Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability

Journal of Medicinal Chemistry

Volumn 50, Issue 24, 2007, Pages 6201-6211

  Hess, Shmuel ^a   Ovadia, Oded ^a   Shalev, Deborah E ^a   Senderovich, Hanoch ^b,e   Qadri, Bashir ^a   Yehezkel, Tamar ^b   Salitra, Yoseph ^b   Sheynis, Tania ^c   Jelinek, Raz ^c   Gilon, Chaim ^a   Hoffman, Amnon ^a,d  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b DeveloGen Israel Ltd   (Israel)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^e Predix Pharmaceuticals Ltd   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; AMOXICILLIN; GLYCINE; HEXAPEPTIDE; MANNITOL; PEPTIDE LIBRARY; PHENAZONE; PHENYLALANINE; TESTOSTERONE;

ANIMAL CELL; ARTICLE; BRUSH BORDER; CELL STRAIN CACO 2; CONTROLLED STUDY; CYCLIZATION; DRUG CONFORMATION; DRUG PENETRATION; DRUG SYNTHESIS; ENZYME STABILITY; HYDROGEN BOND; HYDROPHILICITY; INTESTINE MUCOSA PERMEABILITY; METHYLATION; MOLECULAR SIZE; NONHUMAN; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CYCLIZATION; HUMANS; INTESTINAL ABSORPTION; INTESTINE, SMALL; LIPOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; MANNITOL; METHYLATION; MICROVILLI; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 37848999397     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070836d     Document Type: Article

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