Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo

Journal of Neuroinflammation

Volumn 5, Issue , 2008, Pages

  Mukherjee, Piali ^a,c   Thomas, Sunil ^a   Pasinetti, Giulio Maria ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5A; GLUTAMATE RECEPTOR 2; GLUTAMIC ACID DERIVATIVE; RECEPTOR SUBUNIT; AMINO ACID RECEPTOR STIMULATING AGENT; AMPA RECEPTOR; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2; GLUTAMIC ACID; KAINIC ACID; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DISEASE PREDISPOSITION; EMBRYO; EXCITOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; WILD TYPE; ANIMAL; BRAIN; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE MUTANT; NERVE CELL; NICK END LABELING; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS; BRAIN; COMPLEMENT C5A; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KAINIC ACID; MICE; MICE, KNOCKOUT; NEURONS; RECEPTORS, AMPA; RECOMBINANT PROTEINS;

EID: 39649121460     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-5-5     Document Type: Article

References (35)

1. van Beek J Elward K Gasque P Activation of complement in the central nervous system: Roles in neurodegeneration and neuroprotection Ann NY Acad Sci 2003, 992:56-71 12794047
2. Morgan BP Gasque P Singharo S Piddlesden SJ The role of complement in disorders of the nervous system Immunopharmacology 1997, 38:43-50 10.1016/S0162-3109(97)00059-3 9476113
3. Mukherjee P Pasinetti GM The role of complement anaphylatoxin C5a in neurodegeneration: Implications in Alzheimer's disease J Neuroimmunol 2000, 105:124-130 10.1016/S0165-5728(99)00261-1 10742554
4. Pasinetti GM Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: The role of the complement system Neurobiol Aging 1996, 17:707-716 10.1016/0197-4580(96)00113-3 8892343
5. Gasque P Neal JW Singhrao SK McGreal EP Dean YD Van BJ Morgan BP Roles of the complement system in human neurodegenerative disorders: pro-inflammatory and tissue remodeling activities Mol Neurobiol 2002, 25:1-17 10.1385/MN:25:1:001 11890454
6. Benard M Gonzalez BJ Schouft MT Falluel-Morel A Vaudry D Chan P Vaudry H Fontaine M Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death J Biol Chem 2004, 279:43487-43496 10.1074/ jbc.M404124200 15292245
7. Kimura Y Madhavan M Call MK Santiago W Tsonis PA Lambris JD Del Rio-Tsonis K Expression of complement 3 and complement 5 in newt limb and lens regeneration J Immunol 2003, 170:2331-2339 12594255
8. Farkas I Takahashi M Fukuda A Yamamoto N Akatsu H Baranyi L Tateyama H Yamamoto T Okada N Okada H Complement C5a receptor-mediated signaling may be involved in neurodegeneration in Alzheimer's disease J Immunol 2003, 170:5764-5771 12759460
9. van Beek J Nicole O Ali C Ischenko A MacKenzie ET Buisson A Fontaine M Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death Neuroreport 2001, 12:289-293 10.1097/ 00001756-200102120-00022 11209937
10. Wang Q Yu S Simonyi A Sun GY Sun AY Kainic acid-mediated excitotoxicity as a model for neurodegeneration Mol Neurobiol 2005, 31:3-16 10.1385/ MN:31:1-3:003 15953808
11. Pasinetti GM Tocco G Sakhi S Musleh WD DeSimoni MG Mascarucci P Schreiber S Baudry M Finch CE Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions Neurobiol Dis 1996, 3:197-204 10.1006/nbdi.1996.0020 8980020
12. Tocco G Musleh W Sakhi S Schreiber SS Baudry M Pasinetti GM Complement and glutamate neurotoxicity. Genotypic influences of C5 in a mouse model of hippocampal neurodegeneration Mol Chem Neuropathol 1997, 31:289-300 10.1007/BF02815131 9336770
13. Osaka H McGinty A Hoepken UE Lu B Gerard C Pasinetti GM Expression of C5a receptor in mouse brain: Role in signal transduction and neurodegeneration Neuroscience 1999, 88:1073-1082 10.1016/ S0306-4522(98)00372-8 10336122
14. Mukherjee P Pasinetti GM Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinase-dependent inhibition of caspase 3 J Neurochem 2001, 77:43-49 10.1046/j.1471-4159.2001.00167.x 11279260
15. Osaka H Mukherjee P Aisen PS Pasinetti GM Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity J Cell Biochem 1999, 73:303-311 10.1002/ (SICI)1097-4644(19990601)73:3<303::AID-JCB2>3.0.CO;2-2 10321830
16. Friedman LK Selective reduction of GluR2 protein in adult hippocampal CA3 neurons following status epilepticus but prior to cell loss Hippocampus 1998, 8:511-525 10.1002/ (SICI)1098-1063(1998)8:5<511::AID-HIPO9>3.0.CO;2-W 9825961
17. Chan SL Griffin WS Mattson MP Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease J Neurosci Res 1999, 57:315-323 10.1002/ (SICI)1097-4547(19990801)57:3<315::AID-JNR3>3.0.CO;2-# 10412022
18. Konteatis ZD Siciliano SJ Van Riper G Molineaux CJ Pandya S Fischer P Rosen H Mumford RA Springer MS Development of C5a receptor antagonists. Differential loss of functional responses J Immunol 1994, 153:4200-4205 7930622
19. Vissavajjhala P Janssen WG Hu Y Gazzaley AH Moran T Hof PR Morrison JH Synaptic distribution of the AMPA-GluR2 subunit and its colocalization with calcium-binding proteins in rat cerebral cortex: An immunohistochemical study using a GluR2-specific monoclonal antibody Exp Neurol 1996, 142:296-312 10.1006/exnr.1996.0199 8934561
20. Barnum SR Complement in central nervous system inflammation Immunol Res 2002, 26:7-13 10.1385/IR:26:1-3:007 12403340
21. Reiman R Torres AC Martin BK Ting JP Campbell IL Barnum SR Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis Neurosci Lett 2005, 390:134-138 10.1016/ j.neulet.2005.08.022 16154690
22. Drouin SM Sinha M Sfyroera G Lambris JD Wetsel RA A protective role for the fifth complement component (c5) in allergic airway disease Am J 2006, 173:852-857
23. Leist M Nicotera P Apoptosis, excitotoxicity, and neuropathology Exp Cell Res 1998 ,239:183-201 10.1006/excr.1997.4026 9521837
24. Choi DW Koh JY Peters S Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists J Neurosci 1988, 8:185-196 2892896
25. Larm JA Cheung NS Beart PM Apoptosis induced via AMPA-selective glutamate receptors in cultured murine cortical neurons J Neurochem 1997, 69:617-622 9231719
26. Cheung NS Carroll FY Larm JA Beart PM Giardina SF Kainate-induced apoptosis correlates with c-Jun activation in cultured cerebellar granule cells J Neurosci 1998, 52:69-82 10.1002/ (SICI)1097-4547(19980401)52:1<69::AID-JNR7>3.0.CO;2-I
27. Kawasaki H Morooka T Shimohama S Kimura J Hirano T Gotoh Y Nishida E Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells J Biol Chem 1997, 272:18518-18521 10.1074/jbc.272.30.18518 9228012
28. Liu HN Larocca JN Almazan G Molecular pathways mediating activation by kainate of mitogen-activated protein kinase in oligodendrocyte progenitors Brain Res Mol Brain Res 1999, 66:50-61 10.1016/ S0169-328X(99)00009-1 10095077
29. Fuller G Veitch K Ho LK Cruise L Morris BJ Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase Brain Res Mol Brain Res 2001, 89:126-132 10.1016/S0169-328X(01)00071-7 11311983
30. Lee A Whyte MK Haslett C Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators J Leukocyte Biol 1993, 54:283-288 8409750
31. Hopkins JI Jones J Morgan BP Non-lethal effects of perforin on polymorphonuclear leukocytes Biochem Soc Trans 1998, 26:S50 10909808
32. Friedman LK Veliskova J Kaur J Magrys BW Liu H GluR2(B) knockdown accelerates CA3 injury after kainate seizures J Neuropathol Exp Neurol 2003, 62:733-750 12901700
33. Jia YH Zhu X Li SY Ni JH Jia HT Kainate exposure suppresses activation of GluR2 subunit promoter in primary cultured cerebral cortical neurons through induction of RE1-silencing transcription factor Neurosci Lett 2006, 403:103-108 10.1016/j.neulet.2006.04.027 16701950
34. Gorter JA Petrozzino JJ Aronica EM Rosenbaum DM Opitz T Bennett MV Connor JA Zukin RS Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil J Neurosci 1997, 17:6179-6188 9236229
35. Grooms SY Opitz T Bennett MV Zukin RS Status epilepticus decreases glutamate receptor 2 mRNA and protein expression in hippocampal pyramidal cells before neuronal death Proc Natl Acad Sci USA 2000, 97:3631-3636 16291 10725374 10.1073/pnas.050586497