated macular degeneration, " Archives of Ophthalmology, vol. 122, no. 4, pp. 598-614, 2004.
    • (2004) Archives of Ophthalmology , vol.122 , Issue.4 , pp. 598-614
    • Zarbin, M.A.1
  • 77
    • 67650547973 scopus 로고    scopus 로고
    • Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury
    • J. M.Thurman, B. Renner, K. Kunchithapauthamet al., "Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury, " Journal of Biological Chemistry, vol. 284, no. 25, pp. 16939-16947, 2009.
    • (2009) Journal of Biological Chemistry , vol.284 , Issue.25 , pp. 16939-16947
    • Thurman, J.M.1    Renner, B.2    Kunchithapauthamet, K.3
  • 78
    • 84860671364 scopus 로고    scopus 로고
    • NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components
    • S. L. Doyle, M. Campbell, E. Ozaki et al., "NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components, " Nature Medicine, vol. 18, no. 5, pp. 791-798, 2012.
    • (2012) Nature Medicine , vol.18 , Issue.5 , pp. 791-798
    • Doyle, S.L.1    Campbell, M.2    Ozaki, E.3
  • 79
    • 47849097202 scopus 로고    scopus 로고
    • Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
    • V. Hornung, F. Bauernfeind, A. Halle et al., "Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization, " Nature Immunology, vol. 9, no. 8, pp. 847-856, 2008.
    • (2008) Nature Immunology , vol.9 , Issue.8 , pp. 847-856
    • Hornung, V.1    Bauernfeind, F.2    Halle, A.3
  • 80
    • 10844231850 scopus 로고    scopus 로고
    • Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization
    • P. S. Bora, J. Sohn, J. M. C. Cruz et al., "Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization, " Journal of Immunology, vol. 174, no. 1, pp. 491-497, 2005.
    • (2005) Journal of Immunology , vol.174 , Issue.1 , pp. 491-497
    • Bora, P.S.1    Sohn, J.2    Cruz, J.M.C.3
  • 81
    • 33746190776 scopus 로고    scopus 로고
    • Complement activation via alternative pathway is critical in the development of laserinduced choroidal neovascularization: Role of factor B and factor H
    • N. S. Bora, S. Kaliappan, P. Jha et al., "Complement activation via alternative pathway is critical in the development of laserinduced choroidal neovascularization: role of factor B and factor H, " The Journal of Immunology, vol. 177, no. 3, pp. 1872-1878, 2006.
    • (2006) The Journal of Immunology , vol.177 , Issue.3 , pp. 1872-1878
    • Bora, N.S.1    Kaliappan, S.2    Jha, P.3
  • 83
  • 84
    • 0028014275 scopus 로고
    • Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor fromendothelial cells
    • L. R. Benzaquen, A. Nicholson-Weller, and J. A. Halperin, "Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor fromendothelial cells, " Journal of Experimental Medicine, vol. 179, no. 3, pp. 985-992, 1994.
    • (1994) Journal of Experimental Medicine , vol.179 , Issue.3 , pp. 985-992
    • Benzaquen, L.R.1    Nicholson-Weller, A.2    Halperin, J.A.3
  • 85
    • 80051563642 scopus 로고    scopus 로고
    • Expression of complement component 3 (C3) from an adenovirus leads to pathology in the murine retina
    • S. M. Cashman, A. Desai, K. Ramo, and R. Kumar-Singh, "Expression of complement component 3 (C3) from an adenovirus leads to pathology in the murine retina, " Investigative Ophthalmology and Visual Science, vol. 52, no. 6, pp. 3436-3445, 2011.
    • (2011) Investigative Ophthalmology and Visual Science , vol.52 , Issue.6 , pp. 3436-3445
    • Cashman, S.M.1    Desai, A.2    Ramo, K.3    Kumar-Singh, R.4
  • 86
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • R.Medzhitov, "Origin and physiological roles of inflammation, " Nature, vol. 454, no. 7203, pp. 428-435, 2008.
    • (2008) Nature , vol.454 , Issue.7203 , pp. 428-435
    • Medzhitov, R.1
  • 87
    • 0037791771 scopus 로고    scopus 로고
    • Activation of complement in the central nervous system: Roles in neurodegeneration and neuroprotection
    • J. Van Beek, K. Elward, and P. Gasque, "Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection, " Annals of the New York Academy of Sciences, vol. 992, pp. 56-71, 2003.
    • (2003) Annals of the New York Academy of Sciences , vol.992 , pp. 56-71
    • Van Beek, J.1    Elward, K.2    Gasque, P.3
  • 88
    • 38049107388 scopus 로고    scopus 로고
    • Complement component C1q inhibits β-amyloid-and serum amyloid P-induced neurotoxicity via caspase-and calpain-independent mechanisms
    • K. Pisalyaput and A. J. Tenner, "Complement component C1q inhibits β-amyloid-and serum amyloid P-induced neurotoxicity via caspase-and calpain-independent mechanisms, " Journal of Neurochemistry, vol. 104, no. 3, pp. 696-707, 2008.
    • (2008) Journal of Neurochemistry , vol.104 , Issue.3 , pp. 696-707
    • Pisalyaput, K.1    Tenner, A.J.2
  • 89
    • 79952273376 scopus 로고    scopus 로고
    • Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression
    • M. E. Benoit and A. J. Tenner, "Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression, " The Journal of Neuroscience, vol. 31, no. 9, pp. 3459-3469, 2011.
    • (2011) The Journal of Neuroscience , vol.31 , Issue.9 , pp. 3459-3469
    • Benoit, M.E.1    Tenner, A.J.2
  • 90
    • 46749087854 scopus 로고    scopus 로고
    • Complement C3 deficiency leads to accelerated amyloid β plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice
    • M.Maier, Y. Peng, L. Jiang, T. J. Seabrook, M. C. Carroll, and C. A. Lemere, "Complement C3 deficiency leads to accelerated amyloid β plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice, " Journal of Neuroscience, vol. 28, no. 25, pp. 6333-6341, 2008.
    • (2008) Journal of Neuroscience , vol.28 , Issue.25 , pp. 6333-6341
    • Maier, M.1    Peng, Y.2    Jiang, L.3    Seabrook, T.J.4    Carroll, M.C.5    Lemere, C.A.6
  • 91
    • 84880576637 scopus 로고    scopus 로고
    • Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration
    • J. H. Kam, E. Lenassi, T. H. Malik, M. C. Pickering, and G. Jeffery, "Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration, " The American Journal of Pathology, vol. 183, no. 2, pp. 480-492, 2013.
    • (2013) The American Journal of Pathology , vol.183 , Issue.2 , pp. 480-492
    • Kam, J.H.1    Lenassi, E.2    Malik, T.H.3    Pickering, M.C.4    Jeffery, G.5
  • 92
    • 44449106678 scopus 로고    scopus 로고
    • IFN-γ and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production
    • J. Liu, F. Lin, M. G. Strainic et al., "IFN-γ and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production, " The Journal of Immunology, vol. 180, no. 9, pp. 5882-5889, 2008.
    • (2008) The Journal of Immunology , vol.180 , Issue.9 , pp. 5882-5889
    • Liu, J.1    Lin, F.2    Strainic, M.G.3
  • 93
    • 77955883153 scopus 로고    scopus 로고
    • Complement: A key system for immune surveillance and homeostasis
    • D.Ricklin, G.Hajishengallis, K. Yang, and J. D. Lambris, "Complement: a key system for immune surveillance and homeostasis, " Nature Immunology, vol. 11, no. 9, pp. 785-797, 2010.
    • (2010) Nature Immunology , vol.11 , Issue.9 , pp. 785-797
    • Ricklin, D.1    Hajishengallis, G.2    Yang, K.3    Lambris, J.D.4
  • 94
    • 0031781612 scopus 로고    scopus 로고
    • Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells
    • T. Takabayashi, E. Vannier, J. F. Burke, R. G. Tompkins, J. A. Gelfand, and B. D. Clark, "Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells, " Journal of InfectiousDiseases, vol. 177, no.6, pp. 1622-1628, 1998.
    • (1998) Journal of InfectiousDiseases , vol.177 , Issue.6 , pp. 1622-1628
    • Takabayashi, T.1    Vannier, E.2    Burke, J.F.3    Tompkins, R.G.4    Gelfand, J.A.5    Clark, B.D.6
  • 95
    • 0029974609 scopus 로고    scopus 로고
    • A new biologic role for C3a and C3a desArg: Regulation of TNF-α and IL-1β synthesis
    • T. Takabayashi, E. Vannier, B. D. Clark et al., "A new biologic role for C3a and C3a desArg: regulation of TNF-α and IL-1β synthesis, " The Journal of Immunology, vol. 156, no. 9, pp. 3455-3460, 1996.
    • (1996) The Journal of Immunology , vol.156 , Issue.9 , pp. 3455-3460
    • Takabayashi, T.1    Vannier, E.2    Clark, B.D.3
  • 96
    • 0035847643 scopus 로고    scopus 로고
    • Complement anaphylatoxin c3a is selectively protective against nmda-induced neuronal cell death
    • J. van Beek, O. Nicole, C. Ali et al., "Complement anaphylatoxin c3a is selectively protective against nmda-induced neuronal cell death, " NeuroReport, vol. 12, no. 2, pp. 289-293, 2001.
    • (2001) NeuroReport , vol.12 , Issue.2 , pp. 289-293
    • Van Beek, J.1    Nicole, O.2    Ali, C.3
  • 97
    • 33745667763 scopus 로고    scopus 로고
    • Interleukin-1β and anaphylatoxins exert a synergistic effect onNGF expression by astrocytes
    • A. Jauneau, A. Ischenko, A. Chatagner et al., "Interleukin-1β and anaphylatoxins exert a synergistic effect onNGF expression by astrocytes, " Journal of Neuroinflammation, vol. 3, article 8, 2006.
    • (2006) Journal of Neuroinflammation , vol.3
    • Jauneau, A.1    Ischenko, A.2    Chatagner, A.3
  • 98
    • 0031913982 scopus 로고    scopus 로고
    • Inflammatory signals induce neurotrophin expression in human microglial cells
    • K. Heese, C. Hock, and U. Otten, "Inflammatory signals induce neurotrophin expression in human microglial cells, " Journal of Neurochemistry, vol. 70, no. 2, pp. 699-707, 1998.
    • (1998) Journal of Neurochemistry , vol.70 , Issue.2 , pp. 699-707
    • Heese, K.1    Hock, C.2    Otten, U.3
  • 99
    • 0033562337 scopus 로고    scopus 로고
    • Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity
    • H. Osaka, P. Mukherjee, P. S. Aisen, and G. M. Pasinetti, "Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity, " Journal of Cellular Biochemistry, vol. 73, no. 3, pp. 303-311, 1999.
    • (1999) Journal of Cellular Biochemistry , vol.73 , Issue.3 , pp. 303-311
    • Osaka, H.1    Mukherjee, P.2    Aisen, P.S.3    Pasinetti, G.M.4
  • 100
    • 33746585656 scopus 로고    scopus 로고
    • The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-κB activation
    • S. P. Kastl, W. S. Speidl, C. Kaun et al., "The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-κB activation, " Journal of Thrombosis and Haemostasis, vol. 4, no. 8, pp. 1790-1797, 2006.
    • (2006) Journal of Thrombosis and Haemostasis , vol.4 , Issue.8 , pp. 1790-1797
    • Kastl, S.P.1    Speidl, W.S.2    Kaun, C.3
  • 101
    • 64149093561 scopus 로고    scopus 로고
    • Functions of C5a receptors
    • P. A. Ward, "Functions of C5a receptors, " Journal of Molecular Medicine, vol. 87, no. 4, pp. 375-378, 2009.
    • (2009) Journal of Molecular Medicine , vol.87 , Issue.4 , pp. 375-378
    • Ward, P.A.1
  • 102
    • 77749327561 scopus 로고    scopus 로고
    • Dendritic cell function in allostimulation is modulated by C5aR signaling
    • Q. Peng, K. Li, N. Wang et al., "Dendritic cell function in allostimulation is modulated by C5aR signaling, " The Journal of Immunology, vol. 183, no. 10, pp. 6058-6068, 2009.
    • (2009) The Journal of Immunology , vol.183 , Issue.10 , pp. 6058-6068
    • Peng, Q.1    Li, K.2    Wang, N.3
  • 103
    • 33846495181 scopus 로고    scopus 로고
    • C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion
    • J. M. Thurman, A. M. Lenderink, P. A. Royer et al., "C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion, " The Journal of Immunology, vol. 178, no. 3, pp. 1819-1828, 2007.
    • (2007) The Journal of Immunology , vol.178 , Issue.3 , pp. 1819-1828
    • Thurman, J.M.1    Lenderink, A.M.2    Royer, P.A.3
  • 104
    • 33748761376 scopus 로고    scopus 로고
    • Transcriptional control of the C3a receptor gene in glial cells: Dependence upon AP-1 but not Ets
    • C. B. Martin, S.A. Ingersoll, and B. K. Martin, "Transcriptional control of the C3a receptor gene in glial cells: dependence upon AP-1 but not Ets, "Molecular Immunology, vol. 44, no. 5, pp. 703-712, 2007.
    • (2007) Molecular Immunology , vol.44 , Issue.5 , pp. 703-712
    • Martin, C.B.1    Ingersoll, S.A.2    Martin, B.K.3
  • 105
    • 40249116606 scopus 로고    scopus 로고
    • Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells
    • M.G. Strainic, J. Liu, D.Huang et al., "Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells, " Immunity, vol. 28, no. 3, pp. 425-435, 2008.
    • (2008) Immunity , vol.28 , Issue.3 , pp. 425-435
    • Strainic, M.G.1    Liu, J.2    Huang, D.3
  • 107
    • 0035076597 scopus 로고    scopus 로고
    • Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinasedependent inhibition of caspase 3
    • P. Mukherjee and G. M. Pasinetti, "Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinasedependent inhibition of caspase 3, " Journal of Neurochemistry, vol. 77, no. 1, pp. 43-49, 2001.
    • (2001) Journal of Neurochemistry , vol.77 , Issue.1 , pp. 43-49
    • Mukherjee, P.1    Pasinetti, G.M.2
  • 108
    • 39649121460 scopus 로고    scopus 로고
    • Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo
    • P. Mukherjee, S. Thomas, and G. M. Pasinetti, "Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo, " Journal of Neuroinflammation, vol. 5, article 5, 2008.
    • (2008) Journal of Neuroinflammation , vol.5
    • Mukherjee, P.1    Thomas, S.2    Pasinetti, G.M.3
  • 109
    • 0034717942 scopus 로고    scopus 로고
    • The role of complement anaphylatoxin C5a in neurodegeneration: Implications in Alzheimer's disease
    • P. Mukherjee and G. M. Pasinetti, "The role of complement anaphylatoxin C5a in neurodegeneration: implications in Alzheimer's disease, " Journal of Neuroimmunology, vol. 105, no. 2, pp. 124-130, 2000.
    • (2000) Journal of Neuroimmunology , vol.105 , Issue.2 , pp. 124-130
    • Mukherjee, P.1    Pasinetti, G.M.2
  • 110
    • 72849120050 scopus 로고    scopus 로고
    • Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells
    • N. Shinjyo, A. Stahlberg, M. Dragunow, M. Pekny, and M. Pekna, "Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells, " Stem Cells, vol. 27, no. 11, pp. 2824-2832, 2009.
    • (2009) Stem Cells , vol.27 , Issue.11 , pp. 2824-2832
    • Shinjyo, N.1    Stahlberg, A.2    Dragunow, M.3    Pekny, M.4    Pekna, M.5
  • 111
    • 78649494476 scopus 로고    scopus 로고
    • CNS-specific expression of C3a and C5a exacerbate demyelination severity in the cuprizonemodel
    • S. A. Ingersoll, C. B. Martin, S. R. Barnum, and B. K. Martin, "CNS-specific expression of C3a and C5a exacerbate demyelination severity in the cuprizonemodel, "Molecular Immunology, vol. 48, no. 1-3, pp. 219-230, 2010.
    • (2010) Molecular Immunology , vol.48 , Issue.1-3 , pp. 219-230
    • Ingersoll, S.A.1    Martin, C.B.2    Barnum, S.R.3    Martin, B.K.4
  • 112
    • 33645309347 scopus 로고    scopus 로고
    • Complement: A novel factor in basal and ischemia-induced neurogenesis
    • Y. Rahpeymai, M. A. Hietala, U. Wilhelmsson et al., "Complement: a novel factor in basal and ischemia-induced neurogenesis, " EMBO Journal, vol. 25, no. 6, pp. 1364-1374, 2006.
    • (2006) EMBO Journal , vol.25 , Issue.6 , pp. 1364-1374
    • Rahpeymai, Y.1    Hietala, M.A.2    Wilhelmsson, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.