Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin: In vivo biodistribution and anti-tumor activity

Biomaterials

Volumn 27, Issue 1, 2006, Pages 119-126

  Jae, Hyung Park ^a,b   Kwon, Seunglee ^a   Lee, Minsu ^a   Chung, Hesson ^a   Kim, Ji Hyun ^c   Kim, Yoo Shin ^c   Park, Rang Woon ^c   Kim, In San ^c   Sang, Bong Seo ^d   Kwon, Ick Chan ^a   Seo, Young Jeong ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Kyung Hee University   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

^d JAKWANG Co Ltd   (South Korea)

Author keywords

Drug delivery; Glycol chitosan; Nanoparticle; Self assembly

Indexed keywords

BLOOD; CONCENTRATION (PROCESS); MAGNETIC PERMEABILITY; NANOSTRUCTURED MATERIALS; TUMORS;

DRUG DELIVERY; GLYCOL CHITOSAN; SELF-ASSEMBLED NANOPARTICLES; SOLID TUMORS;

SELF ASSEMBLY;

CHITOSAN; DOXORUBICIN; DRUG CARRIER; FLUORESCEIN ISOTHIOCYANATE; GLYCOL CHITOSAN; NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD LEVEL; CHEMICAL MODIFICATION; CONJUGATE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; HEART; HYDROPHOBICITY; IN VIVO STUDY; LIVER; LUNG PARENCHYMA; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOCOMPATIBLE MATERIALS; BODY WEIGHT; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CHITOSAN; DOXORUBICIN; FLUORESCEIN-5-ISOTHIOCYANATE; LUNG; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; MYOCARDIUM; NANOSTRUCTURES; NEOPLASM TRANSPLANTATION; SWINE; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 24044459756     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2005.05.028     Document Type: Article

References (45)

1. K. Kataoka, T. Matsumoto, M. Yokoyama, T. Okano, Y. Sakurai, S. Fukushima, K. Okamoto, and G.S. Kwon Doxorubicin-loaded poly(ethylene glycol)-poly(β-benzyl-l-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance J Control Release 64 2000 143 153
2. A. Lavasanifar, J. Samuel, and G.S. Kwon Poly(ethylene oxide)-block-poly(l-amino acid) micelles for drug delivery Adv Drug Deliv Rev 54 2002 169 190
3. J.A. Hubbell Enhancing drug function Science 300 2003 595 596
4. Y. Matsumura, and H. Maeda A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent SMANCS Cancer Res 46 1986 6387 6392
5. R. Duncan Polymer conjugates for tumour targeting and intracytoplasmic delivery. The EPR effect as a common gateway Pharm Sci Technol Today 2 1999 441 449
6. R. Gref, Y. Minamitake, M.T. Peracchia, V. Trubetskoy, V. Torchilin, and R. Langer Biodegradable long-circulating polymeric nanospheres Science 263 1994 1600 1603
7. T. Nakanishi, S. Fukushima, K. Okamoto, M. Suzuki, Y. Matsumura, M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka Development of the polymeric micelle carrier system for doxorubicin J Control Release 74 2001 295 302
8. S.C. Lee, Y. Chang, J. Yoon, C. Kim, I.C. Kwon, Y. Kim, and S.Y. Jeong Synthesis and micellar characterization of amphiphilic diblock copolymers based on poly(2-ethyl-2-oxazoline) and aliphatic polyesters Macromolecules 32 1999 1847 1852
9. C. Kim, S.C. Lee, S.W. Kang, I.C. Kwon, Y.H. Kim, and S.Y. Jeong Synthesis and the micellar characteristics of poly(ethylene oxide)-deoxycholic acid conjugates Langmuir 16 2000 4792 4797
10. K.M. Huh, K.Y. Lee, I.C. Kwon, Y.H. Kim, C. Kim, and S.Y. Jeong Synthesis of triarmed poly(ethylene oxide)-deoxycholic acid conjugate and its micellar characteristics Langmuir 16 2000 10566 10568
11. T. Nishikawa, K. Akiyoshi, and J. Sunamoto Macromolecular complexation between bovine serum albumin and the self-assembled hydrogel nanoparticle of hydrophobized polysaccharides J Am Chem Soc 118 1996 6110 6115
12. M. Nichifor, A. Lopes, A. Carpoy, and E. Melo Aggregation in water of dextran hydrophobically modified with bile acids Macromolecules 32 1999 7078 7085
13. K. Na, E.S. Lee, and Y.H. Bae Adriamycin loaded pullulan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH-dependent cell interaction, internalization and cytotoxicity in vitro J Control Release 87 2003 3 13
14. H. Onishi, T. Nagai, and Y. Machida Applications of chitin, chitosan, and their derivatives to drug carriers for microparticulated or conjugated drug delivery systems M.F.A. Goosen Applications of chitin and chitosan 1997 Technomic Publishing Co. Inc. Lancaster 205 231
15. K.Y. Lee, J.H. Kim, I.C. Kwon, and S.Y. Jeong Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin Colloid Polym Sci 278 2000 1216 1219
16. E. Ruel-Gariepy, G. Leclair, P. Hildgen, A. Gupta, and J.C. Leroux Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules J Control Release 82 2002 373 383
17. K. Roy, H.Q. Mao, S.K. Huang, and K.W. Leong Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy Nat Med 5 1999 380 381
18. Y.H. Kim, S.H. Gihm, C.R. Park, K.Y. Lee, T.W. Kim, I.C. Kwon, H. Chung, and S.Y. Jeong Structural characteristics of size-controlled self-aggregates of deoxycholic acid-modified chitosan and their application as a DNA delivery carrier Bioconjugate Chem 12 2001 932 938
19. M. Koping-Hoggard, I. Tubulekas, H. Guan, K. Edwards, M. Nilsson, K.M. Varum, and P. Artursson Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo Gene Ther 8 2001 1108 1121
20. S. Hirano Chitin and chitosan as novel biotechnological materials Polym Int 48 1999 732
21. G. Molinaro, J. Leroux, J. Damas, and A. Adam Biocompatibility of thermosensitive chitosan-based hydrogels: an in vivo experimental approach to injectable biomaterials Biomaterials 23 2002 2717 2722
22. J.H. Park, Y.W. Cho, H. Chung, I.C. Kwon, and S.Y. Jeong Synthesis and characterization of sugar-bearing chitosan derivatives: aqueous solubility and biodegradability Biomacromolecules 4 2003 1087 1091
23. C. Dufes, A.G. Schätzlein, L. Tetley, A.I. Gray, D.G. Watson, J.C. Olivier, W. Couet, and I.F. Uchegbu Niosomes and polymeric chitosan based vesicles bearing transferring and glucose ligands for drug targeting Pharm Res 17 2000 1250 1258
24. R. Hejazi, and M. Amiji Chitosan-based gastrointestinal delivery systems J Control Release 89 2003 151 165
25. K.Y. Lee, W.H. Jo, I.C. Kwon, Y.H. Kim, and S.Y. Jeong Structure determination and interior polarity of self-aggregates prepared from deoxycholic acid-modified chitosan in water Macromolecules 31 1998 378 383
26. K.Y. Lee, I.C. Kwon, Y.H. Kim, W.H. Jo, and S.Y. Jeong Preparation of chitosan self-aggregates as a gene delivery system J Control Release 51 1998 213 220
27. N. Kubota, N. Tatsumoto, T. Sano, and K. Toya A simple preparation of half N-acetylated chitosan highly soluble in water and aqueous organic solvents Carbohydr Res 324 2000 268 274
28. H. Sashiwa, N. Kawasaki, A. Nakayama, E. Muraki, N. Yamamoto, and S. Aiba Chemical modification of chitosan. 14: synthesis of water-soluble chitosan derivatives by simple acetylation Biomacromolecules 3 2002 1126 1128
29. I.F. Uchegbu, L. Sadiq, M. Arastoo, A.I. Gray, W. Wang, R.D. Waigh, and A.G. Schätzlein Quaternary ammonium palmitoyl glycol chitosan - a new polysoap for drug delivery Int J Pharm 224 2001 185 199
30. L. Martin, C.G. Wilson, F. Koosha, L. Tetley, A.I. Gray, S. Senel, and I.F. Uchegbu The release of model macromolecules may be controlled by the hydrophobicity of palmitoyl glycol chitosan hydrogels J Control Release 80 2002 87 100
31. Y.J. Son, J.S. Jang, Y.W. Cho, H. Chung, R.W. Park, I.C. Kwon, I.S. Kim, J.Y. Park, S.B. Seo, C.R. Park, and S.Y. Jeong Biodistribution and anti-tumor efficacy of doxorubicin loaded glycol-chitosan nanoaggregates by EPR effect J Control Release 91 2003 135 145
32. S. Kwon, J.H. Park, H. Chung, I.C. Kwon, S.Y. Jeong, and I.S. Kim Physicochemical characteristics of self-assembled nanoparticles based on glycol chitosan bearing 5β-cholanic acid Langmuir 19 2003 10188 10193
33. J.H. Park, S. Kwon, J.O. Nam, R.W. Park, H. Chung, S.B. Seo, I.S. Kim, I.C. Kwon, and S.Y. Jeong Self-assembled nanoparticles based on glycol chitosan bearing 5β-cholanic acid for RGD peptide delivery J Control Release 95 2004 579 588
34. G. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka Block copolymer micelles for drug delivery: loading and release of doxorubicin J Control Release 48 1997 195 201
35. H. Onishi, and Y. Machida Biodegradation and distribution of water-soluble chitosan in mice Biomaterials 20 1999 175 182
36. K. Kamiyama, H. Onishi, and Y. Machida Biodisposition characteristics of N-succinyl-chitosan and glycol-chitosan in normal and tumor-bearing mice Biol Pharm Bull 22 1999 179 186
37. G.S. Kwon, and T. Okano Polymeric micelles as new drug carriers Adv Drug Deliv Rev 21 1996 107 116
38. S. Stolnik, B. Daudali, A. Arien, J. Whetstone, C.R. Heald, M.C. Garnett, S.S. Davis, and L. Illum The effect of surface coverage and conformation of poly(ethylene oxide) (PEO) chains of poloxamer 407 on the biological fate of model colloidal drug carriers Biochim Biophys Acta 1514 2001 261 279
39. Z. Panagi, A. Beletsi, G. Evangelatos, E. Livaniou, D.S. Ithakissios, and K. Avgoustakis Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA-mPEG nanoparticles Int J Pharm 221 2001 143 152
40. R. Savić, L. Luo, A. Eisenberg, and D. Maysinger Micellar nanocontainers distribute to defined cytoplasmic organelles Science 300 2003 615 618
41. F. Yuan, M. Leunig, S.K. Huang, D.A. Berk, D. Papahadjopoulos, and R.K. Jain Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft Cancer Res 54 1994 3352 3356
42. F. Yuan, M. Dellian, D. Fukumura, M. Leunig, D.A. Berk, V.P. Torchilin, and R.K. Jain Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size Cancer Res 55 1995 3752 3756
43. M. Yokoyama, T. Okano, Y. Sakurai, H. Ekimoto, C. Shibazaki, and K. Kataoka Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood Cancer Res 51 1991 3229 3236
44. S.K. Hobbs, W.L. Monsky, F. Yuan, W.G. Roberts, L. Griffith, V.P. Torchilin, and R.K. Jain Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment Proc Natl Acad Sci USA 95 1998 4607 4612
45. H. Hashizume, P. Baluk, S. Morikawa, J.W. McLean, G. Thurston, S. Roberge, R.K. Jain, and D.M. McDonald Openings between defective endothelial cells explain tumor vessel leakiness Am J Pathol 156 2000 1363 1380