A Sequential Ugi Multicomponent/Cu-Catalyzed Azide-Alkyne Cycloaddition Approach for the Continuous Flow Generation of Cyclic Peptoids

Journal of Organic Chemistry

Volumn 80, Issue 9, 2015, Pages 4590-4602

  Salvador, Carlos Eduardo M ^a,b   Pieber, Bartholomäus ^a   Neu, Philipp M ^a   Torvisco, Ana ^c   Kleber Z Andrade, Carlos ^b   Kappe, C Oliver ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF BRASILIA   (Brazil)

^c GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; HYDROCARBONS;

AZIDE-ALKYNE CYCLOADDITION; CHEMICAL EQUATIONS; CONCURRENT OPERATIONS; CONTINUOUS APPROACH; CONTINUOUS FLOWS; MACRO-CYCLIZATION; NUCLEOPHILIC SUBSTITUTIONS; PROCESS INTENSIFICATION;

SYNTHESIS (CHEMICAL);

ALKYNE; AZIDE; CARBOXYLIC ACID; COPPER; CYCLIC PEPTOID; CYCLOPEPTIDE; PARAFORMALDEHYDE; PEPTIDOMIMETIC AGENT; PEPTOID; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYST; CLICK CHEMISTRY; CONTROLLED STUDY; CYCLIZATION; CYCLOADDITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR RECOGNITION; NUCLEOPHILICITY; PEPTIDE SYNTHESIS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REACTION TIME; RING CLOSING METATHESIS; STAPHYLOCOCCUS AUREUS; X RAY CRYSTALLOGRAPHY; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; MICROWAVE RADIATION; SYNTHESIS;

ALKYNES; AZIDES; CATALYSIS; COPPER; CYCLIZATION; MICROWAVES; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; PEPTIDOMIMETICS;

EID: 84928920208     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/acs.joc.5b00445     Document Type: Article

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