Mechanism of inhibition of P-glycoprotein mediated efflux by Pluronic P123/F127 block copolymers: Relationship between copolymer concentration and inhibitory activity

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 83, Issue 2, 2013, Pages 266-274

  Wei, Zhang ^a,b   Yuan, Shi ^c   Hao, Junguo ^a,b   Fang, Xiaoling ^a,b  

^a FUDAN UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c Shanghai Hengrui Pharmaceuticals Co Ltd   (China)

Author keywords

Cellular uptake; Multidrug resistance; P gp; Pluronic block copolymer; Polymeric micelles

Indexed keywords

ADENOSINE TRIPHOSPHATE; COPOLYMER; DOXORUBICIN; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; POLOXAMER; RHODAMINE 123; RHODAMINE 6G; MICELLE; PLURONIC BLOCK COPOLYMER P123; POLYETHYLENE DERIVATIVE; POLYMER; POLYPROPYLENE; RHODAMINE; UCON 50-HB-5100;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CYTOTOXICITY; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; MEMBRANE POTENTIAL; MICELLE; MITOCHONDRION; MOLECULAR PROBE; MULTIDRUG RESISTANCE; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CHEMICAL PHENOMENA; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; MCF 7 CELL LINE; MEDICINAL CHEMISTRY; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PROCEDURES; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; BREAST NEOPLASMS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICELLES; P-GLYCOPROTEIN; PACLITAXEL; POLOXALENE; POLYETHYLENES; POLYMERS; POLYPROPYLENES; RHODAMINE 123; RHODAMINES;

EID: 84873731069     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.09.014     Document Type: Article

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