Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells

Journal of Infectious Diseases

Volumn 177, Issue 6, 1998, Pages 1622-1628

  Takabayashi, Tsukasa ^b   Vannier, Edouard ^b   Burke, John F ^b   Tompkins, Ronald G ^b   Gelfand, Jeffrey A ^b   Clark, Burton D ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3A; ENDOTOXIN; INTERLEUKIN 6; MESSENGER RNA;

ACUTE PHASE RESPONSE; ARTICLE; CELL ADHESION; COMPLEMENT ACTIVATION; COMPLEMENT BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; INJURY; MONONUCLEAR CELL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN INDUCTION; SEPSIS;

EID: 0031781612     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515316     Document Type: Article

References (16)

1. Weinberg PF, Matthay MA, Webster RO, Roskos KV, Goldstein IM, Murray JF. Biologically active products of complement and acute lung injury in patients with the sepsis syndrome. Am Rev Respir Dis 1984;130:791-6.
2. Heideman M, Norder-Hansson B, Bengtson A, Mollnes TE. Terminal complement complexes and anaphylatoxins in septic and ischemic patients. Arch Surg 1988;123:188-92.
3. Bengtson A, Heideman M. Anaphylatoxin formation in sepsis. Arch Surg 1988;123:645-9.
4. Hack CE, Nuijens JH, Felt-Bersma RJF, et al. Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis. Am J Med 1989;86:20-6.
5. Bokisch VA, Müller-Eberhard HJ. Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase. J Clin Invest 1970;49:2427-36.
6. Hack EC, De Groot ER, Felt-Bersma RJF, et al. Increased plasma levels of interleukin-6 in sepsis. Blood 1989;74:1704-10.
7. Beutler B, Cerami A. The biology of cachectin/TNF: a primary mediator of the host response. Annu Rev Immunol 1989;7:625-55.
8. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996;87:2095-147.
9. Bose M, Farnia P. Proinflammatory cytokines can significantly induce human mononuclear phagocytes to produce nitric oxide by cell maturation-dependent process. Immunol Lett 1995;48:59-64.
10. Zimmerman GA, McIntyre TM, Mehre M, Prescott SM. Endothelial cell associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion. J Cell Biol 1990;110:529-40.
11. Schindler R, Gelfand JA, Dinarello CA. Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccharide or IL-1 itself. Blood 1990;76:1631-8.
12. Takabayashi T, Vannier E, Clark BD, et al. A new biologi role for C3a and C3a des Arg: regulation of tumor necrosis factor a and interleukin-1β synthesis. J Immunol 1996;156:3455-60.
13. Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 1993;119:771-8.
14. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 1990;265:621-36.
15. Hugli TE. Human anaphylatoxin (C3a) from the third component of complement. J Biol Chem 1975;250:8293-301.
16. Morgan EL. The role of prostaglandins in C3a-mediated suppression of human in vitro polyclonal antibody responses. Clin Immunol Immunopathol 1987;44:1-11.