Pegylation of a chlorine6 polymer conjugate increases tumor targeting of photosensitizer

Cancer Research

Volumn 61, Issue 19, 2001, Pages 7155-7162

  Hamblin, M R ^a   Miller, J L ^a   Rizvi, I ^a   Ortel, B ^a   Maytin, E V ^a   Hasan, T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL; PHOTOSENSITIZING AGENT; POLYLYSINE; POLYMER; RADICAL; SINGLET OXYGEN; TALAPORFIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL TYPE; CHEMICAL MODIFICATION; CONFOCAL MICROSCOPY; CONJUGATION; CONTROLLED STUDY; ELECTRON TRANSPORT; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; ILLUMINATION; MACROPHAGE; MOUSE; NONHUMAN; NUDE MOUSE; OVARY CARCINOMA; OXYGEN CONSUMPTION; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; PRIORITY JOURNAL;

ANIMALS; FEMALE; HUMANS; MACROPHAGES; MICE; MICE, NUDE; OVARIAN NEOPLASMS; OXYGEN CONSUMPTION; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POLYETHYLENE GLYCOLS; POLYLYSINE; PORPHYRINS; SUBCELLULAR FRACTIONS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035476243     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Photophysical and photobiological processes in the photodynamic therapy of tumours
2. Intraperitoneal photodynamic therapy of human epithelial ovarian carcinomatosis in a xenograft murine model
3. Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates
4. Biodistribution of charged F(ab′)2 photoimmunoconjugates in a xenograft model of ovarian cancer
5. Treatment of ovarian cancer with photodynamic therapy and immunoconjugates in a murine ovarian cancer model
6. Monoclonal antibody delivery to intraperitoneal tumors in rats: Effects of route of administration and intraperitoneal solution osmolality
7. Human antibody response to the intravenous and intraperitoneal administration of the F(ab′)2 fragment of the OC125 murine monoclonal antibody
8. Photosensitizer delivery mediated by macromolecular carrier systems
9. The uses and properties of PEG-linked proteins
10. Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol
11. Long-circulating (sterically stabilized) liposomes for targeted drug delivery
12. Effect of charge on the interaction of site-specific photoimmunoconjugates with human ovarian cancer cells
13. Tissue localization of photosensitizers and the mechanism of photodynamic tissue destruction
14. Effect of photodynamic therapy on tumor necrosis factor production by murine macrophages
15. The effect of charge on cellular uptake and phototoxicity of polylysine chlorin(e6) conjugates
16. Quantitative analysis of polyethylene glycol (PEG) in PEG-modified proteins/cytokines by aqueous two-phase systems
17. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples
18. MTT assays allow quick and reliable measurement of the response of human turnout cells to photodynamic therapy
19. Characterization of a xenograft model of human ovarian carcinoma which produces intraperitoneal carcinomatosis and metastases in mice
20. The nature of the chromophore responsible for naturally occurring fluorescence in mouse skin
21. A recipe for the preparation of a rodent food that eliminates chlorophyll-based tissue fluorescence
22. Biodistribution of charged 17.1A photoimmunoconjugates in a murine model of hepatic metastasis of colorectal cancer
23. Do all programmed cell deaths occur via apoptosis?
24. Surface modification of haemoglobin-containing liposomes with polyethylene glycol prevents liposome aggregation in blood plasma
25. Hematoporphyrin, and HPD: Photophysics, photochemistry and phototherapy
26. Aggregation effects on the photophysical properties of porphyrins in relation to mechanisms involved in photodynamic therapy
27. Type I and type II mechanisms in the photosensitized lysis of phosphatidylcholine liposomes by hematoporphyrin
28. Differential role of reactive oxygen intermediates in photofrin-I- and photofrin-II-mediated photoenhancement of lipid peroxidation in epidermal microsomal membranes
29. Effects of the micro-environment on the photophysical properties of hematoporphyrin
30. Phototransformations of sensitizers. 1. Significance of the nature of the sensitizer in the photobleaching process and photoproduct formation in aqueous solution
31. Quantum yields and kinetics of the photobleaching of hematoporphyrin. Photofrin II, tetra(4-sulfonatophenyl)-porphine and uroporphyrin
32. Polymer conjugates. Pharmacokinetic considerations for design and development
33. Uptake, intracellular transport, and degradation of polyethylene glycol-modified asialofetuin in hepatocytes
34. Photodynamic therapy: A mitochondrial inducer of apoptosis
35. Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy
36. Photodynamic destruction of lysosomes mediated by Nile blue photosensitizers
37. Subcellular localization patterns and their relationship to photodynamic activity of pyropheophorbide-a derivatives
38. Quantitative analysis of Pc 4 localization in mouse lymphoma (LY-R) cells via double-label confocal fluorescence microscopy
39. Subcellular localization of merocyanine 540 (MC540) and induction of apoptosis in murine myeloid leukemia cells
40. Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates
41. Antioxidant enzyme levels in cancer
42. Enhanced macrophage cytotoxicity against tumor cells treated with photodynamic therapy