Pluronic-based cationic block copolymer for forming pDNA polyplexes with enhanced cellular uptake and improved transfection efficiency

Biomaterials

Volumn 32, Issue 20, 2011, Pages 4594-4603

  Lai, Tsz Chung ^a   Kataoka, Kazunori ^b   Kwon, Glen S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Non viral gene delivery; PDNA; Pluronic; Polyplex

Indexed keywords

BIOMACROMOLECULES; CATIONIC POLYMERS; CATIONOMERS; CELLULAR INTERNALIZATION; CELLULAR UPTAKE; ENHANCED STABILITY; GENE DELIVERY; NON-VIRAL GENE DELIVERY; PDNA; PEGYLATION; PLASMA MEMBRANES; PLASMID DNA (PDNA); PLURONIC BLOCK COPOLYMERS; PLURONICS; POLYPLEX; POLYPLEXES; SMALL MOLECULES; TRANSFECTION ABILITY; TRANSFECTION EFFICIENCY;

BLOCK COPOLYMERS; CELL MEMBRANES; COPOLYMERIZATION; EFFICIENCY; GENE THERAPY; GENE TRANSFER; POLYMERS; SURFACE ACTIVE AGENTS; VIRUSES;

GENE EXPRESSION;

MACROGOL; PLASMID DNA; POLOXAMER;

ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; DRUG UPTAKE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; INTERNALIZATION; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL;

AMINES; CATIONS; CELL LINE, TUMOR; DNA; GENE TRANSFER TECHNIQUES; HUMANS; MATERIALS TESTING; MOLECULAR STRUCTURE; POLOXAMER; POLYETHYLENE GLYCOLS; POLYMERS; TRANSFECTION;

EID: 79955522937     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.02.065     Document Type: Article

References (31)

1. Lehrman S. Virus treatment questioned after gene therapy death. Nature 1999, 401:517-518.
2. Cavazzana-Calvo M., Lagresle C., Hacein-Bey-Abina S., Fischer A. Gene therapy for severe combined immunodeficiency. Annu Rev Med 2005, 56:585-602.
3. Merdan T., Kopecek J., Kissel T. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv Drug Deliv Rev 2002, 54:715-758.
4. Pack D.W., Hoffman A.S., Pun S., Stayton P.S. Design and development of polymers for gene delivery. Nat Rev Drug Discov 2005, 4:581-593.
5. Klibanov A.L., Maruyama K., Torchilin V.P., Huang L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett 1990, 268:235-237.
6. Senior J., Delgado C., Fisher D., Tilcock C., Gregoriadis G. Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. Biochim Biophys Acta 1991, 1062:77-82.
7. Yokoyama M., Okano T., Sakurai Y., Ekimoto H., Shibazaki C., Kataoka K. Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res 1991, 51:3229-3236.
8. Merdan T., Kunath K., Petersen H., Bakowsky U., Voigt K.H., Kopecek J., et al. PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice. Bioconjug Chem 2005, 16:785-792.
9. Ogris M., Brunner S., Schuller S., Kircheis R., Wagner E. PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther 1999, 6:595-605.
10. Takae S., Miyata K., Oba M., Ishii T., Nishiyama N., Itaka K., et al. PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors. J Am Chem Soc 2008, 130:6001-6009.
11. Mishra S., Webster P., Davis M.E. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur J Cell Biol 2004, 83:97-111.
12. Hatakeyama H., Akita H., Kogure K., Oishi M., Nagasaki Y., Kihira Y., et al. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Ther 2007, 14:68-77.
13. Ogris M., Steinlein P., Carotta S., Brunner S., Wagner E. DNA/polyethylenimine transfection particles: influence of ligands, polymer size, and PEGylation on internalization and gene expression. AAPS PharmSci 2001, 3:E21.
14. Oba M., Fukushima S., Kanayama N., Aoyagi K., Nishiyama N., Koyama H., et al. Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alpha(v)beta(3) and alpha(v)beta(5) Integrins. Bioconjug Chem 2007, 18:1415-1423.
15. Kanayama N., Fukushima S., Nishiyama N., Itaka K., Jang W.D., Miyata K., et al. A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells. Chemmedchem 2006, 1:439-444.
16. Itaka K., Ishii T., Hasegawa Y., Kataoka K. Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity. Biomaterials 2010, 31:3707-3714.
17. Miyata K., Fukushima S., Nishiyama N., Yamasaki Y., Kataoka K. PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy. J Control Release 2007, 122:252-260.
18. Han M., Bae Y., Nishiyama N., Miyata K., Oba M., Kataoka K. Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies. J Control Release 2007, 121:38-48.
19. Batrakova E.V., Li S., Alakhov V.Y., Miller D.W., Kabanov A.V. Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells. J Pharmacol Exp Ther 2003, 304:845-854.
20. Batrakova E.V., Vinogradov S.V., Robinson S.M., Niehoff M.L., Banks W.A., Kabanov A.V. Polypeptide point modifications with fatty acid and amphiphilic block copolymers for enhanced brain delivery. Bioconjug Chem 2005, 16:793-802.
21. Yi X., Batrakova E., Banks W.A., Vinogradov S., Kabanov A.V. Protein conjugation with amphiphilic block copolymers for enhanced cellular delivery. Bioconjug Chem 2008, 19:1071-1077.
22. Yang Z., Sahay G., Sriadibhatla S., Kabanov A.V. Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA. Bioconjug Chem 2008, 19:1987-1994.
23. Bromberg L., Deshmukh S., Temchenko M., Iourtchenko L., Alakhov V., Alvarez-Lorenzo C., et al. Polycationic block copolymers of poly(ethylene oxide) and poly(propylene oxide) for cell transfection. Bioconjug Chem 2005, 16:626-633.
24. Vinogradov S.V., Batrakova E.V., Li S., Kabanov A.V. Mixed polymer micelles of amphiphilic and cationic copolymers for delivery of antisense oligonucleotides. J Drug Target 2004, 12:517-526.
25. Darly W.H., Poche D. The preparation of N-carboxyanhydrides of a-aminoacids using bis(trichloromethyl)carbonate. Tetrahedron Lett 1988, 29:5859-5862.
26. Li J.T., Carlsson J., Lin J.N., Caldwell K.D. Chemical modification of surface active poly(ethylene oxide)-poly (propylene oxide) triblock copolymers. Bioconjug Chem 1996, 7:592-599.
27. Harada A., Kataoka K. Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely-charged block-copolymers with poly(ethylene glycol) segments. Macromolecules 1995, 28:5294-5299.
28. Hatakeyama H., Akita H., Harashima H. A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. Adv Drug Deliv Rev 2010.
29. Miyata K., Oba M., Nakanishi M., Fukushima S., Yamasaki Y., Koyama H., et al. Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity. J Am Chem Soc 2008, 130:16287-16294.
30. Oba M., Miyata K., Osada K., Christie R.J., Sanjoh M., Li W., et al. Polyplex micelles prepared from omega-cholesteryl PEG-polycation block copolymers for systemic gene delivery. Biomaterials 2011, 32:652-663.
31. Sriadibhatla S., Yang Z., Gebhart C., Alakhov V.Y., Kabanov A. Transcriptional activation of gene expression by pluronic block copolymers in stably and transiently transfected cells. Mol Ther 2006, 13:804-813.