Recent progress in biomedical applications of pluronic (PF127): Pharmaceutical perspectives

Journal of Controlled Release

Volumn 209, Issue , 2015, Pages 120-138

  Akash, Muhammad Sajid Hamid ^a   Rehman, Kanwal ^b  

^a GOVERNMENT COLLEGE UNIVERSITY   (Pakistan)

^b UNIVERSITY OF AGRICULTURE   (Pakistan)

Author keywords

anti cancer drugs; Biological response modifier; Mixed polymeric micelles; PF127 magnetic nanoparticles; Pluronic F127

Indexed keywords

ABSTRACTING; CONTROLLED DRUG DELIVERY; DISEASES; DRUG INTERACTIONS; FUNCTIONAL POLYMERS; HYDROPHOBICITY; MAGNETIC NANOPARTICLES; MEDICAL APPLICATIONS; MICELLES; ORGANIC POLYMERS; TUMORS;

ANTICANCER DRUG; BIOLOGICAL RESPONSE MODIFIERS; BIOMEDICAL APPLICATIONS; PHARMACEUTICAL PERSPECTIVES; PHARMACEUTICAL SCIENCE; PLURONIC F-127; POLYMERIC MICELLE; THERAPEUTIC POTENTIALS;

TARGETED DRUG DELIVERY;

ANTINEOPLASTIC AGENT; CHITOSAN; CHOLIC ACID; COPOLYMER; FOLIC ACID; GLUTARALDEHYDE; MAGNETIC NANOPARTICLE; POLOXAMER; POLYSORBATE 80; DRUG CARRIER; GEL; MICELLE; NANOPARTICLE;

ARTICLE; CANCER DIAGNOSIS; CANCER THERAPY; CROSS LINKING; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG STABILITY; GENETIC TRANSFECTION; HUMAN; HYDROPHOBICITY; IMMUNOGENICITY; MICELLE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; GEL;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG CARRIERS; GELS; HUMANS; MICELLES; NANOPARTICLES; POLOXAMER;

EID: 84928792240     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.04.032     Document Type: Review

References (235)

1. K. Moebus, J. Siepmann, and R. Bodmeier Alginate-poloxamer microparticles for controlled drug delivery to mucosal tissue Eur. J. Pharm. Biopharm. 72 2009 42 53
2. E.V. Batrakova, and A.V. Kabanov Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers J. Control. Release 130 2008 98 106
3. B. Jeong, S.W. Kim, and Y.H. Bae Thermosensitive sol-gel reversible hydrogels Adv. Drug Deliv. Rev. 54 2002 37 51
4. A. Hatefi, and B. Amsden Biodegradable injectable in situ forming drug delivery systems J. Control. Release 80 2002 9 28
5. M.S.H. Akash, K. Rehman, N. Li, J.-Q. Gao, H. Sun, and S. Chen Sustained delivery of IL-1Ra from Pluronic F127-based thermosensitive gel prolongs its therapeutic potentials Pharm. Res. 29 2012 3475 3485
6. M.S.H. Akash, K. Rehman, H. Sun, and S. Chen Sustained delivery of IL-1Ra from PF127-gel reduces hyperglycemia in diabetic GK-rats PLoS One 8 2013 e55925
7. E.Y. Kim, Z.G. Gao, J.S. Park, H. Li, and K. Han rhEGF/HP-beta-CD complex in poloxamer gel for ophthalmic delivery Int. J. Pharm. 233 2002 159 167
8. Y. Liu, W.L. Lu, J.C. Wang, X. Zhang, H. Zhang, X.Q. Wang, T.Y. Zhou, and Q. Zhang Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic F127 hydrogel for subcutaneous administration: in vitro and in vivo characterization J. Control. Release 117 2007 387 395
9. S. Nie, W.L. Hsiao, W. Pan, and Z. Yang Thermoreversible Pluronic F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies Int. J. Nanomedicine 6 2011 151 166
10. J.G. Wenzel, K.S. Balaji, K. Koushik, C. Navarre, S.H. Duran, C.H. Rahe, and U.B. Kompella Pluronic F127 gel formulations of deslorelin and GnRH reduce drug degradation and sustain drug release and effect in cattle J. Control. Release 85 2002 51 59
11. L. Zhang, D.L. Parsons, C. Navarre, and U.B. Kompella Development and in-vitro evaluation of sustained release poloxamer 407 (P407) gel formulations of ceftiofur J. Control. Release 85 2002 73 81
12. E.J. Ricci, L.O. Lunardi, D.M. Nanclares, and J.M. Marchetti Sustained release of lidocaine from Poloxamer 407 gels Int. J. Pharm. 288 2005 235 244
13. Z. Wei, J. Hao, S. Yuan, Y. Li, W. Juan, X. Sha, and X. Fang Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization Int. J. Pharm. 376 2009 176 185
14. C. Huang, Y. Zhou, Y. Jin, X. Zhou, Z. Tang, X. Guo, and S. Zhou Preparation and characterization of temperature-responsive and magnetic nanomicelles J. Mater. Chem. 21 2011 5660 5670
15. T.K. Jain, S.P. Foy, B. Erokwu, S. Dimitrijevic, C.A. Flask, and V. Labhasetwar Magnetic resonance imaging of multifunctional pluronic stabilized iron-oxide nanoparticles in tumor-bearing mice Biomaterials 30 2009 6748 6756
16. A.V. Kabanov, E.V. Batrakova, and D.W. Miller Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier Adv. Drug Deliv. Rev. 55 2003 151 164
17. S. Danson, D. Ferry, V. Alakhov, J. Margison, D. Kerr, D. Jowle, M. Brampton, G. Halbert, and M. Ranson Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer Br. J. Cancer 90 2004 2085 2091
18. Y. Matsumura, T. Hamaguchi, T. Ura, K. Muro, Y. Yamada, Y. Shimada, K. Shirao, T. Okusaka, H. Ueno, M. Ikeda, and N. Watanabe Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin Br. J. Cancer 91 2004 1775 1781
19. Y. Matsumura Preclinical and clinical studies of anticancer drug-incorporated polymeric micelles J. Drug Target. 15 2007 507 517
20. J.S. Chawla, and M.M. Amiji Cellular uptake and concentrations of tamoxifen upon administration in poly(epsilon-caprolactone) nanoparticles AAPS PharmSci 5 2003 E3
21. A. Oshiro, D.C. da Silva, J.C. de Mello, V.W. de Moraes, L.P. Cavalcanti, M.K. Franco, M.I. Alkschbirs, L.F. Fraceto, F. Yokaichiya, T. Rodrigues, and D.R. de Araujo Pluronics F-127/L-81 binary hydrogels as drug-delivery systems: influence of physicochemical aspects on release kinetics and cytotoxicity Langmuir 30 2014 13689 13698
22. C. He, S.W. Kim, and D.S. Lee In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery J. Control. Release 127 2008 189 207
23. E. Ruel-Gariepy, and J.C. Leroux In situ-forming hydrogels - review of temperature-sensitive systems Eur. J. Pharm. Biopharm. 58 2004 409 426
24. V.P. Torchilin Structure and design of polymeric surfactant-based drug delivery systems J. Control. Release 73 2001 137 172
25. Y. Wang, L. Yu, L. Han, X. Sha, and X. Fang Difunctional pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and pluronic-mediated overcoming multidrug resistance in tumor cell lines Int. J. Pharm. 337 2007 63 73
26. W. Zhang, Y. Shi, Y. Chen, J. Ye, X. Sha, and X. Fang Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors Biomaterials 32 2011 2894 2906
27. W. Zhang, Y. Shi, Y. Chen, S. Yu, J. Hao, J. Luo, X. Sha, and X. Fang Enhanced antitumor efficacy by paclitaxel-loaded Pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance Eur. J. Pharm. Biopharm. 75 2010 341 353
28. T.K. Jain, M.A. Morales, S.K. Sahoo, D.L. Leslie-Pelecky, and V. Labhasetwar Iron oxide nanoparticles for sustained delivery of anticancer agents Mol. Pharm. 2 2005 194 205
29. T.K. Jain, J. Richey, M. Strand, D.L. Leslie-Pelecky, C.A. Flask, and V. Labhasetwar Magnetic nanoparticles with dual functional properties: drug delivery and magnetic resonance imaging Biomaterials 29 2008 4012 4021
30. T.Y. Liu, S.H. Hu, K.H. Liu, R.S. Shaiu, D.M. Liu, and S.Y. Chen Instantaneous drug delivery of magnetic/thermally sensitive nanospheres by a high-frequency magnetic field Langmuir 24 2008 13306 13311
31. D. Cohn, G. Lando, A. Sosnik, S. Garty, and A. Levi PEO-PPO-PEO-based poly(ether ester urethane)s as degradable reverse thermo-responsive multiblock copolymers Biomaterials 27 2006 1718 1727
32. B. Jeong, Y.H. Bae, and S.W. Kim Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers J. Control. Release 63 2000 155 163
33. R. Cairns, I. Papandreou, and N. Denko Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment Mol. Cancer Res. 4 2006 61 70
34. T.L. Hwang, W.R. Lee, S.C. Hua, and J.Y. Fang Cisplatin encapsulated in phosphatidylethanolamine liposomes enhances the in vitro cytotoxicity and in vivo intratumor drug accumulation against melanomas J. Dermatol. Sci. 46 2007 11 20
35. M.A. Liebman, M.I. Roche, B.R. Williams, J. Kim, S.C. Pageau, and J. Sharon Antibody treatment of human tumor xenografts elicits active anti-tumor immunity in nude mice Immunol. Lett. 114 2007 16 22
36. Y. Yang, J. Wang, X. Zhang, W. Lu, and Q. Zhang A novel mixed micelle gel with thermo-sensitive property for the local delivery of docetaxel J. Control. Release 135 2009 175 182
37. D. Banerjee, P. Mayer-Kuckuk, G. Capiaux, T. Budak-Alpdogan, R. Gorlick, and J.R. Bertino Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase Biochim. Biophys. Acta 1587 2002 164 173
38. Y. Zhang, T. Jin, and R.X. Zhuo Methotrexate-loaded biodegradable polymeric micelles: preparation, physicochemical properties and in vitro drug release Colloids Surf. B Biointerfaces 44 2005 104 109
39. J.-M. Oh, M. Park, S.-T. Kim, J.-Y. Jung, Y.-G. Kang, and J.-H. Choy Efficient delivery of anticancer drug MTX through MTX-LDH nanohybrid system J. Phys. Chem. Solids 67 2006 1024 1027
40. T. Minko, E.V. Batrakova, S. Li, Y. Li, R.I. Pakunlu, V.Y. Alakhov, and A.V. Kabanov Pluronic block copolymers alter apoptotic signal transduction of doxorubicin in drug-resistant cancer cells J. Control. Release 105 2005 269 278
41. Y. Chen, W. Zhang, J. Gu, Q. Ren, Z. Fan, W. Zhong, X. Fang, and X. Sha Enhanced antitumor efficacy by methotrexate conjugated pluronic mixed micelles against KBv multidrug resistant cancer Int. J. Pharm. 452 2013 421 433
42. A.K. Singla, A. Garg, and D. Aggarwal Paclitaxel and its formulations Int. J. Pharm. 235 2002 179 192
43. R.B. Weiss, R.C. Donehower, P.H. Wiernik, T. Ohnuma, R.J. Gralla, D.L. Trump, J.R. Baker Jr., D.A. Van Echo, D.D. Von Hoff, and B. Leyland-Jones Hypersensitivity reactions from taxol J. Clin. Oncol. 8 1990 1263 1268
44. M.J. Hawkins, P. Soon-Shiong, and N. Desai Protein nanoparticles as drug carriers in clinical medicine Adv. Drug Deliv. Rev. 60 2008 876 885
45. K.S. Lee, H.C. Chung, S.A. Im, Y.H. Park, C.S. Kim, S.B. Kim, S.Y. Rha, M.Y. Lee, and J. Ro Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer Breast Cancer Res. Treat. 108 2008 241 250
46. H. Devalapally, Z. Duan, M.V. Seiden, and M.M. Amiji Modulation of drug resistance in ovarian adenocarcinoma by enhancing intracellular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticles Clin. Cancer Res. 14 2008 3193 3203
47. E.V. Batrakova, S.V. Vinogradov, S.M. Robinson, M.L. Niehoff, W.A. Banks, and A.V. Kabanov Polypeptide point modifications with fatty acid and amphiphilic block copolymers for enhanced brain delivery Bioconjug. Chem. 16 2005 793 802
48. J.M. Grindel, T. Jaworski, O. Piraner, R.M. Emanuele, and M. Balasubramanian Distribution, metabolism, and excretion of a novel surface-active agent, purified poloxamer 188, in rats, dogs, and humans J. Pharm. Sci. 91 2002 1936 1947
49. E.S. Lee, Y.T. Oh, Y.S. Youn, M. Nam, B. Park, J. Yun, J.H. Kim, H.T. Song, and K.T. Oh Binary mixing of micelles using pluronics for a nano-sized drug delivery system Colloids Surf. B Biointerfaces 82 2011 190 195
50. H. Song, R. He, K. Wang, J. Ruan, C. Bao, N. Li, J. Ji, and D. Cui Anti-HIF-1alpha antibody-conjugated pluronic triblock copolymers encapsulated with Paclitaxel for tumor targeting therapy Biomaterials 31 2010 2302 2312
51. T.F. Yang, C.N. Chen, M.C. Chen, C.H. Lai, H.F. Liang, and H.W. Sung Shell-crosslinked Pluronic L121 micelles as a drug delivery vehicle Biomaterials 28 2007 725 734
52. J.J. Lin, J.S. Chen, S.J. Huang, J.H. Ko, Y.M. Wang, T.L. Chen, and L.F. Wang Folic acid-Pluronic F127 magnetic nanoparticle clusters for combined targeting, diagnosis, and therapy applications Biomaterials 30 2009 5114 5124
53. J. Luo, K. Xiao, Y. Li, J.S. Lee, L. Shi, Y.H. Tan, L. Xing, R. Holland Cheng, G.Y. Liu, and K.S. Lam Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment Bioconjug. Chem. 21 2010 1216 1224
54. Y.T. Ko, A. Kale, W.C. Hartner, B. Papahadjopoulos-Sternberg, and V.P. Torchilin Self-assembling micelle-like nanoparticles based on phospholipid-polyethyleneimine conjugates for systemic gene delivery J. Control. Release 133 2009 132 138
55. N. Li, X. Yang, G. Zhai, and L. Li Multifunctional pluronic/poly(ethylenimine) nanoparticles for anticancer drug J. Colloid Interface Sci. 350 2010 117 125
56. Y. Li, Y. Bi, Y. Xi, and L. Li Enhancement on oral absorption of paclitaxel by multifunctional pluronic micelles J. Drug Target. 21 2013 188 199
57. Y. Li, Y. Zhou, B. De, and L. Li Folate-modified pluronic-polyethylenimine and cholic acid polyion complex micelles as targeted drug delivery system for paclitaxel J. Microencapsul. 31 2014 805 814
58. J.M. Lee, J. Yanagawa, K.A. Peebles, S. Sharma, J.T. Mao, and S.M. Dubinett Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment Crit. Rev. Oncol. Hematol. 66 2008 208 217
59. N. Kamaly, Z. Xiao, P.M. Valencia, A.F. Radovic-Moreno, and O.C. Farokhzad Targeted polymeric therapeutic nanoparticles: design, development and clinical translation Chem. Soc. Rev. 41 2012 2971 3010
60. I. Brigger, C. Dubernet, and P. Couvreur Nanoparticles in cancer therapy and diagnosis Adv. Drug Deliv. Rev. 54 2002 631 651
61. Y.I. Chung, J.C. Kim, Y.H. Kim, G. Tae, S.Y. Lee, K. Kim, and I.C. Kwon The effect of surface functionalization of PLGA nanoparticles by heparin- or chitosan-conjugated pluronic on tumor targeting J. Control. Release 143 2010 374 382
62. J. Cheng, B.A. Teply, I. Sherifi, J. Sung, G. Luther, F.X. Gu, E. Levy-Nissenbaum, A.F. Radovic-Moreno, R. Langer, and O.C. Farokhzad Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery Biomaterials 28 2007 869 876
63. J.Y. Kim, W.I. Choi, Y.H. Kim, G. Tae, S.Y. Lee, K. Kim, and I.C. Kwon In-vivo tumor targeting of pluronic-based nano-carriers J. Control. Release 147 2010 109 117
64. S.H. Kim, J.H. Jeong, K.W. Chun, and T.G. Park Target-specific cellular uptake of PLGA nanoparticles coated with poly(L-lysine)-poly(ethylene glycol)-folate conjugate Langmuir 21 2005 8852 8857
65. Z. Wang, W.K. Chui, and P.C. Ho Design of a multifunctional PLGA nanoparticulate drug delivery system: evaluation of its physicochemical properties and anticancer activity to malignant cancer cells Pharm. Res. 26 2009 1162 1171
66. J. Yang, C.-H. Lee, J. Park, S. Seo, E.-K. Lim, Y.J. Song, J.-S. Suh, H.-G. Yoon, Y.-M. Huh, and S. Haam Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer J. Mater. Chem. 17 2007 2695 2699
67. A. Agarwal, N. Lariya, G. Saraogi, N. Dubey, H. Agrawal, and G.P. Agrawal Nanoparticles as novel carrier for brain delivery: a review Curr. Pharm. Des. 15 2009 917 925
68. P.R. Lockman, R.J. Mumper, M.A. Khan, and D.D. Allen Nanoparticle technology for drug delivery across the blood-brain barrier Drug Dev. Ind. Pharm. 28 2002 1 13
69. A.K. Gupta, and M. Gupta Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications Biomaterials 26 2005 3995 4021
70. Q. Pankhurst, N. Thanh, S. Jones, and J. Dobson Progress in applications of magnetic nanoparticles in biomedicine J. Phys. D Appl. Phys. 42 2009 224001
71. P. Tartaj, M.d.P. Morales, S. Veintemillas-Verdaguer, T. González-Carreño, and C.J. Serna The preparation of magnetic nanoparticles for applications in biomedicine J. Phys. D Appl. Phys. 36 2003 R182
72. J. Qin, S. Laurent, Y.S. Jo, A. Roch, M. Mikhaylova, Z.M. Bhujwalla, R.N. Muller, and M. Muhammed A high-performance magnetic resonance imaging T2 contrast agent Adv. Mater. 19 2007 1874 1878
73. S. Chen, Y. Li, C. Guo, J. Wang, J. Ma, X. Liang, L.R. Yang, and H.Z. Liu Temperature-responsive magnetite/PEO-PPO-PEO block copolymer nanoparticles for controlled drug targeting delivery Langmuir 23 2007 12669 12676
74. S. Park, H.S. Kim, W.J. Kim, and H.S. Yoo Pluronic@Fe3O4 nanoparticles with robust incorporation of doxorubicin by thermo-responsiveness Int. J. Pharm. 424 2012 107 114
75. N. Wang, Y. Guan, L. Yang, L. Jia, X. Wei, H. Liu, and C. Guo Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery J. Colloid Interface Sci. 395 2013 50 57
76. G.-J. Chen, Y.-Z. Su, C. Hsu, Y.-L. Lo, S.-J. Huang, J.-H. Ke, Y.-C. Kuo, and L.-F. Wang Angiopep-Pluronic F127-conjugated superparamagnetic iron oxide nanoparticles as nanotheranostic agents for BBB targeting J. Mater. Chem. B 2 2014 5666 5675
77. S. Baek, and K. Na A nano complex of hydrophilic phthalocyanine and polyethylenimine for improved cellular internalization efficiency and phototoxicity Colloids Surf. B Biointerfaces 101 2013 493 500
78. J. Usuda, H. Kato, T. Okunaka, K. Furukawa, H. Tsutsui, K. Yamada, Y. Suga, H. Honda, Y. Nagatsuka, T. Ohira, M. Tsuboi, and T. Hirano Photodynamic therapy (PDT) for lung cancers J. Thorac. Oncol. 1 2006 489 493
79. B.W. Henderson, and T.J. Dougherty How does photodynamic therapy work? Photochem. Photobiol. 55 1992 145 157
80. K. Chen, A. Preuss, S. Hackbarth, M. Wacker, K. Langer, and B. Roder Novel photosensitizer-protein nanoparticles for photodynamic therapy: photophysical characterization and in vitro investigations J. Photochem. Photobiol. B Biol. 96 2009 66 74
81. S.J. Lee, H. Koo, D.E. Lee, S. Min, S. Lee, X. Chen, Y. Choi, J.F. Leary, K. Park, S.Y. Jeong, I.C. Kwon, K. Kim, and K. Choi Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system Biomaterials 32 2011 4021 4029
82. D. Ling, B.C. Bae, W. Park, and K. Na Photodynamic efficacy of photosensitizers under an attenuated light dose via lipid nano-carrier-mediated nuclear targeting Biomaterials 33 2012 5478 5486
83. W. Miao, G. Shim, S. Lee, S. Lee, Y.S. Choe, and Y.K. Oh Safety and tumor tissue accumulation of pegylated graphene oxide nanosheets for co-delivery of anticancer drug and photosensitizer Biomaterials 34 2013 3402 3410
84. M.R. Hamblin, J.L. Miller, I. Rizvi, B. Ortel, E.V. Maytin, and T. Hasan Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizer Cancer Res. 61 2001 7155 7162
85. K. Na, and Y.H. Bae Self-assembled hydrogel nanoparticles responsive to tumor extracellular pH from pullulan derivative/sulfonamide conjugate: characterization, aggregation, and adriamycin release in vitro Pharm. Res. 19 2002 681 688
86. J.S. Park, T.H. Han, K.Y. Lee, S.S. Han, J.J. Hwang, D.H. Moon, S.Y. Kim, and Y.W. Cho N-acetyl histidine-conjugated glycol chitosan self-assembled nanoparticles for intracytoplasmic delivery of drugs: endocytosis, exocytosis and drug release J. Control. Release 115 2006 37 45
87. J. Hyung Park, S. Kwon, M. Lee, H. Chung, J.H. Kim, Y.S. Kim, R.W. Park, I.S. Kim, S. Bong Seo, I.C. Kwon, and S. Young Jeong Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin: in vivo biodistribution and anti-tumor activity Biomaterials 27 2006 119 126
88. C.L. Gebhart, S. Sriadibhatla, S. Vinogradov, P. Lemieux, V. Alakhov, and A.V. Kabanov Design and formulation of polyplexes based on pluronic-polyethyleneimine conjugates for gene transfer Bioconjug. Chem. 13 2002 937 944
89. A.V. Kabanov, E.V. Batrakova, and V.Y. Alakhov Pluronic block copolymers for overcoming drug resistance in cancer Adv. Drug Deliv. Rev. 54 2002 759 779
90. A.V. Kabanov, E.V. Batrakova, and V.Y. Alakhov Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery J. Control. Release 82 2002 189 212
91. M. Wang, P. Lu, B. Wu, J.D. Tucker, C. Cloer, and Q. Lu High efficiency and low toxicity of polyethyleneimine modified pluronics (PEI-pluronic) as gene delivery carriers in cell culture and dystrophic mdx mice J. Mater. Chem. 22 2012 6038 6046
92. H. Park, and K. Na Conjugation of the photosensitizer Chlorin e6 to Pluronic F127 for enhanced cellular internalization for photodynamic therapy Biomaterials 34 2013 6992 7000
93. G.A. Kostenich, I.N. Zhuravkin, and E.A. Zhavrid Experimental grounds for using Chlorin e6 in the photodynamic therapy of malignant tumors J. Photochem. Photobiol. B Biol. 22 1994 211 217
94. J.F. Hainfeld, D.N. Slatkin, T.M. Focella, and H.M. Smilowitz Gold nanoparticles: a new X-ray contrast agent Br. J. Radiol. 79 2006 248 253
95. W.S. Kuo, C.N. Chang, Y.T. Chang, M.H. Yang, Y.H. Chien, S.J. Chen, and C.S. Yeh Gold nanorods in photodynamic therapy, as hyperthermia agents, and in near-infrared optical imaging Angew. Chem. Int. Ed. Engl. 49 2010 2711 2715
96. D.P. O'Neal, L.R. Hirsch, N.J. Halas, J.D. Payne, and J.L. West Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles Cancer Lett. 209 2004 171 176
97. X. Qian, X.H. Peng, D.O. Ansari, Q. Yin-Goen, G.Z. Chen, D.M. Shin, L. Yang, A.N. Young, M.D. Wang, and S. Nie In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags Nat. Biotechnol. 26 2008 83 90
98. J.L. Vivero-Escoto, and Y.T. Huang Inorganic-organic hybrid nanomaterials for therapeutic and diagnostic imaging applications Int. J. Mol. Sci. 12 2011 3888 3927
99. M.C. Daniel, and D. Astruc Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology Chem. Rev. 104 2004 293 346
100. J. Zhou, J. Ralston, R. Sedev, and D.A. Beattie Functionalized gold nanoparticles: synthesis, structure and colloid stability J. Colloid Interface Sci. 331 2009 251 262
101. J. Shan, and H. Tenhu Recent advances in polymer protected gold nanoparticles: synthesis, properties and applications Chem. Commun. (Camb.) 2007 4580 4598
102. T. Azzam, L. Bronstein, and A. Eisenberg Water-soluble surface-anchored gold and palladium nanoparticles stabilized by exchange of low molecular weight ligands with biamphiphilic triblock copolymers Langmuir 24 2008 6521 6529
103. T. Sakai, and P. Alexandridis Single-step synthesis and stabilization of metal nanoparticles in aqueous pluronic block copolymer solutions at ambient temperature Langmuir 20 2004 8426 8430
104. T. Simon, S.C. Boca, and S. Astilean Pluronic-nanogold hybrids: synthesis and tagging with photosensitizing molecules Colloids Surf. B Biointerfaces 97 2012 77 83
105. M.S.H. Akash, K. Rehman, and S. Chen IL-1Ra and its delivery strategies: inserting the association in perspective Pharm. Res. 30 2013 2951 2966
106. M.S.H. Akash, K. Rehman, H. Sun, and S. Chen Assessment of release kinetics, stability and polymer interaction of poloxamer 407-based thermosensitive gel of interleukin-1 receptor antagonist Pharm. Dev. Technol. 19 2014 278 284
107. H.M.N. El-Din, A.W.M. El-Naggar, and F.I. Abu-El Fadle Radiation synthesis of pH-sensitive hydrogels from carboxymethyl cellulose/poly(ethylene oxide) blends as drug delivery systems Int. J. Polym. Mater. Polym. Biomater. 62 2013 711 718
108. H.-R. Lin, C.-Y. Hsu, and Y.-L. Lo Preparation and characterization of dual phase transition oral hydrogel for sustained release of epirubicin Int. J. Polym. Mater. Polym. Biomater. 62 2013 763 769
109. K. Pal, V.K. Singh, A. Anis, G. Thakur, and M.K. Bhattacharya Hydrogel-based controlled release formulations: designing considerations, characterization techniques and applications Polym. Plast. Technol. Eng. 52 2013 1391 1422
110. K.M. Rao, B. Mallikarjuna, K.S.V. Krishna Rao, K. Sudhakar, K.C. Rao, and M.C.S. Subha Synthesis and characterization of pH sensitive poly (hydroxy ethyl methacrylate-co-acrylamidoglycolic acid) based hydrogels for controlled release studies of 5-fluorouracil Int. J. Polym. Mater. Polym. Biomater. 62 2013 565 571
111. M.S.H. Akash, K. Rehman, A. Parveen, and M. Ibrahim Antibody-drug conjugates as drug carrier systems for bioactive agents Int. J. Polym. Mater. Polym. Biomater. 2015 10.1018/14786419.2015.1041940
112. M.S.H. Akash, K. Rehman, and S. Chen Pluronic F127-based thermosensitive gels for delivery of therapeutic proteins and peptides Polym. Rev. 54 2014 573 597
113. Y. Lee, H.J. Chung, S. Yeo, C.-H. Ahn, H. Lee, P.B. Messersmith, and T.G. Park Thermo-sensitive, injectable, and tissue adhesive sol-gel transition hyaluronic acid/pluronic composite hydrogels prepared from bio-inspired catechol-thiol reaction Soft Matter 6 2010 977 983
114. H.F. Salem Sustained-release progesterone nanosuspension following intramuscular injection in ovariectomized rats Int. J. Nanomedicine 5 2010 943 954
115. K.H. Sun, Y.S. Sohn, and B. Jeong Thermogelling poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) disulfide multiblock copolymer as a thiol-sensitive degradable polymer Biomacromolecules 7 2006 2871 2877
116. C.J. Wu, and G. Schmidt Thermosensitive and dissolution properties in nanocomposite polymer hydrogels Macromol. Rapid Commun. 30 2009 1492 1497
117. H.J. Chung, Y. Lee, and T.G. Park Thermo-sensitive and biodegradable hydrogels based on stereocomplexed pluronic multi-block copolymers for controlled protein delivery J. Control. Release 127 2008 22 30
118. W.E. Hennink, and C.F. van Nostrum Novel crosslinking methods to design hydrogels Adv. Drug Deliv. Rev. 54 2002 13 36
119. J.I. Lee, H.S. Kim, and H.S. Yoo DNA nanogels composed of chitosan and pluronic with thermo-sensitive and photo-crosslinking properties Int. J. Pharm. 373 2009 93 99
120. J.H. Ryu, Y. Lee, W.H. Kong, T.G. Kim, T.G. Park, and H. Lee Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials Biomacromolecules 12 2011 2653 2659
121. S.J. Huang, S.L. Sun, T.H. Feng, K.H. Sung, W.L. Lui, and L.F. Wang Folate-mediated chondroitin sulfate-Pluronic 127 nanogels as a drug carrier Eur. J. Pharm. Sci. 38 2009 64 73
122. C. Lin, P. Zhao, F. Li, F. Guo, Z. Li, and X. Wen Thermosensitive in situ-forming dextran-pluronic hydrogels through Michael addition Mater. Sci. Eng. C Mater. Biol. Appl. 30 2010 1236 1244
123. G. Niu, F. Du, L. Song, H. Zhang, J. Yang, H. Cao, Y. Zheng, Z. Yang, G. Wang, H. Yang, and S. Zhu Synthesis and characterization of reactive poloxamer 407 s for biomedical applications J. Control. Release 138 2009 49 56
124. K. Wang, X. Xu, T. Liu, S. Fu, G. Guo, Y. Gu, F. Luo, X. Zhao, Y. Wei, and Z. Qian Synthesis and characterization of biodegradable pH-sensitive hydrogel based on poly(ε-caprolactone), methacrylic acid, and Pluronic (L35) Carbohydr. Polym. 79 2010 755 761
125. H.S. Yoo Photo-cross-linkable and thermo-responsive hydrogels containing chitosan and pluronic for sustained release of human growth hormone (hGH) J. Biomater. Sci. Polym. Ed. 18 2007 1429 1441
126. Y. Liu, Y.Y. Zhu, G. Wei, and W.Y. Lu Effect of carrageenan on poloxamer-based in situ gel for vaginal use: improved in vitro and in vivo sustained-release properties Eur. J. Pharm. Sci. 37 2009 306 312
127. S.Y. Park, H.J. Chung, Y. Lee, and T.G. Park Injectable and sustained delivery of human growth hormone using chemically modified pluronic copolymer hydrogels Biotechnol. J. 3 2008 669 675
128. T. Ur-Rehman, S. Tavelin, and G. Grobner Chitosan in situ gelation for improved drug loading and retention in poloxamer 407 gels Int. J. Pharm. 409 2011 19 29
129. S.H. Oh, J.K. Kim, K.S. Song, S.M. Noh, S.H. Ghil, S.H. Yuk, and J.H. Lee Prevention of postsurgical tissue adhesion by anti-inflammatory drug-loaded pluronic mixtures with sol-gel transition behavior J. Biomed. Mater. Res. A 72 2005 306 316
130. A.-L. Kjøniksen, M.T. Calejo, K. Zhu, B. Nyström, and S.A. Sande Stabilization of pluronic gels by hydrophobically modified hydroxyethylcellulose Int. J. Polym. Mater. Polym. Biomater. 64 2014 76 83
131. T. Gratieri, G.M. Gelfuso, E.M. Rocha, V.H. Sarmento, O. de Freitas, and R.F. Lopez A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery Eur. J. Pharm. Biopharm. 75 2010 186 193
132. X. Li, S. Chen, B. Zhang, M. Li, K. Diao, Z. Zhang, J. Li, Y. Xu, X. Wang, and H. Chen In situ injectable nano-composite hydrogel composed of curcumin, N,O-carboxymethyl chitosan and oxidized alginate for wound healing application Int. J. Pharm. 437 2012 110 119
133. R.A.A. Muzzarelli Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone Carbohydr. Polym. 76 2009 167 182
134. T. Serno, R. Geidobler, and G. Winter Protein stabilization by cyclodextrins in the liquid and dried state Adv. Drug Deliv. Rev. 63 2011 1086 1106
135. C. Ju, J. Sun, P. Zi, X. Jin, and C. Zhang Thermosensitive micelles-hydrogel hybrid system based on poloxamer 407 for localized delivery of paclitaxel J. Pharm. Sci. 102 2013 2707 2717
136. C.Y. Gong, S. Shi, P.W. Dong, B. Yang, X.R. Qi, G. Guo, Y.C. Gu, X. Zhao, Y.Q. Wei, and Z.Y. Qian Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel: part 1 - synthesis, characterization, and acute toxicity evaluation J. Pharm. Sci. 98 2009 4684 4694
137. S.H. Hsu, Y.L. Leu, J.W. Hu, and J.Y. Fang Physicochemical characterization and drug release of thermosensitive hydrogels composed of a hyaluronic acid/Pluronic f127 graft Chem. Pharm. Bull. 57 2009 453 458
138. X.Y. Xiong, K.C. Tam, and L.H. Gan Polymeric nanostructures for drug delivery applications based on pluronic copolymer systems J. Nanosci. Nanotechnol. 6 2006 2638 2650
139. M.S.H. Akash, K. Rehman, H. Sun, and S. Chen Natural and synthetic polymers as drug carriers for delivery of therapeutic proteins Polym. Rev. 2015 10.1080/15583724.15582014.15995806
140. R.V. Kulkarni, V. Sreedhar, S. Mutalik, C.M. Setty, and B. Sa Interpenetrating network hydrogel membranes of sodium alginate and poly(vinyl alcohol) for controlled release of prazosin hydrochloride through skin Int. J. Biol. Macromol. 47 2010 520 527
141. H.R. Lin, K.C. Sung, and W.J. Vong In situ gelling of alginate/pluronic solutions for ophthalmic delivery of pilocarpine Biomacromolecules 5 2004 2358 2365
142. J.Y. Fang, S.H. Hsu, Y.L. Leu, and J.W. Hu Delivery of cisplatin from pluronic co-polymer systems: liposome inclusion and alginate coupling J. Biomater. Sci. Polym. Ed. 20 2009 1031 1047
143. C.C. Chen, C.L. Fang, S.A. Al-Suwayeh, Y.L. Leu, and J.Y. Fang Transdermal delivery of selegiline from alginate-pluronic composite thermogels Int. J. Pharm. 415 2011 119 128
144. K. Moebus, J. Siepmann, and R. Bodmeier Novel preparation techniques for alginate-poloxamer microparticles controlling protein release on mucosal surfaces Eur. J. Pharm. Sci. 45 2012 358 366
145. S.R. Van Tomme, C.F. van Nostrum, S.C. de Smedt, and W.E. Hennink Degradation behavior of dextran hydrogels composed of positively and negatively charged microspheres Biomaterials 27 2006 4141 4148
146. E.A. Appel, X.J. Loh, S.T. Jones, C.A. Dreiss, and O.A. Scherman Sustained release of proteins from high water content supramolecular polymer hydrogels Biomaterials 33 2012 4646 4652
147. L. Yu, Z. Zhang, H. Zhang, and J. Ding Biodegradability and biocompatibility of thermoreversible hydrogels formed from mixing a sol and a precipitate of block copolymers in water Biomacromolecules 11 2010 2169 2178
148. J.J. Escobar-Chavez, M. Lopez-Cervantes, A. Naik, Y.N. Kalia, D. Quintanar-Guerrero, and A. Ganem-Quintanar Applications of thermo-reversible Pluronic F-127 gels in pharmaceutical formulations J. Pharm. Pharm. Sci. 9 2006 339 358
149. S.Y. Lee, and G. Tae Formulation and in vitro characterization of an in situ gelable, photo-polymerizable pluronic hydrogel suitable for injection J. Control. Release 119 2007 313 319
150. K.W. Chun, J.B. Lee, S.H. Kim, and T.G. Park Controlled release of plasmid DNA from photo-cross-linked pluronic hydrogels Biomaterials 26 2005 3319 3326
151. A. Sosnik, and D. Cohn Ethoxysilane-capped PEO-PPO-PEO triblocks: a new family of reverse thermo-responsive polymers Biomaterials 25 2004 2851 2858
152. D.D. Guo, S.H. Hong, H.L. Jiang, J.H. Kim, A. Minai-Tehrani, J.E. Kim, J.Y. Shin, T. Jiang, Y.K. Kim, Y.J. Choi, C.S. Cho, and M.H. Cho Synergistic effects of Akt1 shRNA and paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel on breast cancer Biomaterials 33 2012 2272 2281
153. D.D. Guo, C.X. Xu, J.S. Quan, C.K. Song, H. Jin, D.D. Kim, Y.J. Choi, M.H. Cho, and C.S. Cho Synergistic anti-tumor activity of paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel in vitro and in vivo Biomaterials 30 2009 4777 4785
154. L. Mayol, F. Quaglia, A. Borzacchiello, L. Ambrosio, and M.I. La Rotonda A novel poloxamers/hyaluronic acid in situ forming hydrogel for drug delivery: rheological, mucoadhesive and in vitro release properties Eur. J. Pharm. Biopharm. 70 2008 199 206
155. M. Agueros, V. Zabaleta, S. Espuelas, M.A. Campanero, and J.M. Irache Increased oral bioavailability of paclitaxel by its encapsulation through complex formation with cyclodextrins in poly(anhydride) nanoparticles J. Control. Release 145 2010 2 8
156. R. Andrade Acevedo, L. Machon, and N. Chavez Effectiveness of a mouthwash containing Triclosan and Gantrez in the reduction of biofilm and gingivitis: a clinical pilot study J. Contemp. Dent. Pract. 10 2009 E033 040
157. A.S. Porfire, V. Zabaleta, C. Gamazo, S.E. Leucuta, and J.M. Irache Influence of dextran on the bioadhesive properties of poly(anhydride) nanoparticles Int. J. Pharm. 390 2010 37 44
158. K. Yoncheva, P. Calleja, M. Agueros, P. Petrov, I. Miladinova, C. Tsvetanov, and J.M. Irache Stabilized micelles as delivery vehicles for paclitaxel Int. J. Pharm. 436 2012 258 264
159. P. Arbos, M.A. Campanero, M.A. Arangoa, M.J. Renedo, and J.M. Irache Influence of the surface characteristics of PVM/MA nanoparticles on their bioadhesive properties J. Control. Release 89 2003 19 30
160. E. Moreno, J. Schwartz, E. Larraneta, P.A. Nguewa, C. Sanmartin, M. Agueros, J.M. Irache, and S. Espuelas Thermosensitive hydrogels of poly(methyl vinyl ether-co-maleic anhydride) - Pluronic((R)) F127 copolymers for controlled protein release Int. J. Pharm. 459 2014 1 9
161. L. Bromberg, V.Y. Alakhov, and T.A. Hatton Self-assembling Pluronic®-modified polycations in gene delivery Curr. Opin. Colloid Interface Sci. 11 2006 217 223
162. M.-M. Fan, X. Zhang, J. Qin, B.-J. Li, X. Sun, and S. Zhang Self-assembly pluronic and β-cyclodextrin to hollow nanospheres for enhanced gene delivery Macromol. Rapid Commun. 32 2011 1533 1538
163. W. Liang, H. Gong, D. Yin, S. Lu, and Q. Fu High-molecular-weight polyethyleneimine conjuncted pluronic for gene transfer agents Chem. Pharm. Bull. 59 2011 1094 1101
164. S. Fusco, A. Borzacchiello, and P.A. Netti Perspectives on: PEO-PPO-PEO triblock copolymers and their biomedical applications J. Bioact. Compat. Polym. 21 2006 149 164
165. K.S. Oh, R.S. Kim, J. Lee, D. Kim, S.H. Cho, and S.H. Yuk Gold/chitosan/pluronic composite nanoparticles for drug delivery J. Appl. Polym. Sci. 108 2008 3239 3244
166. J.H. Lee, J.H. Kim, S.H. Oh, S.J. Kim, Y.S. Hah, B.W. Park, D.R. Kim, G.J. Rho, G.H. Maeng, R.H. Jeon, H.C. Lee, J.R. Kim, G.C. Kim, U.K. Kim, and J.H. Byun Tissue-engineered bone formation using periosteal-derived cells and polydioxanone/Pluronic F127 scaffold with pre-seeded adipose tissue-derived CD146 positive endothelial-like cells Biomaterials 32 2011 5033 5045
167. S.H. Oh, J.H. Kim, K.S. Song, B.H. Jeon, J.H. Yoon, T.B. Seo, U. Namgung, I.W. Lee, and J.H. Lee Peripheral nerve regeneration within an asymmetrically porous PLGA/Pluronic F127 nerve guide conduit Biomaterials 29 2008 1601 1609
168. H. Hu, J. Yu, Y. Li, J. Zhao, and H. Dong Engineering of a novel Pluronic F127/graphene nanohybrid for pH responsive drug delivery J. Biomed. Mater. Res. A 100 2012 141 148
169. A.V. Kabanov, and V.Y. Alakhov Pluronic block copolymers in drug delivery: from micellar nanocontainers to biological response modifiers Crit. Rev. Ther. Drug Carrier Syst. 19 2002 1 72
170. W.D. Ma, H. Xu, C. Wang, S.F. Nie, and W.S. Pan Pluronic F127-g-poly(acrylic acid) copolymers as in situ gelling vehicle for ophthalmic drug delivery system Int. J. Pharm. 350 2008 247 256
171. W. Zhang, K. Gilstrap, L. Wu, C.R. K, M.A. Moss, Q. Wang, X. Lu, and X. He Synthesis and characterization of thermally responsive Pluronic F127-chitosan nanocapsules for controlled release and intracellular delivery of small molecules ACS Nano 4 2010 6747 6759
172. L. Klouda, and A.G. Mikos Thermoresponsive hydrogels in biomedical applications Eur. J. Pharm. Biopharm. 68 2008 34 45
173. V. Alakhov, G. Pietrzynski, K. Patel, A. Kabanov, L. Bromberg, and T.A. Hatton Pluronic block copolymers and pluronic poly(acrylic acid) microgels in oral delivery of megestrol acetate J. Pharm. Pharmacol. 56 2004 1233 1241
174. D.A. Chiappetta, and A. Sosnik Poly(ethylene oxide)-poly(propylene oxide) block copolymer micelles as drug delivery agents: improved hydrosolubility, stability and bioavailability of drugs Eur. J. Pharm. Biopharm. 66 2007 303 317
175. A.K. Gupta, R.R. Naregalkar, V.D. Vaidya, and M. Gupta Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications Nanomedicine (London) 2 2007 23 39
176. T. Osaka, T. Matsunaga, T. Nakanishi, A. Arakaki, D. Niwa, and H. Iida Synthesis of magnetic nanoparticles and their application to bioassays Anal. Bioanal. Chem. 384 2006 593 600
177. S. Liang, Y. Wang, J. Yu, C. Zhang, J. Xia, and D. Yin Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy J. Mater. Sci. Mater. Med. 18 2007 2297 2302
178. K.E. Scarberry, E.B. Dickerson, J.F. McDonald, and Z.J. Zhang Magnetic nanoparticle-peptide conjugates for in vitro and in vivo targeting and extraction of cancer cells J. Am. Chem. Soc. 130 2008 10258 10262
179. Y. Yang, J.S. Jiang, B. Du, Z.F. Gan, M. Qian, and P. Zhang Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting J. Mater. Sci. Mater. Med. 20 2009 301 307
180. X.H. Peng, X. Qian, H. Mao, A.Y. Wang, Z.G. Chen, S. Nie, and D.M. Shin Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy Int. J. Nanomedicine 3 2008 311 321
181. G. Tosi, L. Costantino, B. Ruozi, F. Forni, and M.A. Vandelli Polymeric nanoparticles for the drug delivery to the central nervous system Expert Opin. Drug Deliv. 5 2008 155 174
182. T.J. Chen, T.H. Cheng, C.Y. Chen, S.C. Hsu, T.L. Cheng, G.C. Liu, and Y.M. Wang Targeted Herceptin-dextran iron oxide nanoparticles for noninvasive imaging of HER2/neu receptors using MRI J. Biol. Inorg. Chem. 14 2009 253 260
183. J. Zhang, and R.D. Misra Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: core-shell nanoparticle carrier and drug release response Acta Biomater. 3 2007 838 850
184. M. Garinot, V. Fievez, V. Pourcelle, F. Stoffelbach, A. des Rieux, L. Plapied, I. Theate, H. Freichels, C. Jerome, J. Marchand-Brynaert, Y.J. Schneider, and V. Preat PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination J. Control. Release 120 2007 195 204
185. C. Sun, R. Sze, and M. Zhang Folic acid-PEG conjugated superparamagnetic nanoparticles for targeted cellular uptake and detection by MRI J. Biomed. Mater. Res. A 78 2006 550 557
186. A.R. Hilgenbrink, and P.S. Low Folate receptor-mediated drug targeting: from therapeutics to diagnostics J. Pharm. Sci. 94 2005 2135 2146
187. H.S. Yoo, and T.G. Park Folate-receptor-targeted delivery of doxorubicin nano-aggregates stabilized by doxorubicin-PEG-folate conjugate J. Control. Release 100 2004 247 256
188. J.P. Behr Synthetic gene transfer vectors II: back to the future Acc. Chem. Res. 45 2012 980 984
189. S.K. Samal, M. Dash, S. Van Vlierberghe, D.L. Kaplan, E. Chiellini, C. van Blitterswijk, L. Moroni, and P. Dubruel Cationic polymers and their therapeutic potential Chem. Soc. Rev. 41 2012 7147 7194
190. S. Agarwal, Y. Zhang, S. Maji, and A. Greiner PDMAEMA based gene delivery materials Mater. Today 15 2012 388 393
191. M. Jager, S. Schubert, S. Ochrimenko, D. Fischer, and U.S. Schubert Branched and linear poly(ethylene imine)-based conjugates: synthetic modification, characterization, and application Chem. Soc. Rev. 41 2012 4755 4767
192. Y. Wen, Z. Guo, Z. Du, R. Fang, H. Wu, X. Zeng, C. Wang, M. Feng, and S. Pan Serum tolerance and endosomal escape capacity of histidine-modified pDNA-loaded complexes based on polyamidoamine dendrimer derivatives Biomaterials 33 2012 8111 8121
193. C.V. Synatschke, A. Schallon, V. Jerome, R. Freitag, and A.H. Muller Influence of polymer architecture and molecular weight of poly(2-(dimethylamino)ethyl methacrylate) polycations on transfection efficiency and cell viability in gene delivery Biomacromolecules 12 2011 4247 4255
194. A.M. Funhoff, S. Monge, R. Teeuwen, G.A. Koning, N.M. Schuurmans-Nieuwenbroek, D.J. Crommelin, D.M. Haddleton, W.E. Hennink, and C.F. van Nostrum PEG shielded polymeric double-layered micelles for gene delivery J. Control. Release 102 2005 711 724
195. G.A. Husseini, and W.G. Pitt Micelles and nanoparticles for ultrasonic drug and gene delivery Adv. Drug Deliv. Rev. 60 2008 1137 1152
196. R. Sharma, J.S. Lee, R.C. Bettencourt, C. Xiao, S.F. Konieczny, and Y.Y. Won Effects of the incorporation of a hydrophobic middle block into a PEG-polycation diblock copolymer on the physicochemical and cell interaction properties of the polymer-DNA complexes Biomacromolecules 9 2008 3294 3307
197. L. Bromberg, S. Deshmukh, M. Temchenko, L. Iourtchenko, V. Alakhov, C. Alvarez-Lorenzo, R. Barreiro-Iglesias, A. Concheiro, and T.A. Hatton Polycationic block copolymers of poly(ethylene oxide) and poly(propylene oxide) for cell transfection Bioconjug. Chem. 16 2005 626 633
198. E. Jeon, H.D. Kim, and J.S. Kim Pluronic-grafted poly-(L)-lysine as a new synthetic gene carrier J. Biomed. Mater. Res. A 66 2003 854 859
199. T.C. Lai, K. Kataoka, and G.S. Kwon Pluronic-based cationic block copolymer for forming pDNA polyplexes with enhanced cellular uptake and improved transfection efficiency Biomaterials 32 2011 4594 4603
200. Y.K. Valeeva, T.Y. Dorodnykh, N.A. Alexandrova, E.M. Zubin, A.V. Kachalova, E.M. Volkov, M.B. Gottikh, and N.S. Melik-Nubarov Block copolymers of pluronics and poly-(2 dimethylamino + ethyl methacrylate) for delivery of oligonucleotides into tumor cells J. Drug Deliv. Sci. Technol. 16 2006 245 252
201. S.V. Vinogradov, E.V. Batrakova, S. Li, and A.V. Kabanov Mixed polymer micelles of amphiphilic and cationic copolymers for delivery of antisense oligonucleotides J. Drug Target. 12 2004 517 526
202. M. Wang, B. Wu, P. Lu, C. Cloer, J.D. Tucker, and Q. Lu Polyethylenimine-modified pluronics (PCMs) improve morpholino oligomer delivery in cell culture and dystrophic mdx mice Mol. Ther. 21 2013 210 216
203. S. Mishra, L.Y. Peddada, D.I. Devore, and C.M. Roth Poly(alkylene oxide) copolymers for nucleic acid delivery Acc. Chem. Res. 45 2012 1057 1066
204. E.V. Batrakova, S. Li, V.Y. Alakhov, D.W. Miller, and A.V. Kabanov Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells J. Pharmacol. Exp. Ther. 304 2003 845 854
205. Z. Yang, G. Sahay, S. Sriadibhatla, and A.V. Kabanov Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA Bioconjug. Chem. 19 2008 1987 1994
206. X. Yi, E. Batrakova, W.A. Banks, S. Vinogradov, and A.V. Kabanov Protein conjugation with amphiphilic block copolymers for enhanced cellular delivery Bioconjug. Chem. 19 2008 1071 1077
207. S.J. Huang, T.P. Wang, S.I. Lue, and L.F. Wang Pentablock copolymers of Pluronic F127 and modified poly(2-dimethyl amino)ethyl methacrylate for internalization mechanism and gene transfection studies Int. J. Nanomedicine 8 2013 2011 2027
208. K. Takara, T. Sakaeda, and K. Okumura An update on overcoming MDR1-mediated multidrug resistance in cancer chemotherapy Curr. Pharm. Des. 12 2006 273 286
209. G. Szakacs, J.K. Paterson, J.A. Ludwig, C. Booth-Genthe, and M.M. Gottesman Targeting multidrug resistance in cancer Nat. Rev. Drug Discov. 5 2006 219 234
210. L. Xiao, X. Xiong, X. Sun, Y. Zhu, H. Yang, H. Chen, L. Gan, H. Xu, and X. Yang Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles Biomaterials 32 2011 5148 5157
211. J. Wang, H. Qu, L. Jin, W. Zeng, L. Qin, F. Zhang, X. Wei, W. Lu, C. Zhang, and W. Liang Pegylated phosphotidylethanolamine inhibiting P-glycoprotein expression and enhancing retention of doxorubicin in MCF7/ADR cells J. Pharm. Sci. 100 2011 2267 2277
212. E.M. Collnot, C. Baldes, M.F. Wempe, R. Kappl, J. Huttermann, J.A. Hyatt, K.J. Edgar, U.F. Schaefer, and C.M. Lehr Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity Mol. Pharm. 4 2007 465 474
213. E.V. Batrakova, S. Li, Y. Li, V.Y. Alakhov, and A.V. Kabanov Effect of pluronic P85 on ATPase activity of drug efflux transporters Pharm. Res. 21 2004 2226 2233
214. E.V. Batrakova, S. Li, W.F. Elmquist, D.W. Miller, V.Y. Alakhov, and A.V. Kabanov Mechanism of sensitization of MDR cancer cells by pluronic block copolymers: selective energy depletion Br. J. Cancer 85 2001 1987 1997
215. E.V. Batrakova, S. Li, S.V. Vinogradov, V.Y. Alakhov, D.W. Miller, and A.V. Kabanov Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization J. Pharmacol. Exp. Ther. 299 2001 483 493
216. A.V. Kabanov Polymer genomics: an insight into pharmacology and toxicology of nanomedicines Adv. Drug Deliv. Rev. 58 2006 1597 1621
217. Z. Wei, S. Yuan, J. Hao, and X. Fang Mechanism of inhibition of P-glycoprotein mediated efflux by Pluronic P123/F127 block copolymers: relationship between copolymer concentration and inhibitory activity Eur. J. Pharm. Biopharm. 83 2013 266 274
218. C.P. Oliveira, L.C. Vasconcellos, M.E. Ribeiro, N.M. Ricardo, T.V. Souza, M. Costa Fde, C. Chaibundit, S.G. Yeates, and D. Attwood The effect of polymeric additives on the solubilisation of a poorly-soluble drug in micellar solutions of Pluronic F127 Int. J. Pharm. 409 2011 206 208
219. A. Unciti-Broceta, F. Diezmann, C.Y. Ou-Yang, M.A. Fara, and M. Bradley Synthesis, penetrability and intracellular targeting of fluorescein-tagged peptoids and peptide-peptoid hybrids Bioorg. Med. Chem. 17 2009 959 966
220. H.Y. Wang, J.X. Chen, Y.X. Sun, J.Z. Deng, C. Li, X.Z. Zhang, and R.X. Zhuo Construction of cell penetrating peptide vectors with N-terminal stearylated nuclear localization signal for targeted delivery of DNA into the cell nuclei J. Control. Release 155 2011 26 33
221. Y.Y. Li, L. Li, H.Q. Dong, X.J. Cai, and T.B. Ren Pluronic F127 nanomicelles engineered with nuclear localized functionality for targeted drug delivery Mater. Sci. Eng. C Mater. Biol. Appl. 33 2013 2698 2707
222. M.R. Hodel, A.H. Corbett, and A.E. Hodel Dissection of a nuclear localization signal J. Biol. Chem. 276 2001 1317 1325
223. K.T. Oh, T.K. Bronich, and A.V. Kabanov Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic block copolymers J. Control. Release 94 2004 411 422
224. I. Pepic, J. Lovric, A. Hafner, and J. Filipovic-Grcic Powder form and stability of Pluronic mixed micelle dispersions for drug delivery applications Drug Dev. Ind. Pharm. 40 2014 944 951
225. M.S.H. Akash, K. Rehman, and S. Chen Polymeric-based particulate systems for delivery of therapeutic proteins Pharm. Dev. Technol. 2015 10.3109/10837450.10832014.10999785
226. T. Nakanishi, S. Fukushima, K. Okamoto, M. Suzuki, Y. Matsumura, M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka Development of the polymer micelle carrier system for doxorubicin J. Control. Release 74 2001 295 302
227. W. Xu, Y. Cui, P. Ling, and L.B. Li Preparation and evaluation of folate-modified cationic pluronic micelles for poorly soluble anticancer drug Drug Deliv. 19 2012 208 219
228. Z. Du, S. Pan, Q. Yu, Y. Li, Y. Wen, W. Zhang, M. Feng, and C. Wu Paclitaxel-loaded micelles composed of folate-poly (ethylene glycol) and poly (γ-benzyl l-glutamate) diblock copolymer Colloids Surf. A Physicochem. Eng. Asp. 353 2010 140 148
229. F.M. Andreopoulos, and I. Persaud Delivery of basic fibroblast growth factor (bFGF) from photoresponsive hydrogel scaffolds Biomaterials 27 2006 2468 2476
230. B. Balakrishnan, M. Mohanty, A.C. Fernandez, P.V. Mohanan, and A. Jayakrishnan Evaluation of the effect of incorporation of dibutyryl cyclic adenosine monophosphate in an in situ-forming hydrogel wound dressing based on oxidized alginate and gelatin Biomaterials 27 2006 1355 1361
231. K. Hori, C. Sotozono, J. Hamuro, K. Yamasaki, Y. Kimura, M. Ozeki, Y. Tabata, and S. Kinoshita Controlled-release of epidermal growth factor from cationized gelatin hydrogel enhances corneal epithelial wound healing J. Control. Release 118 2007 169 176
232. H.J. Yoo, and H.D. Kim Synthesis and properties of waterborne polyurethane hydrogels for wound healing dressings J. Biomed. Mater. Res. B Appl. Biomater. 85 2008 326 333
233. J.S. Choi, and H.S. Yoo Pluronic/chitosan hydrogels containing epidermal growth factor with wound-adhesive and photo-crosslinkable properties J. Biomed. Mater. Res. A 95 2010 564 573
234. J.K. Armstrong, H.J. Meiselman, and T.C. Fisher Inhibition of red blood cell-induced platelet aggregation in whole blood by a nonionic surfactant, poloxamer 188 (RheothRx injection) Thromb. Res. 79 1995 437 450
235. E.V. Batrakova, S. Li, Y. Li, V.Y. Alakhov, W.F. Elmquist, and A.V. Kabanov Distribution kinetics of a micelle-forming block copolymer Pluronic P85 J. Control. Release 100 2004 389 397