Difunctional Pluronic copolymer micelles for paclitaxel delivery: Synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines

International Journal of Pharmaceutics

Volumn 337, Issue 1-2, 2007, Pages 63-73

  Wang, Yongzhong ^a,b   Yu, Li ^c   Han, Limei ^a   Sha, Xianyi ^a   Fang, Xiaoling ^a  

^a FUDAN UNIVERSITY   (China)

^b ANHUI UNIVERSITY   (China)

^c ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Folate; Micelles; Multidrug resistance (MDR); Paclitaxel; Pluronic block copolymer; Tumor cell targeting

Indexed keywords

COPOLYMER; COPOLYMER L101; COPOLYMER P105; DRUG CARRIER; FOLATE RECEPTOR; FOLIC ACID; PACLITAXEL; POLOXAMER; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CELL KILLING; COVALENT BOND; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG POTENTIATION; DRUG UPTAKE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INTERNALIZATION; MICELLE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL MEMBRANE; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG COMPOUNDING; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; FOLIC ACID; HUMANS; INHIBITORY CONCENTRATION 50; MICELLES; PACLITAXEL; POLOXAMER; RECEPTORS, CELL SURFACE; SOLUBILITY; TIME FACTORS;

EID: 34248588338     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.12.033     Document Type: Article

References (23)

1. Alakhov V.Y., Moskaleva E.Y., Batrakova E.V., and Kabanov A.V. Hypersensitization of multidrug resistant human ovarian carcinoma cells by Pluronic P85 block copolymer. Bioconjug. Chem. 7 (1996) 209-216
2. Caldwell, K.M.E., Carlsson, P.J.E., Li, J.T., 1996. Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands. United States Patent No. 551,670 (14 May).
3. Fujita H., Ooya T., and Yui N. Thermally induced localization of cyclodextrins in a polyrotaxane consisting of β-cyclodextrins and poly(ethylene glycol)-poly(propylene glycol) triblock copolymer. Macromolecules 32 (1999) 2534-2541
4. Gaisford S., Beezer E.A., and Mitchell C.J. Diode-array UV spectrometric evidence for cooperative interactions in binary mixtures of Pluronics F77, F87, and F127. Langmuir 13 (1997) 2606-2607
5. Kabanov A.V., Batrakova E.V., and Alakhov V.Y. Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery. J. Contr. Release 82 (2002) 189-212
6. Kabanov A.V., Batrakova E.V., and Alakhov V.Y. Pluronic block copolymers for overcoming drug resistance in cancer. Adv. Drug Deliv. Rev. 54 (2002) 759-779
7. Kim S.C., Kim D.W., Shim Y.H., Bang J.S., Oh H.S., Wan K.S., and Seo M.H. In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy. J. Contr. Release 72 (2001) 191-202
8. Krishnadas A., Rubinstein I., and Onyuksel H. Sterically stabilized phospholipid mixed micelles: in vitro evaluation as a novel carrier for water-insoluble drugs. Pharm. Res. 20 (2003) 297-302
9. Lee J.R., and Low S.P. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. Biochim. Biophys. Acta 1233 (1995) 134-144
10. Lee S.C., Kim C., Kwon I.C., Chung H., and Jeong S.Y. Polymeric micelles of poly(2-ethyl-2-oxazoline)-block-poly(epsilon-caprolactone) copolymer as a carrier for paclitaxel. J. Contr. Release 89 (2003) 437-446
11. Lee E.S., Na K., and Bae Y.H. Polymeric micelle for tumor pH and folate-mediated targeting. J. Contr. Release 91 (2003) 103-113
12. Lee E.S., Na K., and Bae Y.H. Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor. J. Contr. Release 103 (2005) 405-418
13. Minko T., Batrakova E.V., Li S., Li Y., Pakunlu R.I., Alakhov V.Y., and Kabanov A.V. Pluronic block copolymers alter apoptotic signal transduction of doxorubicin in drug-resistant cancer cells. J. Contr. Release 105 (2005) 269-278
14. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
15. Nagarajan R. Solubilization of hydrocarbons and resulting aggregate shape transitions in aqueous solutions of Pluronic (PEO-PPO-PEO) block copolymers. Colloids Surf. B: Biointerfaces 16 (1999) 55-72
16. Nagarajan R., and Ganesh K. Comparison of solubilization of hydrocarbons in (PEO-PPO) diblock versus (PEO-PPO-PEO) triblock copolymer micelles. J. Colloid Interface Sci. 184 (1996) 489-499
17. Oh K.T., Bronich T.K., and Kabanov A.V. Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic block copolymers. J. Contr. Release 94 (2004) 411-422
18. Rapoport N., Pitt W.G., Sun H., and Nelson J.L. Drug delivery in polymeric micelles: from in vitro to in vivo. J. Contr. Release 91 (2003) 85-95
19. Rowinsky E.K. Donehower R.C., Paclitaxel (taxol). N. Engl. J. Med. 332 (1995) 1004-1014
20. Singla A.K., Garg A., and Aggarwal D. Paclitaxel and its formulations. Int. J. Pharm. 235 (2002) 179-192
21. Thomas H., and Coley H.M. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting P-glycoprotein. Cancer Control 10 (2003) 159-165
22. Vredenburg R.M., Ojima I., Veith J., Pera P., Kee K., Cabral F., Sharma A., Kanter P., Greco W.R., and Bernacki R.J. Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance. J. Natl. Cancer Inst. 93 (2001) 1234-1245
23. Zhang X., Jackson J.K., and Burt H.M. Development of amphiphilic diblock copolymers as micellar carriers of taxol. Int. J. Pharm. 132 (1996) 195-206