Polycationic block copolymers of poly(ethylene oxide) and poly(propylene oxide) for cell transfection

Bioconjugate Chemistry

Volumn 16, Issue 3, 2005, Pages 626-633

  Bromberg, Lev ^a   Deshmukh, Smeet ^a   Temchenko, Marina ^a   Iourtchenko, Ludmila ^b   Alakhov, Valery ^b   Alvarez Lorenzo, Carmen ^c   Barreiro Iglesias, Rafael ^c   Concheiro, Angel ^c   Hatton, T Alan ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b Building 18 ^*  (Canada)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCK COPOLYMERS; CERIUM OXIDE; DNA; ETHERS; ETHYLENE; FREE RADICAL POLYMERIZATION; FREE RADICALS; MOLECULAR BIOLOGY; PROPYLENE;

BLOCK CO POLYMERS; CATIONICS; CELL TRANSFECTION; DIMETHYLAMINOETHYL METHACRYLATES; METHACRYLATE COPOLYMERS; ONE STEP SYNTHESIS; PLURONIC P123; POLY(PROPYLENE OXIDE); PROPYLENE OXIDE; SURFACE ACTIVITIES;

POLYETHYLENE OXIDES;

COPOLYMER; MACROGOL; POLY(2 N (DIMETHYLAMINOETHYL)METHACRYLATE); POLY(PROPYLENE OXIDE); POLYCATION; SURFACTANT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE TARGETING; GENETIC TRANSFECTION; HYDRODYNAMICS; MOLECULAR WEIGHT; NONHUMAN; POLYMERIZATION; STOICHIOMETRY; SURFACE PROPERTY; SYNTHESIS;

EID: 18844376628     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc049749f     Document Type: Article

References (31)

1. Ilies, M. A., Seitz, W. A., and Balaban, A. T. (2002) Cationic lipids in gene delivery: principles, vector design and therapeutical applications. Curr. Pharm. Des. 8 (27), 2441-2473.
2. Gebhart, C. L., and Kabanov, A. V. (2001) Evaluation of polyplexes as gene transfer agents. J. Controlled Release 73, 401-416.
3. Merdan, T., Kopecek, J., and Kissel, T. (2002) Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv. Drug Deliv. Rev. 54 (5), 715-758.
4. Kabanov, A. V., and Kabanov, V. A. (1998) Interpolyelectrolyte and block ionomer complexes for gene delivery: physiochemical aspects. Adv. Drug Deliv. Rev. 30 (1-3), 49-60.
5. Thomas, M., and Klibanov, A. M. (2003) Non-viral gene therapy, polycation-mediated DNA delivery. Appl Microbiol Biotechnol. 62, 27-34.
6. Wagner, E. (2004) Strategies to improve DNA polyplexes for in vivo gene transfer: will "artificial viruses" be the answer? Pharm. Res. 21 (1), 8-14.
7. Nguyen, H. K., Lemieux, P., Vinogradov, S. V., Gebhart, C. L., Guerin, N., Paradis, G., Bronich, T. K., Alakhov, V. Y., and Kabanov, A. V. (2000) Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents. Gene Ther. 7 (2), 126-138.
8. Tan, J. F., Ravi, P., Tool, H. P., Hatton, T. A., and Tam, K. C. (2005) Association behavior of biotinylated and non-biotinylated poly(ethylene oxide)-o-poly(2-(diethylamino)-ethyl methacrylate). Biomacromolecules (in press).
9. Toncheva, V., Wolfert, M. A., Das, P. R., Oupicky, D., Ulbrich, K., Seymour, L. W., and Schacht, E. H. (1998) Novel vectors for gene delivery formed by self-assembly of DNA with poly-(lysine) grafted with hydrophilic polymers. Biochim. Biophys. Acta 1380, 354-368.
10. Dubruel, P., and Schacht, E. H. (2000) Effect of polyethylene oxide blocks or grafts on the physicochemical properties of poly-(2-N- (dimethylaminoethyl)methacrylate) DNA complexes of polycations and DNA. Bioact. Compat. Polym. 15, 279-296.
11. Lemieux, P., Vinogradov, S. V., Gebhart, C. L., Guerin, N., Paradis, G., Nguyen, H. K., Ochietti, B., Suzdaltseva, Y. G., Baratakova, E. V., Bronich, T. K., St-Pierre, Y., Alakhov, V. Y., and Kabanov, A. V. (2000) Block and graft copolymers and NanoGel copolymer networks for DNA delivery into cell. J. Drug Target. 8 (2), 91-105.
12. Gebhart, C. L., Sriadibhatla, S., Vinogradov, S., Lemieux, P., Alkahov, V., and Kabanov, V. A. (2002) Design and formulation of polyplexes based on Pluronic-polyethyleneimine conjugates for gene transfer. Bioconjugate Chem. 13 (5), 937-944.
13. Ochietti, B., Lemieux, P., Kabanov, A. V., Vinogradov, S., St-Pierre, Y., and Alakhov, V. (2002) Inducing neutrophil recruitment in the liver of ICAM-1-deficient mice using polyethyleneimine grafted with Pluronic P123 as an organspecific carrier for transgenic ICAM-1. Gene Ther. 14, 939-945.
14. Ochietti, B., Guerin, N., Vinogradov, S. V., St-Pierre, Y., Lemieux, P., Kabanov, A. V., and Alakhov, V. Y. (2002) Altered organ accumulation of oligonucleotides using polyethyleneimine grafted with poly(ethylene oxide) or pluronic as carriers. J. Drug Target. 2, 113-121.
15. Belenkov, A. I., Alakhov, V. Y., Kabanov, A. V., Vinogradov, S. V., Panasci, L. C., Monia, B. P., and Chow, T. Y. (2004) Polyethyleneimine grafted with pluronic P85 enhances Ku86 antisense delivery and the ionizing radiation treatment efficacy in vivo. Gene Ther. 11 (22), 1665-1672.
16. van de Wetering, P., Zuidam, N. J., van Steenbergen, M. J., van der Houwen, O. A. G. J., Underberg, M. J. M., and Hennink, W. E. (1998) A mechanistic study of hydrolytic stability of poly(2-(dimethylamino)ethyl methacrylate). Macromolecules 31, 8063-8068.
17. Vamvakaki, M., Billingham, N. C., and Armes, S. P. (1999) Synthesis of controlled structure water-soluble diblock copolymers via oxyanionic polymerization. Macromolecules 32 (6), 2088-2090.
18. Bromberg, L., Temchenko, M., and Hatton, T. A. (2003) Smart microgel studies. Polyelectrolyte and drug-absorbing properties of microgels from polyether-modified poly(acrylic acid). Langmuir 19 (21), 8675-8684.
19. Deshpande, M. C., Garnett, M. C., Vamvakaki, M., Bailey, L., Armes, S. P., and Stolnik, S. (2002) Influence of polymer architecture on the structure of complexes formed by PEG-tertiary amine methacrylate copolymers and phosphorothioate oligonucleotide. J. Controlled Release 81 (1-2), 185-199.
20. Lampela, P., Soininen, P., Urtti, A., Männistö, P. T., and Raasmaja, A. (2004) Synergism in gene delivery by small PEIs and three different nonviral vectors. Int. J. Pharm. 270, 175-184.
21. Tauer, K., Antonietti, M., Rosengarten, L., and Miller, H. (1998) Initiators based on poly(ethylene glycol) for starting heterophase polymerizations: generation of block copolymers and new particle morphologies. Macromol. Chem. Phys. 199, 897-890.
22. Tauer, P., Westbroek, J., De Strycker, P., Dubruel, P., Temmerman, E., and Schacht, E. H. (2002) Flow-through cell for on-line amperometric determination of Ce(IV) during polymerization reactions. Anal. Chem. 74, 915-920.
23. Nagarajan, S., Sabdham, K., and Spinivasan, V. (1995) Redox polymerization process: an efficient tool for the synthesis of block copolymers. J. Polym. Sci., Polym. Chem. 33, 2925-2933.
24. Rungsardthong, U., Deshpande, M., Bailey, L., Vamvakaki, M., Armes, S. P., Garnett, M. C., and Stolnik, S. (2001) Copolymers of amine methacrylate with poly(ethylene glycol) as vectors for gene therapy. J. Controlled Release 73 (2-3), 359-380.
25. Přádny, M., and Ševčik, S. (1987) Precursors of hydrophilic polymers, 7. Potentiometric properties and structure of copolymers of 2-dimethylaminoethyl methacrylate. Makromol. Chem. 188 (2), 227-238.
26. Batrakova, E., Lee, S., Li, S., Venne, A., Alakhov, V., and Kabanov, A. (1999) Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells. Pharm. Res. 16 (9), 1373-1379.
27. Kozlov, M. Y., Melik-Nubarov, N. S., Batrakova, E. V., and Kabanov, A. V. (2000) Relationship between pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes. Macromolecules 33 (9), 3305-3313.
28. 2O microemulsions by tuning the temperature. Langmuir 19 (21), 8611-8614.
29. An, S. W., Thomas, R. K., Baines, F. L., Bullingham, N. C., Armes, S. P., and Penfold, J. (1998) Neutron reflectivity of an adsorbed water-soluble block copolymer at the air/water interface: the effects of pH and ionic strength. J. Phys. Chem. B 102, 5120-5126.
30. Krylova, O. O., Melik-Nubarov, N. S., Badun, G. A., Ksenofontov, A. L., Menger, F. M., and Yaroslavov, A. A. (2003) Pluronic L61 accelerates flip-flop and transbilayer doxorubicin permeation. Chemistry 9 (16), 3930-3936.
31. Kuo, J.-H. S. (2003) Effect of Pluronic block copolymers on the reduction of serum-mediated inhibition of gene transfer of polyethyleneimine-DNA complexes. Biotechnol. Appl. Biochem. 37, 267-271.