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note
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All the reactions were performed with a self-tuneable microwave synthesizer. The MW experiments were performed in a self-tuning single mode CEM Discover Focused Synthesizer apparatus. The instrument continuously adjusted the applied wattage to maintain the desired temperature.
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For comparison, the reaction in Scheme 1 (entry 1) was also conducted using a preheated oil bath under otherwise identical conditions as for the microwave reaction, i.e., (sealed vial), RNHCHO, base, 100°C, 10 min. As expected, lower conversion (7%) was observed with the traditional thermal conditions as compared to that with microwave irradiation (81%, Table 1).
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